Vulvar Lichen Sclerosus clinical trials
The registry lists 33 studies for Vulvar Lichen Sclerosus across more than 10 countries. 10 are recruiting or about to start. 29 of them are mainly about Vulvar Lichen Sclerosus (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-02.
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Who runs them
Medstar Health Research Institute (2) · Center for Vulvovaginal Disorders (2) · University of Texas Southwestern Medical Center (2) · Fundación Eduardo Anitua (1) · 1st Federal Budgetary Healthcare Institution Volga District Medical Center (1) · Daniela de Fátima Teixeira da Silva (1) · Deana Funaro (1) · University of South Alabama (1)
What is being tested here
Drugs under test in Vulvar Lichen Sclerosus studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 4
- Dec 2026Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy. · Milosz Pietrus
- Jan 2027Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen Sclerosus · Federal State Budget Institution Research Center for Obstetrics, Gynecology and Perinatology Ministry of Healthcare
- Jan 2027Methotrexate for Severe Vulvar Lichen Sclerosus · Clinica Dermatologica Arbache ltda
- Sep 2027Nemolizumab for LS · University of Texas Southwestern Medical Center
Who these studies take
Of the 6 Vulvar Lichen Sclerosus studies recruiting now, 4 (67%) set no upper age limit and 2 (33%) stop at 75 or younger. 0 (0%) take children under 18. 6 (100%) are for women only and 0 (0%) for men only; 0 (0%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 5 (83%) | 0 (0%) |
| 30 | 6 (100%) | 0 (0%) |
| 40 | 6 (100%) | 0 (0%) |
| 50 | 5 (83%) | 0 (0%) |
| 65 | 4 (67%) | 0 (0%) |
| 75 | 4 (67%) | 0 (0%) |
| 85 | 4 (67%) | 0 (0%) |
Across all 33 studies, recruiting or not: 15% stop at 75 or younger and 9% at 65; 9% take children; 100% are for women only and 0% for men only; 9% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 33 of 33. search them.
- Nemolizumab for LSNot yet recruitingNCT07704775Phase 21 country
- Efficacy of Collagendep in Reducing Vulvar Dryness in Patients With Lichen Sclerosus Treated With Fat GraftingNot yet recruitingNCT07450625Not applicable
- VALOR: Vaginal Atrophy & Long-term Observation of RecoveryRecruitingNCT05953090Not applicable1 country
- Dynamic Quadripolar Radiofrequency VS Topical Corticosteroids in Women With Vulvar Lichen SclerosusRecruitingNCT07363733Not applicable1 country
- Methotrexate for Severe Vulvar Lichen SclerosusRecruitingNCT07352917Phase 21 country
- Use of Topical Testosterone and Estrogen vs Estrogen Alone in Vulvodynia: a Randomized Controlled TrialNot yet recruitingNCT07260825Phase 2/31 country
- To Compare Inflammatory Biomarkers Before and After Treatment With Clobetasol or Fractional CO2 Laser, in Women With Histologically Confirmed Vulvar Lichen Sclerosus, Without Prior Corticosteroid Treatment.RecruitingNCT07240519Not applicable1 country
- Treatment of Vulvar Lichen Sclerosus With Corticosteroid Ointment, Calcineurin Inhibitor Ointment, and Platelet-Rich Plasma (PRP) Therapy.Not yet recruitingNCT07240389Not applicable1 country
- StrataMGT in the Reduction of Vulvar Lichen Sclerosus (LS) SymptomsRecruitingNCT06662942Phase 11 country
- A Comparative Study on the Efficacy of AI Temperature-controlled Radiofrequency Technology and Electrical Stimulation in the Treatment of Vulvar LeukoplakiaRecruitingNCT05250466Not applicable1 country
- Use of Platelet Rich Plasma From Cord Blood vs Placebo in the Treatment of Vulvar Lichen SclerosusCompletedNCT06661382Phase 1/21 country
- A Study to Evaluate Platelet Rich Plasma to Treat Vulvar Lichen SclerosusCompletedNCT04967170Phase 1/21 country
- Clinical Trial to Demonstrate That the Dual Laser Therapy is Effective for the Treatment of Vulvar Lichen SclerosusCompletedNCT03926299Not applicable1 country
- Efficacy and Safety of MC2-25 Cream & Vehicle in Women With Vulvar Lichen Sclerosus (VLS)CompletedNCT06132919Phase 21 country
- Does Steroid Plus CO2 Laser Improve Lichen Sclerosus Symptoms Compared to Steroids Alone?TerminatedNCT05243563Phase 2/31 country
- Fractionated CO2 Laser With and Without Clobetasol for Treatment of Vulvar Lichen SclerosusCompletedNCT04951206Phase 41 country
- Plasma Rich in Growth Factors (PRGF) for the Treatment of Lichen Sclerosus Atrophicus of the VulvaWithdrawnNCT05364515Phase 3
- StrataMGT for the Treatment of Vulvar Lichen SclerosusCompletedNCT06360705Not applicable1 country
- Laser Treatment for Vulvar Lichen SclerosusTerminatedNCT04134494Not applicable1 country
- Early Detection of Vulval CAncer Through Self-Examination (EDuCATE): Intervention StudyCompletedNCT04952961Not applicable1 country
- Characterizing the Microbiome in Postmenopausal Women With Vulvar Lichen SclerosusCompletedNCT051471291 country
- Progesterone vs Clobetasol Propionate in Vulvar Lichen SclerosusTerminatedNCT01126255Phase 21 country
- The CO2RE® System for Vulvar Lichen SclerosusCompletedNCT04148651Not applicable1 country
- Efficacy and Safety of the Neodymium Laser in Treatment of Urogenital Tract Diseases in WomenCompletedNCT052512201 country
- Carbon Dioxide(CO2)Fractional Laser Plus Photodynamic Therapy in Female Patients With Vulvar Lichen SclerosusStatus unknownNCT05228483Not applicable1 country
- Clobetasol Propionate Versus Fractionated Carbon Dioxide Laser for the Treatment of Lichen SclerosusCompletedNCT02573883Phase 31 country
- Evaluation of Vulvar Lichen Sclerosus Treatment Using Adipose Tissue Associated With Autologous Platelet-rich Plasma.CompletedNCT03961126Phase 21 country
- Diagnostic Accuracy of "Three Rings Vulvoscopy" for Detection of Vulvar DermatosisCompletedNCT02732145Not applicable1 country
- The Comfort and Adherence of Rivelin® Plain Patches in Vulva Lichen Sclerosus PatientsCompletedNCT03686800Not applicable1 country
- Platelet Rich Plasma (PRP) for Vulvar Lichen SclerosusCompletedNCT03045172Not applicable1 country
- Vulvar Lichen Sclerosus: Comparison Between Clobetasol Propionate, Photodynamic Therapy and Low-Intensity LaserCompletedNCT02416531Not applicable1 country
- Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen SclerosusCompletedNCT00757874Phase 21 country
- Topical 0.05% Clobetasol Propionate in Vaseline Versus UVA-1 Phototherapy in Vulvar Lichen SclerosusCompletedNCT01400022Not applicable1 country