Cytochrome P-450 CYP3A Inhibitors: all 906 studies that test it

Page 1 of 10. Open to participants first (60), then studies with results posted, then the rest; newest registration first within each.

• Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy.Not yet recruitingNCT07887022Phase 3
• An Adaptive Platform Trial for Evaluation of Novel Treatment Regimens in Children and Adolescents With HIV in AfricaNot yet recruitingNCT07792096Phase 3
• A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy ParticipantsRecruitingNCT07783503Phase 1
• The Effectiveness of Itraconazole Pulse Therapy vs Topical 2% Ketoconazole in the Treatment of Moderate to Severe Seborrheic Dermatitis of Scalp.RecruitingNCT07734441Early Phase 1
• Study on Drug Interactions Affecting the Pharmacokinetics of RSS0343 TabletNot yet recruitingNCT07696091Phase 1
• Effectiveness and Safety of Darunavir/Cobicistat Plus Lamivudine Compared With Darunavir/Cobicistat Plus Tenofovir Alafenamide/Emtricitabine in Virologically Suppressed People Living With HIV at 24 and 48 Weeks of Follow-upRecruitingNCT07678268Phase 4
• Ketoconazole Effects on the Daily Cortisol Rhythm in Mild Autonomous Cortisol SecretionRecruitingNCT07649317Phase 1
• Pharmacological Intervention to Prevent NOAF After TAVRNot yet recruitingNCT07519161Not applicable
• Comparative Efficacy of 100-, 200-, & 400-mg Amiodarone in Patients With Paroxysmal AF Depending on Plasma ConcentrationEnrolling by invitationNCT07487714Phase 4
• Study on the Drug Interaction Between Buagafuran and VoriconazoleNot yet recruitingNCT07457203Phase 1
• Catequentinib Hydrochloride (AL3818) Drug-Drug Interaction Study in Healthy VolunteersNot yet recruitingNCT07438886Phase 1
• Comparing the Efficacy of Oral Fluconazole Versus Oral Itraconazole in Treating Resistant Tinea CorporisRecruitingNCT07342153Phase 4
• Comparison of the Efficacy of Topical Luliconazole 2% Cream vs Topical Ketoconazole 1% Cream in the Treatment of Pityriasis Versicolor.Not yet recruitingNCT07333170Phase 4
• Comparative Efficacy of Topical 1% Clotrimazole vs Oral Itraconazole in the Treatment of Pityriasis VersicolorNot yet recruitingNCT07331792Phase 1/2
• Vonoprazan vs Proton Pump Inhibitor With Vitamin D or Probiotics Based Triple Therapy for Eradication of Helicobacter Pylori InfectionRecruitingNCT07293910Phase 2
• Itraconazole Therapy In Bronchiectasis With Airway MoldRecruitingNCT07283497Phase 4
• Comparative Study Evaluating Safety and Effectiveness of ( Proton Pump Inhibitor Versus Vonoprazan ) Based Triple Therapy With or Without Zinc to Eradicate H. Pylori InfectionRecruitingNCT07275827Phase 3
• Evaluation of Two Different Regimens of the Antiarrhythmic Drug Amiodarone to Maintain Normal Sinus Rhythm After Electrical Cardioversion in Patients With Persistent Atrial FibrillationRecruitingNCT07273994Phase 4
• Pharmacokinetic Comparison of Vonafexor Acid and Its Lysine Salt and Evaluation of Potential Drug-Drug InteractionsRecruitingNCT07251153Phase 1
• Comparison Between Continuous and Pulse Itraconazole in Tinea Capitis in ChildrenRecruitingNCT07184203Not applicable
• Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy SubjectsNot yet recruitingNCT07181265Phase 1
• Prospective Study of Frontline Antibiotics Therapy in the Treatment of Early-stage HP-negative Gastric MALT LymphomaNot yet recruitingNCT07144657Phase 2
• Comparison of Omeprazole vs Vonoprazon in Treatment of H Pylori InfectionNot yet recruitingNCT07040839Phase 4
• Comparison of Two Treatment Regimens of Helicobacter Pylori InfectionNot yet recruitingNCT07021729Phase 4
• Comparison of Efficacy of Oral Fluconazole Versus Oral Itraconazole in the Treatment of Pityriasis VersicolorRecruitingNCT06922344Phase 4
• Prophylactic Anti-aRrhythmic Therapy With Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest With Initial Shockable RhythmRecruitingNCT06835491Phase 3
• Efficacy and Safety of Intravenous + Oral Vs. Oral Amiodarone in Preventing Recurrence After Catheter Ablation in Patients with Persistent Atrial FibrillationNot yet recruitingNCT06742866Not applicable
• Itraconazole in Combination With Ablation for the Prevention of Esophageal Cancer in Patients With High-risk Barrett's EsophagusRecruitingNCT06732388Phase 2
• Early Amiodarone in Shockable Cardiac ArrestRecruitingNCT06680869Phase 3
• Evaluation of Cardioverter Capacity of Amiodarone Pre-electrical Cardioversion in Persistent Atrial FibrillationNot yet recruitingNCT06645249Phase 4
• Ketoconazole Contributes to Cryptorchidism Outcome Via Modulating Macrophage Trem2RecruitingNCT06560086Not applicable
• Role of Eplerenone in Reducing Recurrence of Atrial Fibrillation in Patients With Structural Heart DiseaseRecruitingNCT06556732Phase 1
• A Study To Evaluate The Effect Of Rifampicin Or Ltraconazole On Pharmacokinetics Of Ensartinib In Healthy VolunteersNot yet recruitingNCT06492525Phase 1
• STARLITE for Unresectable High-Grade GliomasRecruitingNCT06428045Phase 1
• Improvement of PPROM Management With Prophylactic Antimicrobial Therapy (iPROMPT)RecruitingNCT06396078Phase 4
• Drug-drug Interaction Study of HRS-1780 Tablets in Healthy SubjectsNot yet recruitingNCT06344936Phase 1
• A Study to Provide Continued Access to Study Drug to Children and Adolescents Who Have Completed Clinical Studies Involving Gilead HIV TreatmentsRecruitingNCT06337032Phase 4
• Antifungal Agents and Infrared Thermotherapy Alone or in Combination in the Treatment of SporotrichosisRecruitingNCT06300138Not applicable
• Clarithromycin Treatment to Prevent Sepsis Progression in CAP (REACT)RecruitingNCT06294600Phase 3
• A Randomized Trial of Prednisolone, Itraconazole, or Their Combination in Allergic Bronchopulmonary AspergillosisRecruitingNCT06174922Phase 3
• Compare Oral Itraconazole and Standard Care Versus Standard Care Alone in Patients With Non-cystic Fibrosis Related Bronchiectasis With Chronic Aspergillus Infection in Reducing Bronchiectasis ExacerbationsRecruitingNCT06160713Phase 3
• Amiodarone for the Prevention of Atrial Fibrillation After Minimally Invasive Esophagectomy in Patients With Esophageal CancerRecruitingNCT06067438Phase 2
• A Trial to Assess Cobicistat Boosted Venetoclax in Combination With Azacitidine in Adult Patients With Newly Diagnosed AMLRecruitingNCT06014489Phase 2
• A "Screen and Treat" Helicobacter Pylori Eradication Trial in Adolescents in Three Regions of ChileRecruitingNCT05926804Not applicable
• Efficacy and Safety of Terbinafine and ItraconazoleNot yet recruitingNCT05881980Phase 2/3
• Short Term Anti-aRrhythmic Therapy for Post-Operative AF in Cardiac Surgery Patients Pilot TrialRecruitingNCT05841056Phase 3
• Improving Osimertinib Exposure and Cost-effectiveness Using Pharmacokinetic Boosting With CobicistatRecruitingNCT05748093Phase 4
• Intralesional Voriconazole, or Intralesional Cryotherapy, or Oral Doxycycline in the Treatment of Cutaneous LeishmaniasisRecruitingNCT05708625Phase 3
• A Phase II Trial to Evaluate the Effect of Itraconazole on Pathologic Complete Response Rates in Resectable Esophageal CancerRecruitingNCT05563766Phase 2
• Flecainide Versus Amiodarone in the Cardioversion of Paroxysmal Atrial Fibrillation at the Emergency Department, in Patients With Coronary Artery Disease Without Residual IschemiaRecruitingNCT05549752Phase 3
• Pragmatic Amiodarone Trial to Reduce Postoperative Atrial Fibrillation in Patients Undergoing Cardiac SurgeryNot yet recruitingNCT05543278Phase 4
• Oral Itraconazole Versus Combination of Systemic Glucorticoids and Oral Itraconazole in CPA-ABPA Overlap SyndromeRecruitingNCT05444946Not applicable
• EPIC-Peds: A Study to Learn About the Study Medicine Called PF-07321332 (Nirmatrelvir)/Ritonavir in Patients Under 18 Years of Age With COVID-19 That Are Not Hospitalized But Are at Risk for Severe DiseaseRecruitingNCT05261139Phase 3
• Helicobacter Pylori Eradication and Follow-upRecruitingNCT05061732Phase 4
• Evaluating the Effect of Itraconazole on Pathologic Complete Response Rates in Esophageal CancerRecruitingNCT04018872Phase 2
• Prevention of Postop Atrial Fibrillation Through Intraoperative Inducibility of Atrial Fibrillation and Amiodarone TreatmentRecruitingNCT03868150Phase 4
• Azoles Targeting Recurrent High Grade GliomasNot yet recruitingNCT03763396Early Phase 1
• Signal TrAnsduction Pathway Activity Analysis in OVarian cancERRecruitingNCT03458221Phase 2/3
• Alternation in the Human Microbiome With Commonly Used Topical MedicationsRecruitingNCT03437005Phase 1
• Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired PneumoniaRecruitingNCT02735707Phase 3
• A Study of the Effects of Food and Cobicistat on Plixorafenib Pharmacokinetics in Healthy Participants.CompletedNCT06385119Phase 1Results posted
• RECOVER-VITAL: Platform Protocol, Appendix to Measure the Effects of Paxlovid on Long COVID SymptomsCompletedNCT05965726Phase 2Results posted
• The Potential of Givinostat as DDI Victim in Co-administration P-gp Inhibitor (Part 2)CompletedNCT05845567Phase 1Results posted
• A Study to Understand the Effect of Itraconazole on the Levels of a Study Medicine Called ARV-471 in Healthy AdultsCompletedNCT05538312Phase 1Results posted
• A Study to Learn About the Medicine (PF-07321332 or Nirmatrelvir/Ritonavir) in Healthy Lactating WomenCompletedNCT05441215Phase 1Results posted
• A Study to Learn About the Study Medicines (Nirmatrelvir Plus Ritonavir) in People Aged 12 Years or Older With COVID-19 and a Compromised Immune SystemCompletedNCT05438602Phase 2Results posted
• A Study to Learn About the Study Medicine PF-07321332 and Ritonavir in Adult Healthy Chinese Participants.CompletedNCT05339334Phase 1Results posted
• Relative Bioavailability Study of PF-07321332/Ritonavir Oral Powder Relative to the Commercial Tablets in Healthy ParticipantsCompletedNCT05263921Phase 1Results posted
• Relative Bioavailability Study of 4 Different Formulations of PF-07321332 Relative to the Commercial Tablet FormulationCompletedNCT05263895Phase 1Results posted
• Tepotinib Drug-Drug Interaction Study With Itraconazole in Healthy ParticipantsCompletedNCT05203822Phase 1Results posted
• Food Effect Study to Evaluate the Effect of High-Fat Meal on the Relative Bioavailability of PF-07321332 Boosted With Ritonavir in Healthy Adult ParticipantsCompletedNCT05129475Phase 1Results posted
• PF-07321332/Ritonavir and Ritonavir on Dabigatran Study in Healthy ParticipantsCompletedNCT05064800Phase 1Results posted
• Clinical Trial of Lurbinectedin (PM01183) in Patients With Advanced Solid TumorsCompletedNCT05063318Phase 1Results posted
• Repeated Amiodarone Dosing In Cardiac surgicaL ProceduresTerminatedNCT05004077Phase 4Results posted
• A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of KRP-A218 in Healthy SubjectsCompletedNCT04908800Phase 1Results posted
• Treatment of Selinexor in Combination With Clarithromycin, Pomalidomide and Dexamethasone for Relapsed Refractory Multiple Myeloma PatientsTerminatedNCT04843579Phase 2Results posted
• Effects of Itraconazole and Rifampin on the Blood Tazemetostat LevelsCompletedNCT04537715Phase 1Results posted
• Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)CompletedNCT04432376Phase 2/3Results posted
• A Phase II Study of Daratumumab, Clarithromycin, Pomalidomide And Dexamethasone (D-ClaPd) In Multiple Myeloma Patients Previously Exposed to DaratumumabActive, not recruitingNCT04302324Phase 2Results posted
• Phase 1 Three Part SAD, MAD & Cross-Over Study of ZP-059 in Healthy and Asthmatic SubjectsCompletedNCT04229303Phase 1Results posted
• Efficacy and Safety of Vonoprazan Compared to Lansoprazole in Participants With Helicobacter Pylori InfectionCompletedNCT04167670Phase 3Results posted
• Itraconazole Oral AbsorptionCompletedNCT04035187Phase 4Results posted
• Clarithromycin Mechanisms in Hypersomnia SyndromesCompletedNCT04026958Phase 2Results posted
• A Study of LY3154885 in Healthy ParticipantsTerminatedNCT04014361Phase 1Results posted
• Impact of Steady State Cobicistat and Darunavir/Cobicistat on the Pharmacokinetics and Pharmacodynamics of Oral Anticoagulants (Rivaroxaban, Apixaban) in Health VolunteersCompletedNCT03864406Phase 1Results posted
• Clinical Study to Evaluate the Therapeutic Equivalence of Ketoconazole Cream 2% in the Treatment of Tinea PedisCompletedNCT03824912Phase 3Results posted
• Treatment of Chronic Delta Hepatitis With Lonafarnib, Ritonavir and Lambda InterferonCompletedNCT03600714Phase 2Results posted
• Modulation of GABA-A Receptors in Parkinson Disease-Transdermal Flumazenil ArmCompletedNCT03440112Phase 1/2Results posted
• Oral Calcitriol With Ketoconazole in CRPCTerminatedNCT03261336Phase 2Results posted
• A Two-part Study to Compare a Tablet and Capsule Formulation of GSK2838232 With and Without Food, and to Assess the Safety and Drug Levels of Repeated Once-daily Doses of GSK2838232 Without RitonavirCompletedNCT03234036Phase 1Results posted
• Intraoperative Amiodarone to Prevent Atrial Fibrillation in Lung Transplant PatientsCompletedNCT03221764Phase 2Results posted
• Dose-Ranging Study for Miconazole Oil for Treatment of OtomycosisCompletedNCT03130738Phase 2Results posted
• A Study to Evaluate the Pharmacokinetics (PK) of Darunavir (DRV) and Cobicistat (COBI) After a Single Oral Administration of Darunavir/Cobicistat Fixed-Dose Combination in Healthy Japanese Adult ParticipantsCompletedNCT03123848Phase 4Results posted
• Efficacy and Safety of Ravidasvir + Danoprevir/r 12-week Oral Therapy in Treatment-Naive Non Cirrhotic G1 CHC TaiwanCompletedNCT03020095Phase 2Results posted
• Efficacy and Safety of Danoprevir/r + PR 12-week Triple Therapy in Treatment-Naive, Non-Cirrhotic, G1 CHC China IICompletedNCT03020004Phase 2Results posted
• Open Label Efficacy and Safety of Anti-MAP (Mycobacterium Avium Ssp. Paratuberculosis) Therapy in Adult Crohn's DiseaseCompletedNCT03009396Phase 3Results posted
• Two Different Antibiotic Agents to Treat Generalized Aggressive PeriodontitisCompletedNCT02969928Phase 2/3Results posted
• PrOD for Non-Cirrhotic Patients With HCV-1b Receiving HemodialysisCompletedNCT02874066Phase 4Results posted
• Clarithromycin as Adjuvant to Periodontal DebridementCompletedNCT02829983Not applicableResults posted
• Efficacy, Safety, and Tolerability of Ledipasvir/Sofosbuvir (LDV/SOF) Treatment for HIV/HCV Co-infected Participants Who Switch to Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (E/C/F/TAF) or Emtricitabine/Rilpivirine/Tenofovir Alafenamide (F/R/TAF) Prior to LDV/SOF HCV TreatmentCompletedNCT02707601Phase 3Results posted

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