Herpes Simplex clinical trials
The registry lists 166 studies for Herpes Simplex across more than 10 countries. 12 are recruiting or about to start. 98 of them are mainly about Herpes Simplex (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its 2 narrower conditions too, such as Herpes Genitalis: 260 studies, 17 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
National Institute of Allergy and Infectious Diseases (NIAID) (20) · GlaxoSmithKline (16) · University of Washington (8) · Genocea Biosciences, Inc. (6) · Maruho Europe Limited (5) · Glaxo Wellcome (4) · National Center for Research Resources (NCRR) (4) · University of Alabama at Birmingham (4)
What is being tested here
Drugs under test in Herpes Simplex studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6
- Dec 2026A Phase Ⅱa Study of the Safety, Tolerability and Efficacy of BD111 in Herpes Simplex Virus Type I Stromal Keratitis · Shanghai BDgene Co., Ltd.
- Dec 2026A Phase I Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell) · Changchun BCHT Biotechnology Co.
- Jan 2027Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover Option · Greg Bew
- Mar 2027A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Allogenic Hematopoietic Cell Transplantation (HCT) Participants. · ModernaTX, Inc.
- Mar 2027Randomized, Placebo-controlled, Double-blind Study of 2LHERP® in Orofacial Herpes Infections. · Labo'Life
- Apr 2027Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic Diseases · University of Sao Paulo General Hospital
Who these studies take
Of the 10 Herpes Simplex studies recruiting now, 4 (40%) set no upper age limit and 1 (10%) stop at 75 or younger. 6 (60%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (20%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (40%) | 4 (40%) |
| 18 | 10 (100%) | 10 (100%) |
| 30 | 10 (100%) | 10 (100%) |
| 40 | 10 (100%) | 10 (100%) |
| 50 | 10 (100%) | 10 (100%) |
| 65 | 10 (100%) | 10 (100%) |
| 75 | 9 (90%) | 9 (90%) |
| 85 | 8 (80%) | 8 (80%) |
Across all 166 studies, recruiting or not: 47% stop at 75 or younger and 43% at 65; 37% take children; 10% are for women only and 5% for men only; 32% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 11, 2026.
Studies
Recruiting first, then most recently updated. Showing 50 of 166. Browse all 166 → or search them.
- The Natural History of Severe Viral Infections and Characterization of Immune Defects in Patients Without Known ImmunocompromiseRecruitingNCT010117121 country
- Genetic Studies of Chronic Active Epstein-Barr DiseaseRecruitingNCT000325131 country
- Natural History Study of GATA2 Deficiency and Related DisordersRecruitingNCT019058261 country
- Randomized, Placebo-controlled, Double-blind Study of 2LHERP® in Orofacial Herpes Infections.RecruitingNCT04065971Phase 41 country
- Prevention of Recurrence of Herpes Simplex in Autoimmune Rheumatic DiseasesRecruitingNCT07341386Phase 41 country
- Acyclovir in Ventilated Patients With Pneumonia and HSV-1 in BALRecruitingNCT06134492Phase 31 country
- A Phase I Clinical Trial of Recombinant Herpes Zoster Vaccine (CHO Cell)Enrolling by invitationNCT07633197Phase 11 country
- Evaluating Benzoyl Peroxide for Preventing Recurrence of HSV-1 Outbreaks With Rescue Crossover OptionNot yet recruitingNCT07032649Phase 21 country
- Quantification & Classification of Inflammatory Cells in Uveitis Using OCTRecruitingNCT070657471 country
- A Phase Ⅱa Study of the Safety, Tolerability and Efficacy of BD111 in Herpes Simplex Virus Type I Stromal KeratitisRecruitingNCT06474442Phase 21 country
- Esketamine Combined Pulsed Radiofrequency for Acute/Subacute Zoster-associated Trigeminal NeuralgiaRecruitingNCT06890897Not applicable1 country
- Bronchoscopic Score for Prediction of Herpes Simplex-virus Type 1 (HSV-1) ReactivationRecruitingNCT053314171 country
- A Study on the Reactogenicity, Safety, Immune Response, and Efficacy of a Targeted Immunotherapy Against HSV in Healthy Participants Aged 18-40 Years or in Participants Aged 18-60 Years With Recurrent Genital HerpesCompletedNCT05298254Phase 1/28 countries
- A Study to Evaluate the Efficacy, Safety, and Immunogenicity of mRNA-1647 Cytomegalovirus (CMV) Vaccine in Allogenic Hematopoietic Cell Transplantation (HCT) Participants.Active, not recruitingNCT05683457Phase 21 country
- Neonatal Phase 1 Valacyclovir StudyCompletedNCT05468619Phase 11 country
- Trial on Efficacy and Safety of Pritelivir Tablets for Treatment of Acyclovir-resistant Mucocutaneous HSV (Herpes Simplex Virus) Infections in Immunocompromised SubjectsCompletedNCT03073967Phase 315 countries
- Trial Evaluating the Immunogenicity and Safety of an Adjuvanted Epstein-Barr Virus (EBV) Glycoprotein 350 Vaccine in EBV-seronegative PersonsCompletedNCT05683834Phase 1/21 country
- Using Artificial Intelligence to Help Doctors Identify Different Skin Conditions and Improve Patient CareCompletedNCT074289541 country
- HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade GliomaWithdrawnNCT04482933Phase 21 country
- Valacyclovir in Neonatal Herpes Simplex Virus DiseaseCompletedNCT04448392Phase 11 country
- A Study on the Reactogenicity, Safety and Immune Response of a Targeted Immunotherapy Against HSV in Healthy Japanese Participants Aged 18-40 YearsCompletedNCT05989672Phase 11 country
- Detection of Herpesvirus DNA (CMV, EBV, HHV-6 and HSV) in Colonic Tissue: Impact on Ulcerative Colitis Flare-upTerminatedNCT03172195Not applicable1 country
- Post-marketing Study for the Evaluation of Profilm Cold SoresCompletedNCT06734728Not applicable1 country
- Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Doses of IM-250 in Healthy VolunteersCompletedNCT06435507Phase 11 country
- Phase III Study of ASP2151 in Herpes Simplex PatientsCompletedNCT01959295Phase 31 country
- Open-label Study of ASP2151 in Herpes Simplex PatientsCompletedNCT02209324Phase 31 country
- A Study of mRNA-1647 Cytomegalovirus Vaccine in Liver Transplant Candidates and RecipientsWithdrawnNCT06133010Phase 2
- NOWDx Test for the Diagnosis of Herpes Simplex Virus Type 2WithdrawnNCT042940301 country
- Potential Influence of Esomeprazole on the Pharmacokinetics of PritelivirCompletedNCT05513625Phase 11 country
- Treatment of Herpes Labialis by Photodynamic TherapyCompletedNCT04037475Not applicable1 country
- Safety Study of Monoclonal Antibodies to Reduce the Vaginal Transmission of HSV and HIVCompletedNCT02579083Phase 11 country
- Efficacy of Lazolex® Gel in the Treatment of Herpes SimplexCompletedNCT06089252Phase 2
- Pharmacokinetics of Understudied Drugs Administered to Children Per Standard of CareCompletedNCT014313265 countries
- Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)CompletedNCT03702231Phase 21 country
- PTH - Preemptive Treatment for HerpesviridaeCompletedNCT02152358Phase 41 country
- Effect of Tenofovir on Genital Herpes Simplex Virus (HSV) SheddingCompletedNCT01448616Phase 41 country
- Host RNA Expression Profiles and Protein Biomarkers in Neonatal Herpes Simplex Virus InfectionCompletedNCT052269491 country
- The Epidemiology, Management, and the Associated Burden of Related Conditions in Alopecia AreataCompletedNCT042395211 country
- Safety and Efficacy of CRISPR/Cas9 mRNA Instantaneous Gene Editing Therapy to Treat Refractory Viral KeratitisCompletedNCT04560790Not applicable1 country
- Valganciclovir (Valcyte) for Chronic Fatigue Syndrome Patients Who Have Elevated Antibody Titers Against Human Herpes Virus 6 (HHV-6)and Epstein-Barr Virus (EBV)CompletedNCT00478465Phase 1/21 country
- A Pilot Trial of Herpesvirus Treatment in Idiopathic Pulmonary Fibrosis (IPF)CompletedNCT02871401Phase 11 country
- Topical Corticosteroid Use in Addition to Oral Antivirals for Prevention of Recurrence of Herpes Simplex Virus (HSV) KeratitisWithdrawnNCT03626376Phase 41 country
- Comparison of Foscarnet Versus Vidarabine in the Treatment of Herpes Infection in Patients With AIDS Who Have Not Had Success With AcyclovirCompletedNCT00000985Phase 31 country
- The Safety and Effectiveness of Valacyclovir HCl in the Treatment of Herpes Simplex or Varicella/Zoster Infections in HIV-1 Infected ChildrenWithdrawnNCT00001054Phase 1
- Treatment of Acyclovir-Resistant Mucocutaneous Herpes Simplex Disease in Patients With AIDS: Open Label Pilot Study of Topical TrifluridineCompletedNCT00000635Not applicable1 country
- Study to Assess Brincidofovir Treatment of Serious Diseases or Conditions Caused by Double-stranded DNA VirusesCompletedNCT01143181Phase 31 country
- Trial on Efficacy and Safety of Pritelivir Ointment for Treatment of Labial HerpesCompletedNCT02871492Phase 21 country
- A Study on the Reactogenicity, Safety and Immune Response of a Vaccine Against Herpes Simplex Virus (HSV)-2 in Healthy Participants Aged 18-40 YearsTerminatedNCT04762511Phase 11 country
- Pharmacokinetics of Valacyclovir Oral Solution in ChildrenTerminatedNCT04081480Not applicable1 country
- Efficacy of Oral Famciclovir 125mg Comparing to Aciclovir 200 mg Treatment in Patients With Active Recurrent Genital HerpesCompletedNCT01281007Phase 31 country