Transposition of Great Vessels clinical trials
The registry lists 44 studies for Transposition of Great Vessels across more than 10 countries. 9 are recruiting or about to start. 24 of them are mainly about Transposition of Great Vessels (how this is decided). Per ClinicalTrials.gov, last updated 2026-07-23.
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Who runs them
Hospital Universitari Vall d'Hebron Research Institute (3) · Assistance Publique - Hôpitaux de Paris (3) · Boston Children's Hospital (3) · National Heart, Lung, and Blood Institute (NHLBI) (2) · University of Michigan (2) · Oslo University Hospital (2) · PECA Labs (1) · Nantes University Hospital (1)
What is being tested here
Drugs under test in Transposition of Great Vessels studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Oxygen | 0 | 0 | 1 |
| Nitric Oxide | 0 | 1 | 1 |
| Epoetin Alfa | 0 | 0 | 1 |
| Dexmedetomidine | 0 | 0 | 1 |
| Eplerenone | 0 | 0 | 1 |
| Simendan | 0 | 0 | 1 |
| Acetylcysteine | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 2
- Dec 2026COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve Dysfunction · Edwards Lifesciences
- Jun 2027Fibrosis, Valvular and Ventricular Function in Patients With TGA · Universitaire Ziekenhuizen KU Leuven
Who these studies take
Of the 8 Transposition of Great Vessels studies recruiting now, 4 (50%) set no upper age limit and 4 (50%) stop at 75 or younger. 6 (75%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (50%) | 4 (50%) |
| 18 | 6 (75%) | 6 (75%) |
| 30 | 4 (50%) | 4 (50%) |
| 40 | 4 (50%) | 4 (50%) |
| 50 | 4 (50%) | 4 (50%) |
| 65 | 4 (50%) | 4 (50%) |
| 75 | 4 (50%) | 4 (50%) |
| 85 | 4 (50%) | 4 (50%) |
Across all 44 studies, recruiting or not: 48% stop at 75 or younger and 48% at 65; 73% take children; 5% are for women only and 2% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
Studies
Recruiting first, then most recently updated. Showing 44 of 44. search them.
- COMPASSION S3 - Evaluation of the SAPIEN 3 Transcatheter Heart Valve in Patients With Pulmonary Valve DysfunctionRecruitingNCT02744677Not applicable1 country
- Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i RegistryRecruitingNCT069320815 countries
- Cardiovascular Risk in Children With Chronic Conditions StudyRecruitingNCT070869891 country
- NIRS in Congenital Heart Defects - Correlation With EchocardiographyRecruitingNCT041064791 country
- Effects Branch PA Stenting d-TGA, ToF and TARecruitingNCT05809310Not applicable1 country
- An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital Heart DiseaseRecruitingNCT067680081 country
- MASA Valve Early Feasibility StudyRecruitingNCT05452720Not applicable1 country
- Cardiovascular Magnetic Resonance in Adults With SysTemic Right Ventricle (STAR)RecruitingNCT056908541 country
- Canadian Adult Congenital Heart Disease Intervention RegistryNot yet recruitingNCT042885961 country
- Cardiac Resynchronization Therapy in Adult Congenital Heart Disease With Systemic Right Ventricle: RIGHT-CRTCompletedNCT05524324Not applicable1 country
- Acute Maternal Hyperoxygenation for Fetal Transposition of the Great Arteries (TGA)CompletedNCT03771534Not applicable1 country
- Measurement of the Prevalence of Sensory Integration Disorders in Babies Having Heart Disease Surgery for Transposition of the Great Vessels Before 6 Months of AgeCompletedNCT051378731 country
- Genetics of Ventriculo-arterial DiscordanceActive, not recruitingNCT05330338Not applicable1 country
- Haemodynamics and Function of the Atria in Congenital Heart Disease by Cardiovascular Magnetic ResonanceCompletedNCT021614711 country
- Fibrosis, Valvular and Ventricular Function in Patients With TGAActive, not recruitingNCT025889891 country
- Targeting Normoxia in Neonates With Cyanotic Congenital Heart Disease in the Intra-operative and Immediate Post-operative PeriodCompletedNCT04452188Not applicable1 country
- Nitric Oxide During Bypass for Arterial Switch OperationCompletedNCT03661385Phase 34 countries
- Systemic Right Ventricle Long-term OutcomeCompletedNCT062580832 countries
- The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart DiseaseCompletedNCT030731221 country
- Comprehensive Long-term Follow up of Adults With Arterial Switch OperationActive, not recruitingNCT043354485 countries
- Influence of Timing of Switch Operation in Transposition of Great ArteriesCompletedNCT051601161 country
- Characterization of the Cardiac Reinnervation of Patients With Transposition of the Great Arteries Long After Repair With the Arterial Switch Operation. Correlation With Electrocardiographic and Exercise Test ParametersCompletedNCT034698431 country
- Outcomes of Transposition of the Great Arteries After Arterial Switch OperationCompletedNCT050897731 country
- Sudden Cardiac Death in Systemic Right VentricleCompletedNCT038338431 country
- Clinical Impact of Rapid Prototyping 3D Models for Surgical ManagementWithdrawnNCT04788082Not applicable1 country
- A Retrospective Comparison of the Efficacy and Safety of Celsior® in Pediatric Cardiac Surgery for Transposition of the Great VesselsStatus unknownNCT046162221 country
- Oxygen Consumption-based Assessments of Hemodynamics in Neonates Following Congenital Heart Surgery (Oxy-CAHN Study)CompletedNCT02184169Not applicable1 country
- Initiation of Resuscitation While Attached to the Cord With Congenital Heart DiseaseWithdrawnNCT03690245Not applicable1 country
- Erythropoetin Neuroprotection for Neonatal Cardiac SurgeryCompletedNCT00513240Phase 1/21 country
- Late Function After Surgery for Transposition of the Great ArteriesCompletedNCT030784131 country
- A Phase I Study of Dexmedetomidine Bolus and Infusion in Corrective Infant Cardiac Surgery: Safety and PharmacokineticsCompletedNCT01915277Phase 11 country
- CT Coronary Angiography After Arterial Switch OperationCompletedNCT01153776Not applicable1 country
- MRI Study After Arterial Switch Operation in Patients With Transposition of the Great ArteriesCompletedNCT019164991 country
- Eplerenone in Systemic Right VentricleCompletedNCT00703352Phase 41 country
- Assessing Neurodevelopment in Congenital Heart Disease.Status unknownNCT02996630Not applicable1 country
- Comparison of Hematocrit Levels in Infant Heart SurgeryCompletedNCT00006183Phase 31 country
- Infant Heart Surgery: Central Nervous System Sequelae of Circulatory ArrestCompletedNCT00000470Phase 3
- Reproduction and Survival After Cardiac Defect RepairCompletedNCT00005190
- Cardiovascular MRI and Cardiopulmonary Exercise Capacity After Neonatal ASO) in Young AdultsStatus unknownNCT02415491Not applicable1 country
- Effects of Beta-adrenergic in Adults w/Transposition of Great Arteries on Systemic Ventricular FunctionCompletedNCT003133521 country
- Levosimendan Administration in Neonates With Transposition of the Great ArteriesCompletedNCT01120106Phase 21 country
- Physical Training in Transposition of the Great ArteriesCompletedNCT00837603Not applicable1 country
- N-Acetylcysteine in Neonatal Congenital Heart Surgery (INACT Study)CompletedNCT00374088Phase 21 country
- Hypertonic Saline Dextran in Pediatric Cardiac SurgeryCompletedNCT00199771Phase 2