Protease Inhibitors: all 1,856 studies that test it
Page 1 of 19. Open to participants first (69), then studies with results posted, then the rest; newest registration first within each.
- A Clinical Study of Ixazomib to Reactivate HIV and Reduce HIV Reservoir SizeNot yet recruitingNCT07881809Phase 2
- An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in AfricaNot yet recruitingNCT07792096Phase 3
- Study of Secutrelvir in Participants With COVID-19RecruitingNCT07746544Phase 3
- A Study of Secutrelvir in Participants With Coronavirus Disease 2019 (COVID-19) Who Are at High Risk for Progression to Severe DiseaseRecruitingNCT07743580Phase 3
- Safety and Efficacy Study of Sivelestat in Neuromyelitis Optica Spectrum DisorderRecruitingNCT07738952Phase 1/2
- Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With Darunavir/Cobicistat Plus Tenofovir Alafenamide/Emtricitabine in Virologically Suppressed People Living With HIV at 24 and 48 Weeks of Follow-upRecruitingNCT07678268Phase 4
- Ulinastatin on Systemic Immune-Inflammation in Patients With Complicated Intra-Abdominal InfectionNot yet recruitingNCT07672496Not applicable
- Safety and Effectiveness of Sebetralstat (KVD900) for Short-Term Prophylaxis Before Procedures in People With Hereditary Angioedema (KONTROL)RecruitingNCT07654829Phase 4
- Tiprelestat Versus Placebo When Added to Standard of Care for the Treatment of Pulmonary Arterial Hypertension (PAH)Not yet recruitingNCT07601295Phase 2
- A Study of the Preliminary Efficacy of DARE-HPV to Treat High-risk Persistent Human Papillomavirus (hrHPV)RecruitingNCT07601074Phase 2
- SARS-CoV-2 and Herpesvirus Inhibition for Ending Long COVID DysfunctionNot yet recruitingNCT07597902Phase 2
- Sivelestat Sodium as an Adjunct to Endovascular Thrombectomy for Acute Anterior Circulation Large-Vessel OcclusionRecruitingNCT07552610Not applicable
- Rapid and Simultaneous Initiation of Four Guideline-Directed CKD Therapies (RAPID-CKD)Enrolling by invitationNCT07547878Phase 4
- Effect of Perioperative Ulinastatin on Postoperative Stroke in Patients With Brain TumorNot yet recruitingNCT07520370Not applicable
- Trial of Oral Community SVMP INhibitors for SnakebiteNot yet recruitingNCT07500233Phase 2
- Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform TrialNot yet recruitingNCT07485010Phase 2
- Effects of Cofrogliptin on Beta-Cell Function in LADA PatientsNot yet recruitingNCT07460336Not applicable
- Racecadotril for Organ Injury in Sepsis PatientsEnrolling by invitationNCT07454421Phase 1/2
- Glycemic Variability of Combination Therapies in T2DMRecruitingNCT07442006Phase 4
- AI-assisted Subtyping-directed Precision Treatment in Acute Aortic DissectionNot yet recruitingNCT07382375Not applicable
- Phase 4, Double-blind Study Evaluating the Response on Computed Tomography (CT) Lung Density Decline Rates of Respreeza / Zemaira Weekly for 3 Years in Adults With alpha1 Antitrypsin Deficiency (AATD)RecruitingNCT07326592Phase 4
- Clinical Trial With Aprotinin in the Acute Respiratory Distress Syndrome TreatmentRecruitingNCT07317050Phase 3
- Treating Anemia in Myelofibrosis With Repurposed Drugs (Nelfinavir) That Restore Iron Delivery to the Bone MarrowRecruitingNCT07281781Phase 1/2
- Bacteriophage Therapy for Mycobacterium Abscessus Pulmonary InfectionEnrolling by invitationNCT07228702Phase 1
- Early-stage Trial to Determine a Safe and Effective Dose for Ratutrelvir in Patients With Mild to Moderate COVID-19RecruitingNCT07157007Phase 2
- Sivelestat Treatment for Postoperative Organ Protection in Type A Aortic DissectionNot yet recruitingNCT07156656Phase 4
- A Multicenter, Randomized, Open-Label, Parallel-Controlled Clinical Study Comparing the Efficacy and Safety of Cofrogliptin Versus Acarbose in Drug-Naïve Patients With Type 2 DiabetesNot yet recruitingNCT07122102Not applicable
- Study of the Pharmacokinetics and Safety of Glecaprevir/Pibrentasvir Initiated in Pregnancy in Women With Hepatitis C With and Without HIVRecruitingNCT07040319Phase 1/2
- A Study to Learn About the Study Medicine Ibuzatrelvir in Adults With COVID-19 Who Are Severely ImmunocompromisedRecruitingNCT07013474Phase 3
- Autophagy Maintenance (AUTOMAIN)RecruitingNCT06971744Phase 2
- Prevention of Nephrotoxin-Induced Acute Kidney Injury Using CilastatinRecruitingNCT06886464Phase 2
- Effect Camostat for Kidney Protection in Chronic Kidney DiseaseRecruitingNCT06794593Phase 2
- Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical TrialRecruitingNCT06792214Phase 4
- Oral Fosamprenavir for GERDNot yet recruitingNCT06704100Phase 2
- Safety and Efficacy of Conestat Alfa for ACE-Induced AngioedemaNot yet recruitingNCT06679426Phase 3
- A Study to Learn About a Study Medicine Called Ibuzatrelvir in Adult and Adolescent Patients With COVID-19 Who Are Not Hospitalized But Are at Risk For Severe DiseaseRecruitingNCT06679140Phase 3
- Effect of Alpha-1 Antitrypsin Supplementation on Alcohol-Associated HepatitisRecruitingNCT06582329Phase 2
- STARLITE for Unresectable High-Grade GliomasRecruitingNCT06428045Phase 1
- Efficacy and Safety of Sivelestat Sodium and Dexamethasone in the Treatment of ARDSRecruitingNCT06387823Not applicable
- Adaptive Platform Trial for Personnalisation of Sepsis Treatment in Children and Adults: a Multi-national, Treatable Traits-guided, Adaptive, Exploratory, Bayesian Basket TrialRecruitingNCT06381661Phase 2
- A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV TreatmentsRecruitingNCT06337032Phase 4
- Bioequivalence Study of Generic Racecadotril 100 mg Capsules Under Fasting ConditionsNot yet recruitingNCT06297174Phase 1
- Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)RecruitingNCT06195267Not applicable
- A Trial of SP2086 With Hepatic InsufficiencyNot yet recruitingNCT06035406Phase 1
- Efficiency and Safety of Paxlovid for COVID-19 Patients With Severe Chronic Kidney DiseaseRecruitingNCT05938140Phase 4
- LUSZ Treatment Efficacy in Hospitalized COVID-19 PatientsRecruitingNCT05925140Phase 1
- Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and MortalityRecruitingNCT05895240Phase 4
- Ixazomib Plus Low-dose Lenalidomide Versus Ixazomib Alone for Maintenance Treatment of High Risk Multiple MyelomaRecruitingNCT05722405Phase 4
- Glecaprevir/Pibrentasvir for Post-traumatic Stress DisorderRecruitingNCT05637879Phase 2/3
- MDPK67b in Patients With Prostate CancerRecruitingNCT05580107Phase 1
- A Study of SDX-7320 in Combination With Eribulin for People With Breast CancerRecruitingNCT05570253Phase 2
- Zemaira Eosinophilic Esophagitis Pilot StudyRecruitingNCT05485155Phase 2
- Evexomostat Plus PI3K or AKT Inhibitor and Fulvestrant in Patients With a PI3K Alteration and HR+/Her2- Breast CancerRecruitingNCT05455619Phase 1/2
- Lopinavir/Ritonavir in PLWH With High-Grade AINRecruitingNCT05334004Phase 1
- EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe DiseaseRecruitingNCT05261139Phase 3
- Finding Treatments for COVID-19: A Trial of Antiviral Pharmacodynamics in Early Symptomatic COVID-19 (PLATCOV)RecruitingNCT05041907Phase 2
- COAST Therapy in Advanced Solid Tumors and Prostate CancerRecruitingNCT05036226Phase 1/2
- Open-label Berotralstat Access to HAE Patients Previously Enrolled in Berotralstat StudiesEnrolling by invitationNCT04933721Phase 3
- AGILE (Early Phase Platform Trial for COVID-19)RecruitingNCT04746183Phase 1/2
- A Phase 3 Study to Evaluate the Safety and Efficacy of APL-1202 as a Single-agent Oral Treatment Versus Intravesical Instillation of Epirubicin Hydrochloride in naïve Intermediate-risk NMIBC PatientsRecruitingNCT04736394Phase 3
- Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme ReductionRecruitingNCT04383262Phase 2
- Randomised Evaluation of COVID-19 TherapyRecruitingNCT04381936Phase 3
- Trial of Ixazomib for Kaposi SarcomaRecruitingNCT04305691Phase 2
- Nelfinavir, Cisplatin, and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by SurgeryRecruitingNCT04169763Phase 1
- Strategic Treatment Reduction in Very Early Liver Disease With 4 Weeks Sofosbuvir Plus Glecepravir-pibrentasvirRecruitingNCT03855917Phase 4
- Ixazomib Maintenance in Patients With Newly Diagnosed Mantle Cell Lymphoma(MCL)RecruitingNCT03616782Phase 2
- Long Term Safety of Alpha1-Proteinase Inhibitor in Subjects With Alpha1 Antitrypsin DeficiencyEnrolling by invitationNCT02796937Phase 3
- Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired PneumoniaRecruitingNCT02735707Phase 3
- Very Early Intensive Treatment of Infants Living With HIV to Achieve HIV RemissionRecruitingNCT02140255Phase 1/2
- Open-Label Safety, PK, and Efficacy Trial of Sebetralstat (KVD900) in Pediatric Patients (Ages 2-11) With HAE Type I or IICompletedNCT06467084Phase 3Results posted
- A Study to Learn PF-07817883 Blood Levels After Administration of Tablets of Study Drug to Healthy Adult VolunteersCompletedNCT06122194Phase 1Results posted
- A Study to Explore Safety, Pharmacokinetics, and Early Clinical Signal of Efficacy of DS-2325a in Patients With Netherton SyndromeTerminatedNCT05979831Phase 1/2Results posted
- RECOVER-VITAL: Platform Protocol, Appendix to Measure the Effects of Paxlovid on Long COVID SymptomsCompletedNCT05965726Phase 2Results posted
- PROTECT-APT 1: Early Treatment and Post-Exposure Prophylaxis of COVID-19CompletedNCT05954286Phase 2Results posted
- A Phase 2, Safety and Efficacy of Bemnifosbuvir (BEM) and Ruzasvir (RZR) in Subjects With Chronic HCVCompletedNCT05904470Phase 2Results posted
- A Study to Learn About the Study Medicine Called Nirmatrelvir/Ritonavir in People Who Are Healthy Volunteers Co-administered the Medicine RosuvastatinCompletedNCT05898672Phase 1Results posted
- Anti-SARS-CoV-2 Monoclonal Antibodies for Long COVID (COVID-19)Active, not recruitingNCT05877508Phase 2Results posted
- A Study to Learn About How Itraconazole Affects the Blood Level of Study Medicine (PF-07817883) in Healthy Adults.CompletedNCT05822440Phase 1Results posted
- A Study to Understand the Effect and Safety of the Study Medicine PF-07817883 in Adults Who Have Symptoms of COVID-19 But Are Not HospitalizedCompletedNCT05799495Phase 2Results posted
- PF-07304814 for Inpatients With COVID-19 (An ACTIV-3/TICO Treatment Trial)TerminatedNCT05780541Phase 3Results posted
- Improving Response to Immunotherapy in Patients With Advanced Hepatocellular Carcinoma and Chronic Hepatitis C Virus Infection With Direct-Acting Antiviral TherapyTerminatedNCT05717400Phase 4Results posted
- A Study to Learn Safety and Blood Levels of PF-07817883 in Healthy PeopleCompletedNCT05580003Phase 1Results posted
- Paxlovid for Treatment of Long CovidCompletedNCT05576662Phase 2Results posted
- A Study to Learn About a Repeat 5-Day Treatment With the Study Medicines (Called Nirmatrelvir/Ritonavir) in People 12 Years Old or Older With Return of COVID-19 Symptoms and SARS-CoV-2 Positivity After Finishing Treatment With Nirmatrelvir/RitonavirCompletedNCT05567952Phase 2Results posted
- Relative Bioavailability Study of Nirmatrelvir/Ritonavir Oral Powder Relative to the Commercial Tablets and Estimation of the Effect of Food on Bioavailability of the Nirmatrelvir/Ritonavir Oral Powder in Healthy Participants.CompletedNCT05544786Phase 1Results posted
- PBI-0451 (Pomotrelvir) Phase 2 Study in Nonhospitalized Symptomatic Adults With COVID-19TerminatedNCT05543707Phase 2Results posted
- Relative Bioavailability Study of Nirmatrelvir/Ritonavir 4 Different Fixed Dose Combination Tablets Relative to the Commercial Tablets in Healthy ParticipantsCompletedNCT05525910Phase 1Results posted
- A Study to Measure the Amount of Study Medicine in Blood in Adult Participants With COVID-19 and Severe Kidney DiseaseTerminatedNCT05487040Phase 1Results posted
- Berotralstat Treatment in Children With Hereditary AngioedemaActive, not recruitingNCT05453968Phase 3Results posted
- A Study to Learn About the Medicine (PF-07321332 or Nirmatrelvir/Ritonavir) in Healthy Lactating WomenCompletedNCT05441215Phase 1Results posted
- A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune SystemCompletedNCT05438602Phase 2Results posted
- A Study to Learn About the Study Medicine PF-07321332 and Ritonavir in Adult Healthy Chinese Participants.CompletedNCT05339334Phase 1Results posted
- Effectiveness and Safety of Combination of Amlodipine and Zofenopril in Hypertensive Patients Versus Each MonotherapyCompletedNCT05279807Phase 4Results posted
- Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy ParticipantsCompletedNCT05263921Phase 1Results posted
- Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet FormulationCompletedNCT05263895Phase 1Results posted
- A Phase III, Crossover Trial Evaluating the Efficacy and Safety of KVD900 (Sebetralstat) for On-Demand Treatment of Angioedema Attacks in Adolescent and Adult Patients With Hereditary Angioedema (HAE)CompletedNCT05259917Phase 3Results posted
- Effectiveness and Safety of Combination of Nebivolol and Zofenopril in Hypertensive patIents Versus Each MonotherapyCompletedNCT05257148Phase 4Results posted
- Safety, Tolerability, and Treatment Effect of Belnacasan in Patients With COVID-19CompletedNCT05164120Phase 2Results posted
- Food Effect Study to Evaluate the Effect of High-Fat Meal on the Relative Bioavailability of PF-07321332 Boosted With Ritonavir in Healthy Adult ParticipantsCompletedNCT05129475Phase 1Results posted
- PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy ParticipantsCompletedNCT05064800Phase 1Results posted