mTOR inhibitors: all 1,276 studies that test it
Page 2 of 13. Open to participants first (126), then studies with results posted, then the rest; newest registration first within each.
- Percutaneous Administration of Sirolimus in the Treatment of Superficial Complicated Vascular AnomaliesRecruitingNCT04921722Phase 4
- Methods of T Cell Depletion Trial (MoTD)RecruitingNCT04888741Phase 2
- Weekly Sirolimus TherapyRecruitingNCT04861064Phase 2
- Sirolimus Treatment Of Patients With SLENot yet recruitingNCT04736953Phase 2
- Inetetamab Plus Rapamycin and Chemotherapy for HER2+ Metastatic Breast Cancer With Abnormal Activation of PAM PathwayNot yet recruitingNCT04736589Phase 3
- Sirolimus for Graves' Orbitopathy (GO)Not yet recruitingNCT04598815Phase 2
- Trametinib and Everolimus for Treatment of Pediatric and Young Adult Patients With Recurrent Gliomas (PNOC021)RecruitingNCT04485559Phase 1
- Sirolimus in Combination With Metronomic Chemotherapy in Children With High-Risk Solid TumorsRecruitingNCT04469530Phase 2
- Temsirolimus Adventitial Delivery to Improve ANGioplasty and/or Atherectomy Revascularization Outcomes Below the KneeRecruitingNCT04433572Phase 3
- Sirolimus in the Treatment for Infantile Hepatic Hemangioendothelioma(IEEH)Not yet recruitingNCT04406870Phase 4
- Implantable Microdevice for the Delivery of Drugs and Their Effect on Tumors in Patients With Metastatic or Recurrent SarcomaRecruitingNCT04199026Not applicable
- Efficiency of Everolimus for the Treatment of Kidney Transplanted Patients Presenting a Missing Self-induced NK-mediated RejectionRecruitingNCT03955172Not applicable
- Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell DiseaseRecruitingNCT03587272Phase 2
- Signal TrAnsduction Pathway Activity Analysis in OVarian cancERRecruitingNCT03458221Phase 2/3
- Canadian Profiling and Targeted Agent Utilization Trial (CAPTUR)RecruitingNCT03297606Phase 2
- The Effect and Safety Profile of Thymoglobulin® in Primary Cardiac Transplant RecipientsEnrolling by invitationNCT03292861Phase 2
- Efficacy of Rapamycin in the Treatment of Cervico-facial Lymphatic MalformationsRecruitingNCT03243019Phase 2
- Nonmyeloablative Stem Cell Transplant in Children With Sickle Cell Disease and a Major ABO-Incompatible Matched Sibling DonorRecruitingNCT03214354Phase 2
- Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell DiseaseRecruitingNCT03121001Phase 2
- Cyclophosphamide and Sirolimus for the Treatment of Metastatic, RAI-refractory, Differentiated Thyroid CancerRecruitingNCT03099356Phase 2
- European Proof-of-Concept Therapeutic Stratification Trial of Molecular Anomalies in Relapsed or Refractory TumorsRecruitingNCT02813135Phase 1/2
- Efficacy and Safety of Sirolimus in Vascular Anomalies That Are Refractory to Standard CareRecruitingNCT02638389Phase 3
- Phase I/II Trial of Everolimus in Combination With Lonafarnib in ProgeriaEnrolling by invitationNCT02579044Phase 1/2
- Metronomic Therapy for Pediatric Patients With Solid Tumors at High Risk of RecurrenceRecruitingNCT02446431Early Phase 1
- Safety and Efficacy of Everolimus Treatment in Liver Transplantation for Liver CancerEnrolling by invitationNCT02081755Phase 4
- Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous MalformationsRecruitingNCT02042326Phase 2
- A Study Testing the Use of a Perivascular Sirolimus Formulation (Sirogen) in ESRD Patients Undergoing AV Fistula SurgeryCompletedNCT05425056Phase 3Results posted
- Sirolimus for Nosebleeds in HHTCompletedNCT05269849Phase 2Results posted
- Stopping TSC Onset and Progression 2: Epilepsy Prevention in TSC InfantsCompletedNCT04595513Phase 1/2Results posted
- Study to Evaluate the Efficacy and Safety of Sirolimus in Subjects With Metastatic, Mismatch Repair Deficient Solid Tumors After ImmunotherapyTerminatedNCT04393454Phase 2Results posted
- Sirolimus and Durvalumab for the Treatment of Stage I-IIIA Non-small Cell Lung CancerTerminatedNCT04348292Phase 1Results posted
- Sirolimus Treatment in Hospitalized Patients With COVID-19 PneumoniaCompletedNCT04341675Phase 2Results posted
- Everolimus Plus Mycophenolic Acid for Kidney Preservation in Liver Transplant Recipients With Impaired Kidney FunctionTerminatedNCT04258423Phase 3Results posted
- Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor PathwayCompletedNCT04200911Early Phase 1Results posted
- Enhancing Self Regulation Among SmokersCompletedNCT04161144Phase 2Results posted
- Everolimus Monotherapy as Immunosuppression After Liver TransplantTerminatedNCT04063865Phase 3Results posted
- RAPA-Keloid Study of Keloid RegressionCompletedNCT04049552Early Phase 1Results posted
- Sirolimus in Previously Treated Idiopathic Multicentric Castleman DiseaseActive, not recruitingNCT03933904Phase 2Results posted
- A Phase 0/I Study of Ribociclib (LEE011) in Combination With Everolimus in Preoperative Recurrent High-Grade Glioma Patients Scheduled for ResectionCompletedNCT03834740Early Phase 1Results posted
- Dose-Ranging Efficacy and Safety Study of Topical Rapamycin Cream for Facial Angiofibroma Associated With Tuberous Sclerosis ComplexCompletedNCT03826628Phase 2/3Results posted
- Altering Memories That Increase Risk of Relapse in Alcohol Use DisordersCompletedNCT03732248Phase 1Results posted
- Liver Transplantation With Tregs at UCSFTerminatedNCT03654040Phase 1/2Results posted
- A Futility Trial of Sirolimus in Multiple System AtrophyTerminatedNCT03589976Phase 2Results posted
- Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex.CompletedNCT03525834Phase 4Results posted
- Tolerance by Engaging Antigen During Cellular HomeostasisCompletedNCT03504241Phase 1Results posted
- Comparison of the Efficacy and Safety of Sirolimus Versus Everolimus Versus Mycophenolate in Kidney TransplantationCompletedNCT03468478Phase 4Results posted
- Auranofin and Sirolimus in Treating Participants With Ovarian CancerTerminatedNCT03456700Phase 2Results posted
- SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath TumorsCompletedNCT03433183Phase 2Results posted
- Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain TumorsCompletedNCT03387020Phase 1Results posted
- Tacrolimus/Everolimus vs. Tacrolimus/MMF in Pediatric Heart Transplant Recipients Using the MATE ScoreCompletedNCT03386539Phase 3Results posted
- Topical Sirolimus Ointment for Cutaneous Angiofibromas in Subjects With Tuberous Sclerosis ComplexTerminatedNCT03363763Phase 2Results posted
- Study of Dasatinib in Combination With Everolimus for Children and Young Adults With Gliomas Harboring Platelet-Derived Growth Factor Receptor (PDGFR) AlterationsTerminatedNCT03352427Phase 2Results posted
- A Study of Everolimus Plus Exemestane in Chinese Postmenopausal Women With Estrogen Receptor Positive, Locally Advanced, Recurrent, or Metastatic Breast Cancer After Recurrence or Progression on Non-steroidal Aromatase InhibitorCompletedNCT03312738Phase 2Results posted
- Discovery of Sirolimus Sensitive Biomarkers in BloodCompletedNCT03304678Phase 2Results posted
- Resveratrol and Sirolimus in Lymphangioleiomyomatosis TrialCompletedNCT03253913Phase 2Results posted
- Study in Post-menopausal Women With Hormone Receptor Positive, HER2-negative Advanced Breast CancerCompletedNCT03176238Phase 3Results posted
- Evaluation of the Safety and Tolerability of Niraparib With Everolimus in Advanced Gynecologic Malignancies and BreastCompletedNCT03154281Phase 1Results posted
- Sirolimus and Familial Adenomatous Polyposis (FAP)CompletedNCT03095703Phase 2Results posted
- Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell DiseaseActive, not recruitingNCT03077542Phase 1/2Results posted
- Trial of Sirolimus for Cognitive Impairment in Sturge-Weber SyndromeCompletedNCT03047980Phase 2/3Results posted
- CLEVER Pilot Trial: A Phase II Pilot Trial of HydroxyChLoroquine, EVErolimus or the Combination for Prevention of Recurrent Breast CancerActive, not recruitingNCT03032406Phase 2Results posted
- Calcineurin Inhibitor-Free GVHD Prevention Regimen After Related Haplo PBSCTCompletedNCT03018223Phase 1Results posted
- RAD001 and Neurocognition in PTEN Hamartoma Tumor SyndromeCompletedNCT02991807Phase 1/2Results posted
- Sirolimus (Rapamune ) for Relapse Prevention in People With Severe Aplastic Anemia Responsive to Immunosuppressive TherapyActive, not recruitingNCT02979873Phase 2Results posted
- Conversion From MPA to Zortress (Everolimus) for GI Toxicity Post-renal TransplantationTerminatedNCT02974686Phase 4Results posted
- Using Topical Sirolimus 2% for Patients With Epidermolysis Bullous Simplex (EBS) StudyCompletedNCT02960997Phase 2Results posted
- Once-daily Regimen With Envarsus® to Optimize Immunosuppression Management and Outcomes in Kidney Transplant RecipientsCompletedNCT02954198Not applicableResults posted
- A Trial to Evaluate Efficacy and Safety of Lenvatinib in Combination With Everolimus in Subjects With Unresectable Advanced or Metastatic Non Clear Cell Renal Cell Carcinoma (nccRCC) Who Have Not Received Any Chemotherapy for Advanced DiseaseCompletedNCT02915783Phase 2Results posted
- Effect of mTOR Inhibition and Other Metabolism Modulating Interventions on the ElderlyCompletedNCT02874924Phase 2Results posted
- Palbociclib With Everolimus + Exemestane In BCCompletedNCT02871791Phase 1/2Results posted
- SCHEDULE Follow Up Visit 5-7 yrCompletedNCT02864706Phase 4Results posted
- Phase IV Study of the Safety and Efficacy of Everolimus in Adult Patients With Progressive pNET in ChinaCompletedNCT02842749Phase 4Results posted
- Lenvatinib/Everolimus or Lenvatinib/Pembrolizumab Versus Sunitinib Alone as Treatment of Advanced Renal Cell CarcinomaActive, not recruitingNCT02811861Phase 3Results posted
- A Study to Evaluate Steroid-free Treatment for Standard-Risk aGVHD (BMT CTN 1501)CompletedNCT02806947Phase 2Results posted
- Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)CompletedNCT02766465Phase 2Results posted
- Early Allogeneic Hematopoietic Cell Transplantation in Treating Patients With Relapsed or Refractory High-Grade Myeloid NeoplasmsCompletedNCT02756572Phase 2Results posted
- Sirolimus in Conjunction With Eylea vs Eylea Alone for Exudative AMDCompletedNCT02732899Phase 2Results posted
- Treg Therapy in Subclinical Inflammation in Kidney TransplantationCompletedNCT02711826Phase 1/2Results posted
- Sequential Targeting of Cluster of Differentiation 52 (CD52) and Tumor Necrosis Factor (TNF) Allows Early Minimization Therapy in Kidney TransplantationCompletedNCT02711202Not applicableResults posted
- Aging Mammary Stem Cells and Breast Cancer PreventionTerminatedNCT02642094Phase 2Results posted
- Biomarkers in Predicting Treatment Response to Sirolimus and Chemotherapy in Patients With High-Risk Acute Myeloid LeukemiaCompletedNCT02583893Phase 2Results posted
- Sirolimus, Docetaxel, and Carboplatin in Treating Patients With Metastatic Castration-Resistant Prostate CancerTerminatedNCT02565901Phase 1/2Results posted
- Personalized Targeted Inhibitors Treatment in Renal Cell CancerTerminatedNCT02560012Phase 2Results posted
- Sporadic Angiomyolipomas (AMLs) Growth Kinetics While on EverolimusTerminatedNCT02539459Phase 2Results posted
- Trial to Evaluate the Sirolimus-Eluting Collagen Implant on AV Fistula OutcomesCompletedNCT02513303Phase 3Results posted
- Everolimus Therapy in People With Birt-Hogg-Dube Syndrome (BHD)-Associated Kidney Cancer or Sporadic Chromophobe Renal CancerTerminatedNCT02504892Phase 2Results posted
- Examining the Impact of Sirolimus on Ketamine's Antidepressant EffectsCompletedNCT02487485Phase 2Results posted
- Liposomal Doxorubicin, Bevacizumab, and Everolimus in Patients With Locally Advanced TNBC With Tumors Predicted Insensitive to Standard Chemotherapy; A Moonshot InitiativeCompletedNCT02456857Phase 2Results posted
- Study of Lenvatinib in Combination With Everolimus in Participants With Unresectable Advanced or Metastatic Renal Cell Carcinoma (RCC)CompletedNCT02454478Phase 1Results posted
- A Pilot Study To Evaluate The Effects of Everolimus on Brain mTOR Activity and Cortical Hyperexcitability in TSC and FCDCompletedNCT02451696Phase 2Results posted
- Safety and Efficacy of Sirolimus for HIV Reservoir Reduction in Individuals on Suppressive Antiretroviral Therapy (ART)CompletedNCT02440789Phase 1/2Results posted
- Impact of Everolimus on HIV Persistence Post Kidney or Liver TransplantCompletedNCT02429869Phase 4Results posted
- Study of Sirolimus Therapy for Segmental Overgrowth Caused by Somatic PI3K ActivationCompletedNCT02428296Phase 2Results posted
- Sirolimus Versus Anti-Vascular Endothelial Growth Factor (antiVEGF) for Wet AMDCompletedNCT02357342Phase 2Results posted
- Everolimus in Patients With Advanced Solid Malignancies With TSC1, TSC2, NF1, NF2, or STK11 MutationsCompletedNCT02352844Phase 2Results posted
- Long-term Monitoring of Growth and Development of Pediatric Patients Previously Treated With EverolimusCompletedNCT02338609Phase 4Results posted
- Everolimus for Treatment of Disfiguring Cutaneous Lesions in Neurofibromatosis1 CRAD001CUS232TCompletedNCT02332902Phase 2Results posted
- Study of Mutation-Targeted Therapy With Sunitinib or Everolimus in People With Advanced Low- or Intermediate-Grade Neuroendocrine Tumors of the Gastrointestinal Tract and Pancreas With or Without Cytoreductive SurgeryTerminatedNCT02315625Phase 2Results posted
- Everolimus Combined With Anti-estrogen Therapy in Hormone-Receptor-Positive HER-2 Negative Advanced Breast CancerCompletedNCT02291913Phase 2Results posted
- Everolimus and Letrozole in Treating Patients With Recurrent Hormone Receptor Positive Ovarian, Fallopian Tube, or Primary Peritoneal Cavity CancerCompletedNCT02283658Phase 2Results posted