Herpes Labialis clinical trials
The registry lists 53 studies for Herpes Labialis across more than 10 countries. 2 are recruiting or about to start. 49 of them are mainly about Herpes Labialis (how this is decided). Per ClinicalTrials.gov, last updated 2026-10-29.
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Who runs them
NanoBio Corporation (4) · Medivir (4) · GlaxoSmithKline (3) · Squarex, LLC (3) · Transport Pharmaceuticals (2) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · Sprim Advanced Life Sciences (2) · Topical Remedy (2)
What is being tested here
Drugs under test in Herpes Labialis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Acyclovir | 0 | 2 | 4 |
| ME 609 | 0 | 3 | 4 |
| Squaric acid dibutyl ester | 0 | 0 | 3 |
| Famciclovir | 0 | 2 | 3 |
| Nb-001 | 0 | 2 | 3 |
| Valacyclovir | 0 | 0 | 2 |
| Pritelivir | 0 | 0 | 1 |
| Crenigacestat | 0 | 0 | 1 |
| Prebiotics | 0 | 0 | 1 |
| Ethanol | 0 | 0 | 1 |
Who these studies take
Of the 2 Herpes Labialis studies recruiting now, 0 (0%) set no upper age limit and 0 (0%) stop at 75 or younger. 1 (50%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (100%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 1 (50%) | 1 (50%) |
| 18 | 2 (100%) | 2 (100%) |
| 30 | 2 (100%) | 2 (100%) |
| 40 | 2 (100%) | 2 (100%) |
| 50 | 2 (100%) | 2 (100%) |
| 65 | 2 (100%) | 2 (100%) |
| 75 | 2 (100%) | 2 (100%) |
| 85 | 2 (100%) | 2 (100%) |
Across all 53 studies, recruiting or not: 51% stop at 75 or younger and 32% at 65; 13% take children; 0% are for women only and 2% for men only; 26% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 53. Browse all 53 → or search them.
- Viral Infections in Healthy and Immunocompromised HostsRecruitingNCT013060841 country
- Hand Sanitizer Use for Herpes Simplex Virus-1RecruitingNCT06135844Early Phase 11 country
- A Study to Compare Sitavig (Acyclovir) Buccal Tablet With a Placebo in the Treatment of Herpes Labialis in Participants Whose Immune System Works NormallyCompletedNCT05098938Phase 31 country
- Post-marketing Study for the Evaluation of Profilm Cold SoresCompletedNCT06734728Not applicable1 country
- Treatment of Herpes Labialis by Photodynamic TherapyCompletedNCT04037475Not applicable1 country
- Monoclonal Antibody Therapy Against Chronic Herpes Simplex Virus 1 InfectionTerminatedNCT04539483Phase 21 country
- An Investigation Into the Efficacy of Herpecin L at Reducing the Frequency and Severity of Cold SoresCompletedNCT05796635Not applicable1 country
- Immune Response and General Immune Health in Subjects Infected With Herpes Simplex Virus Type 1 (HSV-1)CompletedNCT03661541Phase 11 country
- Double-blind, Vehicle-controlled Study of the Efficacy and Safety of SADBE in Subjects With Recurrent Herpes LabialisCompletedNCT02965781Phase 1/21 country
- Comparative Safety and Efficacy of Two Antiviral Treatments in the Treatment of Recurrent Herpes Simplex LabialisCompletedNCT02265913Phase 31 country
- A Phase 2, Muti-Center Study of Repeat Dosing of Squaric Acid Dibutyl Ester in Subjects With Herpes LabialisTerminatedNCT03521479Phase 21 country
- Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial HerpesCompletedNCT02871492Phase 21 country
- Safety and Pharmacokinetics of Famciclovir Single 1500 mg Dose in Adolescents With Recurrent Herpes LabialisCompletedNCT00878072Phase 2/31 country
- Botulinum Toxin A for Herpes LabialisTerminatedNCT01225341Not applicable1 country
- An Open Label Study to Evaluate the Safety and Efficacy of BOR15001L7 for the Treatment of Cold Sores in Patients With Recurrent Herpes LabialisStatus unknownNCT03977792Phase 2
- Safety, Tolerability and Therapeutic Efficacy of Topical ZEP-3 Ointment (1.0%) for the Treatment of Cold SoresCompletedNCT02483182Phase 21 country
- Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for Episodic Treatment of Cold SoresCompletedNCT03192306Phase 21 country
- Bioequivalence Study of Aciclovir 5% Cream in Japanese Healthy VolunteersCompletedNCT00711776Phase 11 country
- Effectiveness and Clinical Mechanism of Huanglian-Jiedu Decoction in Patients With Intense-exuberant Stomach Fire SyndromeStatus unknownNCT03469232Phase 1/21 country
- VALTREX(Valacyclovir) Once Daily for Viral Shedding In Subjects Newly Diagnosed With HSV-2CompletedNCT00306293Phase 41 country
- Immune Evidence to the Consumption of Lactobacillus GG and FOS Consumption in Patients With Herpes LabialisCompletedNCT03310294Not applicable
- Immune Response to the Consumption of Lactobacillus GG and FOS in Patients With Recurrent Herpes LabialisCompletedNCT03307772Not applicable
- Safety and Efficacy of Squaric Acid Dibutyl Ester for the Treatment of Herpes LabialisCompletedNCT01971385Phase 11 country
- Study of a New Topical Natural Health Product for the Treatment of Herpes LabialisStatus unknownNCT02582086Not applicable1 country
- Evaluation of Cold Sore Treatments on Ultra Violet (UV) Induced Cold SoresCompletedNCT01902303Phase 21 country
- A Double-Blind, Randomized, Placebo-Controlled Study of Topical VDO for the Treatment of Herpes Simplex LabialisCompletedNCT02207881Phase 21 country
- Safety and Efficacy of Merlin (Ethanol and Glycolic Acid Mixture) for the Treatment of Cold SoresCompletedNCT01985321Phase 21 country
- An Exploratory Study to Investigate the Inflammatory Response During a Cold Sore EpisodeCompletedNCT01653509Phase 11 country
- Clinical Assessment of the Effectiveness and Safety of Herpes Patch SOS in the Treatment of Herpes Simplex Labialis in Comparison to a Competitor's Product.CompletedNCT02157090Not applicable1 country
- Open Label Safety Study of Xerese Cream in the Treatment of Recurrent Herpes Labialis in Children 6-11 Years OldCompletedNCT01574612Phase 31 country
- Zinc for the Treatment of Herpes Simplex Labialis (HSL)CompletedNCT00809809Phase 31 country
- Safety and Efficacy Study of a New Treatment for Recurrent Symptoms of Oral Herpes Virus InfectionCompletedNCT01308424Phase 1/21 country
- NB-001 Treatment of Recurrent Herpes LabialisStatus unknownNCT01695187Phase 31 country
- A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes LabialisCompletedNCT01321359Phase 31 country
- A Multicenter Study of NB-001 in the Treatment of Recurrent Herpes Labialis (SHaRCS)CompletedNCT01324466Phase 31 country
- Famciclovir Pediatric Formulation in Children 1 to 12 Years of Age With Herpes Simplex InfectionCompletedNCT00098059Phase 32 countries
- Non-inferiority Comparison of Efficacy and Safety of Penciclovir 10mg/g to Acyclovir 50mg/g in the Treatment of Recurrent Herpes LabialisCompletedNCT01257074Phase 31 country
- Phase 3 Clinical Study for the Treatment of Cold SoreCompletedNCT00769314Phase 37 countries
- Study of a Cold Sore Patch for the Treatment of Herpes LabialisCompletedNCT01484067Not applicable1 country
- A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes LabialisTerminatedNCT00913692Phase 21 country
- A Comparative Study of the Efficacy of Penciclovir 10mg/g (1%) Cream in Preventing the Appearance of Classical Lesion in Recurrent Cold Sore SufferersCompletedNCT00820534Phase 41 country
- Study to Evaluate Using a Cold Sore Patch to Treat Herpes LabialisCompletedNCT01208298Not applicable1 country
- Place Controlled Study to Treat Recurrent Herpes Labialis.CompletedNCT00914745Phase 21 country
- Safety Study of ME-609 for Treatment of Herpes Simplex Labialis in AdolescentsCompletedNCT00375570Phase 3
- Efficacy and Safety Study of ME-609 and Acyclovir for Treatment of Herpes Simplex LabialisCompletedNCT00361881Phase 31 country
- Study of ME-609 and Acyclovir for Treatment of Herpes Simplex Labialis in Immunocompromised PatientsCompletedNCT00735761Phase 3
- Efficacy of Acyclovir in Combination With a Glucocorticosteroid on UV-Induced Herpes LabialisCompletedNCT00736437Phase 2
- Safety, Pharmacokinetics, and Efficacy Study of NB-001 to Treat Recurrent Herpes LabialisCompletedNCT00453401Phase 21 country
- Valacyclovir+Temovate Gel for the Treatment of Herpes LabialisCompletedNCT00297011Phase 21 country
- Iontophoretic Application of Acyclovir Gel to Treat Cold SoresCompletedNCT00469300Phase 21 country