Adrenergic alpha-Agonists: all 451 studies that test it

Page 2 of 5. Open to participants first (88), then studies with results posted, then the rest; newest registration first within each.

• Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®)CompletedNCT03723447Phase 4Results posted
• Exparel and Marcaine for Pain Management in Thoracoscopic Lobectomy PatientsCompletedNCT03682224Phase 3Results posted
• Distribution, Pharmacokinetics and Extent of Sensory Blockade in ESP BlocksCompletedNCT03476642Phase 4Results posted
• Crystalloid Liberal or Vasopressors Early Resuscitation in SepsisCompletedNCT03434028Phase 3Results posted
• Subcutaneous Bupivacaine Decrease Post-op Pain in Patients Undergoing C-SectionTerminatedNCT03383588Phase 2Results posted
• Safety and Tolerability of Oxymetazoline and Energy-Based Therapy in Participants With RosaceaCompletedNCT03380390Phase 4Results posted
• Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic TeenagersCompletedNCT03366298Phase 4Results posted
• An Evaluation of the Reduction in Erythema in Adult Patients With Moderate to Severe Persistent Facial Erythema Associated With RosaceaCompletedNCT03352323Phase 3Results posted
• Comparing Blood Loss and Visualization After the Preoperative Use of Topical 0.05% Oxymetazoline Versus 1:1000 Epinephrine Prior to Endoscopic Sinus SurgeryCompletedNCT03228914Phase 4Results posted
• Prophylactic Topical Epinephrine to Reduce Bleeding in Transbronchial Lung BiopsiesCompletedNCT03126968Phase 2/3Results posted
• Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle FracturesCompletedNCT02967172Phase 4Results posted
• Comparison of Epinephrine and Phenylephrine/Ketorolac With Regards to Pupil SizeTerminatedNCT02895035Phase 4Results posted
• Efficacy of Peri-Incisional Multimodal Drug Injection Following Operative Management of Femur FracturesCompletedNCT02793947Phase 4Results posted
• Evaluate Use of Caudal Nerve Blocks in Adult Penile ProsthesisCompletedNCT02740127Phase 3Results posted
• The Prevention of Hypotension After Epidural Analgesia After Major SurgeryCompletedNCT02722746Phase 1/2Results posted
• Goal-Directed Intraoperative Fluid Management Using FloTrac© Monitoring in High-Risk Neurosurgical PatientsCompletedNCT02701582Not applicableResults posted
• Posterior Capsular Injection With Femoral Nerve Block for Total Knee ArthroplastyCompletedNCT02701296Not applicableResults posted
• Ultrasound-guided Fascia Iliaca Compartment Block Versus Periarticular InfiltrationCompletedNCT02658240Not applicableResults posted
• Postoperative Pain Control After Periarticular Injection During Total Knee ArthroplastyTerminatedNCT02570503Phase 4Results posted
• TAP vs Surgical Infiltration of Local Anesthetic in Laparoscopic and Robotic HysterectomyCompletedNCT02519023Phase 4Results posted
• Prospective Hemodynamic and Pharmacokinetic Analysis of Oxymetazoline AbsorptionCompletedNCT02453841Not applicableResults posted
• Does the Addition of Epinephrine Prolong the Duration of Spinal Anesthesia for Repeat Cesarean Section?CompletedNCT02369510Phase 4Results posted
• Hip Scope Fascia-iliaca (FI) Block StudyCompletedNCT02365961Phase 4Results posted
• Phenylephrine vs. Norepinephrine Infusion After Spinal Anesthesia for Cesarean DeliveryCompletedNCT02354833Phase 4Results posted
• The Effect of Intranasal Vasoconstrictor Medications on Hemodynamic Parameters: A Randomized Double-blind, Placebo-controlled Trial.CompletedNCT02285634Not applicableResults posted
• Phenylephrine Versus Norepinephrine for Septic Shock in Critically Ill PatientsTerminatedNCT02203630Phase 4Results posted
• Safety and Efficacy of AGN-199201 and AGN-190584 in Patients With PresbyopiaCompletedNCT02197806Phase 2Results posted
• Comparison Study of Transversus Abdominal Plane, Paravertebral and Epidural Blocks in Laparoscopic ColectomyTerminatedNCT02164929Not applicableResults posted
• Safety and Efficacy of Oxymetazoline HCl Cream 1.0% in Patients With Persistent Erythema Associated With RosaceaCompletedNCT02132117Phase 3Results posted
• Efficacy and Safety of AGN-199201 in Patients With Persistent Erythema Associated With RosaceaCompletedNCT02131636Phase 3Results posted
• Randomized Trial of Rectal Indomethacin and Papillary Spray of Epinephrine Versus Rectal Indomethacin to Prevent Post-ERCP PancreatitisCompletedNCT02116309Not applicableResults posted
• Efficacy of Ropivacaine (With Epinephrine) in BABA Endoscopic and Robotic ThyroidectomyCompletedNCT02112370Phase 3Results posted
• Efficacy of Rectal Infiltration of Exparel for Analgesic Benefit Following HemorrhoidectomyTerminatedNCT02104414Phase 4Results posted
• A Long-Term Safety and Efficacy Study AGN-19920 in Patients With Persistent Erythema Associated With RosaceaCompletedNCT02095158Phase 3Results posted
• Effectiveness of Oxymetazoline Added on Nasal Steroid in Rhinitis With Persistent Nasal ObstructionCompletedNCT01847131Phase 4Results posted
• Control of Tourniquet Pain With an Axillary Ring of Subcutaneous Local AnestheticCompletedNCT01829399Phase 4Results posted
• Femoral Nerve Block for Femur Fracture Repair in PediatricsTerminatedNCT01759407Phase 2Results posted
• AGN-199201 for the Treatment of Erythema With RosaceaCompletedNCT01735201Phase 2Results posted
• Comparison of Topical Vasoconstriction in Endoscopic Sinus SurgeryCompletedNCT01706952Phase 4Results posted
• Voiding Function After Mid-Urethral Slings With and Without Local Anesthetic: Randomized Controlled TrialCompletedNCT01583166Not applicableResults posted
• Safety and Tolerability of AGN-199201 in Patients With Erythema Associated With RosaceaCompletedNCT01579084Phase 1Results posted
• Methemoglobin Levels in Generally Anesthetized Pediatric Dental Patients Receiving Local AnestheticsCompletedNCT01402869Not applicableResults posted
• Study to Assess the Absorption and Tolerability of Intranasal Ketorolac Tromethamine and to Assess the Effects of Oxymetazoline Hydrochloride and Fluticasone Propionate on the Absorption and Tolerability of Intranasal Ketorolac Tromethamine in Participants With Allergic RhinitisCompletedNCT01365650Phase 1Results posted
• Safety and Effectiveness of Kovacaine Nasal Spray for Dental AnesthesiaCompletedNCT01302483Phase 2Results posted
• Effectiveness Study of Different Local Anesthetic MixturesCompletedNCT01243112Phase 4Results posted
• Pharmacokinetics (PK) Study of Epinephrine Inhalation Aerosol in Healthy VolunteersCompletedNCT01143051Phase 1/2Results posted
• Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver TransplantationCompletedNCT01080625Not applicableResults posted
• Periarticular Multimodal Drug Injections in Total Knee ArthroplastyCompletedNCT00901628Phase 4Results posted
• Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Acute Allergic Conjunctivitis.CompletedNCT00770133Phase 3Results posted
• Ketotifen/Naphazoline Ophthalmic Solution in the Conjunctival Allergen Challenge Model of Allergic Conjunctivitis.CompletedNCT00769886Phase 3Results posted
• Mechanisms of Hypoglycemia Associated Autonomic FailureTerminatedNCT00678145Phase 2Results posted
• Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic ShockCompletedNCT00604019Phase 3Results posted
• Intranasal Steroids and Oxymetazoline in Allergic RhinitisCompletedNCT00584987Phase 4Results posted
• Study of Mometasone Furoate Nasal Spray and Oxymetazoline Nasal Spray Given Together Once A Day To Treat Seasonal Allergic Rhinitis (P04500)CompletedNCT00552110Phase 2Results posted
• Low-dose Epinephrine Infusion Tests in Adolescent and Pediatric PatientsTerminatedNCT00548886Not applicableResults posted
• Comparing Vasopressin and Adrenaline in Patients With Cardiac ArrestCompletedNCT00358579Phase 3Results posted
• Preemptive Local Anesthesia in Vaginal SurgeryCompletedNCT00318292Phase 4Results posted
• Ropivacaine Alone Versus Ropivacaine Plus Lidocaine With or Without Epinephrine for Supraclavicular Brachial Plexus Block in Upper Limb Orthopedic SurgeryCompletedNCT07907666Phase 4
• Comparison of Lidocaine With and Without Adrenaline for Reducing EcchymosisCompletedNCT07897201Not applicable
• Norepinephrine Infusion vs Bolus vs Ephedrine for Blood Pressure Stability During Cesarean Delivery in Women With PreeclampsiaCompletedNCT07842783Not applicable
• Dopamine Versus Epinephrine for Pediatric Fluid-Refractory Hypotensive Septic ShockActive, not recruitingNCT07775001Not applicable
• Comparing Two Agents Used to Stop Bleeding During Tonsil Removal Surgery: Adrenaline Versus Hydrogen PeroxideCompletedNCT07675278Not applicable
• Oxymetazoline Bridge Therapy With Intranasal Corticosteroids in Pediatric Allergic RhinitisCompletedNCT07593898Phase 4
• A Study to Learn More About How Well Oxymetazoline HCl 0.05% Nasal Gel Works and How Safe It Is in Healthy AdultsCompletedNCT07582328Phase 2
• Effect of Adding a Low-Dose Epinephrine Bolus Prior to Infusion on Maternal Hemodynamic Stability During Cesarean SectionCompletedNCT07480889Phase 3
• Comparison of Systemic Opioid (Morphine) and Pre-Incision Bilateral Scalp Nerve Block for Pain Management in Craniotomy PatientsCompletedNCT07425678Phase 4
• Norepinephrine vs. Phenylephrine for Hypotension in Low-Dose Spinal Anesthesia for Cesarean DeliveryCompletedNCT07327320Phase 4
• Management of Post-Induction Hypotension in Emergency Abdominal SurgeryTerminatedNCT07259655Phase 4
• Paracervical Injection and Opioid Use After Vaginal Hysterectomy for ProlapseCompletedNCT07213635Phase 4
• Steroid Treatment for Elimination of Rebound Obstruction From Intranasal DecongestantsTerminatedNCT07168148Phase 2
• Norepinephrine vs. Phenylephrine for Spinal Hypotension in Cesarean SectionCompletedNCT07153601Not applicable
• Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in ElderlyCompletedNCT07077265Not applicable
• Prophylactic Perioperative Infusion of Ephedrine Versus Noradrenaline in Patients Undergoing Cesarean Delivery Under Spinal AnesthesiaCompletedNCT07067944Not applicable
• Prophylactic Noradrenaline Infusion and Its Impact on Post-induction HypotensionCompletedNCT07022730Not applicable
• Ephedrine Versus Norepinephrine and Fetal Acid-Base Status During Cesarean Delivery Under Spinal AnesthesiaCompletedNCT06921473Phase 4
• Assessment of Local Anaesthesia Effectiveness in Symptomatic Irreversible PulpitisCompletedNCT06862570Phase 2
• Norepinephrine ED90 Bolus After Spinal Anesthesia in Cesarean SectionCompletedNCT06574555Phase 4
• Pharmacokinetics Study of DESF in Adults With Oral Allergy SyndromeCompletedNCT06527937Phase 2
• Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension.CompletedNCT06508359Not applicable
• Management of Postspinal Anesthesia Hypotension During Elective Cesarean Section: Baby Norepinephrine Versus EphedrineCompletedNCT06498076Not applicable
• The Role of Nasal Breathing for Perfomance in Elite Athletes.CompletedNCT06480071Not applicable
• The Effect of Early Norepinephrine on Stroke Volume Index, Cardiac Index, Lactate, and Arterial Elastance in Pediatric Septic ShockCompletedNCT06461390Phase 2/3
• Effects of Inhaled Epinephrine on Systemic Allergic Reactions During Allergy Testing Immunotherapy or Oral ChallengesCompletedNCT06445374Phase 1
• Intrathecal Dexmedetomidine vs EpinephrineCompletedNCT06418308Phase 4
• Combining Lidocaine and Ropivacaine for an Infraclavicular Brachial Plexus Nerve BlockCompletedNCT06381622Phase 3
• Ultrasound-guided Infraclavicular Block With Lidocaine or Ropivacaine for Closed Reduction of Distal Radius FracturesCompletedNCT06379490Phase 3
• Comparing the Efficiency of Two Approaches in Patients at Risk of Developing Intraoperative Floppy Iris SyndromeCompletedNCT06266962Phase 4
• Epinephrine in Irrigation Fluid for Visualization During Ankle SurgeryWithdrawnNCT06264596Phase 3
• Comparative Bioavailability of Intranasal EpinephrineCompletedNCT06205134Phase 1/2
• The Effect of Vasopressor on Pressure Injury DevelopmentCompletedNCT06163352Not applicable
• ED90 of Norepinephrine and Phenylephrine Infusions Under Intensive TreatmentCompletedNCT06158048Not applicable
• ED90 of Norepinephrine and Phenylephrine Infusions in Preeclamptic PatientsCompletedNCT06158022Not applicable
• ED90 of Norepinephrine and Phenylephrine Boluses Under Intensive TreatmentStatus unknownNCT06158009Not applicable
• Intensive Versus Standard Treatment for Spinal Anesthesia-induced Hypotension in Preeclamptic PatientsCompletedNCT06151431Not applicable
• Prophylactic Tranexamic Acid Versus Adrenaline During Flexible BronchoscopyCompletedNCT06145191Not applicable
• The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKACompletedNCT06112548Not applicable
• Goal-directed Fluid Therapy During Deep Inferior Epigastric Perforator (DIEP) Free Flap Breast ReconstructionTerminatedNCT06080178Phase 4
• Vasopressor Outcomes in Spine SurgeryCompletedNCT06053398Early Phase 1
• WALANT Versus Axillary Brachial Plexus Block in Carpal Tunnel ReleaseCompletedNCT06040840Not applicable
• Study of Inhaled DMC-IH1 and Intramuscular (EpiPen®) Epinephrine in Healthy Male and Female Participants.CompletedNCT06013150Phase 1

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