Cytochrome P-450 CYP3A Inhibitors clinical trials

Studies

Open first, then newest update. How each study uses a medicine is read from its arms, and is right about nine times in ten. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing one of them · 906

• Improving Osimertinib Exposure and Cost-effectiveness Using Pharmacokinetic Boosting With CobicistatRecruitingPhase 4Maastricht University Medical CenterNCT05748093Written as Cobicistat
• A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV TreatmentsRecruitingPhase 4Gilead SciencesNCT06337032Written as E/C/F/TAF
• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired PneumoniaRecruitingPhase 3UMC UtrechtNCT02735707Written as Hydroxychloroquine + lopinavir/ritonavir
• Compare Oral Itraconazole and Standard Care Versus Standard Care Alone in Patients With Non-cystic Fibrosis Related Bronchiectasis With Chronic Aspergillus Infection in Reducing Bronchiectasis ExacerbationsRecruitingPhase 3Post Graduate Institute of Medical Education and Research, ChandigarhNCT06160713Written as Itraconazole 65 MG
• Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy.Not yet recruitingPhase 3ElsanNCT07887022Written as Amiodarone
• A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal CancerRecruitingPhase 2VA Office of Research and DevelopmentNCT05563766Written as Itraconazole
• A Trial to Assess Cobicistat Boosted Venetoclax in Combination With Azacitidine in Adult Patients With Newly Diagnosed AMLRecruitingPhase 2Stichting Hemato-Oncologie voor Volwassenen NederlandNCT06014489Written as Cobicistat
• A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy ParticipantsRecruitingPhase 1Novartis PharmaceuticalsNCT07783503Written as Itraconazole
• Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's EsophagusRecruitingPhase 2National Cancer Institute (NCI)NCT06732388Written as Itraconazole
• Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori InfectionRecruitingPhase 3Tanta UniversityNCT07275827Written as Vonoprazan + amoxicillin + clarithromycin
• Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori InfectionRecruitingPhase 2Tanta UniversityNCT07293910Written as Clarithromycin 500 mg
• Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot TrialRecruitingPhase 3Population Health Research InstituteNCT05841056Written as Amiodarone Hydrochloride 200 MG
• Antifungal Agents and Infrared Thermotherapy Alone or in Combination in the Treatment of SporotrichosisRecruitingNot applicableFirst Hospital of China Medical UniversityNCT06300138Written as Itraconazole
• Ketoconazole Effects on the Daily Cortisol Rhythm in Mild Autonomous Cortisol SecretionRecruitingPhase 1National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT07649317Written as Ketoconazole
• An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in AfricaNot yet recruitingPhase 3University College, LondonNCT07792096Written as Ritonavir (RTV)
• Itraconazole Therapy In Bronchiectasis With Airway MoldRecruitingPhase 4Mayo ClinicNCT07283497Written as Itraconazole 200 mg
• The Effectiveness of Itraconazole Pulse Therapy vs Topical 2% Ketoconazole in the Treatment of Moderate to Severe Seborrheic Dermatitis of Scalp.RecruitingEarly Phase 1Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur PakistanNCT07734441Written as Itraconazole (200 mg)
• Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 TabletNot yet recruitingPhase 1Reistone Biopharma Company LimitedNCT07696091Written as RSS0343 Tablet; Clarithromycin Tablets
• Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With Darunavir/Cobicistat Plus Tenofovir Alafenamide/Emtricitabine in Virologically Suppressed People Living With HIV at 24 and 48 Weeks of Follow-upRecruitingPhase 4Instituto Mexicano del Seguro SocialNCT07678268Written as Dual therapy: darunavir/cobicistat + lamivudine
• Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac SurgeryNot yet recruitingPhase 4Massachusetts General HospitalNCT05543278Written as Amiodarone

See all 906 studies that test one of the cytochrome p-450 cyp3a inhibitors →