Drug
Nintedanib clinical trials
Also written BIBF 1120, Vargatef, Ofev® and Intedanib.
- studies test it
- 136
- open now
- 11
- in phase 3
- 24
- first study started
- 2002
Keep track of what changes. Save the nintedanib studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Name
- OVEF
- 2
Other names
Studies by the year they started
135 studies that test it; most in 2014 (12); 1 more planned to start later
| Year | Studies |
|---|---|
| 2002 | 1 |
| 2003 | 2 |
| 2004 | 1 |
| 2005 | 7 |
| 2006 | 5 |
| 2007 | 1 |
| 2008 | 2 |
| 2009 | 7 |
| 2010 | 2 |
| 2011 | 9 |
| 2012 | 6 |
| 2013 | 6 |
| 2014 | 12 |
| 2015 | 12 |
| 2016 | 11 |
| 2017 | 7 |
| 2018 | 4 |
| 2019 | 5 |
| 2020 | 7 |
| 2021 | 10 |
| 2022 | 2 |
| 2023 | 5 |
| 2024 | 6 |
| 2025 | 3 |
| 2026 | 2 |
By phase
A phase 1/2 study counts in both.
- Phase 1
- 53
- Phase 2
- 57
- Phase 3
- 24
- Phase 4
- 9
- No phase
- 1
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 70 · Other 66
Boehringer Ingelheim (56) · European Organisation for Research and Treatment of Cancer - EORTC (4) · Assistance Publique - Hôpitaux de Paris (3) · Roswell Park Cancer Institute (3) · Sunshine Lake Pharma Co., Ltd. (2) · Hospices Civils de Lyon (2) · Memorial Sloan Kettering Cancer Center (2) · M.D. Anderson Cancer Center (2)
Often tested with
Tested in the same studies.
Pirfenidone (11) · Docetaxel (5) · Afatinib (5) · Yinfenidone (2) · Pemetrexed (2) · Vinorelbine (2) · Paclitaxel (2) · Tocilizumab (2)
Studies
Open first, then newest update. How each study uses nintedanib is read from its arms, and is right about nine times in ten.
Testing it · 136
- A Study to Compare the Efficacy and Safety of BMS-986353 (Zolacabtagene- Autoleucel / Zola-cel), CD19-CAR T Cells, Versus Standard of Care in Participants With Active Systemic SclerosisNot yet recruitingPhase 3Juno Therapeutics, Inc., a Bristol-Myers Squibb CompanyNCT07335562Written as Nintedanib
- Nintedanib With or Without Dextromethorphan in Patients With Idiopathic Pulmonary Fibrosis (IPF)Not yet recruitingPhase 2First Affiliated Hospital of Wenzhou Medical UniversityNCT07583589Written as Nintedanib,Dextromethorphan
- Study of the Efficacy of Nintedanib+Tocilizumab in Patients With Systemic Sclerosis and Interstitial Lung DiseaseRecruitingPhase 3National Institute of Geriatrics, Rheumatology and Rehabilitation, PolandNCT06297096Written as Nintedanib
- A Prospective, Multicenter Exploratory Clinical Study on Consolidation Therapy With Tislelizumab Combined With Nintedanib for Limited-stage Small Cell Lung CancerNot yet recruitingPhase 4The Affiliated Hospital of Qingdao UniversityNCT07485920Written as Tislelizumab and nintedanib
- Efficacy of Nintedanib for Treatment of Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) PatientsRecruitingPhase 2Dr. Romain LazorNCT04976036Written as Nintedanib
- Nintedanib in Patients With Bronchiolitis Obliterans Syndrome Following Hematopoietic Stem Cell TransplantationRecruitingPhase 2University Hospital, Basel, SwitzerlandNCT03805477Written as Nintedanib
- Nintedanib for Improving Reproductive Outcomes in AdenomyosisNot yet recruitingPhase 3Sun Yat-sen UniversityNCT07162961Written as Nintedanib
- Nintedanib Plus EGFR TKI In EGFR-mutated Non-small Cell Lung Cancer PatientsRecruitingPhase 1/2China Medical University HospitalNCT06071013Written as Nintedanib, gefitinib, erlotinib, afatinib, osimertinib
- RCT of Nintedanib in Fibrotic SarcoidosisRecruitingPhase 4Post Graduate Institute of Medical Education and Research, ChandigarhNCT06479603Written as Nintedanib
- Nintedanib Treatment in Unicentric Castleman DiseaseNot yet recruitingPhase 2Assistance Publique - Hôpitaux de ParisNCT06643091Written as Nintedanib
- Nintedanib for the Treatment of SARS-Cov-2 Induced Pulmonary FibrosisRecruitingPhase 3Assistance Publique - Hôpitaux de ParisNCT04541680Written as Nintedanib 150 MG [Ofev]
- Myositis Interstitial Lung Disease Nintedanib TrialCompletedPhase 4Rohit Aggarwal, MDNCT05799755Written as Nintedanib
- Phase II Study of Docetaxel +/- Nintedanib in Breast CancerCompletedPhase 2Centre Oscar LambretNCT01658462Written as Nintedanib
- Study to Determine Potential for Drug-drug Interactions When Co-administering Deupirfenidone (LYT-100) and NintedanibCompletedPhase 1PureTechNCT06717100Written as Nintedanib 150 MG [Ofev]
- Study To Investigate The Potential DDI Between HEC585 And Pirfenidone/Nintedanib In Healthy SubjectsCompletedPhase 1Sunshine Lake Pharma Co., Ltd.NCT07588646Written as Nintedanib
- The Study of the Use of Nintedanib in Slowing Lung Disease in Patients With Fibrotic or Non-Fibrotic Interstitial Lung Disease Related to COVID-19CompletedPhase 4Icahn School of Medicine at Mount SinaiNCT04619680Written as Nintedanib
- Phase I/II Study of Nivolumab and Ipilimumab Combined With Nintedanib in Non Small Cell Lung CancerActive, not recruitingPhase 1/2H. Lee Moffitt Cancer Center and Research InstituteNCT03377023Written as Nintedanib
- A Study to Evaluate Long-term Safety of Nintedanib in Children and Adolescents With Interstitial Lung Disease (InPedILD®-ON)CompletedPhase 3Boehringer IngelheimNCT05285982Written as Nintedanib (Ofev®)
- Management of Progressive Disease in Idiopathic Pulmonary FibrosisCompletedPhase 4Hospices Civils de LyonNCT03939520Written as pirfenidone and nintedanib
- Trial Of Pembrolizumab And NintedanibCompletedPhase 1Gustave Roussy, Cancer Campus, Grand ParisNCT02856425Written as Nintedanib
See all 136 studies that test nintedanib →
Given in every arm · 10 — nintedanib is usual care beside what is tested
- A Study to Evaluate Pharmacokinetics and Drug-drug Interactions of ENV-101 (Taladegib) in Healthy ParticipantsRecruitingPhase 1Endeavor Biomedicines, Inc.NCT07454291Written as nintedanib
- Nintedanib Alone or in Combination With Capecitabine in Refractory Metastatic Colorectal Cancer [LUME-Colon 2]TerminatedPhase 2Boehringer IngelheimNCT02780700Written as Nintedanib
- Dose Escalation Study of BIBF 1120 in Patients With Advanced Gynaecological MalignanciesCompletedPhase 1Boehringer IngelheimNCT02182245Written as BIBF 1120
- A Study in Healthy Men to Find the Best Formulation for Once Daily Intake of NintedanibCompletedPhase 1Boehringer IngelheimNCT05262751Written as Ofev®
- Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal CancerCompletedPhase 1/2Roswell Park Cancer InstituteNCT02393755Written as Nintedanib
- Study of Pulmonary Rehabilitation in Patients With Idiopathic Pulmonary Fibrosis (IPF)TerminatedPhase 4Boehringer IngelheimNCT03717012Written as Nintedanib
- Efficacy and Safety of Nintedanib Co-administered With Sildenafil in Idiopathic Pulmonary Fibrosis Patients With Advanced Lung Function ImpairmentCompletedPhase 3Boehringer IngelheimNCT02802345Written as Nintedanib
- Safety, Tolerability and PK of Nintedanib in Combination With Pirfenidone in IPFCompletedPhase 4Boehringer IngelheimNCT02579603Written as Nintedanib
- BIBF 1120 Versus Bevacizumab in Metastatic Colorectal CancerCompletedPhase 2Boehringer IngelheimNCT00904839Written as BIBF 1120
- Relative Bioavailability of a Single Dose of Nintedanib Given Alone and in Combination With Multiple Doses of RifampicinCompletedPhase 1Boehringer IngelheimNCT01770392Written as Nintedanib
Codes
What other systems call nintedanib · ClinicalTrials.gg INT005300
- MeSH (NLM) C530716nintedanibConfirmed ClinicalTrials.gov, NLM, Wikidata
- UNII (FDA) G6HRD2P839NINTEDANIBConfirmed FDA, NLM, Wikidata
- RxNorm 1592737Confirmed FDA, Wikidata
- Wikidata Q15149723nintedanibConfirmed FDA, NLM, Wikidata
- NCI Thesaurus C62765NintedanibOne source FDA
- DrugBank DB09079One source Wikidata
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C530716 | nintedanib | Confirmed ClinicalTrials.gov, NLM, Wikidata |
| UNII (FDA) | G6HRD2P839 | NINTEDANIB | Confirmed FDA, NLM, Wikidata |
| RxNorm | 1592737 | — | Confirmed FDA, Wikidata |
| Wikidata | Q15149723 | nintedanib | Confirmed FDA, NLM, Wikidata |
| NCI Thesaurus | C62765 | Nintedanib | One source FDA |
| DrugBank | DB09079 | — | One source Wikidata |
Also registered as nintedanib esylate (UNII 42F62RTZ4G · RxNorm 1592736).
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.