Methotrexate: all 649 studies that test it

Page 2 of 7. Open to participants first (88), then studies with results posted, then the rest; newest registration first within each.

• Study of Pegloticase (KRYSTEXXA®) Plus Methotrexate in Patients With Uncontrolled GoutCompletedNCT03635957Phase 4Results posted
• Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung CancerCompletedNCT03520842Phase 2Results posted
• Selinexor in Combination With Fludarabine and Cytarabine in Patients With Refractory or Relapsed Acute Myeloid LeukemiaTerminatedNCT03071276Phase 2Results posted
• Filgotinib Alone and in Combination With Methotrexate (MTX) in Adults With Moderately to Severely Active Rheumatoid Arthritis Who Are Naive to MTX TherapyCompletedNCT02886728Phase 3Results posted
• Methotrexate Withdrawal Study of Tofacitinib Modified Release Formulation in Subjects With Rheumatoid ArthritisCompletedNCT02831855Phase 4Results posted
• A Study of Subjects With Psoriatic Arthritis to Investigate the Effectiveness of Adalimumab Introduction Compared With Methotrexate Dose Escalation (CONTROL)CompletedNCT02814175Phase 4Results posted
• Low Dose Oral Methotrexate in Pediatric Crohn's Disease Patients Initiating Anti-Tumor Necrosis Factor (Anti-TNF) TherapyCompletedNCT02772965Phase 3Results posted
• Bone Marrow Transplantation vs Standard of Care in Patients With Severe Sickle Cell Disease (BMT CTN 1503)CompletedNCT02766465Phase 2Results posted
• Triple Combination Therapy in High Risk Crohn's Disease (CD)CompletedNCT02764762Phase 4Results posted
• MTX Discontinuation and Vaccine ResponseCompletedNCT02748785Phase 4Results posted
• A Study Comparing Upadacitinib (ABT-494) Monotherapy to Methotrexate (MTX) Monotherapy in Adults With Rheumatoid Arthritis (RA) Who Have an Inadequate Response to MTX (SELECT-MONOTHERAPY)CompletedNCT02706951Phase 3Results posted
• Macular Edema Ranibizumab v. Intravitreal Anti-inflammatory Therapy TrialCompletedNCT02623426Phase 3Results posted
• Transarterial Chemoperfusion: Cisplatin, Methotrexate, Gemcitabine for Unresectable Pleural MesotheliomaCompletedNCT02611037Phase 2Results posted
• Cardiovascular Inflammation Reduction Trial - Inflammation Imaging StudyCompletedNCT02576067Phase 3Results posted
• Study to Assess Changes in the Immune Profile in Adults With Early Rheumatoid ArthritisCompletedNCT02557100Phase 4Results posted
• Total Therapy for Infants With Acute Lymphoblastic Leukemia (ALL) IActive, not recruitingNCT02553460Phase 1/2Results posted
• Effects of Abatacept in Patients With Early Rheumatoid ArthritisCompletedNCT02504268Phase 3Results posted
• IL-7 and IL-7R Expression in RA Patients With Active vs. Inactive Disease Treated With DMARD or CIMZIACompletedNCT02451748Phase 4Results posted
• Microtransplantation to Treat Refractory or Relapsed Hematologic Malignancies in Younger PatientsTerminatedNCT02433483Phase 2Results posted
• Evaluate if Response to Infliximab or Adalimumab May be Regained With an ImmunomodulatorTerminatedNCT02413047Not applicableResults posted
• Chemotherapy Before Surgery in Treating Patients With High Grade Upper Urinary Tract CancerCompletedNCT02412670Phase 2Results posted
• Etanercept and Methotrexate in Combination or as Monotherapy in Psoriatic ArthritisCompletedNCT02376790Phase 3Results posted
• Study of Etanercept Monotherapy vs Methotrexate Monotherapy for Maintenance of Rheumatoid Arthritis RemissionCompletedNCT02373813Phase 3Results posted
• Inflammation and Coronary Endothelial FunctionCompletedNCT02366091Phase 2Results posted
• New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System InvolvementCompletedNCT02329080Phase 2Results posted
• Peginterferon Alfa-2a to Enhance Anti-leukemic Responses After Allogeneic Transplantation in Acute Myeloid LeukemiaCompletedNCT02328755Phase 1/2Results posted
• A Study Assessing the Efficacy and Safety of Sarilumab Added to MTX in Japanese Patients With Moderately to Severely Active Rheumatoid Arthritis (SARIL-RA-KAKEHASI)CompletedNCT02293902Phase 3Results posted
• A Study to Evaluate the Pharmacokinetics, Efficacy and Safety of Intravenous Golimumab in Pediatric Participants With Active Polyarticular Course Juvenile Idiopathic Arthritis Despite Methotrexate TherapyCompletedNCT02277444Phase 3Results posted
• JAK Inhibitor Before Donor Stem Cell Transplant in Treating Patients With Primary or Secondary MyelofibrosisCompletedNCT02251821Phase 2Results posted
• Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHDCompletedNCT02220985Phase 2Results posted
• Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203)CompletedNCT02208037Phase 2Results posted
• A Study of Tacrolimus/Methotrexate and Tocilizumab to Prevent Acute Graft-Versus-Host Disease (AGVD) After Allogeneic Hematopoietic Stem Cell TransplantCompletedNCT02206035Phase 2Results posted
• Concomitant Longitudinal Evaluation of Adalimumab With Methotrexate in the Real World: the CLEAR StudyCompletedNCT02196701Phase 3Results posted
• An Efficacy And Safety Study Evaluating Tofacitinib With And Without Methotrexate Compared To Adalimumab With MethotrexateCompletedNCT02187055Phase 4Results posted
• S1314, Co-expression Extrapolation (COXEN) Program to Predict Chemotherapy Response in Patients With Bladder CancerCompletedNCT02177695Phase 2Results posted
• Optimal Treatment for Women With a Persisting Pregnancy of Unknown LocationCompletedNCT02152696Phase 3Results posted
• Blinatumomab and Combination Chemotherapy or Dasatinib, Prednisone, and Blinatumomab in Treating Older Patients With Acute Lymphoblastic LeukemiaActive, not recruitingNCT02143414Phase 2Results posted
• Individualized High Dose Methotrexate to Treat Cancer in Children Who Have a Significant Risk for Side Effects to MethotrexateCompletedNCT02076997Not applicableResults posted
• A Study of Tocilizumab (RoActemra/Actemra) in Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Participants With Active Rheumatoid Arthritis and an Inadequate Response to Current Non-Biologic DMARD Therapy or the First Anti-TNF Biologic AgentCompletedNCT02046603Phase 3Results posted
• Combination Chemotherapy in Treating Younger Patients With Newly Diagnosed, Non-metastatic Desmoplastic MedulloblastomaCompletedNCT02017964Phase 2Results posted
• A Study of MabThera/Rituxan (Rituximab) in Combination With Methotrexate in Patients With Rheumatoid Arthritis and Inadequate Response to DMARD TherapyCompletedNCT02006706Phase 3Results posted
• A Study of Subcutaneous RoActemra/Actemra (Tocilizumab) as Monotherapy or in Combination With Methotrexate or Other Non-Biologic DMARDs in Patients With Active Rheumatoid ArthritisCompletedNCT01995201Phase 3Results posted
• A Study on Safety and Efficacy of Tocilizumab (RoActemra/Actemra) Alone or in Combination With Non-Biologic Antirheumatics in Participants With Rheumatoid ArthritisCompletedNCT01987479Phase 3Results posted
• Chemotherapy for Relapsed Epstein Barr Virus Associated LymphomaTerminatedNCT01964755Phase 2Results posted
• Tac, Mini-MTX, MMF Versus Tac, MTX for GVHD PreventionCompletedNCT01951885Phase 3Results posted
• Safety and Effectiveness of Low-Dose Methotrexate for Reducing Inflammation in HIV-Infected Adults on ARV MedicationsCompletedNCT01949116Phase 2Results posted
• A Study of Subcutaneous Tocilizumab as Monotherapy and/or in Combination With Non-Biologic Disease Modifying Anti-Rheumatic Drugs (DMARDs) in Participants With Rheumatoid ArthritisCompletedNCT01941095Phase 3Results posted
• Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in ChildrenCompletedNCT01858740Phase 2Results posted
• A Study of the Impact of Methotrexate (MTX) Discontinuation on the Efficacy of Subcutaneous (SC) Tocilizumab (TCZ) With MTXCompletedNCT01855789Phase 3Results posted
• Methotrexate and Mycophenolate Mofetil for UVEITISCompletedNCT01829295Phase 3Results posted
• RCT for Women With a Persisting Pregnancy of Unknown LocationTerminatedNCT01800162Phase 1/2Results posted
• Vorinostat Plus Tacrolimus & Methotrexate to Prevent Graft vs Host Disease Following Unrelated Stem Cell TransplantCompletedNCT01790568Phase 2Results posted
• Vorinostat, Tacrolimus, and Methotrexate in Preventing GVHD After Stem Cell Transplant in Patients With Hematological MalignanciesCompletedNCT01789255Phase 2Results posted
• Standard of Care vs. Bortezomib in Graft-Versus Host Disease After Hematopoietic Stem Cell TransplantCompletedNCT01754389Phase 2Results posted
• Co-Administration Of Methotrexate And CP-690,550CompletedNCT01745055Phase 1Results posted
• Exposure Study Comparing 3 Routes of Methotrexate (MTX) AdministrationCompletedNCT01737944Phase 1/2Results posted
• Pharmacokinetics of Adalimumab With Methotrexate for Treatment of Patients With Ulcerative Colitis (UC)TerminatedNCT01716039Phase 2Results posted
• A Study in Participants With Moderate to Severe Rheumatoid ArthritisCompletedNCT01711359Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Severe Active Rheumatoid Arthritis, Comparing Tapering Versus Maintaining the Methotrexate DosageTerminatedNCT01661140Phase 4Results posted
• A Study of the Effectiveness and Safety of Ustekinumab (STELARA) and CNTO 1959 Administered Under the Skin of Patients With Active Rheumatoid Arthritis, Despite Existing Methotrexate TherapyCompletedNCT01645280Phase 2Results posted
• Comparison of Methotrexate (MTX) and the VIBEX™ MTX DeviceCompletedNCT01618968Phase 2Results posted
• Cardiovascular Inflammation Reduction TrialCompletedNCT01594333Phase 3Results posted
• A Study of RoActemra/Actemra (Tocilizumab) With or Without Methotrexate in Patients With Mild to Moderate Rheumatoid Arthritis With an Inadequate Response to MethotrexateCompletedNCT01587989Phase 3Results posted
• Ofatumumab in Combination With Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Dexamethasone Alternating With Ofatumumab in Combination With Cytarabine and Methotrexate in Treating Patients With Newly Diagnosed Mantle Cell LymphomaCompletedNCT01527149Phase 2Results posted
• A Multi-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of Certolizumab Pegol in Combination With Methotrexate in the Treatment of Disease Modifying Antirheumatic Drugs (DMARD)-naïve Adults With Early Active Rheumatoid ArthritisCompletedNCT01521923Phase 3Results posted
• NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic LymphomaCompletedNCT01451515Phase 2Results posted
• A Clinical Trial in Patients With Breast Cancer Susceptibility Gene (BRCA) Defective TumoursCompletedNCT01432145Phase 2Results posted
• Study of Two Different Starting Doses of Methotrexate When Starting Treatment in Rheumatoid ArthritisCompletedNCT01404429Phase 4Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate Versus RoActemra/Actemra Monotherapy in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateCompletedNCT01399697Phase 4Results posted
• Methotrexate in Induction and Maintenance of Steroid Free Remission in Ulcerative ColitisCompletedNCT01393405Phase 2Results posted
• Trial of Low-Dose Methotrexate and I 131 Tositumomab for Previously Untreated, Advanced-Stage, Follicular LymphomaTerminatedNCT01389076Phase 2Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Non-biologic DMARDsCompletedNCT01353859Phase 3Results posted
• Pilot Study of Leuprolide to Improve Immune Function After Allogeneic Bone Marrow TransplantationCompletedNCT01338987Phase 2Results posted
• Treatment of Non-infectious Intermediate and Posterior Uveitis Associated Macular Edema With Intravitreal MethotrexateTerminatedNCT01314417Phase 1/2Results posted
• A Study of RoActemra/Actemra (Tocilizumab) in Combination With Methotrexate in Patients With Active Rheumatoid Arthritis Who Have an Inadequate Response to Disease-Modifying Antirheumatic Drugs (DMARDs) (ALABASTER)CompletedNCT01235507Phase 3Results posted
• First-line Antimetabolites as Steroid-sparing Treatment Uveitis Pilot TrialCompletedNCT01232920Phase 3Results posted
• A Rheumatoid Arthritis Study in Participants on a Background Treatment of MethotrexateTerminatedNCT01198002Phase 3Results posted
• Methotrexate or Pentostatin for Graft-versus-host Disease Prophylaxis in Risk-adapted Allogeneic Bone Marrow Transplantation for Hematologic MalignanciesCompletedNCT01188798Phase 3Results posted
• Study to Determine the Effects of Different Doses of Methotrexate (MTX) When Taken With Adalimumab in Subjects With Early Rheumatoid Arthritis (RA)CompletedNCT01185301Phase 3Results posted
• A Study to Determine the Effect of Methotrexate (MTX) Dose on Clinical Outcome and Ultrasonographic Signs in Subjects With Moderately to Severely Active Rheumatoid Arthritis (RA) Treated With Adalimumab (MUSICA)CompletedNCT01185288Phase 4Results posted
• Tandem Auto-Allo Transplant for LymphomaCompletedNCT01181271Phase 2Results posted
• Outpatient Administration of High Dose Methotrexate (HD MTX) in Patients With OsteosarcomaCompletedNCT01176981Phase 3Results posted
• Effects of Tofacitinib (CP-690,550) on Magnetic Resonance Imaging (MRI)- Assessed Joint Structure In Early Rheumatoid Arthritis (RA)CompletedNCT01164579Phase 2Results posted
• A Study of the Effects of RoActemra/Actemra on Vaccination in Patients With Rheumatoid Arthritis on Background Methotrexate (VISARA)CompletedNCT01163747Phase 4Results posted
• Trial of Sirolimus and Methotrexate in Relapsed/Refractory Lymphoblastic Leukemia and LymphomaCompletedNCT01162551Phase 2Results posted
• A Canadian Study to Evaluate Early Use of Adalimumab After Methotrexate Failure in Early Rheumatoid ArthritisCompletedNCT01162421Phase 4Results posted
• Efficacy and Safety Study of Abatacept Subcutaneous Plus Methotrexate in Inducing Remission in Adults With Very Early Rheumatoid ArthritisCompletedNCT01142726Phase 3Results posted
• Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell TransplantTerminatedNCT01118013Phase 2Results posted
• Study of Therapeutic Options for Subjects Discontinuing Efalizumab and Experiencing Disease RecurrenceCompletedNCT01079988Phase 4Results posted
• A Study With Tocilizumab [RoActemra/Actemra] Monotherapy or in Combination With Methotrexate in Patients With Rheumatoid Arthritis (PICTURE)CompletedNCT01063062Phase 3Results posted
• A Study of Tocilizumab and Methotrexate in Combination or as Monotherapy in Treatment-Naïve Patients With Early Rheumatoid ArthritisCompletedNCT01034137Phase 3Results posted
• Dose Dense MVAC for Muscle Invasive Bladder CancerCompletedNCT01031420Phase 2Results posted
• Donor Stem Cell Transplant in Treating Patients With High-Risk Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaCompletedNCT01027000Phase 2Results posted
• Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus TumorsTerminatedNCT01014767Phase 3Results posted
• Trial for Patients With Newly Diagnosed Primary Central Nervous System (CNS) LymphomaCompletedNCT01011920Phase 2Results posted
• A Study of Tocilizumab as Monotherapy and in Combination With Methotrexate Versus Methotrexate in Patients With Early Moderate to Severe Rheumatoid ArthritisCompletedNCT01007435Phase 3Results posted
• The Efficacy and Safety of Adding Methotrexate to Etanercept in PsoriasisCompletedNCT01001208Phase 3Results posted
• A Study of MabThera (Rituximab) in Patients With Rheumatoid Arthritis and an Inadequate Response to MethotrexateCompletedNCT01000610Phase 4Results posted
• Liposomal Cytarabine and High-Dose Methotrexate in Treating Patients With Central Nervous System Metastases From Breast CancerCompletedNCT00992602Phase 2Results posted
• Treatment of Older Adults With Acute Lymphoblastic LeukemiaCompletedNCT00973752Phase 2Results posted

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