An interventional study of Adrenaline and Hydrogen Peroxide in Chronic Tonsillitis, Tonsillar Hypertrophy, Tonsillitis and Tonsillectomy, sponsored by Rawalpindi Medical College. Completed at 1 site in Pakistan. Open to participants aged 5 Years to 18 Years. Per ClinicalTrials.gov, last updated 2026-06-30.
Sponsored by Rawalpindi Medical College · Not applicable, Interventional, and Treatment
The goal of this quasi-experimental study is to compare the effectiveness of topical adrenaline and 3% hydrogen peroxide for controlling bleeding (hemostasis) during tonsil removal surgery in patients aged 5 to 18 years. The main questions it aims to answer are: 1. Which substance leads to faster bleeding control during surgery? 2. Which substance results in less total blood loss during surgery? Researchers compared the adrenaline group to the hydrogen peroxide group to see if one agent was more effective at managing bleeding than the other. Participants underwent a tonsillectomy where surgeons applied either gauze soaked in adrenaline (1:100,000 solution) or gauze soaked in 3% hydrogen peroxide to the tonsil area to stop bleeding.
This study was conducted as a quasi-experimental comparative analysis to evaluate the efficacy of two common topical hemostatic agents, adrenaline (1:100,000 solution) and 3% hydrogen peroxide, during elective tonsillectomy. All procedures were performed in the Department of Otorhinolaryngology at Rawalpindi Teaching Hospital. Surgeons of a consistent training level performed all tonsillectomies using the dissection technique to minimize inter-operator variability. The allocation of patients to either the adrenaline or hydrogen peroxide group was determined by the surgical date (even-numbered dates for adrenaline; odd-numbered dates for hydrogen peroxide). To maintain measurement rigor, blood loss was assessed by personnel blinded to the group assignment, utilizing both gravimetric and volumetric methods. The dry weight of standard surgical gauze was recorded preoperatively and compared against the weight of blood-soaked gauze post-use to estimate blood volume, utilizing a blood specific gravity of 1.055 g/mL. Additionally, suction canister volumes were measured, with adjustments made for any irrigation fluid used during the procedure. Intraoperative hemostasis was defined as the complete cessation of bleeding from the tonsillar fossa without the requirement for further hemostatic intervention. Time to achieve hemostasis was recorded by the operating team and categorized into four intervals: \<1 minute, 1-3 minutes, 3-5 minutes, and >5 minutes. Total intraoperative blood loss was calculated as the aggregate of the gravimetric (gauze) and volumetric (suction) assessments and was ordinally classified as mild (16-75 mL), moderate (76-275 mL), or severe (>275 mL). Statistical analysis was performed using IBM SPSS Statistics version 25.0, employing the Mann-Whitney U test for non-normally distributed time-to-hemostasis data and the Chi-square test for ordinal blood loss categories.
103 studies on the registry are indexed under Tonsillitis; 12 are open to participants now.
This study's enrollment of 64 is below the median of 100 across 87 interventional studies indexed under Tonsillitis.
Browse Tonsillitis studies →Rawalpindi Medical College is the lead sponsor of 24 studies on the registry; 6 are open to participants now.
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Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Cancer (malignancy)
Malignancy means cancer. Criteria about another or earlier malignancy ask whether you have had a different cancer, usually within a set number of years.
Some are commonly allowed, such as treated skin cancers other than melanoma and early cancers removed completely — check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this group receive topical application of adrenaline (1:100,000 solution) via gauze pieces immediately following the removal of tonsils during the surgical procedure to achieve hemostasis.
Drug: Adrenaline
Participants in this group receive topical application of 3% hydrogen peroxide via gauze pieces immediately following the removal of tonsils during the surgical procedure to achieve hemostasis.
Drug: Hydrogen Peroxide
Topical application of 1:100,000 adrenaline solution.
Also known as: Epinephrine
Topical application of 3% hydrogen peroxide solution.
Also known as: H2O2
Severity of intraoperative blood loss during tonsillectomy as classified by combined gravimetric and volumetric assessment.
Total volume of blood lost during the surgical procedure, determined by the sum of blood volume calculated from the gravimetric method (pre- and post-operative weight of surgical gauze) and the volumetric method (suction canister volume). Results are categorized ordinally as: Mild (16-75 mL), Moderate (76-275 mL), or Severe (\>275 mL).
Time frame: Measured during the intraoperative period, specifically from the time of hemostatic agent application until the completion of the tonsillectomy procedure.
Time to achieve intraoperative hemostasis during tonsillectomy as measured in minutes.
Time from the application of the hemostatic agent until the complete cessation of bleeding from the tonsillar fossa, as recorded by the surgical team. Time is recorded in categorical intervals: \<1 minute, 1-3 minutes, 3-5 minutes, and \>5 minutes.
Time frame: Measured during the intraoperative period, specifically from the time of hemostatic agent application until the completion of the tonsillectomy procedure.
Plan to share: No — Individual participant data (IPD) will not be made publicly available as part of a general data-sharing plan; however, the data that support the findings of this study are available from the corresponding author upon reasonable request.
Ran from Feb 2024 to primary completion in Jan 2025, 11 months.
Of 29 non-industry interventional studies with no phase under Tonsillitis, half reached primary completion within 20 months of starting (the median), counting those still running; a quarter within 10 and three quarters within 49. This study's 11 months is below that.
Counting every sponsor, half of 29 studies reached it within 20 months; a quarter within 10 and three quarters within 49.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jun 2026. You cannot join it, but the record below documents what was studied.
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Studies of the drugs tested here: Epinephrine · Hydrogen Peroxide
Rawalpindi Medical College