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Restless Legs Syndrome clinical trials

The registry lists 259 studies for Restless Legs Syndrome across more than 10 countries. 38 are recruiting or about to start. 217 of them are mainly about Restless Legs Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-06.

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Status

Completed
173
Recruiting
25
Status unknown
19
Terminated
13
Not yet recruiting
12
Withdrawn
8

Phase

Phase 2
49
Phase 3
47
Phase 4
30
Phase 1
14

Where

United States
107
Germany
28
France
17
Turkey
17
Japan
12
Spain
11

Who runs them

Boehringer Ingelheim (21) · GlaxoSmithKline (16) · XenoPort, Inc. (14) · UCB Pharma (11) · Noctrix Health, Inc. (9) · University Hospital, Montpellier (7) · TC Erciyes University (6) · Brigham and Women's Hospital (5)

What is being tested here

Drugs under test in Restless Legs Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Ferric carboxymaltose127
Ferrous sulfate103
BRC-002101
Prednisone101
Cannabis sativa flowering TOP101
Dipyridamole111
Crisugabalin101
Gabapentin enacarbil0620
Pramipexole0616
Rotigotine0916

Drug classes tested here Dopamine agonists 48

Coming up

1phase 3 study under way
14studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 25 Restless Legs Syndrome studies recruiting now, 10 (40%) set no upper age limit and 12 (48%) stop at 75 or younger. 0 (0%) take children under 18. 4 (16%) are for women only and 0 (0%) for men only; 10 (40%) take healthy volunteers.

Recruiting studies that take each age, of 25
AgeWomenMen
100 (0%)0 (0%)
1818 (72%)15 (60%)
3022 (88%)18 (72%)
4023 (92%)20 (80%)
5022 (88%)20 (80%)
6522 (88%)20 (80%)
7515 (60%)13 (52%)
8512 (48%)10 (40%)

Across all 259 studies, recruiting or not: 32% stop at 75 or younger and 19% at 65; 12% take children; 7% are for women only and <1% for men only; 20% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Restless Legs Syndrome studies take

Of 53 interventional studies with no phase under Restless Legs Syndrome, half reached primary completion within 12 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase12 mo5–40 · 53 studies—13 mo5–42 · 46 studies
Observational33 mo6–70 · 17 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Started recruiting1

Newly registered1

Studies

Recruiting first, then most recently updated. Showing 50 of 259. Browse all 259 → or search them.