Drug
Lomustine clinical trials
Also written CCNU, CeeNU, WR-139017 and 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea.
- studies test it
- 51
- open now
- 7
- in phase 3
- 11
- first study started
- 1994
Keep track of what changes. Save the Lomustine studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
51 studies that test it; most in 2003 (4)
| Year | Studies |
|---|---|
| 1994 | 1 |
| 1996 | 2 |
| 1997 | 1 |
| 1998 | 1 |
| 2000 | 2 |
| 2001 | 1 |
| 2002 | 1 |
| 2003 | 4 |
| 2005 | 3 |
| 2006 | 1 |
| 2007 | 1 |
| 2008 | 1 |
| 2009 | 2 |
| 2010 | 2 |
| 2012 | 3 |
| 2013 | 1 |
| 2014 | 3 |
| 2015 | 1 |
| 2016 | 2 |
| 2017 | 3 |
| 2018 | 2 |
| 2020 | 1 |
| 2021 | 2 |
| 2022 | 3 |
| 2023 | 1 |
| 2024 | 1 |
| 2025 | 2 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 15
- Phase 2
- 25
- Phase 3
- 11
- No phase
- 3
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 14 · Other 37
Children's Oncology Group (5) · Philogen S.p.A. (4) · M.D. Anderson Cancer Center (4) · Alliance for Clinical Trials in Oncology (2) · Eli Lilly and Company (2) · Radiation Therapy Oncology Group (2) · Memorial Sloan Kettering Cancer Center (2) · University Hospital, Bonn (2)
Often tested with
Tested in the same studies.
Temozolomide (13) · Vincristine (10) · Procarbazine (10) · Bevacizumab (5) · Cisplatin (4) · Onfekafusp alfa (4) · Cyclophosphamide (3) · Etoposide (2)
Studies
Open first, then newest update. How each study uses Lomustine is read from its arms, and is right about nine times in ten.
Testing it · 51
- VorAsidenib With Lomustine In Patients With rEcurrent IDH-mutaNT Glioma Harboring IDH1 and/or IDH2 MutationsNot yet recruitingPhase 1Megan ManticaNCT07629089Written as Lomustine
- Laser Interstitial Thermal Therapy (LITT) and Lomustine (CCNU) for Recurrent GlioblastomaRecruitingPhase 1University of California, DavisNCT07145112Written as Lomustine
- Lomustine Combined With Anlotinib as Interventional Therapy for Extensive-stage Small Cell Lung Cancer Resistant to Second-line and Above TreatmentNot yet recruitingPhase 2Yayi HeNCT07632209Written as Lomustine
- Lomustine in Addition to Standard of Care in Patients With MGMT Methylated GlioblastomaRecruitingPhase 3Vastra Gotaland RegionNCT06419946Written as Lomustine
- Investigator-Initiated Study of Imipramine Hydrochloride and Lomustine in Recurrent GlioblastomaRecruitingPhase 2The University of Texas Health Science Center at San AntonioNCT04863950Written as Lomustine
- A Study to Evaluate the Safety and Efficacy of L19TNF With Alkylating Chemotherapy for Patients With Recurrent IDH-mutant Astrocytoma or OligodendrogliomaNot yet recruitingPhase 2Philogen S.p.A.NCT07120984Written as L19TNF and CCNU
- A Study to Evaluate Safety and Efficacy of L19TNF Plus Lomustine in Patients With Glioblastoma at First ProgressionRecruitingPhase 1/2Philogen S.p.A.NCT04573192Written as Lomustine
- Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated GlioblastomaActive, not recruitingPhase 3NRG OncologyNCT05095376Written as Lomustine
- Reduced Craniospinal Radiation Therapy and Chemotherapy in Treating Younger Patients With Newly Diagnosed WNT-Driven MedulloblastomaActive, not recruitingPhase 2Children's Oncology GroupNCT02724579Written as Lomustine
- A Study With L19TNF in Combination With Lomustine in Patients With Glioblastoma at Progression or RecurrenceActive, not recruitingPhase 2Philogen S.p.A.NCT06336291Written as Lomustine
- Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade GliomaActive, not recruitingPhase 3Alliance for Clinical Trials in OncologyNCT00887146Written as CCNU
- A Study in Recurrent Glioblastoma (GB)CompletedPhase 2Eli Lilly and CompanyNCT01582269Written as Lomustine
- A Study of Selinexor in Combination With Standard of Care Therapy for Newly Diagnosed or Recurrent GlioblastomaTerminatedPhase 1/2Karyopharm Therapeutics IncNCT04421378Written as Lomustine (CCNU)
- A Dose-Escalation Study in Participants With Recurrent Malignant GliomaCompletedPhase 1Eli Lilly and CompanyNCT01682187Written as Lomustine
- Observation or Radiation Therapy With or Without Combination Chemotherapy in Treating Patients With Low-Grade GliomaCompletedPhase 2/3Radiation Therapy Oncology GroupNCT00003375Written as lomustine
- Safety and Efficacy of Different Administration Sequences of L19TNF With Lomustine in Glioblastoma at First ProgressionWithdrawnPhase 1Philogen S.p.A.NCT05304663Written as Lomustine
- A Longitudinal Assessment of Tumor Evolution in Patients With Brain CancerCompletedPhase 1Saint John's Cancer InstituteNCT03425292Written as Lomustine
- Nab-sirolimus in Recurrent High Grade Glioma and Newly Diagnosed GlioblastomaCompletedPhase 2Aadi Bioscience, Inc.NCT03463265Written as nab-sirolimus + lomustine
- Golden Halo, Static Magnetic and Electric Field Device, in Recurrent GlioblastomaWithdrawnNot applicableVarun Monga, MDNCT05410301Written as Lomustine
- Radiation Therapy, Temozolomide, and Lomustine in Treating Young Patients With Newly Diagnosed GliomasCompletedPhase 2Children's Oncology GroupNCT00100802Written as Lomustine
See all 51 studies that test Lomustine →
Given in every arm · 15 — Lomustine is usual care beside what is tested
- A Study of Catequentinib Hydrochloride (AL3818) in Endometrial, LGSOC, STS or GBM CancersNot yet recruitingPhase 1/2Advenchen Pharmaceuticals, LLC.NCT07811297Written as CCNU
- A Study of Treatment for Medulloblastoma Using Sodium Thiosulfate to Reduce Hearing LossRecruitingPhase 3Children's Oncology GroupNCT05382338Written as Lomustine
- Lomustine With and Without Reirradiation for First Progression of Glioblastoma: a Randomized Phase III StudyRecruitingPhase 3European Organisation for Research and Treatment of Cancer - EORTCNCT05904119Written as Lomustine
- Tofacitinib in Recurrent GBM PatientsCompletedPhase 3University of Texas Southwestern Medical CenterNCT05326464Written as Lomustine
- Comparison of Radiation Therapy Regimens in Combination With Chemotherapy in Treating Young Patients With Newly Diagnosed Standard-Risk MedulloblastomaCompletedPhase 3Children's Oncology GroupNCT00085735Written as Lomustine
- 9-ING-41 in Patients With Advanced CancersActive, not recruitingPhase 2Actuate Therapeutics Inc.NCT03678883Written as Lomustine
- Pediatric Trial of Indoximod With Chemotherapy and Radiation for Relapsed Brain Tumors or Newly Diagnosed DIPGActive, not recruitingPhase 2Theodore S. JohnsonNCT04049669Written as Lomustine
- Personalized Risk-Adapted Therapy in Post-Pubertal Patients With Newly-Diagnosed MedulloblastomaTerminatedPhase 2European Organisation for Research and Treatment of Cancer - EORTCNCT04402073Written as Lomustine
- Lerapolturev in Recurrent Malignant GliomaCompletedPhase 2Istari Oncology, Inc.NCT02986178Written as Lomustine
- Phase II Trial of Romiplostim for Thrombocytopenia Induced by Lomustine at First Progression of MGMT Promoter-meth GlioblastomaWithdrawnPhase 2European Organisation for Research and Treatment of Cancer - EORTCNCT04933942Written as Lomustine
- Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) PatientsStatus unknownPhase 3Orbus Therapeutics, Inc.NCT02796261Written as Lomustine
- FMISO PET Study of GlioblastomaCompletedNot applicableMassachusetts General HospitalNCT02076152Written as CCNU
- Bevacizumab and Lomustine for Recurrent GBMCompletedPhase 3European Organisation for Research and Treatment of Cancer - EORTCNCT01290939Written as lomustine
- Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS TumorsCompletedPhase 1Indiana UniversityNCT00005796Written as lomustine
- Combination Chemotherapy and Radiation Therapy With or Without Methotrexate in Treating Young Patients With Newly Diagnosed GliomasStatus unknownPhase 3German Society for Pediatric Oncology and Hematology GPOH gGmbHNCT00278278Written as lomustine
As the comparator · 13 — what is tested is compared with Lomustine
- A Trial to Evaluate Multiple Regimens in Newly Diagnosed and Recurrent GlioblastomaRecruitingPhase 2/3Global Coalition for Adaptive ResearchNCT03970447Written as Lomustine
- Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBMRecruitingPhase 3CarTheraNCT05902169Written as Lomustine
- Anti-Lag-3 (Relatlimab) and Anti-PD-1 Blockade (Nivolumab) Versus Standard of Care (Lomustine) for the Treatment of Patients With Recurrent GlioblastomaSuspendedPhase 2National Cancer Institute (NCI)NCT06325683Written as Lomustine
- Study to Evaluate Safety, Tolerability, and Optimal Dose of Candidate GBM Vaccine VBI-1901 in Recurrent GBM SubjectsTerminatedPhase 1/2VBI Vaccines Inc.NCT03382977Written as Lomustine
- A Study of Berubicin in Adult Subjects With Recurrent Glioblastoma MultiformeActive, not recruitingPhase 2CNS Pharmaceuticals, Inc.NCT04762069Written as Lomustine
- Regorafenib in Relapsed GlioblastomaCompletedPhase 2Istituto Oncologico Veneto IRCCSNCT02926222Written as Lomustine
- A Phase II/III Study of High-dose, Intermittent Sunitinib in Patients With Recurrent Glioblastoma MultiformeStatus unknownPhase 2/3Amsterdam UMC, location VUmcNCT03025893Written as Lomustine
- Adult Study: ABT-414 Alone or ABT-414 Plus Temozolomide vs. Lomustine or Temozolomide for Recurrent Glioblastoma Pediatric Study: Evaluation of ABT-414 in Children With High Grade GliomasCompletedPhase 2AbbVieNCT02343406Written as Lomustine
- The Toca 5 Trial: Toca 511 & Toca FC Versus Standard of Care in Patients With Recurrent High Grade GliomaTerminatedPhase 2/3Tocagen Inc.NCT02414165Written as Lomustine
- Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed GliomasCompletedPhase 3Radiation Therapy Oncology GroupNCT00004259Written as CCNU
- Enzastaurin Versus Lomustine in GlioblastomaCompletedPhase 3Eli Lilly and CompanyNCT00295815Written as lomustine
- Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM PatientsStatus unknownPhase 2/3Sichuan J.Z. Bio-chemical Science and Technology Development Co., LtdNCT03758014Written as Lomustine
- Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary GlioblastomaTerminatedPhase 3Isarna Therapeutics GmbHNCT00761280Written as lomustine
Codes
What other systems call Lomustine · ClinicalTrials.gg INT007746
- MeSH (NLM) D008130LomustineConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 7BRF0Z81KGLOMUSTINEConfirmed FDA, NLM, Wikidata
- RxNorm 6466Confirmed FDA, Wikidata
- Wikidata Q415378lomustineConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C617LomustineOne source FDA
- DrugBank DB01206One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D008130 | Lomustine | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 7BRF0Z81KG | LOMUSTINE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6466 | — | Confirmed FDA, Wikidata |
| Wikidata | Q415378 | lomustine | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C617 | Lomustine | One source FDA |
| DrugBank | DB01206 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.