An interventional study of Unconscious Trauma Reactivation plus Eye Movements and Active Trauma Memory Reactivation plus Eye Movements in Post-traumatic Stress Disorder (PTSD) and Intrusive Memories of Traumatic Event(s), sponsored by Shaanxi Normal University. Recruiting at 1 site in China. Open to participants aged 18 Years to 50 Years. Per ClinicalTrials.gov, last updated 2026-10-15.
Sponsored by Shaanxi Normal University · Not applicable, Interventional, and Treatment
Among 28 studies in Stress Disorders, Post-Traumatic with a site in China — 15 open to participants now, 18 under way, none of them phase 3. Stress Disorders, Post-Traumatic · China.
Among the 28 studies in Stress Disorders, Post-Traumatic with a site in China, this one is the 12th largest by planned enrollment of the 22 interventional ones that give a count, is one of 7 that started in 2026, is one of 22 with no phase, reaches primary completion later than 17 of the 17 other live ones, and was the 27th registered.
2,682 studies on the registry are indexed under Stress Disorders, Post-Traumatic; 601 are open to participants now.
This study's planned enrollment of 117 is above the median of 69 across 2,196 interventional studies indexed under Stress Disorders, Post-Traumatic.
Browse Stress Disorders, Post-Traumatic studies →15 of the 28 studies in Stress Disorders, Post-Traumatic with a site in China are open now, in 1 country. Each count lists the studies.
Of the 417 Stress Disorders, Post-Traumatic studies recruiting now, 186 (45%) set no upper age limit and 205 (49%) stop at 75 or younger; 63 take children under 18; 89 take healthy volunteers.
This study: 18 Years to 50 Years · all sexes · no healthy volunteers.
The full table on the hub →28 studies; the count open now beside each. This study's row is marked.
First in 2011; this study’s year is marked. 7 started in 2026.
Median enrollment 119 across the 22 interventional studies, 278 across the 6 observational. Of the 9 that completed or were terminated, 0 (0%) have results posted.
None of the 28 has an industry lead sponsor. The 10 most frequent:
Shaanxi Normal University is the lead sponsor of 4 studies on the registry; 3 are open to participants now.
Shaanxi Normal University has 2 studies filed under Stress Disorders, Post-Traumatic — fewer than ten, so there is no comparison to draw.
6 of the studies in Stress Disorders, Post-Traumatic with a site in China that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07325734Peking UniversityThe Effectiveness of Guided Written Exposure Therapy for Complex PTSD in Adolescents | 2026-11-25 |
| NCT06434766Second Affiliated Hospital, Zhejiang University, School of MedicineMulticenter iTBS Neuromodulation for PTSD Treatment | 2026-12 |
| NCT07632131First Affiliated Hospital of Fujian Medical UniversityPreventive Narrative Exposure Intervention for PTSD in ICU Patients After Cardiopulmonary Bypass Cardiac Surgery | 2027-02-28 |
| NCT07747415Sir Run Run Shaw HospitalPTSD Risk Prediction Model for EICU Survivors | 2027-03-30 |
| NCT07644338Shanghai Mental Health CenterThe Efficacy and Safety of Temporal Interference Stimulation in the Treatment of Post-Traumatic Stress Disorder | 2027-05 |
Among the 28 studies in Stress Disorders, Post-Traumatic with a site in China, from their registry updates:
Post-Traumatic Stress Disorder (PTSD) and trauma-related symptoms are often characterized by recurrent intrusive memories that cause distress and interfere with daily functioning. Although trauma-focused interventions such as Eye Movement Desensitization and Reprocessing (EMDR) may be effective, they often involve engagement with trauma-related memories, which can be distressing for some individuals and may affect treatment acceptability. This randomized controlled trial will evaluate a standardized eye-movement-based procedure for trauma-exposed individuals experiencing recurrent intrusive memories. Participants will be randomly assigned to one of several memory-related task conditions involving eye movements. The study will assess the frequency and distress of trauma-related intrusive memories at prespecified assessment points, as well as PTSD symptoms, intervention-related distress, acceptability, and safety. Findings from this trial may help inform the development of tolerable approaches for targeting trauma-related intrusive memories.
Any optional exploratory follow-up conducted after discontinuation will be independent of the main RCT and will be used only to collect descriptive feasibility, safety, and acceptability information. Data from such follow-up will not be included in the primary or secondary efficacy analyses of the main RCT and, if reported, will be presented separately from the RCT outcomes.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
DSM diagnostic criteria
The American Psychiatric Association’s manual of mental health diagnoses. DSM-5 (2013, revised as DSM-5-TR in 2022) replaced DSM-IV, and some studies still name the older edition. “Meets DSM criteria for …” means diagnosed by that edition’s diagnostic criteria, usually by a clinician in an interview.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Informed consent
Before you join, the study team explains what taking part involves — its purpose, what happens, the risks and possible benefits — and answers your questions, so you can decide freely. Consent is usually recorded on a form (the informed consent form, ICF) signed by you or, where the law allows, by someone legally authorised to decide for you.
You can keep asking questions during the study, you are told of new information that matters, and you can choose to leave at any time.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Participants in this arm will complete a standardized procedure of trauma-related visual cues together with eye movements. The procedure is intended to minimize conscious awareness of the trauma-related cues.
Behavioral: Unconscious Trauma Reactivation plus Eye Movements
Participants in this arm will complete a standardized EMDR-informed procedure involving active recall of a trauma-related memory together with eye movements.
Behavioral: Active Trauma Memory Reactivation plus Eye Movements
Participants in this arm will complete a standardized neutral memory recall procedure together with eye movements. The neutral material will be unrelated to the participant's traumatic experience or intrusive memories.
Behavioral: Neutral Memory Reactivation plus Eye Movements
Participants will complete a procedure involving unconscious activation combined with eye movements.
Participants will complete a standardized procedure involving recall of a trauma-related memory combined with eye movements.
Participants will complete a standardized procedure involving recall of a neutral memory combined with eye movements.
Number of trauma-related intrusive memories
Total number of trauma-related intrusive memories recorded in a daily diary over the 7-day assessment period.
Time frame: Day 66 - 72(all arms) controlling for baseline week
Number of trauma-related intrusive memories
Number of trauma-related intrusive memories assessed via a daily diary.
Time frame: Day 18 - 24 , Day 42 - 48(all arms) controlling for baseline week
Intrusive memory ratings
This 7-item questionnaire assesses a number of intrusive memory characteristics. These characteristics include: frequency (7-point categorical response from 'never' to 'many times a day'); distress (0=not at all to 10=extremely); disruption to concentration (0=not at all to 10=extremely); interference with what you were doing (how much (0=not at all to 10=extremely) and for how long (6-point categorical response from '\<1min' to '\>60mins')); impact on work functioning (0=not at all to 10=extremely); impact on functioning in other areas of life (0=not at all to 10=extremely).
Time frame: Baseline(day 0), day 24, day 48, day 72, 2 months after the last intervention(all arms)
Post-Intervention Questionnaire
A 3-item questionnaire assessed participants' immediate subjective experience after each intervention session: distress and aversion experienced during the procedure (0=not at all to 10=very); acceptability of the intervention task (0=not at all to 10=very).
Time frame: Day1, 9, 17, 25, 33, 41, 49, 57, 65 (all arms)
PTSD Checklist for DSM-5 (PCL-5)
This 20-item measure assesses symptoms of PTSD over the last month. Each of the 20 items is rated on a 5-point Likert scale ranging from 0 (Not at all) to 4 (Extremely). The total score ranges from 0 to 80.
Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)
Clinician-Administered PTSD Scale for DSM-5 (CAPS-5)
Change in PTSD symptom severity as measured by the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5). The CAPS-5 is a structured clinical interview assessing DSM-5 PTSD symptoms. Each of the 20 PTSD symptom items is rated on a severity scale from 0 to 4. The total symptom severity score is calculated by summing the severity ratings for the 20 PTSD symptom items, yielding a total score range from 0 to 80. Higher scores indicate greater PTSD symptom severity. PTSD diagnostic status is determined according to DSM-5 symptom cluster criteria and is not based solely on the total severity score.
Time frame: Baseline (day 0) and day 73 (all arms)
Impact of Event Scale-Revised (IES-R)
This 22-item self-report measure subjective distress caused by traumatic events during the past seven days. It assesses three domains of post-traumatic stress: intrusion, avoidance, and hyperarousal. Each of the 22 items is rated on a 5-point scale according to symptom severity: 0 (Not at all) to 4 (Extremely). The total score is calculated by summing the scores of all 22 items, yielding a total score range from 0 to 88.
Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)
Beck Depression Inventory-II (BDI-II)
The Beck Depression Inventory-II (BDI-II) is a 21-item self-report instrument used to assess the existence and severity of depressive symptoms, covering emotional (e.g., sadness, hopelessness), cognitive (e.g., self-reproach, worthlessness), somatic (e.g., fatigue, appetite loss), and behavioral (e.g., loss of interest, social withdrawal) dimensions. Each of the 21 items consists of four statements describing increasing levels of severity, rated on a 4-point scale ranging from 0 (not present) to 3 (severe). The total score is calculated by summing the scores of all 21 items, with a total score range from 0 to 63. Higher scores indicate more severe depressive symptoms.
Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)
State-Trait Anxiety Inventory-State version (STAI-S)
The State Anxiety subscale of the State-Trait Anxiety Inventory (STAI-Form Y-I, S-AI) comprises items 1 to 20 of the inventory. Half of the items describe negative emotions and the other half describe positive emotions. It is designed to evaluate immediate or recent situational experiences of fear, tension, worry, and nervousness, making it particularly useful for assessing state anxiety under stressful conditions. Each of the 20 items is rated on a 4-point scale: 1 (not at all), 2 (somewhat), 3 (moderately so), and 4 (very much so). The total score is calculated by summing the 20 items, yielding a total score range from 20 to 80. Higher scores reflect a greater severity of the subject's current state anxiety symptoms.
Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)
Work and Social Adjustment Scale (WSAS)
The WSAS is a 5-item self-report scale designed to measure the degree of functional impairment in day-to-day activities (work, home management, social leisure, private leisure, and close relationships). Each of the 5 items is rated on a 9-point scale ranging from 0 (Not at all impaired) to 8 (Very severely impaired). The total score is calculated by summing the scores of all 5 items, yielding a total score range from 0 to 40. Lower scores indicate better functioning, while higher scores indicate greater functional impairment. Clinical thresholds are: below 10 (subclinical), 10 to 20 (significant functional impairment), and above 20 (moderately severe or worse psychopathology).
Time frame: Baseline(day 0), day25, day49, day73, 2 months after the last intervention(all arms)
Changes to health
This 4-item questionnaire assesses the number of any new traumatic events, new treatments received and the occurrence of adverse events since the last assessment.
Time frame: Day73 and 2 months after the last intervention(all arms)
Feedback questionnaire
A 5-item questionnaire (0=not at all to 10=very) assessed participants' subjective experience of the intervention: ease of use; perceived helpfulness; willingness to use the intervention if intrusive memories recur in the future; willingness to recommend the intervention to others with similar intrusive memories; whether they perceived the task as related to their condition during the experiment.
Time frame: Day65 (all arms)
Number of trauma-related intrusive memories
Number of trauma-related intrusive memories assessed via a single item .
Time frame: 2 months after the last intervention (all arms)
Subliminal Perception Check
Administered only to the unconscious trauma cue group. Following each intervention session, participants will be asked whether they perceived any image using a single-item binary choice (Yes/No). If the response is "Yes," participants will be asked to provide an open-ended description.
Time frame: Day1, 9, 17, 25, 33, 41, 49, 57, 65 (the Unconscious Reactivation group only)
Plan to share: Yes
Supporting information: Study protocol, Statistical analysis plan, Analytic code
No publications or documents are linked to this record.
Start is estimated for Oct 2026; primary completion for Sep 2028, 22 months later.
Of 1,064 non-industry interventional studies with no phase under Stress Disorders, Post-Traumatic, half reached primary completion within 35 months of starting (the median), counting those still running; a quarter within 17 and three quarters within 53. This study's planned 22 months is below that.
Counting every sponsor, half of 1,092 studies reached it within 34 months; a quarter within 17 and three quarters within 53.
Start moved once since we started tracking on Sep 25, 2026: Aug 2026 → Oct 2026, on Oct 15, 2026.
Earlier changes are on the record history on ClinicalTrials.gov ↗
How these figures are worked out, and which studies are left out of them.
From the registry record's own update history. This site started tracking changes on Sep 25, 2026; for anything earlier, see the record history on ClinicalTrials.gov ↗
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Stress Disorders, Post-Traumatic →
Shaanxi Normal University