Methotrexate: all 649 studies that test it

Page 3 of 7. Open to participants first (88), then studies with results posted, then the rest; newest registration first within each.

• An Effectiveness and Safety Study of Intravenous Golimumab in Patients With Active Rheumatoid Arthritis Despite Treatment With Methotrexate TherapyCompletedNCT00973479Phase 3Results posted
• Safety and Feasibility Study of Combination of State of Art Chemoimmunotherapy, Intensive Central Nervous System Prophylaxis and Scrotal Irradiation to Treat Primary Diffuse Large B-cell Lymphoma of TestisCompletedNCT00945724Phase 2Results posted
• A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to MethotrexateCompletedNCT00934648Phase 4Results posted
• Mechanism of Action Study for PsoriasisCompletedNCT00932113Phase 4Results posted
• Methotrexate, Vincristine, Pegylated L-Asparaginase and Dexamethasone (MOAD) in Acute Lymphoblastic Leukemia (ALL) SalvageCompletedNCT00905034Phase 2Results posted
• Study of Augmented Hyper-CVAD in Acute Lymphoblastic Leukemia SalvageCompletedNCT00890656Phase 2Results posted
• Rituximab and Combination Chemotherapy in Treating Patients With Previously Untreated Mantle Cell LymphomaCompletedNCT00878254Phase 2Results posted
• Augmented Berlin-Frankfurt-Munster (BFM) Therapy for Adolescent/Young Adults With Acute Lymphoblastic Leukemia or Acute Lymphoblastic LymphomaCompletedNCT00866749Phase 2Results posted
• Long-term Treatment Study of Certolizumab Pegol (CDP870) as Add-on Medication to Methotrexate in Japanese Rheumatoid Arthritis (RA) PatientsCompletedNCT00851318Phase 3Results posted
• Dose Optimization of Infliximab in Moderate to Severe Plaque Psoriasis (Study P05315)TerminatedNCT00833053Phase 3Results posted
• Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic CancerTerminatedNCT00818961Phase 2Results posted
• Efficacy of Methotrexate in Myasthenia GravisCompletedNCT00814138Phase 2Results posted
• A Study of Tocilizumab and Methotrexate Treatment Strategies (Adding Tocilizumab to Methotrexate Versus Switching to Tocilizumab) in Patients With Active Rheumatoid Arthritis With Inadequate Response to Prior Methotrexate TreatmentCompletedNCT00810199Phase 3Results posted
• Graft-Versus-Host Disease (GVHD) Prophylaxis After Allogeneic Peripheral Blood Hematopoietic Cell TransplantationCompletedNCT00803010Phase 2Results posted
• Utility of Intravitreal Methotrexate in Diabetic Macular Edema Resistant to Conventional TherapiesTerminatedNCT00779142Not applicableResults posted
• A Rheumatoid Arthritis Study to Assess Early Response to Abatacept+MTX as Defined by Improvement of Synovitis Measures by Power Doppler UltrasonographyCompletedNCT00767325Phase 3Results posted
• METhotrexate Therapy Effects in the Physical Capacity of Patients With ISchemic Heart Failure (METIS Trial)CompletedNCT00759811Phase 2/3Results posted
• A Study to Assess the Effect of Tocilizumab Plus Methotrexate on Safety and Signs and Symptoms in Patients With Moderate to Severe Active Rheumatoid ArthritisCompletedNCT00754572Phase 3Results posted
• Chemotherapy Followed by Allogeneic Stem Cell Transplantation for Hematologic MalignanciesCompletedNCT00741455Not applicableResults posted
• A Trial of Anti-TNF Chimeric Monoclonal Antibody (cA2) in Korean Patients With Active Rheumatoid Arthritis Despite Methorexate (Extension Part)(Study P05645)(COMPLETED)CompletedNCT00732875Phase 3Results posted
• Methotrexate Polyglutamate Levels as a Marker for the Clinical Outcome in the Treatment of Rheumatoid ArthritisCompletedNCT00695188Phase 4Results posted
• Efficacy and Safety of Etanercept in Active RA Despite Methotrexate Therapy in JapanCompletedNCT00688103Phase 4Results posted
• CAMEO: Canadian Methotrexate and Etanercept Outcome StudyCompletedNCT00654368Phase 4Results posted
• Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous SystemCompletedNCT00653068Phase 3Results posted
• Combined Treatment of Methotrexate + Glucocorticoids Versus Glucocorticoids Alone in Patients With PM and DMCompletedNCT00651040Phase 3Results posted
• Open-label Leucovorin Pharmacokinetic Study in Patients Receiving High Dose Methotrexate With or Without VoraxazeCompletedNCT00634504Phase 1Results posted
• Sunitinib, Cyclophosphamide, and Methotrexate in Treating Patients With Metastatic Breast CancerTerminatedNCT00616122Phase 1/2Results posted
• Dose Dense Adjuvant CMF (Cyclophosphamide, Methotrexate, Fluorouracil) at 14 and 10-11 Day Intervals for Women With Early Stage Breast CancerCompletedNCT00615901Not applicableResults posted
• Combined Immunochemotherapy Followed By Reduced Dose Radiation Therapy (RT) for Patients With Newly Diagnosed Primary Central Nervous System LymphomaCompletedNCT00594815Not applicableResults posted
• Study of Sequential Administration of Oral 6-Thioguanine After Methotrexate in Patients With LCHCompletedNCT00588536Phase 2Results posted
• Phase II Study of Chemotherapy and Pamidronate for the Treatment of Newly Diagnosed OsteosarcomaCompletedNCT00586846Phase 2Results posted
• Allogeneic Stem Cell Transplant for Patients With Severe Aplastic AnemiaTerminatedNCT00578903Phase 2Results posted
• Medroxyprogesterone +/- Cyclophosphamide & Methotrexate in Hormone Receptor-Negative Recurrent/Metastatic Breast CancerCompletedNCT00577122Phase 2Results posted
• Combination Chemotherapy Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or High-Risk Primary Refractory Hodgkin LymphomaCompletedNCT00574496Phase 2Results posted
• Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00558519Phase 2Results posted
• Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous LeukemiaCompletedNCT00553202Phase 2Results posted
• Total Therapy Study XVI for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCompletedNCT00549848Phase 3Results posted
• Phase IIIB Subcutaneous Abatacept Monotherapy StudyCompletedNCT00547521Phase 3Results posted
• A Study of MabThera (Rituximab) in Primary Central Nervous System Lymphoma.TerminatedNCT00517699Phase 2Results posted
• Phase I/II Study of Pentostatin Combined With Tacrolimus and Mini-Methotrexate for GVHD Prevention After MUD BMTCompletedNCT00506922Phase 1/2Results posted
• Neoadjuvant Chemotherapy With Methotrexate, Vinblastine, Adriamycin and Cisplatin (M-VAC) Plus Avastin in Patients With Urothelial CancerCompletedNCT00506155Phase 2Results posted
• A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Agents.CompletedNCT00504777Phase 4Results posted
• A Non-Comparative Study to Assess the Safety of MabThera (Rituximab) in Patients With Rheumatoid Arthritis.CompletedNCT00502996Phase 3Results posted
• A Pilot Study of MabThera (Rituximab) Evaluated by MRI in Patients With Rheumatoid Arthritis.CompletedNCT00502853Phase 4Results posted
• S0521, Combination Chemotherapy With or Without Gemtuzumab Followed By Tretinoin, Mercaptopurine, and Methotrexate or Observation in Treating Patients With Acute Promyelocytic LeukemiaCompletedNCT00492856Phase 3Results posted
• A Study of Ocrelizumab in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Are Naive to Methotrexate (FILM)TerminatedNCT00485589Phase 3Results posted
• Bortezomib, Rituximab and Combination Chemotherapy in Treating Participants With Mantle Cell LymphomaCompletedNCT00477412Phase 1/2Results posted
• ALL Adult Consortium Trial: Adult ALL TrialCompletedNCT00476190Phase 2Results posted
• A Study of MabThera (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis Who Have Had an Inadequate Response to Anti-TNF Therapies.CompletedNCT00462345Phase 4Results posted
• R-MACLO-IVAM and Thalidomide in Untreated Mantle Cell LymphomaCompletedNCT00450801Phase 2Results posted
• Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based RegimenCompletedNCT00448357Phase 1/2Results posted
• Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other DiseaseCompletedNCT00448201Phase 2Results posted
• Trial of Early Aggressive Drug Therapy in Juvenile Idiopathic ArthritisCompletedNCT00443430Phase 4Results posted
• A Pharmacokinetic and Pharmacodynamic Study of MabThera (Rituximab) Plus Methotrexate in Patients With Rheumatoid Arthritis (RA)TerminatedNCT00422942Phase 2Results posted
• Study Comparing Etanercept With Usual DMARD Therapy in Subjects With Rheumatoid Arthritis in the Asia Pacific RegionCompletedNCT00422227Phase 4Results posted
• Combination Chemotherapy in Treating Young Patients With Newly Diagnosed T-Cell Acute Lymphoblastic Leukemia or T-cell Lymphoblastic LymphomaCompletedNCT00408005Phase 3Results posted
• Bortezomib Plus Tacrolimus and Methotrexate to Prevent Graft Versus Host Disease (GVHD) After Mismatched Allogeneic Non-Myeloablative Blood Stem Cell TransplantationCompletedNCT00369226Phase 1/2Results posted
• Evaluate Whether Combination Therapy With Methotrexate and Raptiva in Psoriasis Patients is Safe and Increases EfficacyCompletedNCT00368654Phase 1/2Results posted
• Remicade Study in Psoriatic Arthritis Patients Of Methotrexate-Naïve Disease (RESPOND) (Study P04422)CompletedNCT00367237Phase 3Results posted
• A Study of Safety and Effectiveness of Golimumab in Participants With Active Rheumatoid Arthritis Despite Methotrexate TherapyCompletedNCT00361335Phase 3Results posted
• Cyclophosphamide and Anti-thymocyte Globulin Followed By Methotrexate and Cyclosporine in Preventing Chronic Graft-Versus-Host Disease in Patients With Severe Aplastic Anemia Undergoing Donor Bone Marrow TransplantCompletedNCT00343785Phase 2Results posted
• Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk MedulloblastomaCompletedNCT00336024Phase 3Results posted
• Low-Dose or High-Dose Conditioning Followed by Peripheral Blood Stem Cell Transplant in Treating Patients With Myelodysplastic Syndrome or Acute Myelogenous LeukemiaCompletedNCT00322101Phase 3Results posted
• A Study to Evaluate the Safety and Efficacy of Rituximab in Combination With Methotrexate Compared to Methotrexate Alone in Patients With Active Rheumatoid ArthritisCompletedNCT00299130Phase 3Results posted
• Study of Rituximab-HCVAD Alternating With Rituximab-Methotrexate-Cytarabine Versus Standard Rituximab-CHOP Every 21 Days for Patients With Newly Diagnosed High Risk Aggressive B-Cell Non-Hodgkin's Lymphomas in Patients 60 Years Old or YoungerCompletedNCT00290498Phase 2Results posted
• Efficacy of the HCVIDDOXIL Regimen in Patients With Newly Diagnosed Peripheral T-Cell LymphomaCompletedNCT00290433Phase 2Results posted
• Chemotherapy and HAART to Treat AIDS-related Primary Brain LymphomaCompletedNCT00267865Phase 2Results posted
• An Efficacy and Safety Study of Golimumab in Patients With Active Rheumatoid Arthritis Despite Methotrexate TherapyCompletedNCT00264550Phase 3Results posted
• A Study of the Safety and Efficacy of Golimumab in Subjects With Rheumatoid Arthritis That Are Methotrexate-naiveCompletedNCT00264537Phase 3Results posted
• Combination Chemotherapy and Alemtuzumab in Treating Patients With Relapsed or Refractory Acute Lymphoblastic LeukemiaTerminatedNCT00262925Phase 2Results posted
• A Study of the Safety and Efficacy of Rituximab in Patients With Moderate to Severe Rheumatoid Arthritis Receiving MethotrexateCompletedNCT00243412Phase 2Results posted
• Efficacy and Safety of Adalimumab and Methotrexate (MTX) Versus MTX Monotherapy in Subjects With Early Rheumatoid ArthritisCompletedNCT00195663Phase 3Results posted
• Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast CancerTerminatedNCT00194792Phase 2Results posted
• Combination Chemotherapy and Filgrastim Before Surgery in Treating Patients With HER2-Positive Breast Cancer That Can Be Removed By SurgeryCompletedNCT00194779Phase 2Results posted
• Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic LeukemiaCompletedNCT00186875Phase 2Results posted
• CINJALL: Treatment for Children With Acute Lymphocytic LeukemiaCompletedNCT00176462Phase 2Results posted
• Therapy for Newly Diagnosed Patients With Acute Lymphoblastic LeukemiaCompletedNCT00137111Phase 3Results posted
• Treatment of Patients With Newly Diagnosed Acute Myeloid Leukemia or MyelodysplasiaCompletedNCT00136084Phase 3Results posted
• Remission and Joint Damage Progression in Early Rheumatoid ArthritisCompletedNCT00122382Phase 3Results posted
• S0501 Fludarabine, Melphalan, and Donor Stem Cell Transplant Followed By Tacrolimus and Methotrexate in Treating Patients for Relapsed LymphomaTerminatedNCT00121186Phase 2Results posted
• Bevacizumab With or Without Cyclophosphamide and Methotrexate: A Pilot Study in Women With Operable Breast CancerCompletedNCT00121134Not applicableResults posted
• S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic LeukemiaCompletedNCT00109837Phase 2Results posted
• Combination Chemotherapy and Radiation Therapy in Treating Patients With Acute Lymphoblastic Leukemia That Has Relapsed in the CNS or TestesCompletedNCT00096135Not applicableResults posted
• Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RTCompletedNCT00084838Phase 2Results posted
• Reduced-Intensity Regimen Before Allogeneic Transplant for Patients With Relapsed Non-Hodgkin's or Hodgkin's LymphomaTerminatedNCT00057954Phase 2Results posted
• Modified Stem Cell Transplant Procedure to Treat Patients With Blood and Immune System CancersCompletedNCT00051311Phase 2Results posted
• Reduced-Intensity Regimen Before Donor Bone Marrow Transplant in Treating Patients With Myelodysplastic SyndromesCompletedNCT00045305Phase 2Results posted
• S0213 Chemotherapy Plus Rituximab in Treating Patients With Mantle Cell LymphomaCompletedNCT00041132Phase 2Results posted
• Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform NeurofibromasCompletedNCT00030264Phase 2Results posted
• Low-dose Oral Cyclophosphamide and Methotrexate Maintenance for Hormone Receptor-negative Early Breast CancerCompletedNCT00022516Phase 3Results posted
• Chemotherapy, Stem Cell Transplantation and Donor and Patient Vaccination for Treatment of Multiple MyelomaCompletedNCT00006184Phase 2Results posted
• 4B951, Combination Chemotherapy in Treating Patients With Bladder CancerTerminatedNCT00005047Phase 3Results posted
• Methotrexate With or Without Cyclophosphamide in Treating Patients With Lymphocytic LeukemiaTerminatedNCT00003910Phase 2Results posted
• Specialized Blood Cell Transplants for Cancers of the Blood and Bone MarrowCompletedNCT00003838Phase 2Results posted
• Methotrexate Compared With Dactinomycin in Treating Patients With Gestational Trophoblastic NeoplasiaCompletedNCT00003702Phase 3Results posted
• Stem Cell Transplantation for Metastatic Solid TumorsTerminatedNCT00001880Phase 2Results posted
• Comparative Study of Intralesional Methotrexate Versus Intralesional Triamcinolone Acetonide in Treatment of Nail PsoriasisCompletedNCT07875608Phase 2
• Sequential vs. Combined Letrozole and Methotrexate for Tubal Ectopic Pregnancy.Active, not recruitingNCT07842796Phase 2/3
• Comparative Study of Leflunomide Plus Methotrexate Versus Methotrexate Monotherapy in Refractory Polyarticular Juvenile Idiopathic Arthritis PatientsCompletedNCT07428551Phase 4
• Drug-Drug Interaction of Rifampicin and Cyclosporine on Methotrexate Pharmacokinetics in Healthy SubjectsActive, not recruitingNCT07196449Phase 1

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