Prediabetic State clinical trials
The registry lists 918 studies for Prediabetic State across more than 10 countries. 232 are recruiting or about to start. 579 of them are mainly about Prediabetic State (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
ClinicalTrials.gov finds 1,387 studies for Prediabetic State. How that becomes 916 here
This page counts the studies the registry files under Prediabetic State, and those it files under no condition that list Prediabetic Statethemselves. Each study its search finds is placed by how the registry filed it and by the conditions it lists. ClinicalTrials.gov counts as of Nov 8, 2026. How condition pages count
- 1,387Found by its condition searchIt reads the conditions a study lists and their synonyms, and also titles and keywords.
- −1List Prediabetic State as a condition, but the registry did not file them under itMost often written as “Awarness of Physcian About Prediabetes” (1). The registry filed them under other conditions only, most often Glucose Intolerance (1).
- −470Match it another way79 name it in the title and 391 by a synonym or other text the search reads.
- 916The count on this page1 of them list Prediabetic State in their own words; the registry filed them under no condition.
Get an email when these change. Save the Prediabetic State studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
Johns Hopkins University (12) · Stanford University (12) · VA Office of Research and Development (11) · Diabetes Foundation, India (10) · Ohio State University (10) · University of Toronto (10) · Columbia University (9) · Indiana University (8)
What is being tested here
Drugs under test in Prediabetic State studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dapagliflozin | 4 | 2 | 11 |
| Semaglutide | 4 | 1 | 7 |
| Metformin | 2 | 7 | 33 |
| Trichlorosucrose | 2 | 0 | 2 |
| Vitamin D | 1 | 1 | 4 |
| Mirabegron | 1 | 0 | 2 |
| Diazoxide | 1 | 0 | 2 |
| Insulin, Regular, Human | 1 | 0 | 2 |
| Octreotide | 1 | 0 | 2 |
| Glucagon | 1 | 0 | 2 |
Drug classes tested here GLP-1 receptor agonists 5 open · SGLT2 inhibitors 4 open · Statins 1 open · DPP-4 inhibitors 12
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest
- Nov 2026Study EHR Risk Stratification Tools · University of California, Los Angeles
- Nov 2026Screening for Dysglycemia During Postpartum Period in Women With GDM · University of Sao Paulo General Hospital
- Nov 2026Effects of Sweetener Consumption on Risk Factors for Heart Disease in Prediabetic Subjects · Charite University, Berlin, Germany
- Nov 2026Whey Protein Ingestion and Glucose Control in Pre- and Post Diabetic Individuals · University of Arkansas
- Nov 2026A Retrospective Real-World Cohort Study · Novo Nordisk A/S
- Nov 2026Medically Intensive Nutrition Therapy Program for Obesity and Diabetes in a Low-income Population · Massachusetts General Hospital
- Nov 2026Pilot RCT of PIPE-AI for Prediabetes and Diabetes Self-Management · The Hong Kong Polytechnic University
- Nov 2026Longitudinal Multi-Omic Profiles to Reveal Mechanisms of Obesity-Mediated Insulin Resistance · Stanford University
- Dec 2026Nested Pilot Study Comparing Two Treatments to Reduce Type 2 Diabetes Risk in At-Risk Delawareans · University of Delaware
- Dec 2026Semaglutide Effects in Obese Youth With Prediabetes/New Onset Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease · Yale University
Who these studies take
Of the 145 Prediabetic State studies recruiting now, 51 (35%) set no upper age limit and 84 (58%) stop at 75 or younger. 12 (8%) take children under 18. 8 (6%) are for women only and 1 (1%) for men only; 54 (37%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 7 (5%) | 6 (4%) |
| 18 | 87 (60%) | 85 (59%) |
| 30 | 105 (72%) | 100 (69%) |
| 40 | 121 (83%) | 116 (80%) |
| 50 | 127 (88%) | 121 (83%) |
| 65 | 114 (79%) | 110 (76%) |
| 75 | 77 (53%) | 75 (52%) |
| 85 | 52 (36%) | 50 (34%) |
Across all 918 studies, recruiting or not: 63% stop at 75 or younger and 37% at 65; 8% take children; 5% are for women only and 2% for men only; 39% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Prediabetic State studies take
Of 30 phase 4 interventional studies under Prediabetic State, half reached primary completion within 40 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 42 mo22–69 · 27 studies | — | — |
| Phase 3 | 28 mo18–40 · 18 studies | — | — |
| Phase 4 | 40 mo20–47 · 30 studies | — | — |
| Interventional, no phase | 23 mo11–37 · 424 studies | 14 mo6–29 · 46 studies | 25 mo12–39 · 378 studies |
| Observational | 69 mo24–… · 48 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting4
- Food-i-Sense Analytics: Integrating AI Into Continuous Glucose Monitoring Data Analysis for Precision Nutrition.Nov 5, 2026NCT07626658
- Neuromodulation for Metabolic DysfunctionOct 29, 2026NCT07597161
- AI-Driven Metabolic Cohort in Overweight/Obese Chinese AdultsOct 27, 2026NCT07584330
- Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in PrediabetesOct 21, 2026NCT07289880
Stopped1
Newly registered7
- Improving the Recruitment and Retention in the Intensive Diabetes Prevention Program at Hong Kong in District Health CentersNov 10, 2026NCT07930195
- Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With HyperglycemiaOct 29, 2026NCT07903870
- Different Aerobic-to-Resistance Training Ratios in Adults Aged 50 Years and Older With PrediabetesOct 29, 2026NCT07904962
- Effect of SGLT2 Inhibitor on Metabolic-Dysfunction-Associated Fatty Liver Disease in Patients With Insulin ResistanceOct 23, 2026NCT07891234
- LIfestyle MEtabotype Study B (LIME-B)Oct 22, 2026NCT07888257
Show 2 moreShow fewer
- Continuous Glucose Monitoring and Dietary Self-Management in Adults in NamwonOct 22, 2026NCT07890740
- Piloting FUERTE: Federally qUalified Health Centers Engaging Hispanic Men at Risk of diabeTEsOct 16, 2026NCT07878806
Studies
Recruiting first, then most recently updated. Showing 50 of 918. Browse all 918 → or search them.
- Improving the Recruitment and Retention in the Intensive Diabetes Prevention Program at Hong Kong in District Health CentersNot yet recruitingNCT07930195Not applicable
- Probiotics, Cognition and Metabolic Health in Young Adults With Overweight or ObesityRecruitingNCT07073781Not applicable1 country
- Effects of Lean Pork Loin Intake on Protein Homeostasis and Glucose Regulation in Prediabetic AdultsRecruitingNCT06025292Not applicable1 country
- Truway Diagnostic Tools in Primary CareEnrolling by invitationNCT07209527Early Phase 11 country
- Food-i-Sense Analytics: Integrating AI Into Continuous Glucose Monitoring Data Analysis for Precision Nutrition.RecruitingNCT076266581 country
- A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 ObesityRecruitingNCT07794579Phase 312 countries
- CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With PrediabetesRecruitingNCT07140848Not applicable1 country
- Different Aerobic-to-Resistance Training Ratios in Adults Aged 50 Years and Older With PrediabetesNot yet recruitingNCT07904962Not applicable1 country
- Whole Food for Families: A Pilot RCT of a Dietary Guidelines-Based Intervention to Prevent Type 2 DiabetesRecruitingNCT06482944Not applicable1 country
- Evaluation of the Effectiveness of Implementing a Screening Strategy for the Diagnosis of Prediabetes and Type 2 Diabetes Mellitus in Primary Health Care in a Brazilian MunicipalityNot yet recruitingNCT07846319Not applicable1 country
- Smartwatch-based Intervention for Cardiovascular Health (SWITCH)RecruitingNCT07372729Not applicable1 country
- Efficacy of the pA1c®HI Postbiotic in Metabolic Regulation in Healthy Individuals With HyperglycemiaNot yet recruitingNCT07903870Early Phase 11 country
- Neuromodulation for Metabolic DysfunctionRecruitingNCT07597161Not applicable1 country
- LIfestyle MEtabotype Study B (LIME-B)RecruitingNCT07888257Not applicable1 country
- AI-Driven Metabolic Cohort in Overweight/Obese Chinese AdultsRecruitingNCT075843301 country
- Trial of CGM Technology in Persons Living With PrediabetesNot yet recruitingNCT07639593Not applicable1 country
- Effect of SGLT2 Inhibitor on Metabolic-Dysfunction-Associated Fatty Liver Disease in Patients With Insulin ResistanceNot yet recruitingNCT07891234Phase 41 country
- Continuous Glucose Monitoring and Dietary Self-Management in Adults in NamwonNot yet recruitingNCT07890740Not applicable1 country
- Efficacy of Diacylglycerol Oil on Metabolic Risk Factors in PrediabetesRecruitingNCT07289880Not applicable1 country
- New T-UP: Engaging Vulnerable Students in Diabetes PreventionRecruitingNCT07225218Not applicable1 country
- SMART GOALS for Youth With PrediabetesRecruitingNCT06067451Not applicable1 country
- Real-World Outcomes of Tirzepatide in Pakistani Adults With Obesity, Prediabetes, and Type 2 DiabetesNot yet recruitingNCT078095681 country
- Diabetes Prevention Through Genetics, Familial History and Behavior ChangeNot yet recruitingNCT07815236Phase 2/3
- Piloting FUERTE: Federally qUalified Health Centers Engaging Hispanic Men at Risk of diabeTEsNot yet recruitingNCT07878806Not applicable1 country
- PreventT2 Together: Examining the Efficacy of Couple-based Lifestyle Intervention to Prevent Type 2 DiabetesRecruitingNCT06690788Not applicable1 country
- Understanding Metabolism and Inflammation Risks for Diabetes in AdolescentsRecruitingNCT060074041 country
- LIfestyle MEtabotype Study ARecruitingNCT078686011 country
- Glycemic Impact of NNS Via the Gut MicrobiomeEnrolling by invitationNCT07868432Not applicable1 country
- Effects of Different Fish Oil Types on Type 2 Diabetes Risk Factors in High-Risk AdultsRecruitingNCT07575438Phase 21 country
- Pharmacist-Led Continuous Glucose Monitoring for PrediabetesRecruitingNCT075293661 country
- How a Mediterranean Diet With Potatoes Impacts Heart and Metabolic Health in Adults With Pre-DiabetesRecruitingNCT06817252Not applicable1 country
- Insulin and Insulin Pulses During FastingRecruitingNCT06424015Not applicable1 country
- Wake Forest Alzheimer's Disease Clinical CoreRecruitingNCT031408651 country
- RESET-INSPIRE Study: Insulin Sensitivity & Population Intervention With Real-time Evaluation Using CGMRecruitingNCT078611911 country
- Mediterranean Diet and Blood Sugar StudyRecruitingNCT07229781Not applicable1 country
- Training Induced Muscle-Adipose EV CommunicationNot yet recruitingNCT07106450Not applicable1 country
- Multimodal Risk Factor Graph Mapping, Metabolic Subtyping, and Digital Intelligent Chronic Disease Management for Prediabetes: An Integrated Cohort and Case-Control Clinical StudyNot yet recruitingNCT07854002
- Precision Nutrition for Obesity and Prediabetes Prevention in Under-supported CommunitiesNot yet recruitingNCT07850531Not applicable1 country
- PREdiabetes GLycemic Impact and Data EvaluationRecruitingNCT07599072Not applicable1 country
- A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARERecruitingNCT05909046Not applicable1 country
- Precise Eating Time to Improve Glycemic Control and Cardiometabolic Health in Prediabetes and DiabetesRecruitingNCT07171281Not applicable1 country
- Effects of Hourly Stair-Climbing Exercise Snacks on Metabolic and Vascular Health in Adults With PrediabetesRecruitingNCT07847684Not applicable1 country
- A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular EventsRecruitingNCT06112418Not applicable1 country
- Studies of Blood Glucose and the Microbiome in Tumors and Cysts of the PancreasNot yet recruitingNCT07843147
- Whole Food Fibers for Support of Key Gut Bacteria for Human HealthNot yet recruitingNCT07840170Not applicable1 country
- Returning to Normoglycemia With Targeted Use of Real-time CGM Data and Nutrition-focused Lifestyle ChangesNot yet recruitingNCT07832474Not applicable1 country
- Georgia CEAL RESTORES Family Diabetes StudyRecruitingNCT07808723Not applicable1 country
- Optimizing Implementation of the Intensive Diabetes Prevention ProgramNot yet recruitingNCT07412912Not applicable
- Efficacy and Safety of Oral Controlled-release Nicotinic Acid (CIR-NA) for the Remission of Prediabetes. (CONCEPT)RecruitingNCT07286747Phase 21 country
- The Effect of Time-Restricted Eating in 24-hour Metabolic Homeostasis and Diurnal RhythmNot yet recruitingNCT07820384Not applicable1 country