Drug
Levodopa clinical trials
Also written CVT-301.
- studies test it
- 105
- open now
- 6
- in phase 3
- 17
- first study started
- 1998
Keep track of what changes. Save the Levodopa studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Development codes
Combined with it in one product
Studies by the year they started
104 studies that test it; most in 2009 (10); 1 more planned to start later
| Year | Studies |
|---|---|
| 1998 | 1 |
| 2000 | 1 |
| 2001 | 2 |
| 2002 | 2 |
| 2003 | 2 |
| 2004 | 4 |
| 2005 | 7 |
| 2006 | 7 |
| 2007 | 4 |
| 2008 | 6 |
| 2009 | 10 |
| 2010 | 8 |
| 2011 | 2 |
| 2012 | 6 |
| 2013 | 4 |
| 2014 | 3 |
| 2015 | 7 |
| 2016 | 6 |
| 2017 | 3 |
| 2018 | 2 |
| 2019 | 6 |
| 2020 | 2 |
| 2021 | 4 |
| 2022 | 2 |
| 2023 | 2 |
| 2026 | 1 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 21
- Phase 2
- 31
- Phase 3
- 17
- Phase 4
- 30
- No phase
- 10
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 43 · Other 62
Acorda Therapeutics (10) · Bial - Portela C S.A. (5) · Novartis (5) · The University of Texas Health Science Center, Houston (4) · University Hospital Muenster (4) · Emory University (3) · New York State Psychiatric Institute (3) · AbbVie (prior sponsor, Abbott) (3)
Often tested with
Tested in the same studies.
Carbidopa (41) · Entacapone (13) · Opicapone (4) · Carbidopa, levodopa drug combination (3) · Ropinirole (3) · Benserazide (3) · Cabergoline (2) · Pramipexole (2)
Studies
Open first, then newest update. How each study uses Levodopa is read from its arms, and is right about nine times in ten.
Testing it · 105
- Cortical Electrophysiology of Response Inhibition in Parkinson's DiseaseRecruitingPhase 4Emory UniversityNCT06234995Written as Levodopa
- Gastrointestinal Dopamine Decarboxylase and Levodopa PharmacokineticsNot yet recruitingPhase 4Beth Israel Deaconess Medical CenterNCT07793461Written as Levodopa (L-dopa)
- Study of L-dopa Treatment in Patients With a Neurodevelopmental Disorder (CTNNB1 Gene)RecruitingNot applicableUniversity Hospital, MontpellierNCT07614126Written as L-Dopa
- Dopamine Modulation of Motivation and Motor Function in Major Depression & InflammationRecruitingNot applicableCharite University, Berlin, GermanyNCT05909267Written as L-dopa/Carbidopa
- Basic and Clinical Studies of Levodopa/Carbidopa/Entacapone in the Treatment of Early Parkinson's DiseaseRecruitingPhase 4Second Affiliated Hospital of Soochow UniversityNCT06236230Written as levodopa/carbidopa/entacapone
- Improving Therapeutic Learning for PTSDRecruitingPhase 2University of Wisconsin, MadisonNCT04558112Written as L-DOPA
- Dopaminergic Dysfunction in Late-Life DepressionCompletedPhase 2Vanderbilt University Medical CenterNCT04469959Written as L-Dopa
- Levodopa for Diabetic RetinopathyCompletedPhase 2Emory UniversityNCT07444892Written as Levodopa
- eArly levoDopa With Opicapone in Parkinson's paTients wIth motOr fluctuatioNs.CompletedPhase 4Bial - Portela C S.A.NCT04990284Written as L-DOPA/DDCI
- Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PDCompletedNot applicableUniversity Hospital Bispebjerg and FrederiksbergNCT06275633Written as Levodopa
- Acute Effects of Pharmacological Neuromodulation on Leg Motor Activity in Patients With SCI Treated With EESCompletedPhase 1Centre Hospitalier Universitaire VaudoisNCT04052776Written as Levodopa-Carbidopa
- Apokyn for Motor IMProvement of Morning AKinesia Trial (AM IMPAKT)CompletedPhase 4MDD US Operations, LLC a subsidiary of Supernus PharmaceuticalsNCT01770145Written as L-dopa
- The Correlation of Reduction of Levodopa and Non-motor Symptoms of Parkinson's Disease After Deep Brain StimulationCompletedNot applicableQilu Hospital of Shandong UniversityNCT05901350Written as Levodopa
- A Study of L-DOPA for Depression and Slowing in Older AdultsCompletedPhase 4New York State Psychiatric InstituteNCT02744391Written as Levodopa
- L-DOPA vs. Placebo for Depression and Psychomotor Slowing in Older AdultsTerminatedPhase 4New York State Psychiatric InstituteNCT03761030Written as L-DOPA
- Effects of 5HTP and LDOPA on CNS Excitability After SCISuspendedPhase 2/3Jessica M D'AmicoNCT04000919Written as L-DOPA
- Measuring Parkinson's Disease ProgressionCompletedPhase 1Kevin J. Black, MDNCT03205956Written as Levodopa
- Changes in Glutamatergic Neurotransmission of Severe TBI PatientsSuspendedEarly Phase 1Weill Medical College of Cornell UniversityNCT04244058Written as Amantadine + L-DOPA
- Inflammation-related Alterations in Neurocircuitry: Reversal With LevodopaCompletedPhase 4Emory UniversityNCT02513485Written as Levodopa+carbidopa
- Bioavailability of Levodopa 250 mg and Carbidopa 25 mg With Regards to Reference ProductCompletedPhase 1Laboratorios Andromaco S.A.NCT05250141Written as Levodopa 250mg and Carbidopa 25mg Test Drug tablet
See all 105 studies that test Levodopa →
Given in every arm · 20 — Levodopa is usual care beside what is tested
- Etoricoxib in Patients With Parkinsonian DiseaseRecruitingPhase 2Ihab Elsayed HassanNCT07370532Written as L-dopa
- Fexofenadine as Adjuvant Therapy in Parkinson DiseaseRecruitingPhase 2/3Tanta UniversityNCT06785298Written as Levodopa/carbidopa
- Role of Silymarin in Neuroprotection and Symptom Management in Parkinson's DiseaseRecruitingPhase 2Tanta UniversityNCT07001150Written as levodopa-carbidopa
- Montelukast in Parkinson DiseaseCompletedPhase 2/3Mostafa BahaaNCT06113640Written as levodopa-carbidopa
- Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's DiseaseCompletedPhase 2Tanta UniversityNCT05781711Written as levodopa-carbidopa
- A Study to Evaluate SAGE-217 in Participants With Parkinson's DiseaseCompletedPhase 2BiogenNCT03000569Written as Levodopa
- A Study to Examine the Effect of Levodopa-Carbidopa Intestinal Gel (LCIG) Therapy Relative to That of Optimized Medical Treatment (OMT) on Non-motor Symptoms (NMS) Associated With Advanced Parkinson's Disease (PD)CompletedPhase 3AbbVieNCT02549092Written as Levodopa-Carbidopa Intestinal Gel
- Dose-finding Pharmacokinetic Study in Healthy MalesCompletedPhase 1Orion Corporation, Orion PharmaNCT03055936Written as Levodopa
- Follow Up Safety Study of SCH 420814 in Subjects With Parkinson's Disease (P05175)CompletedPhase 2Merck Sharp & Dohme LLCNCT00537017Written as L-dopa
- Safety and Efficacy Study of SYN115 in Parkinson's Patients Using Levodopa to Treat End of Dose Wearing OffCompletedPhase 2/3Biotie Therapies Inc.NCT01283594Written as Levodopa (L-dopa)
- Dyskinesia in Parkinson's Disease (Study P04501)CompletedPhase 2Merck Sharp & Dohme LLCNCT00406029Written as L-dopa
- Rotigotine Versus Placebo, A Study To Evaluate The Efficacy In Advanced Stage Idiopathic Parkinson's Disease PatientsCompletedPhase 3UCB PharmaNCT01646255Written as L-dopa
- Combinational Rehabilitative Therapy and Functional Brain Imaging for Patients Recovering From Motor StrokeCompletedPhase 3Singapore General HospitalNCT02073773Written as Levodopa
- The Effect of BIA 9-1067 at Steady-state on the Levodopa PharmacokineticsCompletedPhase 1Bial - Portela C S.A.NCT02170376Written as Levodopa/carbidopa
- Study of Safety, Tolerability, Pharmacokinetics, and Efficacy of ABT-SLV187 in Subjects With Advanced Parkinson's DiseaseCompletedPhase 2AbbVie (prior sponsor, Abbott)NCT01479127Written as Oral Levodopa/Carbidopa
- Multicentre Study in Four Parallel Groups of Parkinson's Disease (PD) PatientsCompletedPhase 2Bial - Portela C S.A.NCT01568047Written as Levodopa/Carbidopa
- Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients.CompletedPhase 3Bial - Portela C S.A.NCT01227655Written as Levodopa
- Efficacy and Safety of BIA 9-1067 in Idiopathic Parkinson's Disease Patients With "Wearing-off" PhenomenonCompletedPhase 3Bial - Portela C S.A.NCT01568073Written as Levodopa
- A Study of MK0657 in Parkinson's Disease Patients (0657-006)CompletedPhase 1Merck Sharp & Dohme LLCNCT00505843Written as Comparator: levodopa
- An Evaluation of the Pharmacokinetics and Pharmacodynamics of AP09004 in Patients With Parkinson's DiseaseCompletedPhase 2Intec Pharma Ltd.NCT00918177Written as Carbidopa/Levodopa, immediate release
As the comparator · 10 — what is tested is compared with Levodopa
- Effects of PR Oxycodone and of Levodopa, vs Placebo, on Central Neuropathic Pain in Parkinson's DiseaseCompletedPhase 2/3University Hospital, ToulouseNCT02601586Written as Levodopa
- A Pilot Comparative Bioavailability Study of Levodopa Administered Via Levodopa Cyclops® Relative to INBRIJA®CompletedPhase 1PureIMS B.V.NCT06037590Written as INBRIJA®
- Study Comparing Continuous Subcutaneous Infusion Of ABBV-951 With Oral Carbidopa/Levodopa Tablets For Treatment Of Motor Fluctuations In Adult Participants With Advanced Parkinson's DiseaseCompletedPhase 3AbbVieNCT04380142Written as Levodopa/Carbidopa (LD/CD)
- Efficacy of Levodopa/Benserazide Dispersible Tablet on Response Fluctuations in PD Patients With Delayed ONCompletedPhase 4Seoul National University HospitalNCT02769793Written as Levodopa
- A Trial of tPCS on Parkinson's Disease OFF StateStatus unknownNot applicableWestern University, CanadaNCT04054960Written as Levodopa tablet
- Pharmacokinetic Study in Healthy VolunteersCompletedPhase 1Orion Corporation, Orion PharmaNCT02554734Written as levodopa, carbidopa, entacapone
- Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ODM-104 in Healthy VolunteersCompletedPhase 1Orion Corporation, Orion PharmaNCT01840423Written as levodopa/carbidopa
- Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ODM-103 in Healthy VolunteersCompletedPhase 1Orion Corporation, Orion PharmaNCT01688089Written as Levodopa/carbidopa
- Use of Zolpidem in Parkinson's DiseaseWithdrawnPhase 2Rush University Medical CenterNCT01351168Written as Levodopa
- Stalevo in Early Wearing-Off PatientsCompletedPhase 4Orion Corporation, Orion PharmaNCT00125567Written as Levodopa/carbidopa
Codes
What other systems call Levodopa · ClinicalTrials.gg INT007731
- MeSH (NLM) D007980LevodopaConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) 46627O600JLEVODOPAConfirmed FDA, NLM, Wikidata
- RxNorm 6375Confirmed FDA, Wikidata
- Wikidata Q300989levodopaConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C611LevodopaOne source FDA
- DrugBank DB01235One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D007980 | Levodopa | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | 46627O600J | LEVODOPA | Confirmed FDA, NLM, Wikidata |
| RxNorm | 6375 | — | Confirmed FDA, Wikidata |
| Wikidata | Q300989 | levodopa | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C611 | Levodopa | One source FDA |
| DrugBank | DB01235 | — | One source Wikidata |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.