mTOR inhibitors: all 1,276 studies that test it

Page 4 of 13. Open to participants first (126), then studies with results posted, then the rest; newest registration first within each.

• Allo Transplant Followed by Lenalidomide and Sirolimus Maintenance in High-Risk Multiple Myeloma (MM)TerminatedNCT01303965Phase 1/2Results posted
• Trial of RAD001 and Neurocognition in Tuberous Sclerosis Complex (TSC)CompletedNCT01289912Phase 2Results posted
• A Study of Carboplatin, Cetuximab and RAD001 in Advanced Head and Neck CancerCompletedNCT01283334Phase 1/2Results posted
• Study of Velcade and Temsirolimus for Relapsed or Refractory Non-Hodgkin LymphomaCompletedNCT01281917Phase 2Results posted
• Everolimus in Combination With Imatinib Mesylate in Treating Patients With Locally Advanced, Locally Recurrent, or Metastatic Soft Tissue SarcomaCompletedNCT01281865Phase 1/2Results posted
• Everolimus in Combination With Imatinib in Patients With Glivec Refractory/Resistant Gastrointestinal Stromal TumorsCompletedNCT01275222Phase 1/2Results posted
• A Study of Lapatinib in Combination With Everolimus in Patients With Advanced, Triple Negative Breast CancerTerminatedNCT01272141Phase 2Results posted
• Pasireotide & Everolimus in Adult Patients With Radioiodine-Refractory Differentiated & Medullary Thyroid CancerCompletedNCT01270321Phase 2Results posted
• SCHEDULE - Scandinavian Heart Transplant Everolimus de Novo Study With Early Calcineurin Inhibitor (CNI) AvoidanceCompletedNCT01266148Phase 4Results posted
• A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type FibromatosisCompletedNCT01265030Phase 1/2Results posted
• RAD001 and Intravesical Gemcitabine in BCG-Refractory Primary or Secondary Carcinoma In Situ of the BladderCompletedNCT01259063Phase 1/2Results posted
• Temsirolimus With or Without Cetuximab in Patients With Recurrent and/or Metastatic Head and Neck Cancer Who Did Not Respond to Previous TherapyCompletedNCT01256385Phase 2Results posted
• RAD001 (Everolimus) and Pasireotide (SOM230) LAR in Patients With Advanced Uveal MelanomaCompletedNCT01252251Phase 2Results posted
• Sirolimus, Cyclosporine, and Mycophenolate Mofetil in Preventing Graft-versus-Host Disease in Treating Patients With Blood Cancer Undergoing Donor Peripheral Blood Stem Cell TransplantCompletedNCT01251575Phase 2Results posted
• Cytokines Evaluation in Early Calcineurin Inhibitors Withdrawn on Renal TransplantCompletedNCT01239472Phase 4Results posted
• Akt Inhibitor MK2206 or Everolimus in Treating Patients With Refractory Kidney CancerTerminatedNCT01239342Phase 2Results posted
• Study To Evaluate Pharmacokinetics Of Sirolimus In Stable Renal Transplant RecipientsCompletedNCT01236378Phase 1Results posted
• Safety and Efficacy of RAD001 (Everolimus) in Combination With Letrozole in the Treatment of Postmenopausal Women With Locally Advanced or Metastatic Breast CancerCompletedNCT01231659Phase 2Results posted
• Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell TransplantCompletedNCT01231412Phase 3Results posted
• Everolimus and Combination Chemotherapy in Treating Patients With Metastatic Stomach or Esophageal CancerCompletedNCT01231399Phase 1/2Results posted
• Everolimus and Octreotide Acetate With or Without Bevacizumab in Treating Patients With Locally Advanced or Metastatic Pancreatic Neuroendocrine Tumors That Cannot Be Removed by SurgeryCompletedNCT01229943Phase 2Results posted
• Vinorelbine Tartrate and Cyclophosphamide in Combination With Bevacizumab or Temsirolimus in Treating Patients With Recurrent or Refractory RhabdomyosarcomaCompletedNCT01222715Phase 2Results posted
• Study of Everolimus (RAD001) in Combination With LenalidomideCompletedNCT01218555Phase 1Results posted
• A Trial of Everolimis in Patients With Advanced Renal Cell Carcinoma.CompletedNCT01206764Phase 4Results posted
• Reduced Intensity, Partially HLA Mismatched BMT to Treat Hematologic MalignanciesCompletedNCT01203722Phase 1/2Results posted
• Temsirolimus, Carboplatin, and Paclitaxel as First-Line Therapy in Treating Patients With Newly Diagnosed Stage III-IV Clear Cell Ovarian CancerCompletedNCT01196429Phase 2Results posted
• Rapamycin Therapy in Head and Neck Squamous Cell CarcinomaCompletedNCT01195922Phase 1/2Results posted
• Everolimus Versus Sunitinib in Non-Clear Cell Renal Cell CarcinomaTerminatedNCT01185366Phase 2Results posted
• Pilot Trial of Sirolimus/MEC in High Risk Acute Myelogenous Leukemia (AML)CompletedNCT01184898Not applicableResults posted
• A Pilot Study to Determine the Safety and Tolerability of Sirolimus Given With Hyper-CVAD ChemotherapyCompletedNCT01184885Early Phase 1Results posted
• Expanded Phase I Pazopanib and Everolimus in Advanced Solid Tumors and Previously Treated Advanced Urothelial CancerCompletedNCT01184326Phase 1Results posted
• Tandem Auto-Allo Transplant for LymphomaCompletedNCT01181271Phase 2Results posted
• Comparison Of 2 Doses Of Temsirolimus (Torisel) In Patients With Mantle Cell LymphomaCompletedNCT01180049Phase 4Results posted
• 24 Months Follow-up, Two Arm Study to Compare the Cardiovascular Profile in a Regimen With Everolimus + Mycophenolic Acid (MPA) Versus (vs.) a Regimen of CNI+MPA in Maintenance Renal Transplant RecipientsCompletedNCT01169701Phase 4Results posted
• Renal Allograft Function and Histology Following Switching From A Tacrolimus to Sirolimus (SRL)-Based Immunosuppression-TerminatedNCT01166724Phase 3Results posted
• Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and LymphomaCompletedNCT01162551Phase 2Results posted
• Everolimus for Children With NF1 Chemotherapy-Refractory Radiographic Progressive Low Grade GliomasCompletedNCT01158651Phase 2Results posted
• Extension Study to Evaluate the Long-term Efficacy and Safety of Everolimus in Liver Transplant RecipientsCompletedNCT01150097Phase 3Results posted
• Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or K-RAS Mutant Colon CancersTerminatedNCT01149434Phase 1/2Results posted
• Study of Sirolimus Versus Mycophenolate Liver Transplant Recipients With Recurrent Hepatitis C Virus (HCV)CompletedNCT01134952Phase 4Results posted
• Study in Locally Advanced Squamous Cell Carcinoma of Head and NeckTerminatedNCT01133678Phase 2Results posted
• RAD001 Plus Carboplatin in Breast Cancer PatientsCompletedNCT01127763Phase 2Results posted
• Everolimus, Bortezomib and/or Rituximab in Patients With Relapsed/Refractory Waldenstrom's MacroglobulinemiaTerminatedNCT01125293Phase 1/2Results posted
• S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone SurgeryCompletedNCT01120249Phase 3Results posted
• Campath, Calcineurin Inhibitor Reduction and Chronic Allograft NephropathyCompletedNCT01120028Phase 2/3Results posted
• Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell TransplantationTerminatedNCT01116232Phase 2Results posted
• Efficacy, Safety and Evolution of Cardiovascular Parameters in Renal Transplant RecipientsCompletedNCT01114529Phase 3Results posted
• Everolimus Versus Placebo in Head and Neck CancerTerminatedNCT01111058Phase 2Results posted
• Phase II Study of Afinitor vs. Sutent in Patients With Metastatic Non-Clear Cell Renal Cell CarcinomaCompletedNCT01108445Phase 2Results posted
• Chronic Graft-versus-Host Disease Treatment (BMT CTN 0801)CompletedNCT01106833Phase 2/3Results posted
• Temsirolimus and Bevacizumab in Hormone-Resistant Metastatic Prostate Cancer That Did Not Respond to ChemotherapyCompletedNCT01083368Phase 1/2Results posted
• Progression of Renal Interstitial Fibrosis / Tubular Atrophy (IF/TA) According to Epithelial-mesenchymal Transition (EMT) and Immunosuppressive Regimen (Everolimus Based Versus CNI Based) in de Novo Renal Transplant RecipientsCompletedNCT01079143Phase 3Results posted
• Lenalidomide and Temsirolimus in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin LymphomaCompletedNCT01076543Phase 1/2Results posted
• Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin LymphomaCompletedNCT01075321Phase 1/2Results posted
• Everolimus (RAD001) Therapy for Epilepsy in Patients With Tuberous Sclerosis Complex (TSC)CompletedNCT01070316Phase 1/2Results posted
• Letrozole and RAD001 With Advanced or Recurrent Endometrial CancerActive, not recruitingNCT01068249Phase 2Results posted
• Calcineurin Inhibitor Sparing After Kidney TransplantationCompletedNCT01062555Phase 1/2Results posted
• Everolimus, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma MultiformeCompletedNCT01062399Phase 1/2Results posted
• Temsirolimus in Treating Patients With Recurrent or Persistent Cancer of the UterusTerminatedNCT01061606Phase 2Results posted
• A Study to Determine the Safety and Effectiveness of RAD001 (Everolimus) in Patients With LymphangioleiomyomatosisCompletedNCT01059318Phase 2Results posted
• RAD001, Cisplatin and Concurrent Radiation for Locally Advanced, Inoperable Head and Neck CancerTerminatedNCT01057277Phase 1Results posted
• Phase II Study of RAD001 Head and Neck CancerTerminatedNCT01051791Phase 2Results posted
• Carboplatin, Everolimus, and Prednisone in Treating Patients With Metastatic Prostate Cancer That Progressed After DocetaxelCompletedNCT01051570Phase 2Results posted
• Temsirolimus and Perifosine in Treating Patients With Recurrent or Progressive Malignant GliomaCompletedNCT01051557Phase 1/2Results posted
• Study of RAD001 in Soft Tissue Extremity and/or Retroperitoneal SarcomasTerminatedNCT01048723Phase 2Results posted
• RAD001, FOLFOX and Bevacizumab in Treatment of Colorectal CarcinomaCompletedNCT01047293Phase 1/2Results posted
• Global Study Looking at the Combination of RAD001 Plus Best Supportive Care (BSC) and Placebo Plus BSC to Treat Patients With Advanced Hepatocellular Carcinoma.CompletedNCT01035229Phase 3Results posted
• Cisplatin, Paclitaxel, and Everolimus in Treating Patients With Metastatic Breast CancerCompletedNCT01031446Phase 1/2Results posted
• Study of RAD001 and Bevacizumab in Recurrent Ovarian, Peritoneal, and Fallopian Tube CancerCompletedNCT01031381Phase 2Results posted
• Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaCompletedNCT01027000Phase 2Results posted
• Temsirolimus in Treating Patients With Cervical Cancer That Is Recurrent, Locally Advanced, Metastatic, or Cannot Be Removed By SurgeryCompletedNCT01026792Phase 2Results posted
• Non-inferiority Study of Safety and Efficacy of Everolimus With Low Dose Tacrolimus to Mycophenolate Mofetil With Standard Dose Tacrolimus in Kidney Transplant RecipientsCompletedNCT01025817Phase 3Results posted
• Combination of Temsirolimus and Sorafenib in the Treatment of Radioactive Iodine Refractory Thyroid CancerCompletedNCT01025453Phase 2Results posted
• Everolimus (RAD001) for the Treatment of Malignant Pleural Mesothelioma With Merlin/NF2 Loss as a Biomarker to Predict SensitivityCompletedNCT01024946Phase 2Results posted
• Once-a-day Regimen With Everolimus, Low Dose Cyclosporine and Steroids in Comparison With Steroid Withdrawal or Twice a Day Regimen With Everolimus, Low Dose Cyclosporine and Steroids.CompletedNCT01023815Phase 3Results posted
• Study of RAD001 in Patients With Relapsed/Refractory Hodgkin Lymphoma That Has Progressed After High-dose Chemotherapy and Autologous Stem Cell Transplant and/or After Gemcitabine- or Vinorelbine- or Vinblastine-based Treatment.CompletedNCT01022996Phase 2Results posted
• Temsirolimus to Reverse Androgen Insensitivity for Castration-resistant Prostate CancerTerminatedNCT01020305Phase 1/2Results posted
• Everolimus in de Novo Heart Transplant RecipientsCompletedNCT01017029Phase 4Results posted
• Study of Everolimus With Paclitaxel and Carboplatin in Patients With Metastatic MelanomaCompletedNCT01014351Phase 2Results posted
• Temsirolimus and Bevacizumab in Treating Patients With Advanced Endometrial, Ovarian, Liver, Carcinoid, or Islet Cell CancerCompletedNCT01010126Phase 2Results posted
• RAD001 in Combination With Cetuximab and Cisplatin in Recurrent and Metastatic SCCHNTerminatedNCT01009346Phase 1/2Results posted
• Temsirolimus (Torisel®) and Erlotinib (Tarceva®) in Platinum-Refractory/Ineligible, Advanced, Squamous Cell CarcinomaTerminatedNCT01009203Phase 2Results posted
• Daily Everolimus in Combination With Trastuzumab and Vinorelbine in HER2/Neu Positive Women With Locally Advanced or Metastatic Breast CancerCompletedNCT01007942Phase 3Results posted
• Sirolimus Conversions in African-American Renal Transplant RecipientsCompletedNCT01005706Not applicableResults posted
• Everolimus in Treating Patients With Previously Treated Unresectable or Metastatic Esophageal Cancer or Stomach CancerCompletedNCT00985192Phase 2Results posted
• Risk-Based Therapy in Treating Younger Patients With Newly Diagnosed Liver CancerCompletedNCT00980460Phase 3Results posted
• Paclitaxel, Carboplatin, and Bevacizumab or Paclitaxel, Carboplatin, and Temsirolimus or Ixabepilone, Carboplatin, and Bevacizumab in Treating Patients With Stage III, Stage IV, or Recurrent Endometrial CancerActive, not recruitingNCT00977574Phase 2Results posted
• Everolimus (RAD001) in Primary Therapy of Waldenstrom's MacroglobulinemiaCompletedNCT00976248Phase 2Results posted
• Safety and Efficacy Study of Sirolimus in Complicated Vascular AnomaliesCompletedNCT00975819Phase 2Results posted
• Trial of the Combination of Bevacizumab and Everolimus in Patients With Refractory, Progressive Intracranial MeningiomaTerminatedNCT00972335Phase 2Results posted
• Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor SyndromesCompletedNCT00971789Phase 2Results posted
• Efficacy and Safety of Everolimus+EC-MPS After Early CNI Elimination vs EC-MPS +Tacrolimus in Renal Transplant RecipientsCompletedNCT00965094Phase 4Results posted
• Study to Evaluate the Efficacy, Safety and Tolerability of Everolimus in de Novo Renal Transplant Recipients Participating in the Eurotransplant Senior ProgramTerminatedNCT00956293Phase 4Results posted
• Safety and Efficacy Study of Torisel and Liposomal Doxorubicin for Patients With Recurrent SarcomaCompletedNCT00949325Phase 1/2Results posted
• Trial of RAD001 and Erlotinib With Recurrent Head and Neck Squamous Cell CarcinomaCompletedNCT00942734Phase 2Results posted
• RAD001 for Patients With Radioiodine Refractory Thyroid CancerCompletedNCT00936858Phase 2Results posted
• Carboplatin, Paclitaxel, and Everolimus in Treating Patients With Previously Untreated Cancer of Unknown PrimaryCompletedNCT00936702Phase 2Results posted
• Everolimus and Alemtuzumab in Treating Patients With Recurrent Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaCompletedNCT00935792Phase 1/2Results posted
• Phase I/II Study of Weekly Abraxane and RAD001 in Women With Locally Adv. or Metastatic Breast CaTerminatedNCT00934895Phase 1/2Results posted
• Polycystic Liver Disease in Kidney TransplantTerminatedNCT00934791Not applicableResults posted

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