mTOR inhibitors: all 1,276 studies that test it

Page 3 of 13. Open to participants first (126), then studies with results posted, then the rest; newest registration first within each.

• Pharmacokinetically Guided Everolimus in Patients With Breast Cancer, Pancreatic Neuroendocrine Tumors, or Kidney CancerTerminatedNCT02273752Phase 2Results posted
• Phase II Study of Everolimus Beyond ProgressionTerminatedNCT02269670Phase 2Results posted
• A Phase IIIb, Multinational, Multicenter, Open-Label Extension Study Assessing the Long-Term Safety of PRN Intravitreal Injections of DE-109 in Subjects With Non-Infectious Uveitis of the Posterior Segment of the Eye Who Have Participated in the SAKURA Development ProgramCompletedNCT02251938Phase 3Results posted
• Sequentiality of Everolimus and STZ-5FU in Advanced Pancreatic Neuroendocrine TumorCompletedNCT02246127Phase 3Results posted
• Neoadj ph 2 AI Plus Everolimus in Postmenopausal Women w/ ER Pos/HER2 Neg, Low Risk ScoreTerminatedNCT02236572Phase 2Results posted
• Everolimus and Letrozole or Hormonal Therapy to Treat Endometrial CancerCompletedNCT02228681Phase 2Results posted
• Everolimus for Cancer With TSC1 or TSC2 MutationCompletedNCT02201212Phase 2Results posted
• Everolimus for Children With Recurrent or Progressive EpendymomaCompletedNCT02155920Phase 2Results posted
• Topical Sirolimus for the Treatment of Pachyonychia Congenita (PC)CompletedNCT02152007Phase 1Results posted
• Sorafenib Tosylate With or Without Everolimus in Treating Patients With Advanced, Radioactive Iodine Refractory Hurthle Cell Thyroid CancerActive, not recruitingNCT02143726Phase 2Results posted
• S1222 Trial (Everolimus, Anastrozole and Fulvestrant) in Post-Menopausal Stage IV Breast CancerTerminatedNCT02137837Phase 3Results posted
• An Open Label Phase II Trial of Topical Sirolimus for the Treatment of Refractory Oral Chronic Graft-versus-Host-DiseaseTerminatedNCT02123966Phase 2Results posted
• Eribulin Mesylate and Everolimus in Treating Patients With Triple-Negative Metastatic Breast CancerCompletedNCT02120469Phase 1Results posted
• REnal Function in Liver Transplantation: Everolimus With Calcineurin Inhibitor (CNI)-Sparing sTrategyCompletedNCT02115113Phase 3Results posted
• A Study to Compare Vincristine to Sirolimus for Treatment of High Risk Vascular TumorsTerminatedNCT02110069Phase 2Results posted
• Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant FailureActive, not recruitingNCT02105766Phase 2Results posted
• Novartis Everolimus TransitionCompletedNCT02096107Phase 4Results posted
• Open-label, Phase II Study of Stomatitis Prevention With a Steroid-based Mouthwash in Post-menopausal Women With Estrogen-receptor-positive (ER+), Human Epidermal Growth Factor Receptor 2 (HER2)- Metastatic or Locally Advanced Breast CancerCompletedNCT02069093Phase 2Results posted
• SRL (Sirolimus) WithdrawalCompletedNCT02062944Not applicableResults posted
• Everolimus in Patients With Pancreatic Neuroendocrine Tumors Metastatic to the Liver Previously Treated With SurgeryTerminatedNCT02031536Phase 2Results posted
• Everolimus With and Without Temozolomide in Adult Low Grade GliomaTerminatedNCT02023905Phase 2Results posted
• Study to Collect and Assess Long-term Safety of Everolimus in Patients Who Are on Everolimus Treatment in a Novartis-sponsored Study and Are Benefiting From the Treatment as Judged by the Investigator.CompletedNCT02017860Phase 2Results posted
• SCD-Haplo: Phase II Study of HLA-Haploidentical SCT for Aggressive SCDTerminatedNCT02013375Phase 2Results posted
• Comparing Everolimus and Sirolimus in Renal Transplant RecipientsCompletedNCT01976390Not applicableResults posted
• A Phase II Study of Sirolimus and Erlotinib in Recurrent/Refractory Germ Cell TumorsTerminatedNCT01962896Phase 2Results posted
• Therapeutic Trial for Patients With Ewing Sarcoma Family of Tumor and Desmoplastic Small Round Cell TumorsCompletedNCT01946529Phase 2Results posted
• Sirolimus, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Bladder CancerCompletedNCT01938573Phase 1/2Results posted
• Conversion to Everolimus From Calcineurin Inhibitor With Mycophenolic Acid: Impact on Long Term Renal Function in Liver Transplantation.CompletedNCT01936519Not applicableResults posted
• Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® InductionCompletedNCT01935128Phase 4Results posted
• NECTAR Everolimus Plus Cisplatin in Triple (-) Breast CancerCompletedNCT01931163Phase 2Results posted
• Rapalogues for Autism Phenotype in TSC: A Feasibility StudyCompletedNCT01929642Phase 2Results posted
• In Vivo Treg Expansion and Graft-Versus-Host Disease ProphylaxisCompletedNCT01927120Phase 2Results posted
• Role of Everolimus in Highly Sensitized PatientsCompletedNCT01911546Phase 2Results posted
• A Pilot Study Comparing the Safety and Efficacy of Everolimus With Other Medicines in Recipients of ECD/DCD KidneysTerminatedNCT01878786Phase 2/3Results posted
• Sirolimus and Azacitidine in Treating Patients With High Risk Myelodysplastic Syndrome or Acute Myeloid Leukemia That is Recurrent or Not Eligible for Intensive ChemotherapyCompletedNCT01869114Phase 2Results posted
• Non-Myeloablative Conditioning and Bone Marrow TransplantationActive, not recruitingNCT01850108Not applicableResults posted
• 12 Month Athena Study: Everolimus vs. Standard Regimen in de Novo Kidney Transplant PatientsCompletedNCT01843348Phase 3Results posted
• A Phase II Trial of Combined Hydroxychloroquine and Sirolimus in Soft Tissue SarcomaTerminatedNCT01842594Phase 2Results posted
• Phase II Evaluating Efficacy of Temsirolimus in 2 Line Therapy for Patients With Advanced Bladder CancerCompletedNCT01827943Phase 2Results posted
• MPACT Study to Compare Effects of Targeted Drugs on Tumor Gene VariationsCompletedNCT01827384Phase 2Results posted
• A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial CarcinomaCompletedNCT01797523Phase 2Results posted
• Study of Fulvestrant +/- Everolimus in Post-Menopausal, Hormone-Receptor + Metastatic Breast Ca Resistant to AICompletedNCT01797120Phase 2Results posted
• Everolimus Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Everolimus Study.CompletedNCT01789281Phase 4Results posted
• A Phase II Study of Everolimus in Combination With Exemestane Versus Everolimus Alone Versus Capecitabine in Advance Breast Cancer.CompletedNCT01783444Phase 2Results posted
• Irinotecan Hydrochloride and Temozolomide With Temsirolimus or Dinutuximab in Treating Younger Patients With Refractory or Relapsed NeuroblastomaCompletedNCT01767194Phase 2Results posted
• Sirolimus in Kidney Transplant Patients With Squamous Cell Skin CarcinomaTerminatedNCT01764607Phase 2Results posted
• An Open Label Study of Postmenopausal Women With Oestrogen Receptor Positive Locally Advanced or Metastatic Breast Cancer Treated With Everolimus (RAD001) With Exemestane, With Exploratory Epigenetic Marker AnalysisCompletedNCT01743560Phase 4Results posted
• Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung CancerCompletedNCT01737502Phase 1/2Results posted
• PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in ChildrenCompletedNCT01734512Phase 2Results posted
• A Placebo-controlled Study of Efficacy & Safety of 2 Trough-ranges of Everolimus as Adjunctive Therapy in Patients With Tuberous Sclerosis Complex (TSC) & Refractory Partial-onset SeizuresCompletedNCT01713946Phase 3Results posted
• Pharmacokinetics of Sirolimus and Tacrolimus in Liver Transplant Recipients With Tacrolimus ToxicityTerminatedNCT01709136Phase 2/3Results posted
• Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast CancerCompletedNCT01698918Phase 2Results posted
• Phase II Combination of Temsirolimus and Sorafenib in Advanced Hepatocellular CarcinomaCompletedNCT01687673Phase 2Results posted
• Tacrolimus/Everolimus Versus Tacrolimus/Enteric-Coated Mycophenolate SodiumCompletedNCT01680861Phase 3Results posted
• Everolimus After (Chemo)Embolization for Liver Metastases From Digestive Endocrine TumorsCompletedNCT01678664Phase 2Results posted
• S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast CancerActive, not recruitingNCT01674140Phase 3Results posted
• SARC016: Study of Everolimus With Bevacizumab to Treat Refractory Malignant Peripheral Nerve Sheath TumorsCompletedNCT01661283Phase 2Results posted
• Study in Recipients of Renal Transplant Allograft to Evaluate the Impact of Two Immunosuppressive RegimensCompletedNCT01653847Not applicableResults posted
• Using mTOR Inhibitors in the Prevention of BK NephropathyCompletedNCT01649609Not applicableResults posted
• Study of Ibrutinib (a Bruton's Tyrosine Kinase Inhibitor), Versus Temsirolimus in Patients With Relapsed or Refractory Mantle Cell Lymphoma Who Have Received at Least One Prior TherapyCompletedNCT01646021Phase 3Results posted
• Study of (1) Everolimus, (2) Estrogen Deprivation Therapy (EDT) With Leuprolide + Letrozole and (3) Everolimus + EDT in Patients With Unresectable Fibrolamellar Hepatocellular Carcinoma (FLL-HCC)CompletedNCT01642186Phase 2Results posted
• Everolimus in Treating Cutaneous T-cell LymphomaTerminatedNCT01637090Phase 2Results posted
• The Everolimus-Transplant Exit Strategy Trial (E-TEST)TerminatedNCT01636466Phase 3Results posted
• Exemestane-RAD001-MetforminTerminatedNCT01627067Phase 2Results posted
• A National Multi-center Randomized, Open Label Study to Evaluate Efficacy and Safety of Everolimus With EC-MPS Compared to Standard Treatment Combination Tacrolimus and EC-MPS in de Novo Liver Transplant RecipientsCompletedNCT01625377Phase 3Results posted
• Safety and Efficacy Study of Everolimus to Treat BK Virus Infection in Kidney Transplant RecipientsCompletedNCT01624948Phase 4Results posted
• A Trial of Temsirolimus With Etoposide and Cyclophosphamide in Children With Relapsed Acute Lymphoblastic Leukemia and Non-Hodgkins LymphomaCompletedNCT01614197Phase 1Results posted
• Pharmacodynamics, Efficacy and Safety of Basiliximab 40 or 80 mg in Combination With Ciclosporine Microemulsion or Everolimus, in Adult Low Risk de Novo Renal Transplant Recipients (IDEALE Study)CompletedNCT01596062Phase 2Results posted
• An Open-label, Multi-center, Expanded Access Study of Everolimus in Participants With Advanced Neuroendocrine Tumors (NETs) (Core Study) and an Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced NETs (E1)CompletedNCT01595009Phase 4Results posted
• Vandetanib and Everolimus in Treating Patients With Advanced or Metastatic CancerCompletedNCT01582191Phase 1Results posted
• 3-arm Trial to Evaluate Pasireotide LAR/Everolimus Alone/in Combination in Patients With Lung/Thymus NET - LUNA TrialCompletedNCT01563354Phase 2Results posted
• Bevacizumab and Temsirolimus Alone or in Combination With Valproic Acid or Cetuximab in Treating Patients With Advanced or Metastatic Malignancy or Other Benign DiseaseTerminatedNCT01552434Phase 1Results posted
• Efficacy of Everolimus in Combination With Tacrolimus in Liver Transplant RecipientsCompletedNCT01551212Phase 4Results posted
• Everolimus Post Pazopanib Treatment in Metastatic or Advanced Renal Cell CarcinomaTerminatedNCT01545817Phase 2Results posted
• Efficacy, Tolerability and Safety of Early Introduction of Everolimus, Reduced Calcineurin Inhibitors and Early Steroid Elimination Compared to Standard CNI, Mycophenolate Mofetil and Steroid Regimen in Paediatric Renal Transplant RecipientsCompletedNCT01544491Phase 3Results posted
• Topical Rapamycin to Erase Angiofibromas in TSCCompletedNCT01526356Phase 2Results posted
• Everolimus Plus Best Supportive Care vs Placebo Plus Best Supportive Care in the Treatment of Patients With Advanced Neuroendocrine Tumors (GI or Lung Origin)CompletedNCT01524783Phase 3Results posted
• Phase II Study of Alternating Sunitinib and TemsirolimusCompletedNCT01517243Phase 2Results posted
• Sirolimus Injections for Autoimmune ScleritisCompletedNCT01517074Phase 1/2Results posted
• Safety and Efficacy of Everolimus in Metastatic Renal Cell Carcinoma After Failure of First Line Therapy With Sunitinib or PazopanibCompletedNCT01514448Phase 4Results posted
• Letrozole and Lapatinib Followed by Everolimus in Women With Advanced Breast CancerTerminatedNCT01499160Phase 2Results posted
• Everolimus as Second-line Therapy in Metastatic Renal Cell CarcinomaCompletedNCT01491672Phase 2Results posted
• Mechanisms and Treatment of Chronic Allograft Injury (CAI) Due to Calcineurin Inhibitor (CNI) ToxicityTerminatedNCT01473732Not applicableResults posted
• In-vivo Regulatory T Cell Enhancement With Cyclophosphamide and SirolimusTerminatedNCT01453140Phase 1/2Results posted
• Rapamycin as a Means of Interference With Reconsolidation of Posttraumatic Stress Disorder-related Traumatic MemoryCompletedNCT01449955Not applicableResults posted
• Sirolimus for Advanced Age-Related Macular DegenerationCompletedNCT01445548Phase 1/2Results posted
• Phase I-II Everolimus and Sorafenib in Recurrent High-Grade GliomasCompletedNCT01434602Phase 1/2Results posted
• Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2CompletedNCT01419639Phase 2Results posted
• Efficacy Regarding Renal Function of Everolimus in Combination With Specific Standard Immunosuppressive Regimen Lung Transplant RecipientsCompletedNCT01404325Phase 3Results posted
• Everolimus and Bevacizumab in Advanced Non-Clear Cell Renal Cell Carcinoma (RCC)CompletedNCT01399918Phase 2Results posted
• Pazopanib Versus Temsirolimus in Poor-Risk Clear-Cell Renal Cell Carcinoma (RCC)CompletedNCT01392183Phase 2Results posted
• Bortezomib, Rituximab, and Dexamethasone With or Without Temsirolimus in Treating Patients With Untreated or Relapsed Waldenstrom Macroglobulinemia or Relapsed or Refractory Mantle Cell or Follicular LymphomaCompletedNCT01381692Phase 1/2Results posted
• Safety and Efficacy of RAD001 + TACE in Localized Unresectable HCCTerminatedNCT01379521Phase 2Results posted
• Efficacy of Everolimus Alone or in Combination With Pasireotide LAR in Advanced PNETTerminatedNCT01374451Phase 2Results posted
• Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1)TerminatedNCT01365468Phase 2Results posted
• Study Assessing Double-masked Uveitis TreatmentCompletedNCT01358266Phase 3Results posted
• Research Study of ATG and Rituximab in Renal TransplantationTerminatedNCT01318915Early Phase 1Results posted
• RAD001 With Paclitaxel and Carboplatin in First Line Treatment of Patients With Advanced Large Cell Lung Cancer With Neuroendocrine DifferentiationCompletedNCT01317615Phase 4Results posted
• Evaluating Sirolimus to Treat Autoimmune Blistering Dermatosis PemphigusTerminatedNCT01313923Early Phase 1Results posted
• A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain MetastasesCompletedNCT01305941Phase 2Results posted

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