Valacyclovir clinical trials
Also written Valtrex and Valaciclovir.
A product of Acyclovir; its studies count on that page too.
How each study uses Valacyclovir is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Valacyclovir studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- 23 Jun 1995 · VALTREX · NDA 020487 (FDA, Drugs@FDA)
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
82 studies that test it; most in 2005 (8)
| Year | Studies |
|---|---|
| 1997 | 2 |
| 1998 | 1 |
| 1999 | 1 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 1 |
| 2003 | 4 |
| 2004 | 6 |
| 2005 | 8 |
| 2006 | 4 |
| 2007 | 6 |
| 2008 | 3 |
| 2009 | 5 |
| 2010 | 6 |
| 2011 | 2 |
| 2012 | 3 |
| 2013 | 3 |
| 2014 | 1 |
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 3 |
| 2018 | 2 |
| 2019 | 1 |
| 2021 | 3 |
| 2022 | 1 |
| 2023 | 4 |
| 2024 | 2 |
| 2025 | 2 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 26 · Other 61
University of Washington (8) · GlaxoSmithKline (6) · National Institute of Allergy and Infectious Diseases (NIAID) (5) · Glaxo Wellcome (4) · Mylan Pharmaceuticals Inc (3) · Radboud University Medical Center (3) · Candel Therapeutics, Inc. (2) · University of Alabama at Birmingham (2)
Often tested with
Tested in the same studies.
Aglatimagene besadenovec (2) · Valganciclovir (2) · Ganciclovir (2) · Nalotimagene carmaleucel (1) · ASP2151 (1) · Tipranavir (1) · Ritonavir (1) · Prednisolone (1)
Related medicines
As reviewed, each with the page that says it.
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Tested against it · 1 phase 3 study under way
Valacyclovir is the comparator. A study of two new drugs counts under both.
- 1Letermovir · Assistance Publique - Hôpitaux de Paris · next primary completion Aug 2029
Reaching primary completion within a year · 2
Studies that test Valacyclovir.
- Feb 2027A Biomarker Study in Men With Localized Prostate Cancer Treated With Aglatimagene BesadenovecPhase 2 · Candel Therapeutics, Inc.
- Aug 2027VZV in the Enteric Nervous System: Pathogenesis and ConsequencesPhase 4 · Vanderbilt University Medical Center
Studies
Open first, then newest update. How each study uses Valacyclovir is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 87
- SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID DysfunctionRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT07597902Written as Valacyclovir
- VZV in the Enteric Nervous System: Pathogenesis and ConsequencesRecruitingPhase 4Vanderbilt University Medical CenterNCT05550194Written as ValACYclovir 1000 MG
- A Biomarker Study in Men With Localized Prostate Cancer Treated With Aglatimagene BesadenovecRecruitingPhase 2Candel Therapeutics, Inc.NCT07332000Written as aglatimagene besadenovec + valacyclovir
- Virus-Based Gene Therapy (AdV-HSV1-TK and AdV-Flt3L) in Combination With Valacyclovir for the Treatment of Pediatric and Young Adult Patients With Resectable, Recurrent Primary Malignant Brain TumorsRecruitingPhase 1University of Michigan Rogel Cancer CenterNCT06914479Written as Valacyclovir
- Oral Herpesviruses and Oral Mucositis in Patients Receiving Head and Neck RadiotherapyEnrolling by invitationPhase 2Instituto OncoclinicasNCT07363031Written as Valacyclovir
- Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot StudyRecruitingNot applicableNational Taiwan University HospitalNCT07294547Written as Valacyclovir (Valtrex)
- Valacyclovir in Pain Management of Acute Apical AbscessesRecruitingPhase 2University of California, San FranciscoNCT05266040Written as Valacyclovir 500 MG
- Valacyclovir Monotherapy in Pain Management of Acute Periapical Abscesses After Emergency Chamber OpeningRecruitingPhase 4Dow University of Health SciencesNCT06344195Written as Valacyclovir 500 mg
- The Efficacy of Systemic Valacyclovir (Valtrex) on PeriodontitisRecruitingEarly Phase 1University of California, San FranciscoNCT05712343Written as Valacyclovir group
- Neonatal Phase 1 Valacyclovir StudyCompletedPhase 1National Institute of Allergy and Infectious Diseases (NIAID)NCT05468619Written as Valacyclovir
- Valacyclovir for Mild Cognitive ImpairmentCompletedPhase 2New York State Psychiatric InstituteNCT04710030Written as Valacyclovir hydrochloride 500mg caplet
- Anti-viral Therapy in Alzheimer's DiseaseCompletedPhase 2Columbia UniversityNCT03282916Written as Valacyclovir
- Intratumoral Gene Mediated Cytotoxic Immunotherapy in Patients With Resectable Non-Small Cell Lung CancerCompletedPhase 1Candel Therapeutics, Inc.NCT03131037Written as CAN-2409 + valacyclovir
- Valacyclovir in Neonatal Herpes Simplex Virus DiseaseCompletedPhase 1University of Alabama at BirminghamNCT04448392Written as Valacyclovir
- Effect of Valaciclovir on Inter-Appointment Pain in Endodontic Treatment of Necrotic TeethCompletedNot applicableTehran University of Medical SciencesNCT07014397Written as Valacyclovir
- Zoster Eye Disease StudyCompletedPhase 4NYU Langone HealthNCT03134196Written as Masked Oral Valacyclovir
- SBRT and Oncolytic Virus Therapy Before Pembrolizumab for Metastatic TNBC and NSCLCCompletedPhase 2The Methodist Hospital Research InstituteNCT03004183Written as Valacyclovir
- Valacyclovir 1000 mg Tablet Under Fed ConditionsCompletedPhase 1Teva Pharmaceuticals USANCT01149460Written as Valacyclovir
- Fasting Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00649974Written as Valacyclovir Hydrochloride Tablets 1000 mg
- Fed Study of Valacyclovir Hydrochloride Tablets 1000 mg and Valtrex® Tablets 1000 mgCompletedPhase 1Mylan Pharmaceuticals IncNCT00650494Written as Valacyclovir Hydrochloride Tablets 1000mg
See all 87 studies that test Valacyclovir →
Given beside what is tested · 19 — Valacyclovir is usual care or a partner of the new treatment
- Study of an AAV Mediated Dual-Payload Gene Therapy in Patients With High Grade GliomaRecruitingPhase 1/2Trogenix ltdNCT07346144Written as Valaciclovir
- Aglatimagene Besadenovec + Prodrug and Pembrolizumab vs Docetaxel for Stage IV Non-Squamous NSCLC Progressing on Pembrolizumab (AURORA)RecruitingPhase 3Candel Therapeutics, Inc.NCT07660094Written as Valacyclovir
- Efficacy of Electroacupuncture for Acute Herpes Zoster-Associated Pain and Biomarker EvaluationRecruitingNot applicableDexiong HanNCT07515885Written as Valacyclovir, pregabalin and mecobalamin
- Time-limited Triplet Combination of Pirtobrutinib, Venetoclax, and Obinutuzumab for Patients With Treatment-naïve Chronic Lymphocytic Leukemia (CLL) or Richter Transformation (RT)RecruitingPhase 2M.D. Anderson Cancer CenterNCT05536349Written as Valacyclovir
- CAN-2409 Plus Prodrug With Standard of Care Immune Checkpoint Inhibitor for Stage III/IV NSCLCActive, not recruitingPhase 2Candel Therapeutics, Inc.NCT04495153Written as Valacyclovir
- Phase 3 Study of ProstAtak® Immunotherapy With Standard Radiation Therapy for Localized Prostate CancerActive, not recruitingPhase 3Candel Therapeutics, Inc.NCT01436968Written as Aglatimagene besadenovec + valacyclovir
- Randomized Controlled Trial of CAN-2409 Immunotherapy During Active Surveillance for Prostate Cancer (ULYSSES)Active, not recruitingPhase 2Candel Therapeutics, Inc.NCT02768363Written as valacyclovir
- Bortezomib and Rituximab for Patients With Waldenstrom's MacroglobulinemiaActive, not recruitingPhase 2M.D. Anderson Cancer CenterNCT00492050Written as Valacyclovir
- GMCI, Nivolumab, and Radiation Therapy in Treating Patients with Newly Diagnosed High-Grade GliomasCompletedPhase 1Candel Therapeutics, Inc.NCT03576612Written as Valacyclovir
- Phase 2a Study of CAN-2409 With Standard Radiation Therapy for Malignant GliomaCompletedPhase 2Candel Therapeutics, Inc.NCT00589875Written as Valacyclovir
- Trial of Radiation and Gene Therapy Before Nivolumab for Metastatic Non-Small Cell Lung Carcinoma and Uveal MelanomaTerminatedPhase 2Eric Bernicker, MDNCT02831933Written as Valacyclovir
- A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain TumorsCompletedPhase 1Candel Therapeutics, Inc.NCT00634231Written as valacyclovir
- AdV-tk Therapy With Surgery and Chemoradiation for Pancreas Cancer (PaTK01)CompletedPhase 1Candel Therapeutics, Inc.NCT00638612Written as Valacyclovir
- Phase 1b Study of AdV-tk + Valacyclovir Combined With Radiation Therapy for Malignant GliomasCompletedPhase 1Candel Therapeutics, Inc.NCT00751270Written as Valacyclovir
- Intrapleural AdV-tk Therapy in Patients With Malignant Pleural EffusionCompletedPhase 1Candel Therapeutics, Inc.NCT01997190Written as AdV-tk + valacyclovir
- Safety and Efficacy Comparator Trial of a New Drug Against Genital HerpesTerminatedPhase 2AiCuris Anti-infective Cures AGNCT01658826Written as Valacyclovir
- Phase II High Risk Prostate Cancer Trial Using Gene & Androgen Deprivation Therapies, Radiotherapy, & SurgeryStatus unknownPhase 2The Methodist Hospital Research InstituteNCT03541928Written as Valacyclovir
- HSV529 Vaccine in HSV-2 Seropositive AdultsCompletedPhase 1Fred Hutchinson Cancer CenterNCT02571166Written as Valacyclovir
- Early Non-Ablative Fractional Laser Resurfacing for Acne Scars After Treatment With Oral IsotretinoinCompletedNot applicableDavid SmartNCT03514771Written as oral valacyclovir
As the comparator · 12 — what is tested is compared with Valacyclovir
- Study to Compare GS-1179 Versus Valacyclovir in HSV-2 Seropositive Participants With Recurrent Genital HerpesNot yet recruitingPhase 2Gilead SciencesNCT07912996Written as Valacyclovir
- Prenatal Treatment of Congenital Cytomegalovirus Infection With Letermovir Versus ValaciclovirRecruitingPhase 3Assistance Publique - Hôpitaux de ParisNCT05446571Written as Valacyclovir
- A Study Exploring Efficacy of Peginterferon in Patients With Herpes ZosterCompletedPhase 2Shanghai Institute Of Biological ProductsNCT05492591Written as Valacyclovir
- Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 2 InfectionCompletedPhase 2Heidelberg ImmunoTherapeutics GmbHNCT04165122Written as Valaciclovir
- Randomized Trial to Evaluate Suppressive Effect of High-Dose Acyclovir Versus Once-Daily Valacyclovir on Persons With HSV-2CompletedPhase 4University of WashingtonNCT00362297Written as valacyclovir
- Dose-finding Study of ASP2151 in Subjects With Herpes ZosterCompletedPhase 2Astellas Pharma IncNCT00487682Written as Valacyclovir hydrochloride
- A Comparative Study of FV-100 vs. Valacyclovir for the Prevention of Post-Herpetic NeuralgiaTerminatedPhase 3ContraVir Pharmaceuticals, Inc.NCT02412917Written as valacyclovir
- A Study With ASP2151 in Subjects With Recurrent Episodes of Genital HerpesCompletedPhase 2Astellas Pharma IncNCT00486200Written as valacyclovir
- A Study of FV-100 Versus Valacyclovir in Patients With Herpes ZosterCompletedPhase 2Bristol-Myers SquibbNCT00900783Written as valacyclovir
- A Phase 2b Trial of EPB-348 for the Treatment of Herpes ZosterCompletedPhase 2Epiphany BiosciencesNCT00831103Written as Valacyclovir
- Study Comparing the Safety of ASP2151 to Valacyclovir and Placebo in Healthy VolunteersTerminatedPhase 1Astellas Pharma IncNCT00870441Written as Valacyclovir
- Efficacy and Safety of Famciclovir 1-day Treatment Compared to 3-day Treatment With Valacyclovir in Adults With Recurrent Genital HerpesCompletedPhase 3Novartis PharmaceuticalsNCT00306787Written as Valacyclovir
What changed recently
From the registry's own updates since Oct 15, 2026.
Started recruiting1
- SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID DysfunctionOct 28, 2026NCT07597902
Codes
What other systems call Valacyclovir · ClinicalTrials.gg INT006732
- MeSH (NLM) D000077483ValacyclovirConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) MZ1IW7Q79DVALACYCLOVIRConfirmed FDA, NLM, Wikidata
- RxNorm 73645Confirmed FDA, Wikidata
- Wikidata Q418594valacyclovirConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C28235ValacyclovirOne source FDA
- DrugBank DB00577One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D000077483 | Valacyclovir | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | MZ1IW7Q79D | VALACYCLOVIR | Confirmed FDA, NLM, Wikidata |
| RxNorm | 73645 | — | Confirmed FDA, Wikidata |
| Wikidata | Q418594 | valacyclovir | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C28235 | Valacyclovir | One source FDA |
| DrugBank | DB00577 | — | One source Wikidata |
Also registered as valacyclovir hydrochloride (UNII G447S0T1VC · RxNorm 236081) and valacyclovir, d- (UNII 8S9ACT5D06).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.