Natural Killer Cell clinical trials
How each study uses Natural Killer Cell is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study
Get an email when these change. Save the Natural Killer Cell studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Approvals
The first approval found in each region, with its record
- United States
- Not in FDA's approval records
- European Union
- Not in EMA's list of EU-wide authorisations
From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out
How studies write it
Studies that test it under each name
Studies by the year they started
39 studies that test it; most in 2016 (4)
| Year | Studies |
|---|---|
| 2005 | 1 |
| 2006 | 2 |
| 2007 | 1 |
| 2008 | 2 |
| 2009 | 1 |
| 2013 | 2 |
| 2014 | 2 |
| 2015 | 2 |
| 2016 | 4 |
| 2017 | 3 |
| 2018 | 3 |
| 2019 | 1 |
| 2020 | 2 |
| 2021 | 2 |
| 2022 | 1 |
| 2023 | 1 |
| 2024 | 2 |
| 2025 | 4 |
| 2026 | 3 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it, so a study counts once.
Who runs them
Industry 1 · Other 38
M.D. Anderson Cancer Center (5) · National University Hospital, Singapore (4) · St. Jude Children's Research Hospital (2) · Southwest Hospital, China (2) · Dana-Farber Cancer Institute (1) · New Approaches to Neuroblastoma Therapy Consortium (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Institut Paoli-Calmettes (1)
Often tested with
Tested in the same studies.
Interleukin-2 (4) · Dinutuximab (3) · Granulocyte-Macrophage Colony-Stimulating Factor (2) · Cetuximab (2) · Trastuzumab (2) · Lenalidomide (1) · Bortezomib (1) · Anti-GD2 Monoclonal Antibody hu14.18K322A (1)
Coming up
From the study records. Dates are the sponsors’ own estimates and often move.
Reaching primary completion within a year · 6, 1 in phase 3
Studies that test Natural Killer Cell, phase 3 first.
- Dec 2026Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and GanglioneuroblastomaPhase 3 · Federal Research Institute of Pediatric Hematology, Oncology and Immunology
- Dec 2026Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK CellsPhase 1 · New Approaches to Neuroblastoma Therapy Consortium
- Dec 2026A Phase I Single-arm Clinical Study of Donor NK Cells Infusion Combined With Low-dose Interleukin-2 in the Treatment of Acute Myeloid Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.Phase 1 · Peking University First Hospital
- Feb 2027Memory-like Natural Killer (NK) Cell Therapy in Patients With Renal Cell Carcinoma or Urothelial CarcinomaEarly Phase 1 · Dana-Farber Cancer Institute
- Aug 2027NK Cell Infusion for Remission Consolidation in AML: A Phase II TrialPhase 2 · Hospital de Clinicas de Porto Alegre
- Sep 2027NK Cell Injection for Advanced Solid TumorsPhase 1 · BOE Technology Group Co., Ltd.
Studies
Open first, then newest update. How each study uses Natural Killer Cell is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.
Testing it · 39
- Dual Administration Of Intraperitoneal And Intravenous TROP2-Directed CAR-NK With TGF-Beta Receptor 2 (TGFBR2) Knock Out (KO) Therapy For Colorectal Cancer-Related Peritoneal Carcinomatosis: A Phase 1/2 Trial ("Chip-CRC Trial")RecruitingPhase 1/2M.D. Anderson Cancer CenterNCT07411599Written as NK Cells
- NK Cell Injection for Advanced Solid TumorsNot yet recruitingPhase 1BOE Technology Group Co., Ltd.NCT07784777Written as NK CELLS
- A Phase1 Clinical Trial Evaluating Locoregional Delivery Of Engineered NK Cells Containing IL13Ra And EGFvIII Chimeric Antigen Receptor (CAR), IL-21 Secretion And Deleted TGF-BetaR2 And NR3C1 In Recurrent GlioblastomaRecruitingPhase 1M.D. Anderson Cancer CenterNCT07579208Written as NK Cells
- A Phase I Single-arm Clinical Study of Donor NK Cells Infusion Combined With Low-dose Interleukin-2 in the Treatment of Acute Myeloid Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.RecruitingPhase 1Peking University First HospitalNCT06641648Written as NK cell
- A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)RecruitingPhase 1M.D. Anderson Cancer CenterNCT05834244Written as NK Cells
- Chemoimmunotherapy Combined With Autologous NK Cell Therapy for Pediatric Patients With Refractory and Relapsed High-Risk Neuroblastoma and GanglioneuroblastomaRecruitingPhase 3Federal Research Institute of Pediatric Hematology, Oncology and ImmunologyNCT07375563Written as irinotecan, temozolomide, dinutuximab beta, NK-cell product
- Quadruple Immunotherapy for NeuroblastomaRecruitingPhase 2Hong Kong Children's HospitalNCT05754684Written as Natural killer cell
- Phase 1 Study of Locoregional Injections of Ex Vivo Expanded Natural Killer CellsRecruitingPhase 1Nationwide Children's HospitalNCT04254419Written as NK cells
- NK Cell Infusion for Remission Consolidation in AML: A Phase II TrialNot yet recruitingPhase 2Hospital de Clinicas de Porto AlegreNCT06783478Written as NK cell infusion
- Natural Killer Cell Immunotherapy in Combination With PARP-inhibition in Acute Myeloid LeukemiaNot yet recruitingPhase 1/2German Cancer Research CenterNCT05319249Written as NK cells
- Natural Killer Cells and Bortezomib to Treat CancerCompletedPhase 1National Heart, Lung, and Blood Institute (NHLBI)NCT00720785Written as NK cells
- Memory-like Natural Killer (NK) Cell Therapy in Patients With Renal Cell Carcinoma or Urothelial CarcinomaActive, not recruitingEarly Phase 1Dana-Farber Cancer InstituteNCT06318871Written as Cytokine Induced Memory-like Natural Killer (CIML NK) Cells
- Therapy for Children With Advanced Stage NeuroblastomaCompletedPhase 2St. Jude Children's Research HospitalNCT01857934Written as natural killer cell infusion
- Phase I of Infusion of Selected Donor NK Cells After Allogeneic Stem Cell TransplantationCompletedPhase 1Institut Paoli-CalmettesNCT01853358Written as NK Cell infusion
- Immunotherapy of Relapsed Refractory Neuroblastoma With Expanded NK CellsActive, not recruitingPhase 1New Approaches to Neuroblastoma Therapy ConsortiumNCT02573896Written as NK Cells
- NK Cells Treatment for COVID-19CompletedPhase 1Xinxiang medical universityNCT04280224Written as NK Cells
- Camrelizumab in Combination With Apatinib Plus NK Cell for Advanced HCCStatus unknownPhase 2Nanfang Hospital, Southern Medical UniversityNCT05171309Written as NK cell
- Treatment of Malignant Tumors With NK CellStatus unknownPhase 1/2Shenzhen University General HospitalNCT05143125Written as Decitabine combined with NK cell infusion
- Randomised Controlled Phase-2 Trial to Determine the Efficacy of Adoptive Immunotherapy With NK Cells in High-risk AMLTerminatedPhase 2Technische Universität DresdenNCT02229266Written as NK cells
- NK Cell Infusion for Patients With Acute Myeloid LeukemiaStatus unknownPhase 1Peking University People's HospitalNCT04221971Written as chemotherapy combined with NK cells infusion
See all 39 studies that test Natural Killer Cell →
Given beside what is tested · 11 — Natural Killer Cell is usual care or a partner of the new treatment
- Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune DisordersRecruitingPhase 1/2M.D. Anderson Cancer CenterNCT06434363Written as Tafasitamab and NK cells
- Allogeneic NK Cell Therapy Combined With Standard Maintenance Treatment in Advanced Solid TumorsNot yet recruitingPhase 1/2BOE Technology Group Co., Ltd.NCT07551778Written as NK Cells
- NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid TumorsCompletedPhase 1National Cancer Institute (NCI)NCT01875601Written as NK Cell Infusion
- A Study of Allogenic Natural Killer Cells in Combination With Trastuzumab and Pertuzumab in Adult Patients With Refractory Metastatic Her2 Positive Breast Cancer. NK-ACT-BC_2020TerminatedPhase 1Vall d'Hebron Institute of OncologyNCT05385705Written as NK cells
- Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk NeuroblastomaCompletedPhase 1Memorial Sloan Kettering Cancer CenterNCT02650648Written as NK cells
- Therapy for Pediatric Relapsed or Refractory Precursor B-Cell Acute Lymphoblastic Leukemia and LymphomaCompletedPhase 2St. Jude Children's Research HospitalNCT01700946Written as natural killer cell infusion
- NK Cell Based Non-Myeloablative Transplantation in Acute Myeloid DiseasesCompletedPhase 2Masonic Cancer Center, University of MinnesotaNCT01370213Written as NK Cells
- A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and LeukemiasCompletedPhase 1National Cancer Institute (NCI)NCT01287104Written as Natural Killer (NK) Cell Infusion
- A Pilot Study of Immunotherapy Including Haploidentical NK Cell Infusion Following CD133+ Positively-Selected Autologous Hematopoietic Stem Cells in Children With High Risk Solid Tumors or LymphomasCompletedPhase 1St. Jude Children's Research HospitalNCT02130869Written as CD133+ selected autologous stem cell infusion
- Intraperitoneal Natural Killer Cells and INCB024360 for Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal CancerCompletedPhase 1Masonic Cancer Center, University of MinnesotaNCT02118285Written as NK cells
- Natural Killer Cells Plus IL-2 Following Chemotherapy to Treat Advanced Melanoma or Kidney CancerCompletedPhase 2National Cancer Institute (NCI)NCT00328861Written as Natural Killer (NK) Lymphocytes