Selective Serotonin Reuptake Inhibitors: all 1,366 studies that test it

Page 2 of 14. Open to participants first (105), then studies with results posted, then the rest; newest registration first within each.

• The Effects of Fluoxetine and/or DHEARecruitingNCT03228732Early Phase 1
• Treatment of Sleep Apnea in Patients With Cervical Spinal Cord InjuryRecruitingNCT02922894Phase 4
• Pharmaco(Epi)Genetic, Proteomic, and Microbiomic Study of Obsessive-Compulsive DisorderRecruitingNCT02431845Not applicable
• The Psychiatric and Cognitive Phenotypes in Velocardiofacial SyndromeRecruitingNCT00768820Phase 4
• Study of Neuro-Cognitive Correlates of Pediatric Anxiety DisordersRecruitingNCT00018057Phase 2
• A Study to Assess Drug-drug Interaction of ZX008 in Healthy Male and Female Study ParticipantsCompletedNCT06679413Phase 1Results posted
• Open-label Trial Characterizing the PK of 3 SC Olanzapine Extended-release Formulations in Participants With Schizophrenia/Schizoaffective DisorderCompletedNCT06319170Phase 1Results posted
• Safety, Tolerability, and Pharmacokinetic Study of TV-44749 in Chinese Patients With SchizophreniaCompletedNCT06253546Phase 1Results posted
• Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug InteractionsCompletedNCT06192589Phase 1Results posted
• Pediatric Oncology Nutrition Intervention TrialCompletedNCT06175273Phase 2/3Results posted
• A Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of Co-Administration of Roluperidone and Olanzapine in Adult Subjects With Moderate to Severe Negative Symptoms of SchizophreniaCompletedNCT06107803Phase 1Results posted
• Concentration-QT Study of Paroxetine in Healthy AdultsCompletedNCT06065735Phase 1Results posted
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm E (Fluvoxamine 100)CompletedNCT05894564Phase 3Results posted
• ACTIV-6: COVID-19 Study of Repurposed Medications - Arm B (Fluvoxamine)CompletedNCT05890586Phase 3Results posted
• Fluvoxamine for Long COVID-19CompletedNCT05874037Phase 2/3Results posted
• The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory SurgeryCompletedNCT05676294Phase 2Results posted
• Steroid-sparing Therapy (Olanzapine) Versus Dexamethasone-based Therapy for Chemotherapy-induced Nausea and VomitingTerminatedNCT05590923Phase 4Results posted
• Effect of Selective Serotonin Reuptake Inhibitors (SSRIs) and an Opioid on VentilationCompletedNCT05470465Phase 1Results posted
• Fluoxetine Treatment of Depression in Down SyndromeCompletedNCT05458479Phase 4Results posted
• Escitalopram to Placebo in Patients With Localized Pancreatic CancerTerminatedNCT05289830Phase 2Results posted
• A Biomarker-Guided, Randomized, Placebo-Controlled Efficacy and Safety Study of Liafensine in Patients With TRDCompletedNCT05113771Phase 2Results posted
• Vortioxetine for Post-COVID-19 ConditionCompletedNCT05047952Phase 2Results posted
• Vortioxetine to Prevent Return of Symptoms in Children With DepressionTerminatedNCT05014919Phase 3Results posted
• ACTIV-6: COVID-19 Study of Repurposed MedicationsCompletedNCT04885530Phase 3Results posted
• Fluoxetine Mitigation Mental Health Study for Patients With Musculoskeletal TraumaCompletedNCT04850222Phase 2Results posted
• Antidepressant Response in Older Adults With Comorbid PTSD and MDDTerminatedNCT04697693Phase 4Results posted
• Fluvoxamine for Early Treatment of Covid-19 (Stop Covid 2)CompletedNCT04668950Phase 3Results posted
• Olanzapine for Nausea/Vomiting Prophylaxis in Recipients of Hematopoietic Stem Cell TransplantsCompletedNCT04535141Phase 3Results posted
• COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)CompletedNCT04510194Phase 3Results posted
• Olanzapine for the Prevention of Chemotherapy Induced Nausea and Vomiting in Gynecologic Oncology PatientsTerminatedNCT04503668Phase 3Results posted
• CBT-I or Zolpidem/Trazodone for InsomniaCompletedNCT04468776Phase 4Results posted
• Treatment of Tinnitus With Migraine MedicationsCompletedNCT04404439Phase 4Results posted
• Fluoxetine to Reduce Intubation and Death After COVID19 InfectionCompletedNCT04377308Phase 4Results posted
• A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 InfectionCompletedNCT04342663Phase 2Results posted
• Bioequivalence Study of Paroxetine and PAXIL Under Fasting Conditions in Healthy Mexican ParticipantsCompletedNCT04311463Phase 1Results posted
• Predicting SSRI Efficacy in Veterans With PTSDTerminatedNCT04183205Phase 4Results posted
• Brexpiprazole as Combination Therapy With Sertraline in the Treatment of Adults With Post-traumatic Stress DisorderCompletedNCT04174170Phase 3Results posted
• Brexpiprazole as Combination Therapy With Sertraline in Treatment of Adults With PTSDCompletedNCT04124614Phase 3Results posted
• A Pilot Trial of Perinatal Depression Treatment in HIV Infected WomenCompletedNCT04094870Phase 4Results posted
• Promoting Enhanced Pharmacotherapy Choice Through Immunomarkers Evaluation in DepressionTerminatedNCT03993457Phase 4Results posted
• A Study to Investigate the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution in Children and Adults With Epileptic Encephalopathy Including Dravet Syndrome and Lennox-Gastaut SyndromeCompletedNCT03936777Phase 3Results posted
• Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) TreatmentCompletedNCT03927950Phase 4Results posted
• A Study of Escitalopram in the Treatment of Children and Adolescents With Generalized Anxiety DisorderCompletedNCT03924323Phase 4Results posted
• Fenfluramine in CDKL5 Deficiency Disorder (CDD)CompletedNCT03861871Phase 2Results posted
• A Study in People With Depression to Test the Effects of BI 1358894 on Parts of the Brain That Are Involved in EmotionsCompletedNCT03854578Phase 1Results posted
• Poststroke Depression in Hemorrhagic StrokeCompletedNCT03826875Phase 2Results posted
• Contact: Developing New Clinical Management StrategiesCompletedNCT03812588Phase 4Results posted
• Treatment of Sunflower Syndrome With ZX008 (Fenfluramine Hydrochloride) in Children and Young Adults (Ages 4-25).CompletedNCT03790137Phase 3Results posted
• Measuring Ambulation, Motor, and Behavioral Outcomes With Post-Stroke Fluoxetine in TanzaniaCompletedNCT03728153Phase 2Results posted
• Fluoxetine in Pulmonary Arterial Hypertension (PAH) TrialCompletedNCT03638908Phase 2Results posted
• A Trial to Explore Acceptance and Performance of Using a Digital Medicine System With Healthcare Professionals and Adults With Schizophrenia, Schizoaffective Disorder, or First Episode Psychosis on an Oral Atypical AntipsychoticCompletedNCT03568500Phase 4Results posted
• Short and Long-Term Effectiveness of Existing Insomnia Therapies for Patients Undergoing HemodialysisCompletedNCT03534284Phase 3Results posted
• Impact of Escitalopram on Sperm DNA FragmentationTerminatedNCT03527043Phase 2Results posted
• SMART-DAPPER: Leveraging the Depression And Primary-care Partnership for Effectiveness-implementation Research ProjectCompletedNCT03466346Not applicableResults posted
• Anxiety and Depression in Epilepsy: A Treatment StudyCompletedNCT03464383Phase 4Results posted
• A Bioequivalence Study of the Lu AA21004 20 mg and 2×10 mg TabletsCompletedNCT03437564Phase 1Results posted
• Identifying and Treating Depression in Hemodialysis PatientsCompletedNCT03390933Phase 4Results posted
• Treatment of Refractory Nausea and Vomiting in Patients With Breast CancerCompletedNCT03367572Phase 3Results posted
• Bioequivalence Between Single Administration of ASC-01 (Aripiprazole/Sertraline Combination Drug) and Concomitant Single Administration of Aripiprazole and Sertraline, and Food Effect on Pharmacokinetics of ASC-01 in Healthy Male AdultsCompletedNCT03342963Phase 1Results posted
• A Study to Assess the Usability of the Embrace Seizure Detection Watch in Children and Young Adults With Dravet SyndromeTerminatedNCT03299842Phase 3Results posted
• Remediation of Age-related Cognitive Decline: Vortioxetine and Cognitive TrainingCompletedNCT03272711Phase 4Results posted
• Efficacy of Lu AF35700 in Patients With Early-in-disease or Late-in-disease Treatment-resistant SchizophreniaTerminatedNCT03230864Phase 3Results posted
• An Adaptive Algorithm-Based Approach to Treatment for Adolescent DepressionCompletedNCT03222570Phase 2Results posted
• Study to Evaluate the Long-term Safety, Tolerability, and Durability of Treatment Effect of ALKS 3831CompletedNCT03201757Phase 3Results posted
• Study to Evaluate the Efficacy of ALKS 3831 on Body Weight in Young Adults Who Have Been Recently Diagnosed With Schizophrenia, Schizophreniform, or Bipolar I DisorderCompletedNCT03187769Phase 3Results posted
• Olanzapine for the Treatment of Chronic Nausea and/or Vomiting in Advanced Cancer PatientsCompletedNCT03137121Phase 2/3Results posted
• Neural Mechanisms of Monoaminergic Engagement in Late-life Depression Treatment Response (NEMO)CompletedNCT03128021Phase 4Results posted
• Olanzapine for Acute HeadachesCompletedNCT03066622Phase 4Results posted
• THINC-it Vortioxetine - Sensitivity to ChangeCompletedNCT03053362Phase 2/3Results posted
• A Study of Flexible Dose Brexpiprazole as Monotherapy or Combination Therapy in the Treatment of Adults With Post-traumatic Stress Disorder (PTSD)CompletedNCT03033069Phase 2Results posted
• Cryptococcal Antigen Screening Plus SertralineTerminatedNCT03002012Phase 3Results posted
• Goal Achievement After a Change to Vortioxetine in Adults With Major Depressive DisorderCompletedNCT02972632Phase 4Results posted
• Pattern Separation, Brain Derived Neurotrophic Factors, and Mechanisms of VortioxetineTerminatedNCT02969876Phase 4Results posted
• Aprepitant- and Olanzapine- Containing Anti-emetic Regimens With High Dose MelphalanCompletedNCT02939287Phase 3Results posted
• Effect of Vortioxetine, Paroxetine, and Placebo on Sexual Functioning in Healthy VolunteersCompletedNCT02932904Phase 4Results posted
• Abnormal Ventilatory Response to Carbon Dioxide: a Potential Biomarker for Seizure Induced Respiratory Depression & Modification by SSRICompletedNCT02929667Phase 2Results posted
• A 2-Part Study to Investigate the Dose-Ranging Safety and Pharmacokinetics, Followed by the Efficacy and Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy in Children ≥ 2 Years Old and Young Adults With Dravet SyndromeCompletedNCT02926898Phase 3Results posted
• Cost- Effectiveness and Quality of Life Assessment in Bipolar Disorder Depressive EpisodeCompletedNCT02918097Phase 4Results posted
• Cost- Effectiveness and Quality of Life Assessment in Major Depression DisorderCompletedNCT02901249Phase 4Results posted
• A Phase 3, Long-term Safety and Tolerability Study of ALKS 3831 in Adults With SchizophreniaCompletedNCT02873208Phase 3Results posted
• Long-term, Open-label, Flexible-dose, Extension Study of Vortioxetine in Child and Adolescent Participants With Major Depressive Disorder (MDD) From 7 to 18 Years of AgeTerminatedNCT02871297Phase 3Results posted
• An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride HCl) Oral Solution in Children and Young Adults With Dravet SyndromeCompletedNCT02823145Phase 3Results posted
• Safety of Anti-Depressant for Chronic Obstructive Pulmonary Disease (SAD-COPD)TerminatedNCT02813447Not applicableResults posted
• Effects of Sertraline on Brain Connectivity in Adolescents With OCDCompletedNCT02797808Phase 1/2Results posted
• Stress & Premenstrual Symptoms StudyCompletedNCT02777372Phase 4Results posted
• Olanzapine for Nausea After SurgeryCompletedNCT02755116Phase 2Results posted
• The Relationship Among Changes in Brain Network Activation in Adult Outpatients With Major Depressive DisorderCompletedNCT02749721Phase 4Results posted
• Fluoxetine for Visual Recovery After Ischemic StrokeTerminatedNCT02737930Phase 2Results posted
• Effect of Lu AF35700 in Patients With Treatment-resistant SchizophreniaCompletedNCT02717195Phase 3Results posted
• Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Patients Aged 12 to 17 Years With Major Depressive Disorder (MDD)CompletedNCT02709746Phase 3Results posted
• Active Reference (Fluoxetine) Fixed-dose Study of Vortioxetine in Paediatric Participants Aged 7 to 11 Years With Major Depressive Disorder (MDD)CompletedNCT02709655Phase 3Results posted
• A Study of ALKS 3831 in Adults With Schizophrenia (The ENLIGHTEN-2 Study)CompletedNCT02694328Phase 3Results posted
• A Trial of Two Fixed Doses of ZX008 (Fenfluramine HCl) in Children and Young Adults With Dravet SyndromeCompletedNCT02682927Phase 3Results posted
• Study of Neural Responses Induced by Antidepressant EffectsCompletedNCT02674529Phase 2/3Results posted
• A Long-Term Safety and Tolerability Study of ALKS 3831 in Adults With SchizophreniaCompletedNCT02669758Phase 3Results posted
• A Policy Relevant US Trauma Care System Pragmatic Trial for PTSD and ComorbidityCompletedNCT02655354Not applicableResults posted
• Utility of Olanzapine in the Treatment of Opioid Withdrawal in the EDCompletedNCT02643355Not applicableResults posted
• Vortioxetine for Posttraumatic Stress DisorderCompletedNCT02637895Phase 4Results posted
• Study of FOND Versus FOND+O for the Prevention of CINV in Hematology Patients Receiving Highly Emetogenic Chemotherapy RegimensCompletedNCT02635984Phase 3Results posted
• Advancing Personalized Antidepressant Treatment Using PET/MRICompletedNCT02623205Phase 4Results posted

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