mTOR inhibitors: all 1,276 studies that test it
Page 1 of 13. Open to participants first (126), then studies with results posted, then the rest; newest registration first within each.
- Phase I/II Trial of Dinutuximab Beta in Combination With Irinotecan and Rapamycin in Pediatric, Adolescents and Adult Patients With Relapsed/Refractory Bone Tumors.Not yet recruitingNCT07853105Phase 1/2
- Low-Dose Sirolimus for the Treatment of RUNX1 Familial Platelet DisorderRecruitingNCT07844694Phase 1
- A Pilot Study to Examine the Efficacy and Tolerability of Sirolimus on Epidermal Nevi Lesions in Patients 6 Years Old and Above.Not yet recruitingNCT07813533Early Phase 1
- Sirolimus+Ruxolitinib+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to CNINot yet recruitingNCT07796620Phase 1/2
- Everolimus bAsed caLcineurin inhibiTor frEe immunosuppRession oNe Year AfTer lIver transplantatiON (ALTERNATION)RecruitingNCT07739914Phase 3
- A Phase 1 Study of UB-VV500 With Rapamycin in Relapsed/Refractory Multiple MyelomaNot yet recruitingNCT07735546Phase 1
- A Phase 1/2 Study of UB-VV400 With Rapamycin in Relapsed/Refractory B-cell MalignanciesRecruitingNCT07735533Phase 1/2
- Effects of Sirolimus on Asymptomatic ApoE4 CarriersRecruitingNCT07728175Phase 1
- Domatinostat With Sirolimus for Relapsed, Refractory Sarcoma and OsteosarcomaRecruitingNCT07725380Phase 1/2
- A Phase 2 Study of Sirolimus for Injection (Albumin-bound) in Patients With Progressive or Symptomatic Epithelioid HemangioendotheliomaNot yet recruitingNCT07684287Phase 2
- Ventricular mTOR Inhibition to Prevent Hydrocephalus After Brain HemorrhageNot yet recruitingNCT07662174Phase 1/2
- Sirolimus in Patients With Systemic Lupus Erythematosus-Associated Immune ThrombocytopeniaRecruitingNCT07657793Phase 2/3
- Low- vs High-Dose Sirolimus With Prednisolone for KHE and KMPRecruitingNCT07656909Phase 2/3
- Elacestrant With Everolimus for the Treatment of Recurrent Advanced or Metastatic ER-Positive Endometrial CancerNot yet recruitingNCT07634601Phase 2
- Vertebrobasilar Dolichoectasia Treatment With SirolimusNot yet recruitingNCT07634120Phase 2
- Haploidentical Donor Hematopoietic Cell Transplant for Sickle Cell DiseaseRecruitingNCT07616154Phase 2
- Vaccination Response Modulation With a Targeted Rapamycin Protocol StudyNot yet recruitingNCT07587801Phase 2
- Sirolimus Pre-conditioning on T Cell Activity and T-cell Engaging Bispecific Antibody Efficacy in Multiple MyelomaRecruitingNCT07581704Phase 1
- HORUS-Cytomegalovirus Open Proof-of-concept Exploratory TrialNot yet recruitingNCT07570433Phase 4
- A Study to Evaluate the Efficacy and Safety of Everolimus in Patients With Teratment-refractory Vascular AnomaliesNot yet recruitingNCT07477548Phase 2
- Rapamycin Dose-Ranging Efficacy Study in Port Wine StainsNot yet recruitingNCT07436611Phase 2
- Everolimus in CDK12-Deficient Metastatic Colorectal Cancer (EVER-RECODE)Not yet recruitingNCT07435584Phase 1/2
- Adjuvant Intensification for LARNot yet recruitingNCT07407517Phase 3
- Systematic Approach for Children With Orbital Malformation With Sirolimus UseRecruitingNCT07378657Phase 3
- Co-infusion of Treg-enriched Donor Lymphocytes With CD3-depleted Hematopoietic Stem Cell Graft to Prevent Graft-versus Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation Among Children With Hematologic MalignanciesRecruitingNCT07366801Phase 2/3
- A Study Comparing the MAGICTouch™ Sirolimus-coated Balloon With a Paclitaxel-coated Balloon for Treating Severe Narrowing or Blockage in the Femoropopliteal Arteries.Not yet recruitingNCT07359807Phase 2/3
- Phase Ib Study of Avutometinib, Defactinib, and Everolimus in RAS Pathway Mutant Endometrial CancerRecruitingNCT07318324Phase 1
- Gene Replacement Therapy for Treatment of Paediatric Patients With CTNNB1 Neurodevelopmental SyndromeRecruitingNCT07270549Phase 1/2
- Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline MutationsNot yet recruitingNCT07218575Phase 2/3
- Use of Tacrolimus and MTOR Inhibitors With Anticipatory Therapy vs. Tacrolimus and Mycophenolic Acid With Universal Prophylaxis in Renal Recipients at High Risk of Posttransplant Cytomegalovirus.Not yet recruitingNCT07203664Phase 4
- Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal WomenRecruitingNCT07191353Phase 2
- Sirolimus for Injection (Albumin Bound) Combined With Octreotide Long-acting Injection in Patients With Metastatic Gastroenteropancreatic Neuroendocrine TumorsRecruitingNCT07165886Phase 2/3
- A Comparison of Vorolanib Tablets Combined With Everolimus Versus Sunitinib in Patients With Advanced Renal Cell Carcinoma Who Have Progressed After Treatment With Immunotherapy Monotherapy or in Combination With TKINot yet recruitingNCT07165418Phase 3
- Sirolimus Discontinuation Strategies in Kaposiform HemangioendotheliomaRecruitingNCT07131644Phase 2
- Part B- G1X-CGD (Lentiviral Vector Transduced CD34+ Cells) in Patients With X-Linked Chronic Granulomatous DiseaseEnrolling by invitationNCT07113743Phase 1/2
- The Safety and Efficacy Evaluation of Everolimus as an Adjunctive Treatment for Focal Refractory EpilepsyRecruitingNCT07095933Early Phase 1
- Effectiveness of Alternative Therapies in Maintaining Weight Loss Achieved by GLP-1 Medications Post-CessationRecruitingNCT07092618Phase 2/3
- Immunotherapy With Baricitinib and Sirolimus, Alone and in Combination, for the Control of HIV-1 Replication After Antiretroviral Treatment InterruptionNot yet recruitingNCT07081763Phase 2
- A Study to Learn About the Study Medicine Called PF-07248144 in Combination With Fulvestrant in People With HR-positive, HER2-negative Advanced or Metastatic Breast Cancer Who Progressed After a Prior Line of Treatment.RecruitingNCT07062965Phase 3
- Study of ASP2957 in Male Participants With X-linked Myotubular Myopathy Who Need VentilatorsRecruitingNCT07052929Phase 1/2
- An Open-Label, Single-Arm Exploratory Clinical Study of Everolimus for the Treatment of Vascular MalformationsRecruitingNCT07037238Phase 2
- Evaluaion the Short Term Effects of Advograf Plus Rapamiune After Kidney TransplantationRecruitingNCT07033858Not applicable
- Low Dose Sirolimus in People With Post-Acute Sequelae of COVID-19 (PASC) Long COVID-19RecruitingNCT06960928Phase 3
- Base Editing Hematopoietic Stem Cell and T Cell Gene Therapy for CD40L-HyperIgM Syndrome: Single Patient StudyRecruitingNCT06959771Phase 1/2
- Optimize Immunosuppressive Therapy Using Everolimus and Low-dose Calcineurin Inhibitors in Heart Transplant Patients in KoreaNot yet recruitingNCT06942156Phase 4
- A Study of Sirolimus (Albumin-Bound) in Combination With Palbociclib and Fulvestrant for the Treatment of Advanced Breast CancerNot yet recruitingNCT06941142Phase 1
- Sirolimus for Injection (Albumin-bound) Combined With Fulvestrant for HR+/HER2- Advanced/Metastatic Breast Cancer Patients Previously Treated With CDK4/6 InhibitorsNot yet recruitingNCT06929325Phase 3
- Allo HSCT for High Risk HemoglobinopathiesRecruitingNCT06872333Phase 2
- A Study of Sirolimus (Albumin-Bound) in Combination With Palbociclib and Fulvestrant for the Treatment of Advanced Breast CancerRecruitingNCT06856200Not applicable
- Sirolimus for Leigh SyndromeEnrolling by invitationNCT06843811Phase 2
- EVR and EPO for Liver Transplant ToleranceRecruitingNCT06832189Phase 1
- UB-VV400 in Combination With Rapamycin in Relapsed or Refractory B-cell MalignanciesRecruitingNCT06743503Phase 1
- Sirolimus Monotherapy in the Treatment of Antiphospholipid Antibody Related ThrombocytopeniaRecruitingNCT06722586Phase 4
- Sirolomus Adjuvant Treatment of Focal Refractory Epilepsy (SATFRE)RecruitingNCT06719791Early Phase 1
- A Nutritional and Pharmacological Intervention for Body, Brain, and Longevity Effects (NIBBLE)Not yet recruitingNCT06682767Phase 1/2
- Different Doses of Sirolimus for the Treatment of Cystic Lymphatic MalformationsRecruitingNCT06673290Phase 2/3
- RESTOR: PK/PD mTORi Inhibition in Older AdultsRecruitingNCT06658093Early Phase 1
- Efficacy of a Quadruple Immunosuppressor Regimen With mTOR Inhibitors in Sensitized Kidney Transplant PatientsRecruitingNCT06584773Phase 4
- The Safety and Efficacy of Rapamycin on Communicating Hydrocephalus Secondary to Intraventricular HemorrhageRecruitingNCT06563817Phase 2
- Precision Treatment of HR+ HER2- Advanced Breast Cancer Based on SNF Molecular SubtypingNot yet recruitingNCT06561022Phase 2
- A Phase 1 Study of UB-VV111 With and Without Rapamycin in Relapsed/Refractory CD19+ B-cell MalignanciesRecruitingNCT06528301Phase 1
- The Safety and Efficiency of Sirolimus in Primary Antiphospholipid Syndrome: a Randomized Control StudyNot yet recruitingNCT06504420Phase 2
- Everolimus 5 mg vs 10 mg/Daily for Patients With Neuroendocrine TumorsRecruitingNCT06472388Phase 2
- Elacestrant + Everolimus in Patients ER+/HER2-, ESR1mut, Advanced Breast Cancer Progressing to ET and CDK4/6i.RecruitingNCT06382948Phase 3
- Base Editing for Mutation Repair in Hematopoietic Stem & Progenitor Cells for X-Linked Chronic Granulomatous DiseaseRecruitingNCT06325709Phase 1/2
- Fruquintinib Plus Everolimus as 2nd Line Therapy of ccRCC Patients Progressed Post IO and TKI TherapyRecruitingNCT06317298Not applicable
- Safety Study for the Use of Rapamycin in Children With Familial Adenomatous PolyposisNot yet recruitingNCT06308445Phase 2
- Everolimus Combined With PD-1 in Advanced Colorectal Cancer PatientsNot yet recruitingNCT06301386Phase 2
- Expanding Liver Transplant Immunosuppression Minimization Via EverolimusRecruitingNCT06280950Phase 2
- Sirolimus+Abatacept+Mycophenolate Mofetil for Prophylaxis of aGVHD in Patients Receiving Haplo-HSCT Who Are Intolerant to Calcineurin InhibitorsNot yet recruitingNCT06279494Phase 1/2
- Low-Dose Sirolimus to Increase Hematopoietic Function in Patients With RUNX1 Familial Platelet DisorderRecruitingNCT06261060Phase 2
- The Effects of Sirolimus in Patients With Dilated Cardiomyopathy Infected With Kaposi Sarcoma-associated VirusRecruitingNCT06236022Phase 4
- Proteomic Guided First-line Precision Treatment of Renal Clear Cell CarcinomaRecruitingNCT06211790Phase 2
- Combination of Everolimus and 177Lu-DOTATATE in the Treatment of Grades 2 and 3 Refractory Meningioma: a Phase IIb Clinical TrialRecruitingNCT06126588Phase 2
- Hemorrhagic Brainstem Cavernous Malformations Treatment With Sirolimus: aSingle Centre, Randomized, Placebo-controlled Pilot TrialRecruitingNCT06091332Phase 2
- Intestinal & Multivisceral Transplantation for Unresectable Mucinous Carcinoma Peritonei (TRANSCAPE)Not yet recruitingNCT06084780Phase 2
- Advancing Transplantation Outcomes in ChildrenRecruitingNCT06055608Phase 2
- Chidamide/Everolimus for PIK3CA Wild-type/Mutant HR+/HER2- Advanced Breast CancerRecruitingNCT05983107Phase 2
- Everolimus With Investigator's Choice of Chemotherapy in Advanced Triple-Negative Breast Cancer (TNBC) With Luminal Androgen Receptor (LAR) SubtypeRecruitingNCT05954442Phase 3
- Rapalog Pharmacology (RAP PAC) StudyRecruitingNCT05949658Phase 1
- Genetically-informed Therapy for ER+ Breast Cancer Post-CDK4/6 InhibitorRecruitingNCT05933395Phase 2
- Sirolimus in the Treatment of Refractory/Relapsed wAIHARecruitingNCT05925023Not applicable
- Venetoclax Combined With Azactidine in the Treatment of ALALRecruitingNCT05901974Phase 2
- Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin CancerRecruitingNCT05896839Phase 1/2
- Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutantRecruitingNCT05843253Phase 2
- Study of Sirolimus in IgG4-related DiseaseNot yet recruitingNCT05746689Not applicable
- Study to Investigate Outcome of Individualized Treatment in Patients With Metastatic Colorectal CancerRecruitingNCT05725200Phase 2
- SNF Platform Study of HR+/ HER2-advanced Breast CancerRecruitingNCT05594095Phase 2
- Efficacy and Safety of Sirolimus in Children and Adolescents With Juvenile Nasopharyngeal Angiofibroma (JNA)RecruitingNCT05549167Phase 3
- Sirolimus in Cutaneous SarcoidosisNot yet recruitingNCT05458492Phase 2
- The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral Blood Stem Cell TransplantationRecruitingNCT05436418Phase 1/2
- Pilot Trial for Treatment of Recurrent GlioblastomaEnrolling by invitationNCT05432518Early Phase 1
- Thal-Fabs: Reduced Toxicity Conditioning for High Risk ThalassemiaRecruitingNCT05426252Phase 1/2
- Impacts of Mechanistic Target of Rapamycin (mTOR) Inhibition on Aged Human Muscle (Rapamune)RecruitingNCT05414292Not applicable
- Different Doses of Sirolimus for the Maintenance Treatment of Kaposiform HemangioendotheliomaRecruitingNCT05324384Phase 2
- The Role of Sirolimus in Preventing Functional Decline in Older AdultsRecruitingNCT05237687Phase 2
- mTOR as Mediator of Insulin Sensitivity StudyRecruitingNCT05233722Not applicable
- COAST Therapy in Advanced Solid Tumors and Prostate CancerRecruitingNCT05036226Phase 1/2
- Efficacy and Safety of Rapamycin Versus Vigabatrin in the Prevention of Tuberous Sclerosis Complex Symptoms in InfantsRecruitingNCT04987463Phase 2/3
- Sirolimus vs Corticosteroids in Treatment of Thyroid Eye DiseaseRecruitingNCT04936854Phase 2