Astrocytoma clinical trials
The registry lists 688 studies for Astrocytoma across more than 10 countries. 80 are recruiting or about to start. 83 of them are mainly about Astrocytoma (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Glioblastoma too: 2,366 studies, 484 open.
ClinicalTrials.gov finds 2,325 studies for Astrocytoma. How that becomes 687 here
This page counts the studies the registry files under Astrocytoma, and those it files under no condition that list Astrocytomathemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 2,325Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1,618Filed under a narrower condition, counted on its own pageGlioblastoma 1,618
- −6List Astrocytoma as a condition, but the registry did not file them under itMost often written as “Adult Noninfiltrating Astrocytoma” (1), “Adult Infiltrating Astrocytoma” (1), and “Childhood Cerebral Anaplastic Astrocytoma” (1). The registry filed them under other conditions only, most often Oligodendroglioma (4) and Glioma (4).
- −14Match it another way9 name it in the title and 5 in a keyword.
- 687The count on this page8 of them list Astrocytoma in their own words; the registry filed them under no condition.
Get an email when these change. Save the Astrocytoma studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Who runs them
National Cancer Institute (NCI) (89) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (30) · Duke University (27) · Children's Oncology Group (22) · Pediatric Brain Tumor Consortium (18) · City of Hope Medical Center (15) · Wake Forest University Health Sciences (13) · Jonsson Comprehensive Cancer Center (11)
What is being tested here
Drugs under test in Astrocytoma studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Temozolomide | 5 | 14 | 82 |
| Vorasidenib | 3 | 2 | 4 |
| Safusidenib | 3 | 2 | 3 |
| Eflornithine | 2 | 1 | 3 |
| Mirdametinib | 2 | 0 | 2 |
| Irinotecan | 1 | 0 | 22 |
| Bevacizumab | 1 | 1 | 17 |
| Everolimus | 1 | 2 | 9 |
| Valproic Acid | 1 | 1 | 5 |
| Nivolumab | 1 | 0 | 4 |
Drug classes tested here Alkylating agents 5 open · Tyrosine kinase inhibitors (TKIs) 2 open · Immune checkpoint inhibitors 2 open · Angiogenesis inhibitors 1 open · mTOR inhibitors 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Study to Compare Treatment With the Drug Selumetinib Alone Versus Selumetinib and Vinblastine in Patients With Recurrent or Progressive Low-Grade Glioma · Phase 3 · National Cancer Institute (NCI)
- Dec 2026Radiation Therapy With or Without Temozolomide in Treating Patients With Low-Grade Glioma · Phase 3 · Eastern Cooperative Oncology Group
- Nov 2026Pediatric Long-Term Follow-up and Rollover Study · Novartis Pharmaceuticals
- Dec 2026Adaptive Radiotherapy and MRIs Based on Patients With Newly Diagnosed High-Grade Glioma · Columbia University
- Dec 2026Evaluation of ex Vivo Drug Combination Optimization Platform in Recurrent High Grade Astrocytic Glioma · National University Hospital, Singapore
- Dec 2026HSV-tk + Valacyclovir + SBRT + Chemotherapy for Recurrent GBM · David Baskin MD
- Dec 2026Venous Thromboembolism Prevention in Outpatients With Glioma · University of Vermont Medical Center
- Dec 2026Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC) · Radiomedix, Inc.
- Dec 2026Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) Glioblastomas · M.D. Anderson Cancer Center
- Dec 2026HSV-tk and XRT and Chemotherapy for Newly Diagnosed GBM · The Methodist Hospital Research Institute
Who these studies take
Of the 68 Astrocytoma studies recruiting now, 40 (59%) set no upper age limit and 14 (21%) stop at 75 or younger. 15 (22%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 3 (4%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 11 (16%) | 11 (16%) |
| 18 | 65 (96%) | 65 (96%) |
| 30 | 61 (90%) | 61 (90%) |
| 40 | 58 (85%) | 58 (85%) |
| 50 | 58 (85%) | 58 (85%) |
| 65 | 57 (84%) | 57 (84%) |
| 75 | 56 (82%) | 56 (82%) |
| 85 | 51 (75%) | 51 (75%) |
Across all 688 studies, recruiting or not: 31% stop at 75 or younger and 26% at 65; 32% take children; <1% are for women only and <1% for men only; 1% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Astrocytoma studies take
Of 82 phase 1 interventional studies under Astrocytoma, half reached primary completion within 50 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 50 mo35–78 · 82 studies | — | 49 mo35–78 · 72 studies |
| Phase 1/2 | 73 mo53–185 · 25 studies | — | — |
| Phase 2 | 52 mo39–100 · 51 studies | — | 54 mo41–100 · 45 studies |
| Observational | 94 mo54–104 · 25 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting1
Newly registered5
- Observational Connectomics in Adults Undergoing Resection of WHO II-IV GliomaNov 10, 2026NCT07927595
- A Study of SRN-101 Gene Therapy in Adults With Recurrent High-Grade Glioma (ALERT-1)Oct 28, 2026NCT07902037
- Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young AdultsOct 23, 2026NCT07891286
- IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade AstrocytomasOct 22, 2026NCT07888647
- A Multicenter Safety and Immunogenicity Window-of-opportunity Phase 1 Interventional Trial Assessing the Combination of IDH1 Vaccine (IDH1-vac) and Vorasidenib in Adult Patients With Recurrent IDH1R132H-mutant Astrocytoma, Grade 2 - 4 (iVOCAL)Oct 16, 2026NCT07877415
Studies
Recruiting first, then most recently updated. Showing 50 of 688. Browse all 688 → or search them.
- Observational Connectomics in Adults Undergoing Resection of WHO II-IV GliomaRecruitingNCT079275951 country
- A Study of the Drugs Selumetinib vs. Carboplatin and Vincristine in Patients With Low-Grade GliomaRecruitingNCT04166409Phase 33 countries
- HMPL-306 in Participants With Postoperative Residual or Recurrent Grade 2 Glioma Harboring IDH1 or IDH2 MutationsNot yet recruitingNCT07912398Phase 3
- Living Well With Brain Cancer: A Group-Based Intervention to Promote Whole-Person Well-BeingRecruitingNCT07628647Not applicable1 country
- Testing Addition of an Anti-cancer Drug, Vorasidenib to Temozolomide, After Radiation for Advanced Brain CancerRecruitingNCT07215910Phase 31 country
- GI-102 Alone or With Pembrolizumab Before Surgery for Treatment of Recurrent or Progressive IDH Wildtype Glioblastoma and IDH Mutated Grade 4 AstrocytomaRecruitingNCT07301268Phase 21 country
- Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young AdultsNot yet recruitingNCT07891286Phase 21 country
- A Study of Zedoresertib (Debio 0123) in Combination With Temozolomide in Adult Participants With Recurrent or Progressive Glioblastoma and of Zedoresertib (Debio 0123) in Combination With Temozolomide and Radiotherapy in Adult Participants With Newly Diagnosed GlioblastomaRecruitingNCT05765812Phase 1/23 countries
- A Study of SRN-101 Gene Therapy in Adults With Recurrent High-Grade Glioma (ALERT-1)Not yet recruitingNCT07902037Phase 1/2
- Intrathecal Azacitidine and Nivolumab in Patients With Recurrent High-grade GliomaEnrolling by invitationNCT06896110Phase 11 country
- Locoregional Administration of Genetically Engineered Cells (EGFR/IL13Rα2 Pool-CAR T Cells) for the Treatment of Recurrent or Progressive High-Grade GliomasRecruitingNCT07544992Phase 11 country
- IDH1-vac in Patients With Newly Diagnosed IDH1R132H-positive High-grade AstrocytomasNot yet recruitingNCT07888647Phase 21 country
- Intracranial Genetically Modified Immune Cells (TGFβR2KO/IL13Rα2 CAR T-Cells) for the Treatment of Recurrent or Progressive Glioblastoma or Grade 3 or 4 IDH-Mutant AstrocytomaRecruitingNCT06815029Phase 11 country
- Testing the Addition of an Anti-Cancer Drug, Triapine, to the Usual Radiation Therapy for Recurrent Glioblastoma or AstrocytomaRecruitingNCT06860594Phase 11 country
- Implantable Microdevice In Primary Brain TumorsRecruitingNCT04135807Early Phase 11 country
- SIGMA (Safusidenib in IDH1 Mutant Glioma Maintenance)RecruitingNCT05303519Phase 33 countries
- Hypofractionation Trial of Re-irradiation in Good Prognosis Recurrent GlioblastomaRecruitingNCT06344130Phase 11 country
- A Multicenter Safety and Immunogenicity Window-of-opportunity Phase 1 Interventional Trial Assessing the Combination of IDH1 Vaccine (IDH1-vac) and Vorasidenib in Adult Patients With Recurrent IDH1R132H-mutant Astrocytoma, Grade 2 - 4 (iVOCAL)Not yet recruitingNCT07877415Phase 1
- Local, Targeted Therapy With Alpha Emitter [225Ac]Ac-DOTA-SP (TAT) in Glioma (WHO G3-G4) ProgressionRecruitingNCT06975332Not applicable1 country
- Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncologyRecruitingNCT046484621 country
- Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.RecruitingNCT07439172Phase 21 country
- Vorasidenib Maintenance for IDH Mutant AstrocytomaRecruitingNCT06809322Phase 312 countries
- Study of AZD9574 as Monotherapy and in Combination With Anti-cancer Agents in Participants With Advanced Solid MalignanciesRecruitingNCT05417594Phase 1/27 countries
- MSC-DNX-2401 in Treating Patients With Recurrent High-Grade GliomaRecruitingNCT03896568Phase 11 country
- Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain MetastasisRecruitingNCT06047379Phase 1/21 country
- Phase II Elderly/Frail Pts With Newly Diagnosed or Recurrent Malignant Glioma Treated With Cesium-131 GammaTile®Not yet recruitingNCT07821112Phase 21 country
- Safusidenib for Patients With Newly Diagnosed IDH1-mutant CNS WHO Grade 3 Oligodendroglioma and Astrocytoma - a Single Arm Phase II StudyNot yet recruitingNCT07832123Phase 21 country
- VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent GliomaRecruitingNCT07831369Phase 21 country
- Insights Into the Pathophysiology of Neurovascular Uncoupling in Patients With Brain Lesions.RecruitingNCT06797661Not applicable1 country
- A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent GliomaRecruitingNCT05698524Phase 11 country
- SJ901: Evaluation of Mirdametinib in Children, Adolescents, and Young Adults With Low-Grade GliomaRecruitingNCT04923126Phase 1/21 country
- FearLess in NeuroOncologyRecruitingNCT06989086Not applicable1 country
- Vorasidenib Study in Pediatric Participants With Grade 2 Astrocytoma or Oligodendroglioma With an IDH1 or IDH2 MutationRecruitingNCT07286292Phase 22 countries
- Targeted Pediatric High-Grade Glioma TherapyRecruitingNCT058393797 countries
- HSV G207 in Children With Recurrent or Refractory Cerebellar Brain TumorsRecruitingNCT03911388Phase 11 country
- Serial MRI Scans During Radiation TherapyRecruitingNCT04188535Not applicable1 country
- Study of Olutasidenib and Temozolomide in HGGRecruitingNCT06161974Phase 27 countries
- Pediatric Low Grade Glioma - MEKinhibitor TRIal vs ChemotherapyRecruitingNCT05180825Phase 21 country
- The Effect of Glioblastoma PSMA Expression Following Tumour VEGF Blockade From BevacizumabRecruitingNCT070528771 country
- Study of 203Pb-RMX-VH-PIB Dosimetry and Biodistribution in Patients With Glioblastoma Multiform (GBM) and Pancreatic Ductal Adenocarcinoma (PDAC)RecruitingNCT07733674Phase 11 country
- Safety and Efficacy Study of Safusidenib in Participants With Grade 2 IDH1-Mutant GliomaNot yet recruitingNCT07712757Phase 3
- Chemotherapy and Radiation Therapy for the Treatment of IDH Wildtype Gliomas or Non-histological (Molecular) GlioblastomasRecruitingNCT04623931Phase 21 country
- Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK FusionRecruitingNCT06333899Early Phase 16 countries
- Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade GliomasRecruitingNCT07468136Phase 1/21 country
- A Study of 177Lu-PSMA-617 in People With GliomasRecruitingNCT07223034Phase 11 country
- Loupe-Based Intraoperative Fluorescence ImagingRecruitingNCT047800091 country
- Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AARecruitingNCT01269853Phase 1/21 country
- Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutantRecruitingNCT05843253Phase 26 countries
- DB107-Retroviral Replicating Vector (RRV) Combined With DB107-Flucytosine (FC) in Patients With Recurrent Glioblastoma or Anaplastic AstrocytomaRecruitingNCT06264388Phase 21 country
- Multicenter Prospective Study on MRI AI Model for Midline Glioma Subtyping and Prognosis:RecruitingNCT076080031 country