Protease Inhibitors: all 1,856 studies that test it

Page 2 of 19. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.

• Study to Investigate the Mass Balance, Metabolism, and Excretion of [14C]-PF-07304814 in Healthy ParticipantsCompletedNCT05050682Phase 1Results posted
• A Study of a Potential Oral Treatment to Prevent COVID-19 in Adults Who Are Exposed to Household Member(s) With a Confirmed Symptomatic COVID-19 InfectionCompletedNCT05047601Phase 2/3Results posted
• Drug-Drug Interaction Study to Estimate the Effect of PF-07321332/Ritonavir and Ritonavir on Midazolam in Healthy ParticipantsCompletedNCT05032950Phase 1Results posted
• Evaluation of Protease Inhibition for COVID-19 in Standard-Risk Patients (EPIC-SR).TerminatedNCT05011513Phase 2/3Results posted
• Study to Estimate the Effects of Hepatic Impairment on the Pharmacokinetics (PK) of PF-07321332CompletedNCT05005312Phase 1Results posted
• PHASE II SINGLE-CENTER, RANDOMIZED, OPEN-LABEL, PROSPECTIVE, STUDY TO DETERMINE THE IMPACT OF SERIAL PROCALCITONINCompletedNCT04983901Phase 2Results posted
• Drug-Drug Interaction Study Assessing Effect of Carbamazepine on PF-07321332 Boosted With RitonavirCompletedNCT04962230Phase 1Results posted
• Drug-Drug Interaction Study Assessing Effect of Itraconazole on PF-07321332/Ritonavir in Healthy ParticipantsCompletedNCT04962022Phase 1Results posted
• EPIC-HR: Study of Oral PF-07321332/Ritonavir Compared With Placebo in Nonhospitalized High Risk Adults With COVID-19CompletedNCT04960202Phase 2/3Results posted
• Renal Impairment Study of PF-07321332 Boosted With Ritonavir in Adult Participants With Renal Impairment and in Healthy Participants With Normal Renal Function.CompletedNCT04909853Phase 1Results posted
• Study to Evaluate Adverse Events and Change in Disease Activity in Adult and Adolescent Participants With Acute Hepatitis C Virus (HCV) Infection on Treatment With Oral Tablets of Glecaprevir (GLE)/Pibrentasvir (PIB)CompletedNCT04903626Phase 3Results posted
• A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease PatientsTerminatedNCT04837131Phase 2Results posted
• STUDY OF PF-07321332 IN HEALTHY PARTICIPANTSCompletedNCT04756531Phase 1Results posted
• Upamostat, a Serine Protease Inhibitor, or Placebo for Treatment of COVID-19 DiseaseTerminatedNCT04723537Phase 2/3Results posted
• COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Master ProtocolCompletedNCT04662086Phase 2Results posted
• COVID-19 Outpatient Pragmatic Platform Study (COPPS) - Camostat Sub-ProtocolTerminatedNCT04662073Phase 2Results posted
• Drug-drug Interaction (DDI) Study of GSK3640254 With Darunavir/Ritonavir (DRV/RTV) and Etravirine (ETR)CompletedNCT04630002Phase 1Results posted
• The Potential of Camostat in COVID-19TerminatedNCT04625114Phase 2Results posted
• Camostat Efficacy vs. Placebo for Outpatient Treatment of COVID-19 (CAMELOT)CompletedNCT04583592Phase 2Results posted
• Kidney Transplants in Hepatitis C Negative Recipients With Hepatitis C Viremic DonorsCompletedNCT04575896Phase 4Results posted
• COVID-19 Study of Safety and Tolerability of AlvelestatCompletedNCT04539795Phase 1/2Results posted
• First-In-Human Study To Evaluate Safety, Tolerability, And Pharmacokinetics Following Single Ascending And Multiple Ascending Doses of PF-07304814 In Hospitalized Participants With COVID-19.CompletedNCT04535167Phase 1Results posted
• Four Different Experimental Drug Regimens to Standard of Care for the Treatment of Symptomatic Outpatients With COVID-19CompletedNCT04532931Phase 2Results posted
• Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19CompletedNCT04530136Phase 2Results posted
• Oral Camostat Compared With Standard Supportive Care in Mild-Moderate COVID-19 PatientsCompletedNCT04524663Phase 2Results posted
• ACTIV-2: A Study for Outpatients With COVID-19CompletedNCT04518410Phase 2/3Results posted
• QUICKly Eradicate Hepatitis C in Patients Undergoing REnal Transplant With 4 Weeks of Glecaprevir/PibrentasvirTerminatedNCT04515797Phase 4Results posted
• Camostat Mesilate Treating Patients With Hospitalized Patients With COVID-19CompletedNCT04470544Phase 2Results posted
• A Study of AL101 Monotherapy in Patients With Notch Activated Triple Negative Breast CancerTerminatedNCT04461600Phase 2Results posted
• A Trial Looking at the Use of Camostat in People Who Have Tested Positive for Coronavirus (COVID-19) (SPIKE-1)TerminatedNCT04455815Phase 2Results posted
• Novel Agents for Treatment of High-risk COVID-19 Positive PatientsTerminatedNCT04374019Phase 2Results posted
• Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19CompletedNCT04372628Phase 2Results posted
• Treatment for COVID-19 in High-Risk Adult OutpatientsTerminatedNCT04354428Phase 2/3Results posted
• Camostat Mesylate in COVID-19 OutpatientsCompletedNCT04353284Phase 2Results posted
• Safety and Antiviral Activity of BLD-2660 in COVID-19 Hospitalized SubjectsCompletedNCT04334460Phase 2Results posted
• INCB7839 in Treating Children With Recurrent/Progressive High-Grade GliomasCompletedNCT04295759Phase 1Results posted
• A Study of MLN9708 in Japanese Participants With Relapsed and/or Refractory Multiple Myeloma (RRMM)TerminatedNCT04272775Phase 1Results posted
• A Phase II, Cross-over Clinical Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) in the On-demand Treatment of Angioedema Attacks in Adult Subjects With Hereditary Angioedema Type I or IICompletedNCT04208412Phase 2Results posted
• Talabostat and Pembrolizumab for the Treatment of Advanced Solid CancersTerminatedNCT04171219Phase 2Results posted
• Treatment of GVHD in Hematopoietic Stem Cell Transplant (HSCT) Recipients Using AAT Plus Corticosteroids (CS) Compared With Corticosteroids AloneCompletedNCT04167514Phase 3Results posted
• Nivolumab, Ixazomib, Cyclophosphamide, and Dexamethasone in Relapsed/Refractory MyelomaTerminatedNCT04119336Phase 2Results posted
• Ixazomib and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell LymphomaTerminatedNCT04047797Phase 2Results posted
• Glecaprevir/Pibrentasvir Fixed-dose Combination Treatment for Acute Hepatitis C Virus InfectionCompletedNCT04042740Phase 2Results posted
• Safety, Tolerability, Efficacy and Pharmacokinetics of Imipenem/Cilastatin/Relebactam (MK-7655A) in Pediatric Participants With Gram-negative Bacterial Infection (MK-7655A-021)CompletedNCT03969901Phase 2/3Results posted
• Testing the Addition of Ixazomib/Placebo to Lenalidomide in Patients With Evidence of Residual Multiple Myeloma, OPTIMUM TrialCompletedNCT03941860Phase 3Results posted
• Study to Evaluate the Efficacy and Safety of BCX7353 as an Oral Treatment for the Prevention of HAE Attacks in JapanCompletedNCT03873116Phase 3Results posted
• Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Health VolunteersCompletedNCT03864406Phase 1Results posted
• Cardiovascular Disease in HIV and Hepatitis C: Risk Outcomes After Hepatitis C EradicationCompletedNCT03823911Phase 4Results posted
• GAIN Trial: Phase 2/3 Study of COR388 in Subjects With Alzheimer's DiseaseCompletedNCT03823404Phase 2/3Results posted
• PO Ixazomib in Combination With Chemotherapy for Childhood Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphoblastic LymphomaActive, not recruitingNCT03817320Phase 1/2Results posted
• Utilization of Hepatitis C Positive Kidneys in Negative RecipientsCompletedNCT03801707Phase 2/3Results posted
• Ixazomib and Pevonedistat in Treating Patients With Multiple Myeloma That Has Come Back or Does Not Respond to TreatmentCompletedNCT03770260Phase 1Results posted
• Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Participants With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation (SCT)CompletedNCT03748953Phase 3Results posted
• Transplanting Hepatitis C Lungs Into Negative Lung RecipientsCompletedNCT03724149Phase 1/2Results posted
• A Study Of AL101In Patients With Adenoid Cystic Carcinoma (ACC) Bearing Activating Notch MutationsCompletedNCT03691207Phase 2Results posted
• Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin DeficiencyCompletedNCT03679598Phase 2Results posted
• Renal Transplants in Hepatitis C Negative Recipients With Nucleic Acid Positive DonorsCompletedNCT03627299Phase 4Results posted
• Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Lung TransplantTerminatedNCT03625687Phase 4Results posted
• Prevention of De Novo HCV With Antiviral HCV Therapy Post-Liver and Post-Kidney TransplantCompletedNCT03619837Phase 4Results posted
• Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda InterferonCompletedNCT03600714Phase 2Results posted
• A Study to Assess Efficacy and Safety of GLPG1972/S201086 in Participants With Knee OsteoarthritisCompletedNCT03595618Phase 2Results posted
• Imipenem/Cilastatin/Relebactam (MK-7655A) Versus Piperacillin/Tazobactam in Participants With Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia (MK-7655A-016)CompletedNCT03583333Phase 3Results posted
• Study of Ixazomib and Romidepsin in Peripheral T-cell Lymphoma (PTCL)TerminatedNCT03547700Phase 1/2Results posted
• A Drug Interaction Study to Assess the Pharmacokinetics of Narlaprevir and Antiretroviral DrugsCompletedNCT03537404Phase 1Results posted
• A Study of the Use of Hepatitis C Positive Donors for Hepatitis C Negative Lung Transplant Recipients With Post-transplant Treatment With MavyretCompletedNCT03523871Phase 2Results posted
• Ibrutinib and Ixazomib Citrate in Treating Newly Diagnosed, Relapsed or Refractory Waldenstrom MacroglobulinemiaTerminatedNCT03506373Phase 2Results posted
• Pembrolizumab, Ixazomib Citrate, and Dexamethasone in Treating Patients With Relapsed Multiple MyelomaCompletedNCT03506360Phase 2Results posted
• Evaluation of Daclatasvir (DCV) in Combination With Sofosbuvir (SOF) in Children With Chronic Hepatitis C (CHC) InfectionTerminatedNCT03487848Phase 2Results posted
• Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAECompletedNCT03485911Phase 3Results posted
• A Long Term Safety Study of BCX7353 in Hereditary AngioedemaCompletedNCT03472040Phase 2/3Results posted
• A Proof of Concept Pilot Trial of Alpha-1-Antitrypsin for Pre-Emption Of Steroid-Refractory Acute GVHDCompletedNCT03459040Phase 2Results posted
• Abatacept, Ixazomib Citrate, and Dexamethasone in Treating Patients With Multiple Myeloma Resistant to ChemotherapyTerminatedNCT03457142Phase 2Results posted
• A Study of Ixazomib+Daratumumab+Dexamethasone (IDd) in Relapsed and/or Refractory Multiple Myeloma (RRMM)CompletedNCT03439293Phase 2Results posted
• EBR/GZR for HCV-1b Patients Receiving HemodialysisCompletedNCT03420300Phase 4Results posted
• A Study to Evaluate the Efficacy and Safety of Ixazomib in Combination With Lenalidomide and Dexamethasone in Patients With Relapsed and/or Refractory Multiple Myeloma Initially Treated With an Injection of Proteasome Inhibitor-Based TherapyCompletedNCT03416374Phase 4Results posted
• Elbasvir (EBR)/Grazoprevir (GZR) in Pediatric Participants With Chronic Hepatitis C Infection (MK-5172-079)CompletedNCT03379506Phase 2Results posted
• Administration of Zepatier (Grazoprevir Plus Elbasvir) in Chronic Hemodialysis (HD) Patients With Hepatitis CCompletedNCT03365635Phase 4Results posted
• A Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell LymphomaCompletedNCT03323151Phase 1/2Results posted
• Efficacy and Safety of Imipenem+Cilastatin/Relebactam (MK-7655A) in Japanese Participants With Complicated Intra-abdominal Infection or Complicated Urinary Tract Infection (MK-7655A-017)CompletedNCT03293485Phase 3Results posted
• Study of BCX7353 as a Treatment for Attacks of Hereditary AngioedemaCompletedNCT03240133Phase 2Results posted
• Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With Compensated Cirrhosis and With or Without Human Immunodeficiency Virus Co-InfectionCompletedNCT03235349Phase 3Results posted
• A Two-part Study to Compare a Tablet and Capsule Formulation of GSK2838232 With and Without Food, and to Assess the Safety and Drug Levels of Repeated Once-daily Doses of GSK2838232 Without RitonavirCompletedNCT03234036Phase 1Results posted
• A Pharmacokinetics Study of MK-7655A in Pediatric Participants With Gram-negative Infections (MK-7655A-020)CompletedNCT03230916Phase 1Results posted
• A Study to Evaluate the Efficacy and Safety of Glecaprevir/Pibrentasvir (ABT-493/ABT-530) in Treatment-Naive and Treatment-Experienced, Non-Cirrhotic Asian Adults With Chronic Hepatitis C Virus Genotype (GT) 1 to GT6 Infection With or Without Human Immunodeficiency Virus Co-InfectionCompletedNCT03222583Phase 3Results posted
• A Study to Evaluate the Efficacy and Safety of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults in Brazil With Chronic Hepatitis C Virus (HCV) Genotype 1 - 6 InfectionCompletedNCT03219216Phase 3Results posted
• Ixazomib for DesensitizationCompletedNCT03213158Phase 2Results posted
• Efficacy and Safety of 8-weeks of Glecaprevir/Pibrentasvir in Treatment-Naïve Adults With HCV Genotype 1-6 and Aspartate Aminotransferase to Platelet Ratio Index (APRI) ≤1CompletedNCT03212521Phase 3Results posted
• Ixazomib Citrate, Pomalidomide, Dexamethasone, Stem Cell Transplant in Treating Relapsed or Refractory Multiple MyelomaCompletedNCT03202628Phase 2Results posted
• A Study of Ixazomib, Given With Dexamethasone in Adults With Multiple MyelomaCompletedNCT03170882Phase 2Results posted
• Zepatier For Treatment Of Hepatitis C-Negative Patients Who Receive Heart Transplants From Hepatitis C-Positive Donors (HCV)CompletedNCT03146741Phase 1/2Results posted
• A Study for G1b CHC Patients With CKD-3 Treated With Grazoprevir Plus ElbasvirCompletedNCT03144635Phase 4Results posted
• M8891 First in Human in Solid TumorsTerminatedNCT03138538Phase 1Results posted
• A Study to Evaluate the Pharmacokinetics (PK) of Darunavir (DRV) and Cobicistat (COBI) After a Single Oral Administration of Darunavir/Cobicistat Fixed-Dose Combination in Healthy Japanese Adult ParticipantsCompletedNCT03123848Phase 4Results posted
• Trial of Simplified Treatment Monitoring for 8 Weeks Glecaprevir/Pibrentasvir in Chronic Hepatitis C PatientsCompletedNCT03117569Phase 3Results posted
• Hepatitis C Treatment in PWIDs: MAT or Syringe Exchange Assisted-therapy vs Standard of CareCompletedNCT03093415Phase 4Results posted
• Multi-Center, Randomized, Open-Label Study of G/P +/- RBV for NS5A + SOF Previously Treated GT1 HCV SubjectsCompletedNCT03092375Phase 3Results posted
• A Study of Glecaprevir (GLE)/Pibrentasvir (PIB) in Treatment-Naive Adults With Chronic Hepatitis C Virus (HCV) Genotype 1-6 Infection and Compensated CirrhosisCompletedNCT03089944Phase 3Results posted
• Study of Ixazomib to Prevent Recurrent or Late Acute and Chronic Graft-versus-Host Disease 1-year After Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Hematologic MalignanciesCompletedNCT03082677Phase 2Results posted
• Nelfinavir Mesylate in Treating Patients With Kaposi SarcomaCompletedNCT03077451Phase 2Results posted
• CiPA Phase 1 ECG Biomarker Validation StudyCompletedNCT03070470Phase 1Results posted

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