Drug
Procarbazine clinical trials
Also written Matulane, Natulan and Ro 4 6467/1.
- studies test it
- 35
- open now
- 1
- in phase 3
- 12
- first study started
- 1994
Keep track of what changes. Save the Procarbazine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
34 studies that test it; most in 1998 (4)
| Year | Studies |
|---|---|
| 1994 | 1 |
| 1996 | 2 |
| 1997 | 1 |
| 1998 | 4 |
| 1999 | 2 |
| 2000 | 3 |
| 2002 | 3 |
| 2004 | 2 |
| 2007 | 1 |
| 2008 | 2 |
| 2009 | 2 |
| 2010 | 1 |
| 2012 | 2 |
| 2013 | 1 |
| 2015 | 1 |
| 2016 | 2 |
| 2019 | 1 |
| 2021 | 1 |
| 2023 | 1 |
| 2024 | 1 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 3
- Phase 2
- 18
- Phase 3
- 12
- No phase
- 4
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 3 · Other 32
Alliance for Clinical Trials in Oncology (3) · Radiation Therapy Oncology Group (2) · University College, London (2) · Memorial Sloan Kettering Cancer Center (2) · M.D. Anderson Cancer Center (2) · University of Cologne (2) · Children's Oncology Group (2) · Ono Pharmaceutical Co., Ltd. (1)
Often tested with
Tested in the same studies.
Vincristine (22) · Cyclophosphamide (12) · Etoposide (12) · Prednisone (12) · Lomustine (10) · Methotrexate (8) · Bleomycin (5) · Vinblastine (5)
Studies
Open first, then newest update. How each study uses Procarbazine is read from its arms, and is right about nine times in ten.
Testing it · 35
- A Study to Compare Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and NivolumabRecruitingPhase 3National Cancer Institute (NCI)NCT05675410Written as Procarbazine Hydrochloride
- Phase I Study Evaluating Tolerability, Safety, Pharmacokinetics, and Efficacy of Combined ONO-4059 and R-MPV Therapy for PCNSLActive, not recruitingPhase 1Ono Pharmaceutical Co., Ltd.NCT06541665Written as Procarbazine
- Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade GliomaActive, not recruitingPhase 3Alliance for Clinical Trials in OncologyNCT00887146Written as procarbazine
- Study on Tailored Treatment in Elderly Patients With Newly Diagnosed Primary Lymphoma of Central Nervous SystemCompletedPhase 2International Extranodal Lymphoma Study Group (IELSG)NCT03495960Written as Procarbazine
- Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade GliomaCompletedPhase 2/3Radiation Therapy Oncology GroupNCT00003375Written as procarbazine hydrochloride
- Fludeoxyglucose F 18-PET/CT Imaging in Assessing Response to Chemotherapy in Patients With Newly Diagnosed Stage II, Stage III, or Stage IV Hodgkin LymphomaCompletedPhase 3University College, LondonNCT00678327Written as procarbazine hydrochloride
- Combination Chemotherapy Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or High-Risk Primary Refractory Hodgkin LymphomaCompletedPhase 2Memorial Sloan Kettering Cancer CenterNCT00574496Written as procarbazine hydrochloride
- Chemotherapy Based on PET Scan in Treating Patients With Stage I or Stage II Hodgkin LymphomaTerminatedPhase 2ECOG-ACRIN Cancer Research GroupNCT01390584Written as Procarbazine
- Intravenous Chemotherapy or Oral Chemotherapy in Treating Patients With Previously Untreated Stage III-IV HIV-Associated Non-Hodgkin LymphomaCompletedPhase 2AIDS Malignancy ConsortiumNCT01775475Written as procarbazine hydrochloride
- S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin LymphomaCompletedPhase 2SWOG Cancer Research NetworkNCT00822120Written as procarbazine hydrochloride
- RL-MPV Followed by BBC HCT Using Autologous Stem Cells and Maintenance Therapy With Nivolumab for Newly Diagnosed PCNSLStatus unknownPhase 2National Research Center for Hematology, RussiaNCT05425654Written as Rituximab, Methotrexate, Vincristine, Procarbazine, Lenalidomide
- Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant GliomaCompletedPhase 2Wake Forest University Health SciencesNCT00079092Written as procarbazine hydrochloride
- Chemotherapy Based on Positron Emission Tomography Scan in Treating Patients With Stage I or Stage II Hodgkin LymphomaCompletedPhase 2Alliance for Clinical Trials in OncologyNCT01132807Written as Procarbazine Hydrochloride
- Fludarabine, Mitoxantrone, and Dexamethasone (FND) Plus Rituximab for Lymphoma PatientsCompletedPhase 3M.D. Anderson Cancer CenterNCT00577993Written as Procarbazine
- Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Classical Hodgkin LymphomaCompletedPhase 2University of CologneNCT01569204Written as Procarbazine
- Procarbazine Hydrochloride Capsule (Natulan®) Clinical Trial ProtocolStatus unknownNot applicableLee's Pharmaceutical LimitedNCT02800447Written as Natulan
- Radiation Therapy With or Without Chemotherapy in Treating Patients With Anaplastic OligodendrogliomaCompletedPhase 3Radiation Therapy Oncology GroupNCT00002569Written as procarbazine hydrochloride
- Methotrexate, Procarbazine, Lomustine, Dexamethasone, and Cytarabine in Treating Patients With Primary CNS LymphomaCompletedPhase 2OHSU Knight Cancer InstituteNCT00074191Written as procarbazine hydrochloride
- Combined Immunochemotherapy Followed By Reduced Dose Radiation Therapy (RT) for Patients With Newly Diagnosed Primary Central Nervous System LymphomaCompletedNot applicableMemorial Sloan Kettering Cancer CenterNCT00594815Written as Cytarabine, Leucovorin, Methotrexate, Procarbazine, Rituximab, Vincristine
- A Phase II Study VEPEMB In Patients With Hodgkin's Lymphoma Aged ≥ 60 YearsCompletedPhase 2Newcastle-upon-Tyne Hospitals NHS TrustNCT00079105Written as procarbazine hydrochloride
See all 35 studies that test Procarbazine →
Given in every arm · 8 — Procarbazine is usual care beside what is tested
- A Study of the Efficacy and Safety of Lisocabtagene Maraleucel (Liso-cel) as First-Line Therapy in Adults With Transplant-Ineligible Primary Central Nervous System LymphomaRecruitingPhase 2Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyNCT07015242Written as Procarbazine
- Bruton's Tyrosine Kinase (BTK) Inhibitor, Ibrutinib, in Patients With Newly Diagnosed or Refractory/Recurrent Primary Central Nervous System Lymphoma (PCNSL) and Refractory/Recurrent Secondary Central Nervous System Lymphoma (SCNSL)CompletedPhase 1/2Memorial Sloan Kettering Cancer CenterNCT02315326Written as procarbazine
- Comparison of Two Combination Chemotherapy Regimens in Treating Patients With Stage III or Stage IV Hodgkin's LymphomaCompletedPhase 3European Organisation for Research and Treatment of Cancer - EORTCNCT00049595Written as procarbazine hydrochloride
- Study of Safety and Efficacy of Pembrolizumab and Chemotherapy in Participants With Newly Diagnosed Classical Hodgkin Lymphoma (cHL) (MK-3475-C11/KEYNOTE-C11)CompletedPhase 2Merck Sharp & Dohme LLCNCT05008224Written as Procarbazine
- Rituximab, Methotrexate, Vincristine Sulfate, Procarbazine Hydrochloride, and Cytarabine With or Without Radiation Therapy in Treating Patients With Primary Central Nervous System LymphomaCompletedPhase 2Radiation Therapy Oncology GroupNCT01399372Written as Procarbazine
- Rituximab and Combination Chemotherapy in Treating Patients With Primary Central Nervous System LymphomaTerminatedPhase 2Eastern Cooperative Oncology GroupNCT00335140Written as Procarbazine
- Brentuximab Vedotin as Consolidation Treatment in Patients With Stage I/II HL and PET Positivity After 2 Cycles of ABVDCompletedPhase 2The Lymphoma Academic Research OrganisationNCT02298283Written as Procarbazine
- Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant GliomasWithdrawnPhase 3M.D. Anderson Cancer CenterNCT00003564Written as Procarbazine Hydrochloride
As the comparator · 3 — what is tested is compared with Procarbazine
- HD21 for Advanced StagesActive, not recruitingPhase 3University of CologneNCT02661503Written as Procarbazine
- Combination Chemotherapy in Treating Young Patients With Hodgkin's LymphomaCompletedPhase 3Christine Mauz-KörholzNCT00433459Written as procarbazine hydrochloride
- Methotrexate and Temozolomide Versus Methotrexate, Procarbazine, Vincristine and CytarabineStatus unknownPhase 2Assistance Publique - Hôpitaux de ParisNCT00503594Written as Methotrexate , procarbazine ,vincristine ,cytarabine
Codes
What other systems call Procarbazine · ClinicalTrials.gg INT008094
- MeSH (NLM) D011344ProcarbazineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 35S93Y190KPROCARBAZINEConfirmed FDA, NLM, Wikidata
- RxNorm 8702Confirmed FDA, Wikidata
- Wikidata Q418656procarbazineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62072ProcarbazineOne source FDA
- DrugBank DB01168One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D011344 | Procarbazine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 35S93Y190K | PROCARBAZINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 8702 | — | Confirmed FDA, Wikidata |
| Wikidata | Q418656 | procarbazine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62072 | Procarbazine | One source FDA |
| DrugBank | DB01168 | — | One source Wikidata |
Also registered as procarbazine hydrochloride (UNII XH0NPH5ZX8 · RxNorm 66925).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.