Drug
Leuprolide clinical trials
Also written Lupron, Leuprorelin, Lupron Depot and Abbott 43818.
Includes 3 studies of Leuprolide mesylate.
- studies test it
- 151
- open now
- 17
- in phase 3
- 44
- first study started
- 1991
Keep track of what changes. Save the Leuprolide studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Brand
Other names
Studies by the year they started
149 studies that test it; most in 2023 (11)
| Year | Studies |
|---|---|
| 1991 | 1 |
| 1992 | 2 |
| 1993 | 1 |
| 1994 | 2 |
| 1996 | 2 |
| 1997 | 2 |
| 1999 | 2 |
| 2000 | 1 |
| 2001 | 1 |
| 2002 | 1 |
| 2003 | 7 |
| 2004 | 3 |
| 2005 | 6 |
| 2006 | 6 |
| 2007 | 7 |
| 2008 | 5 |
| 2009 | 8 |
| 2010 | 3 |
| 2011 | 4 |
| 2012 | 4 |
| 2013 | 6 |
| 2014 | 5 |
| 2015 | 7 |
| 2016 | 6 |
| 2017 | 8 |
| 2018 | 7 |
| 2019 | 2 |
| 2020 | 7 |
| 2021 | 6 |
| 2022 | 4 |
| 2023 | 11 |
| 2024 | 5 |
| 2025 | 2 |
| 2026 | 5 |
By phase
A phase 1/2 study counts in both.
- Early Phase 1
- 2
- Phase 1
- 15
- Phase 2
- 54
- Phase 3
- 44
- Phase 4
- 21
- No phase
- 20
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 41 · Other 110
Takeda (6) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (5) · M.D. Anderson Cancer Center (5) · Abbott (5) · National Cancer Institute (NCI) (3) · Fudan University (3) · University of Colorado, Denver (3) · University of North Carolina, Chapel Hill (3)
Often tested with
Tested in the same studies.
Goserelin (16) · Bicalutamide (15) · Degarelix (9) · Flutamide (8) · Triptorelin (8) · Abiraterone (8) · Estradiol (7) · Docetaxel (6)
Studies
Open first, then newest update. How each study uses Leuprolide is read from its arms, and is right about nine times in ten.
Testing it · 151
- Phase Ia Trial of HHK001 Compared With Enantone in Patients With EndometriosisRecruitingPhase 1Zhuhai Huahaikang Pharmaceutical Technology Co., Ltd.NCT07755956Written as Leuprorelin Acetate
- Assessing Efficacy of Neoadjuvant ADT in Localized High-Risk Prostate Cancer Patients Utilizing 18F-Flotufolastat PSMA PET/CTRecruitingPhase 2Baptist Health South FloridaNCT07455903Written as Leuprolide
- A Study of Leuprorelin 1-Month (4-Week) Formulation in Children With Central Precocious PubertyRecruitingPhase 4LG ChemNCT07710430Written as Leuprorelin
- Kisspeptin Administration Subcutaneously to Patients With IHHRecruitingPhase 2Stephanie B. Seminara, MDNCT05896293Written as leuprolide acetate
- Leuprolide and Goserelin for Ovarian Function Suppression in Pre- or Peri-menopausal Women With Breast Cancer, OFS TrialRecruitingPhase 2University of Michigan Rogel Cancer CenterNCT07158021Written as Leuprolide
- Comparison of the Therapeutic Effects of Vaginal Repair With Leuprorelin and Vaginal Repair in the Treatment of Cesarean Section Scar DefectRecruitingNot applicableXinhua Hospital, Shanghai Jiao Tong University School of MedicineNCT05206682Written as Leuprorelin
- Treatment of High-Risk Prostate Cancer Guided by Novel Diagnostic Radio- and Molecular TracersRecruitingPhase 2/3Cancer Research AntwerpNCT06282588Written as Depo-Eligard 45 mg
- Effects of Relugolix vs Leuprolide on Cardiac Function in Patients With Prostate CancerRecruitingPhase 2Ohio State University Comprehensive Cancer CenterNCT06330805Written as Leuprolide
- Rezvilutamide for High-Risk Prostate Cancer After SurgeryNot yet recruitingNot applicableFujian Medical University Union HospitalNCT07444983Written as Rezvilutamide and Leuprorelin
- REVELUTION-2: Relugolix+Abiraterone Acetate (AA) Versus Leuprolide+AA Cardiac TrialRecruitingPhase 3Emory UniversityNCT06650579Written as Leuprolide
- A Study on the Efficacy of Androgen Deprivation Therapy Combined With Anti-PD-1 Therapy in Advanced Lung CancerRecruitingNot applicableJinzhou Medical UniversityNCT06512207Written as Leuprorelin acetate + Sintilimab
- Impact of Hormonal Therapy on Prostate Cancer Recurrence After Radical ProstatectomyRecruitingPhase 3Ottawa Hospital Research InstituteNCT05169112Written as Lupron Depot
- Short Versus Long-term Androgen Deprivation Therapy With Salvage Radiotherapy in Prostate Cancer. URONCOR 0624RecruitingPhase 3Instituto de Investigación en Oncología Radioterápica - Fundación Española de Oncología RadioterápicNCT05781217Written as triptorelin, goserelin, leuprorelin
- Evaluate the Efficacy and Safety of DWJ108JRecruitingPhase 3Daewoong Pharmaceutical Co. LTD.NCT06025409Written as Leuprolide Acetate 11.25 MG/ML
- Adenomyosis and ARTRecruitingPhase 4Azienda Ospedaliero-Universitaria di ModenaNCT05937490Written as Enantone
- A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCTNot yet recruitingNot applicableFirst Affiliated Hospital Xi'an Jiaotong UniversityNCT05667428Written as leuprorelin
- A GnRH Agonist IN Pre-menopausal Women STudy to Treat Severe Polycystic Liver DiseaseRecruitingPhase 2University Medical Center GroningenNCT05478083Written as Leuprorelin
- Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance TrialActive, not recruitingPhase 3NRG OncologyNCT05050084Written as Leuprolide
- Efficacy and Safety of DKF-MA102 in Patients With Prostate CancerCompletedPhase 3Dongkook Pharmaceutical Co., Ltd.NCT06490328Written as DKF-MA102
- Bipolar Androgen Therapy to Restore Sensitivity to Androgen Deprivation Therapy for Patients With Metastatic Castration Resistant Prostate CancerActive, not recruitingPhase 1Roswell Park Cancer InstituteNCT06305598Written as Leuprolide Acetate
See all 151 studies that test Leuprolide →
Given in every arm · 79 — Leuprolide is usual care beside what is tested
- Standard Systemic Therapy With or Without Definitive Treatment in Treating Participants With Metastatic Prostate CancerRecruitingPhase 3SWOG Cancer Research NetworkNCT03678025Written as Leuprolide Acetate
- Neoadjuvant ADT + Darolutamide With Pembrolizumab, Followed by Adjuvant Pembrolizumab in Molecularly Stratified High-Risk Prostate CancerRecruitingPhase 2Icahn School of Medicine at Mount SinaiNCT07027124Written as Lupron
- Study of PSMA-targeted Therapy and Androgen Receptor Suppression in Low-volume Metastatic ProstatE Cancer: SPARKLE TrialRecruitingPhase 2Mayo ClinicNCT07650240Written as Leuprolide Acetate
- Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET ImagingRecruitingPhase 3ECOG-ACRIN Cancer Research GroupNCT04423211Written as Leuprolide Acetate
- Talazoparib With Androgen Deprivation Therapy and Abiraterone for the Treatment of Castration Sensitive Prostate CancerRecruitingPhase 2City of Hope Medical CenterNCT04734730Written as Leuprolide Acetate
- A Short-term Preoperative, Evaluating Activity and Safety of Elacestrant Monotherapy as Compared to Elacestrant + Ovarian Function Suppression (LHRH Agonist) in Premenopausal Patients With Stage I-II ER+/HER2- Breast CancerRecruitingPhase 2Gustave Roussy, Cancer Campus, Grand ParisNCT07159451Written as Leuprorelin
- Adjuvant Rezvilutamide in Combination With Androgen Deprivation Therapy in Androgen Receptor-positive, High-risk Salivary Duct CarcinomaRecruitingPhase 2Peking University First HospitalNCT06348264Written as Leuprolide Acetate
- Adjuvant Ovarian Suppression Plus Aromatase Inhibitor or Tamoxifen in Young WomenRecruitingPhase 3First Affiliated Hospital, Sun Yat-Sen UniversityNCT02914158Written as Leuprolide
- S1207 Hormone Therapy With or Without Everolimus in Treating Patients With Breast CancerActive, not recruitingPhase 3SWOG Cancer Research NetworkNCT01674140Written as leuprolide acetate
- Phase IIIb Study of Ribociclib + ET in Early Breast CancerActive, not recruitingPhase 3Novartis PharmaceuticalsNCT05827081Written as Leuprolide
- Veterans Affairs Seamless Phase II/III Randomized Trial of STAndard Systemic theRapy With or Without PET-directed Local Therapy for Oligometastatic pRosTate CancerActive, not recruitingPhase 2/3VA Office of Research and DevelopmentNCT04787744Written as Goserelin, Histrelin, Leuprolide & Triptorelin
- A Study for Subjects With Prostate Cancer Who Previously Participated in an Enzalutamide Clinical StudyActive, not recruitingPhase 2Astellas Pharma Global Development, Inc.NCT02960022Written as Leuprolide acetate
- Antiandrogen Therapy and Radiation Therapy With or Without Docetaxel in Treating Patients With Prostate Cancer That Has Been Removed by SurgeryActive, not recruitingPhase 2/3NRG OncologyNCT03070886Written as Leuprolide
- Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT TrialActive, not recruitingPhase 3NRG OncologyNCT04513717Written as Leuprolide
- Finite Androgen Ablation With or Without Abiraterone Acetate and Prednisone in Treating Patients With Recurrent Prostate CancerActive, not recruitingPhase 2M.D. Anderson Cancer CenterNCT01786265Written as Leuprolide Acetate
- Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE StudyActive, not recruitingPhase 3ECOG-ACRIN Cancer Research GroupNCT04484818Written as Leuprolide Acetate
- A Clinical Study Evaluating The Benefit of Adding Rucaparib to Enzalutamide for Men With Metastatic Prostate Cancer That Has Become Resistant To Testosterone-Deprivation TherapyActive, not recruitingPhase 3Alliance for Clinical Trials in OncologyNCT04455750Written as Leuprolide Acetate
- Study Assessing the Efficacy and Safety of Alpelisib Plus Fulvestrant or Letrozole, Based on Prior Endocrine Therapy, in Patients With PIK3CA Mutant, HR+, HER2- Advanced Breast Cancer Who Have Progressed on or After Prior TreatmentsCompletedPhase 2Novartis PharmaceuticalsNCT03056755Written as Leuprolide
- Palifermin With Leuprolide Acetate for the Promotion of Immune Recovery Following Total Body Irradiation Based T-Cell Depleted Allogeneic Hematopoietic Stem Cell TransplantationActive, not recruitingPhase 2Memorial Sloan Kettering Cancer CenterNCT01746849Written as Lupron
- Enzalutamide, Radiation Therapy and Hormone Therapy in Treating Patients With Intermediate or High-Risk Prostate CancerActive, not recruitingPhase 1Thomas Jefferson UniversityNCT02023463Written as Leuprolide acetate
Showing 20 of 79.
As the comparator · 39 — what is tested is compared with Leuprolide
- A Phase Ia Trial Comparing the Pharmacokinetics/Pharmacodynamics, Safety, and Preliminary Efficacy of HHK001 and Enantone in Patients With EndometriosisNot yet recruitingPhase 1The Third Xiangya Hospital of Central South UniversityNCT07793162Written as Enantone (Leuprorelin Acetate Microspheres for Injection)
- RecoverPC: Relugolix vs GnRH Agonist in Quality of LifeRecruitingPhase 2Dana-Farber Cancer InstituteNCT05765500Written as Leuprolide
- Stereotactic Body Radiation Therapy Plus Immediate or Delayed Androgen Receptor Pathway Inhibitor and Androgen Deprivation Therapy or Salvage Radiation Therapy for the Treatment of Prostate Cancer, DIVINE TrialRecruitingPhase 2Mayo ClinicNCT06378866Written as Leuprolide
- Radiotherapy Combined With a LHRH (Ant)Agonist Versus Apalutamide in Patients With Biochemical Recurrence After RPRecruitingPhase 2Cancer Research AntwerpNCT03899077Written as Leuprorelin Acetate 45Mg Powder for Injection Suspension Vial
- Randomized Study to Evaluate MACE in Patients With Prostate Cancer Treated With Relugolix or Leuprolide AcetateCompletedPhase 3Sumitomo Pharma America, Inc.NCT05605964Written as Leuprolide Acetate
- A Clinical Study of KLH-2109 in Patients With EndometriosisActive, not recruitingPhase 3Kissei Pharmaceutical Co., Ltd.NCT07015268Written as Leuprorelin acetate
- Enzalutamide Versus Standard Androgen Deprivation Therapy for the Treatment Hormone Sensitive Prostate CancerCompletedPhase 2University of Colorado, DenverNCT02278185Written as leuprolide acetate
- A Clinical Study of KLH-2109 in Uterine Fibroids Patient With MenorrhagiaCompletedPhase 3Kissei Pharmaceutical Co., Ltd.NCT05440383Written as Leuprorelin
- Comparison Elagolix vs Depot Leuprolide Prior to Frozen Embryo Transfers in Patients With EndometriosisCompletedEarly Phase 1Colorado Center for Reproductive MedicineNCT04445025Written as Leuprolide Acetate 3.75 MG/ML
- Comparing the Safety and Efficacy in the Use of Hormonal Therapy on Endometriosis Patients After Conservative SurgeryCompletedPhase 3Universitas DiponegoroNCT06145438Written as Leuprolide (as Leuprolide Acetate)
- A Study to Assess the Effectiveness and Safety of Different Doses of ASP1707 Compared to Placebo for Endometriosis Associated Pelvic PainCompletedPhase 2Astellas Pharma Europe B.V.NCT01767090Written as Leuprorelin acetate
- Study to Compare Neoadjuvant Combination of Trastuzumab and Pertuzumab With Concurrent Taxane Chemotherapy or Endocrine Therapy and Quality of Life Assessment Under Adjuvant Therapy in Operable HER2+/HR+ Breast Cancer PatientsCompletedPhase 2Palleos Healthcare GmbHNCT03272477Written as Leuprorelin acetate
- Degarelix in the Treatment of Endometriosis RecurrenceCompletedPhase 3Centre for Endocrinology and Reproductive Medicine, ItalyNCT01712763Written as Leuprolide Acetate 11.25 MG/ML (Enantone 11,25)
- Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western MedicineCompletedPhase 4Children's Hospital of Fudan UniversityNCT03963752Written as Leuprorelin Acetate 3.75mg Injection
- Bay98-7196, Dose Finding / POC StudyCompletedPhase 2BayerNCT02203331Written as Lupron / Leuprolide acetate
- Effect of GTx-758 on Total and Free Testosterone Levels in Men With Prostate CancerTerminatedPhase 2GTxNCT01326312Written as Lupron Depot
- A Trial Comparing Cardiovascular Safety of Degarelix Versus Leuprolide in Patients With Advanced Prostate Cancer and Cardiovascular DiseaseTerminatedPhase 3Ferring PharmaceuticalsNCT02663908Written as Leuprolide
- A Study to Evaluate the Safety and Efficacy of Relugolix in Men With Advanced Prostate CancerCompletedPhase 3Myovant Sciences GmbHNCT03085095Written as Leuprolide Acetate
- Clinical Study to Evaluate Efficacy and Safety of TAK-385 40 mg Compared With Leuprorelin in Patients With EndometriosisCompletedPhase 3ASKA Pharmaceutical Co., Ltd.NCT03931915Written as Leuprorelin acetate
- Comparison Between Two Different Protocols in Polycystic Ovary Symdrome Women Undergoing Intra-cytoplasmic InjectionStatus unknownPhase 4Assiut UniversityNCT04094467Written as Leuprolide Acetate
Showing 20 of 39.
Codes
What other systems call Leuprolide · ClinicalTrials.gg INT008545
- MeSH (NLM) D016729LeuprolideConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) EFY6W0M8TGLEUPROLIDEConfirmed FDA, NLM, Wikidata
- RxNorm 42375Confirmed FDA, Wikidata
- Wikidata Q907160leuprolideConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62042LeuprolideOne source FDA
- DrugBank DB00007One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | D016729 | Leuprolide | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | EFY6W0M8TG | LEUPROLIDE | Confirmed FDA, NLM, Wikidata |
| RxNorm | 42375 | — | Confirmed FDA, Wikidata |
| Wikidata | Q907160 | leuprolide | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62042 | Leuprolide | One source FDA |
| DrugBank | DB00007 | — | One source Wikidata |
Also registered as leuprolide acetate (UNII 37JNS02E7V · RxNorm 203217).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.