Puberty, Precocious clinical trials
The registry lists 75 studies for Puberty, Precocious across more than 10 countries. 18 are recruiting or about to start. 64 of them are mainly about Puberty, Precocious (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09.
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Who runs them
Children's Hospital of Fudan University (7) · Ipsen (4) · Takeda (4) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (3) · Abbott (2) · Shenzhen Center for Disease Control and Prevention (2) · National Center for Research Resources (NCRR) (2)
What is being tested here
Drugs under test in Puberty, Precocious studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Leuprolide | 2 | 6 | 14 |
| Endoxifen | 1 | 0 | 1 |
| Triptorelin | 0 | 5 | 5 |
| Fulvestrant | 0 | 0 | 1 |
| Histrelin | 0 | 1 | 1 |
| Gonadotropin-Releasing Hormone | 0 | 0 | 1 |
| Bicalutamide | 0 | 0 | 1 |
| Anastrozole | 0 | 0 | 1 |
| Ganirelix | 0 | 0 | 1 |
| Letrozole | 0 | 0 | 1 |
Drug classes tested here Aromatase inhibitors 4
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 6, phase 3 first
- Jul 2027A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious Puberty · Phase 3 · Children's Hospital of Fudan University
- Nov 2026Basal LH Threshold for the Diagnosis of Central Precocious Puberty · University Hospital, Strasbourg, France
- Dec 2026Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
- Dec 2026The 3rd COPENHAGEN Puberty Study · Rigshospitalet, Denmark
- Mar 2027Idiopathic Central Precocious Puberty and Associated Neurodevelopmental Syndromes and Pathologies: Evaluation of Frequency and Comparison of Diagnostic and Developmental Characteristics · IRCCS Azienda Ospedaliero-Universitaria di Bologna
- Sep 2027INSL3 as a Biomarker of Pubertal Activation: Role in Evaluating Precocious and Delayed Puberty · IRCCS Azienda Ospedaliero-Universitaria di Bologna
Who these studies take
Of the 14 Puberty, Precocious studies recruiting now, 2 (14%) set no upper age limit and 9 (64%) stop at 75 or younger. 14 (100%) take children under 18. 2 (14%) are for women only and 0 (0%) for men only; 2 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 12 (86%) | 12 (86%) |
| 18 | 8 (57%) | 8 (57%) |
| 30 | 5 (36%) | 5 (36%) |
| 40 | 5 (36%) | 5 (36%) |
| 50 | 5 (36%) | 5 (36%) |
| 65 | 5 (36%) | 5 (36%) |
| 75 | 5 (36%) | 5 (36%) |
| 85 | 5 (36%) | 5 (36%) |
Across all 75 studies, recruiting or not: 79% stop at 75 or younger and 79% at 65; 95% take children; 36% are for women only and 4% for men only; 23% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 50 of 75. Browse all 75 → or search them.
- Natural History Study of Patients With Excess AndrogenRecruitingNCT002501591 country
- Inherited Reproductive DisordersRecruitingNCT015004471 country
- (Z)-Endoxifen in Girls With MAS-Associated Peripheral Precocious PubertyNot yet recruitingNCT07869732Phase 21 country
- Basal LH Threshold for the Diagnosis of Central Precocious PubertyRecruitingNCT078641161 country
- INSL3 as a Biomarker of Pubertal Activation: Role in Evaluating Precocious and Delayed PubertyRecruitingNCT078597871 country
- Observation of Environment and Reproductive-Endocrine EffectsRecruitingNCT062808071 country
- A Study of Leuprorelin 1-Month (4-Week) Formulation in Children With Central Precocious PubertyRecruitingNCT07710430Phase 41 country
- Clinical Study of Traditional Chinese Medicine in the Treatment of Phlegm-dampness Intrinsic Precocious PubertyNot yet recruitingNCT07637019Not applicable1 country
- Early Breast Growth in Girls Aged 6 to 8 Years in the Current Environmental ContextRecruitingNCT06083415Not applicable1 country
- A Trial of Chinese Traditional Medicine Combining With Intradermal Acupuncture for Treating Precocious PubertyRecruitingNCT06510764Phase 31 country
- Idiopathic Central Precocious Puberty and Associated Neurodevelopmental Syndromes and Pathologies: Evaluation of Frequency and Comparison of Diagnostic and Developmental CharacteristicsRecruitingNCT067208441 country
- IDMet (RaDiCo Cohort) (RaDiCo-IDMet)RecruitingNCT059455761 country
- Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPPNot yet recruitingNCT06487143Phase 41 country
- The 3rd COPENHAGEN Puberty StudyRecruitingNCT048846201 country
- Evaluate the Efficacy and Safety of DWJ108JRecruitingNCT06025409Phase 31 country
- Danish Precocious Puberty Study - DAPP Study A National Cohort Study on Incidence and Etiologies for Precocious PubertyNot yet recruitingNCT059579911 country
- Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or PalateRecruitingNCT016011711 country
- Overweight and Obesity and Puberty Development Cohort StudyRecruitingNCT041130701 country
- First Observatory of Precocious Puberty.Active, not recruitingNCT062638681 country
- A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial)Active, not recruitingNCT06129539Phase 35 countries
- A Study of Leuprolide Acetate Depot in Children With Central Precocious PubertyCompletedNCT05341115Phase 41 country
- Hypiend - Multicomponent Behavioral Intervention in Pre-puberal Children (Hypiend-PPC)Active, not recruitingNCT07411001Not applicable1 country
- Efficacy, Safety, and Pharmacokinetics of Leuprolide Mesylate in Subjects With Central Precocious PubertyCompletedNCT05493709Phase 34 countries
- Research of Integrated Traditional Chinese and Western Medicine on Precocious PubertyWithdrawnNCT07325903Early Phase 11 country
- Clinical Observation of Qingwei Huazhuo Decoction (Product: Jinsaiyu) in Improving Children With Precocious Puberty of Phlegm-Dampness Internal Accumulation TypeTerminatedNCT07141615Not applicable1 country
- Spexin and Phoenixin-20 in Girls With Central Precocious PubertyCompletedNCT073590921 country
- A Study of Medical Records From Children With Central Precocious Puberty (CPP) in ChinaCompletedNCT053411281 country
- A Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Paediatric Participants With Central Precocious Puberty.CompletedNCT05029622Phase 31 country
- Impact of the COVID-19 Pandemic on Central Precocious Puberty: a Retrospective Cohort Study from TurkeyCompletedNCT068230761 country
- Diagnostic Power of Basal LH Compared to Peak LH After Stimulus Test in the Diagnosis of Central Precocious PubertyCompletedNCT067206231 country
- Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty.CompletedNCT04736602Phase 31 country
- A Study to Evaluate Leuprolide Acetate 45 mg 6-Month Formulation in Children With Central Precocious Puberty (CPP)CompletedNCT03695237Phase 32 countries
- Evaluation of the Correlation Between Psychological Intervention, Including Providing Knowledge and Tools for Problems Solving, and the Anxiety Level of Female Patients Arriving to ACTH LRH Test - Pilot StudyTerminatedNCT04502836Not applicable1 country
- Faslodex in McCune-Albright SyndromeCompletedNCT00278915Phase 26 countries
- Clinical Trial of Rapid Progressive Central Precocious Puberty With Integrative Chinese and Western MedicineCompletedNCT03963752Phase 41 country
- Effect of Prevalence of BMI on Efficacy of Herbal Medicines in Girls' Sexual PrecocityCompletedNCT046657131 country
- Efficacy and Safety Study of Pamoate of Triptorelin in Children With Precocious PubertyCompletedNCT00564850Phase 31 country
- Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive DisordersCompletedNCT004941691 country
- Effect of Exogenous Growth Hormone on Ocular FindingsStatus unknownNCT053384111 country
- A Study to Assess the Safety and Efficacy of Enantone (Leuprorelin) in Central Precocious Puberty (CPP) Among Chinese ParticipantsCompletedNCT029939261 country
- A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese ParticipantsCompletedNCT02427958Phase 41 country
- The Safety and Pharmacokinetic/Pharmacodynamic Study of CKD-841 in Postmenopausal Female, Phase 1Status unknownNCT04840745Phase 11 country
- Histrelin Subcutaneous Implant in Children With Central Precocious PubertyCompletedNCT00779103Phase 3
- Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in GirlsCompletedNCT01278290Phase 31 country
- PREOPERATIVE GONADOTROPINE-RELEASING HORMONE AGONIST THERAPY BEFORE SURGERY FOR UTERİN FIBROIDSStatus unknownNCT04192812Not applicable1 country
- Study of Leuprolide Acetate Injectable Suspension in the Treatment of Central Precocious PubertyCompletedNCT02452931Phase 36 countries
- Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious PubertyCompletedNCT03316482Phase 41 country
- The Effect of Decaffeinated Green Tea Polyphenol Intake on the Risk of Precocious Puberty Among Obese GirlsStatus unknownNCT03628937Not applicable1 country
- the Association Between Obesity and Early PubertyCompletedNCT04317014
- Clinical Trial of Experienced Chinese Herbal Formulas on Different Types of Precocious PubertyCompletedNCT02650141Not applicable1 country