Drug

Allopurinol clinical trials

Also written Zyloprim.

Includes 1 study of Allopurinol sodium.

studies test it: 116
open now: 8
in phase 3: 20
first study started: 1995

How each study uses Allopurinol is sorted by a rule, right about nine times in ten. Readers can ask us to read every study one by one.Ask us to read each study

Get an email when these change. Save the Allopurinol studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.

Watch these studies

See an example email

Example · made-up studies

Breast cancer · Recruiting: 2 came in, 3 changed

What changed in your saved searches, Oct 31 – Nov 6:

A study of drug A after surgery for early breast cancer

Came in · now Recruiting

Drug B with hormone therapy in advanced breast cancer

Changed

· Sites: 4 added, including Seoul and Busan

· Enrollment: 300 → 450 participants

Exercise during chemotherapy

Now Active, not recruiting

One email a week for all your saved searches. Stop any time.

Approvals

The first approval found in each region, with its record

United States: 19 Aug 1966 · ZYLOPRIM · NDA 016084 (FDA, Drugs@FDA)
European Union: 23 Aug 2018 · Duzallo · EMEA/H/C/004412 (EMA; in a combination; now withdrawn)

From FDA's Drugs@FDA and Purple Book (through openFDA) and the European Medicines Agency, files of Sept 2026 and 27 Oct 2026. National approvals in Europe and other countries are not included. How this is worked out

How studies write it

Studies that test it under each name

Name

Allopurinol: 87
Allopurinol 300 MG: 14
Allopurinol Tablet: 6
Zyloric: 5
Aloprim: 3

Brand

Zyloprim: 14
Zyloprim® 300 mg: 1
Lopurin: 1

Studies by the year they started

112 studies that test it; most in 2008 (8)

Studies that test Allopurinol, by start year
Year	Studies
1995	1
1998	1
2002	1
2003	3
2004	3
2005	3
2006	2
2007	4
2008	8
2009	5
2010	7
2011	6
2012	3
2013	3
2014	8
2015	6
2016	5
2017	6
2018	8
2019	4
2020	6
2021	4
2022	6
2023	5
2024	1
2025	1
2026	2

By phase

A phase 1/2 study counts in both.

Early Phase 1: 4
Phase 1: 20
Phase 2: 43
Phase 3: 20
Phase 4: 27
No phase: 14

What it is tested for

Each study’s main condition, where its own words name it, so a study counts once.

Gout: 14
Hyperuricemia: 7
Cardiovascular Diseases: 6
Precursor Cell Lymphoblastic Leukemia-Lymphoma: 4
Heart Failure: 3
Sleep Apnea, Obstructive: 3
Hypertension: 3
Fibrosis: 2
Diabetic Nephropathies: 2
Leukemia, Myeloid, Acute: 2
Leukemia: 2
Bipolar Disorder: 2

Who runs them

Industry 21 · Other 95

Ardea Biosciences, Inc. (8) · Tanta University (5) · AstraZeneca (5) · University of Dundee (5) · The University of Texas at Arlington (3) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (3) · Instituto Nacional de Cardiologia Ignacio Chavez (3) · Masonic Cancer Center, University of Minnesota (2)

Often tested with

Tested in the same studies.

Verinurad (6) · Lesinurad (4) · Febuxostat (3) · Fludarabine (3) · Cyclophosphamide (3) · Mycophenolic Acid (3) · Rasburicase (3) · Acetovanillone (3)

Coming up

From the study records. Dates are the sponsors’ own estimates and often move.

Tested against it · 2 phase 3 studies under way

Allopurinol is the comparator. A study of two new drugs counts under both.

2Dotinurad · Crystalys Therapeutics · next primary completion Nov 2027

Reaching primary completion within a year · 4, 1 in phase 3

Studies that test Allopurinol, phase 3 first.

May 2027Allopurinol in DepressionPhase 2/3 · Tanta University
Dec 2026Role of Allopurinol in Prevention of Complications Related to Decompensated Cirrhosis of LiverPhase 4 · Bangladesh Medical University
Jun 2027HLA-B*58:01-Guided Therapy for Gout: Effectiveness, Safety, and Cost-EffectivenessPhase 4 · Haiphong University of Medicine and Pharmacy
Oct 2027Allo HSCT Using RIC and PTCy for Hematological DiseasesPhase 2 · Masonic Cancer Center, University of Minnesota

Studies

Open first, then newest update. How each study uses Allopurinol is read from its arms, and is right about nine times in ten. Ask us to read each study. These are the studies that list it as an intervention; a search of ClinicalTrials.gov also finds studies that mention it only in a description, such as earlier treatment.

Testing it · 116

See all 116 studies that test Allopurinol →

Given beside what is tested · 23 — Allopurinol is usual care or a partner of the new treatment

Showing 20 of 23.

As the comparator · 27 — what is tested is compared with Allopurinol

Showing 20 of 27.

Codes

What other systems call Allopurinol · ClinicalTrials.gg INT006928

MeSH (NLM) D000493AllopurinolConfirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA) 63CZ7GJN5IALLOPURINOLConfirmed FDA, NLM, Wikidata
RxNorm 519Confirmed FDA, Wikidata
Wikidata Q412486allopurinolConfirmed FDA, NLM, Wikidata
NCI Thesaurus C224AllopurinolOne source FDA
DrugBank DB00437One source Wikidata

System	Code	Name there	Checked by
MeSH (NLM)	D000493	Allopurinol	Confirmed ClinicalTrials.gov, NLM, Wikidata
UNII (FDA)	63CZ7GJN5I	ALLOPURINOL	Confirmed FDA, NLM, Wikidata
RxNorm	519	—	Confirmed FDA, Wikidata
Wikidata	Q412486	allopurinol	Confirmed FDA, NLM, Wikidata
NCI Thesaurus	C224	Allopurinol	One source FDA
DrugBank	DB00437	—	One source Wikidata

“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.