Connective Tissue Diseases clinical trials
The registry lists 192 studies for Connective Tissue Diseases across more than 10 countries. 57 are recruiting or about to start. 35 of them are mainly about Connective Tissue Diseases (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-09. Counting its 73 narrower conditions too, such as Arthritis, Rheumatoid: 16,534 studies, 3,253 open.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
National Center for Research Resources (NCRR) (15) · Viatris Innovation GmbH (4) · Eli Lilly and Company (4) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (3) · Amgen (3) · Qilu Hospital of Shandong University (3) · Liquidia Technologies, Inc. (3) · Bristol-Myers Squibb (3)
What is being tested here
Drugs under test in Connective Tissue Diseases studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Belimumab | 3 | 2 | 3 |
| Treprostinil | 2 | 2 | 5 |
| Cenerimod | 1 | 3 | 4 |
| Cyclophosphamide | 1 | 0 | 3 |
| Pirfenidone | 1 | 0 | 2 |
| Ralinepag | 1 | 2 | 2 |
| Telitacicept | 1 | 0 | 2 |
| Litifilimab | 1 | 1 | 1 |
| Methoxsalen | 1 | 0 | 1 |
| Fludarabine | 1 | 0 | 1 |
Drug classes tested here Alkylating agents 1 open · Antimetabolites 1 open · Tyrosine kinase inhibitors (TKIs) 4 · JAK inhibitors 3 · Endothelin receptor antagonists 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Dec 2026A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label Extension · Phase 3 · United Therapeutics
- Dec 2026A Research Study to Evaluate the Efficacy and Safety of Cenerimod in Subjects Suffering From Systemic Lupus Erythematosus · Phase 3 · Viatris Innovation GmbH
- Mar 2027A Research Study to Evaluate the Effects of a New Oral Medicine Called Cenerimod in Adults With Systemic Lupus Erythematosus · Phase 3 · Viatris Innovation GmbH
- Dec 2026LUpus Eritematoso Sistemico NETwork and Registry · Società Italiana di Allergologia, Asma e Immunologia Clinica
- Dec 2026Clinical Features and Prognosis of Takayasu's Arteritis With Pulmonary Arteries Involvement · China-Japan Friendship Hospital
- Jan 2027129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH) · Bastiaan Driehuys
- Jan 2027Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic Diseases · Bursa City Hospital
- Mar 2027The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services · Unity Health Toronto
- Mar 2027Impact of Capillaroscopy in the Investigation of Diffuse Interstitial Pneumonias · University Hospital, Bordeaux
- Mar 2027Undifferentiated Connective Tissue Disease Registry · Hospital for Special Surgery, New York
Who these studies take
Of the 44 Connective Tissue Diseases studies recruiting now, 30 (68%) set no upper age limit and 8 (18%) stop at 75 or younger. 5 (11%) take children under 18. 1 (2%) are for women only and 1 (2%) for men only; 6 (14%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (7%) | 3 (7%) |
| 18 | 39 (89%) | 39 (89%) |
| 30 | 41 (93%) | 40 (91%) |
| 40 | 41 (93%) | 40 (91%) |
| 50 | 42 (95%) | 43 (98%) |
| 65 | 42 (95%) | 43 (98%) |
| 75 | 38 (86%) | 39 (89%) |
| 85 | 32 (73%) | 33 (75%) |
Across all 192 studies, recruiting or not: 33% stop at 75 or younger and 15% at 65; 26% take children; 5% are for women only and 2% for men only; 16% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Connective Tissue Diseases studies take
Of 14 phase 2 interventional studies under Connective Tissue Diseases, half reached primary completion within 34 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 2 | 34 mo15–49 · 14 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 192. Browse all 192 → or search them.
- A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the AnkleRecruitingNCT06915233Phase 31 country
- Ganglion Resection Effectiveness TrialRecruitingNCT07162415Not applicable2 countries
- A Study Evaluating the Long-Term Efficacy and Safety of Ralinepag in Subjects With PAH Via an Open-Label ExtensionEnrolling by invitationNCT03683186Phase 333 countries
- A Study to Learn More About the Long-Term Safety of Litifilimab (BIIB059) Injections and it's Effects on Symptoms in Adults With Systemic Lupus Erythematosus (SLE)Enrolling by invitationNCT05352919Phase 328 countries
- Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic SclerosisRecruitingNCT04986605Phase 21 country
- Early Intervention With Inhaled Treprostinil Among Patients With Exercise-Induced Pulmonary Hypertension (EPIH)RecruitingNCT07837830Early Phase 11 country
- Investigation of Type I Interferon Excess in Patients With Systemic Autoimmune Diseases and Genetic Type I InterferonopathiesNot yet recruitingNCT07837986Not applicable1 country
- Single Injection of rAAV9-CMV-hNAGLUop Gene for Patients With Mucopolysaccharidosis (MPS) IIIBNot yet recruitingNCT07818759Phase 1/21 country
- Long-term Safety and Tolerability of Cenerimod in Adults With Systemic Lupus ErythematosusEnrolling by invitationNCT06475742Phase 326 countries
- A Study to Investigate the Long-term Safety and Efficacy of Belimumab in Adults With Interstitial Lung Disease (ILD) Associated With Systemic Sclerosis (SSc) and Other Connective Tissue Diseases (CTD) (BLISSconneCTD-OLE)RecruitingNCT06716606Phase 311 countries
- A Study of the Efficacy and Safety of Belimumab in Adults With Interstitial Lung Disease Associated With Connective Tissue DiseaseRecruitingNCT06572384Phase 318 countries
- ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic DisordersRecruitingNCT043986281 country
- A Study of Healthy Donor CD19-targeted Allogeneic CAR T Cells in Participants With Severe, Refractory Autoimmune DiseasesRecruitingNCT07115745Phase 110 countries
- An Exercise and Lifestyle Programme for Adults With Vascular Ehlers-Danlos Syndrome: A Feasibility StudyNot yet recruitingNCT07697573Not applicable1 country
- The Genetics Navigator: Evaluating a Digital Platform for Genomics Health ServicesRecruitingNCT06455384Not applicable1 country
- A Study of GSK4527363 in Healthy Participants, Systemic Lupus Erythematosus (SLE) Participants, Healthy Chinese, and Japanese Participants and CTD-ILD ParticipantsRecruitingNCT06576271Phase 16 countries
- A Study of the Natural Progression of Interstitial Lung Disease (ILD)RecruitingNCT004703271 country
- ADSCs Therapy in Patients With CTD-ILDRecruitingNCT06574581Phase 1/21 country
- Rheumatoid Arthritis Patients at Risk for Interstitial Lung DiseaseRecruitingNCT032977751 country
- Early Recognition of Progressive Lung Fibrosis in Systemic Rheumatic DiseasesRecruitingNCT07541638Not applicable1 country
- Understanding of Rare Inflammatory Arthritis in Comparison to Classical Inflammatory Arthritis : Tissular Observations and Immune Infiltrate Characterization : the UTOPIC ProjectRecruitingNCT07302074Not applicable1 country
- Open Label Treprostinil Raynaud's StudyRecruitingNCT07112183Phase 41 country
- Impact of Capillaroscopy in the Investigation of Diffuse Interstitial PneumoniasRecruitingNCT07283081Not applicable1 country
- GMEB-SASS: A Gene-Modified Skin Substitute for RDEB TreatmentRecruitingNCT07193134Phase 1/21 country
- Heart Institute Biobank & Registry for Adult Congenital Heart Disease and Related DisordersRecruitingNCT074771971 country
- 129 Xenon MRI as a Biomarker for Diagnosis and Response to Therapy in Pulmonary Arterial Hypertension (PAH)RecruitingNCT06104228Phase 21 country
- Undifferentiated Connective Tissue Disease RegistryRecruitingNCT022343881 country
- Connective Tissue Dry Needling for Low Back Pain Related to Local Posterior Superior Iliac Spine PainNot yet recruitingNCT07345871Not applicable
- Skin Autofluorescence Assessment of Advanced Glycation End Products in Rheumatic DiseasesNot yet recruitingNCT07329556
- A Study to Test Tetrandrine Tablets for Connective Tissue Disease-Related Lung DiseaseRecruitingNCT07319598Phase 41 country
- A Study to Learn About the Safety and Efficacy of the Drug Oleogel-S10 in Japanese Patients With Epidermolysis BullosaRecruitingNCT06917690Phase 31 country
- Clinical Features and Prognosis of Takayasu's Arteritis With Pulmonary Arteries InvolvementRecruitingNCT071848141 country
- LUpus Eritematoso Sistemico NETwork and RegistryNot yet recruitingNCT071756101 country
- Radiologic Features of Rheumatoid Arthritis Interstitial Lung Disease at Chest High Resolution Computed TomographyRecruitingNCT071741022 countries
- Clinical Assessment for Rheumatologic Disease - Research and Advancement in Safety and EfficacyRecruitingNCT071500001 country
- Study for Patients With Connective Tissue Diseases Who Suffer From Pleuropulmonary Symptoms Clinically and RadiologicallyNot yet recruitingNCT071175521 country
- Personalized Outreach for Equitable Treatment in RheumatologyNot yet recruitingNCT07022756Not applicable1 country
- Circulating B-cell, Drug and Anti-drug Antibodies Monitoring in Patients Treated With Rituximab for Autoimmune DisordersRecruitingNCT070377321 country
- Telitacicept for the Treatment of Connective Tissue Disease-associated ThrombocytopeniaRecruitingNCT05998759Phase 21 country
- An Exploratory Clinical Study of Anti-CD19 CAR NK Cells in the Treatment of Systemic Lupus ErythematosusRecruitingNCT06010472Early Phase 11 country
- AYLo - AutoimmunitY and Loss of yRecruitingNCT066960271 country
- Avatrombopag in the Treatment of Adult Immune Thrombocytopenia With AutoantibodiesRecruitingNCT04993885Phase 21 country
- Characterization of "Bamboo" and Other Vocal Cord Lesions Responsible for Dysphonia in Patients With Systemic Autoimmune Diseases (BAMBOO)RecruitingNCT067797991 country
- Home Based Clinical Management of Interstitial Lung Disease in Systemic Rheumatic DiseasesRecruitingNCT06732674Not applicable1 country
- Precision Diagnosis and Care for Families With Pulmonary Fibrosis in IrelandRecruitingNCT067022281 country
- Efficacy and Safety of Prophylactic Treatment for Pneumocystis Jirovecii Pneumonia in Patients With Autoimmune Inflammatory Rheumatic DiseaseRecruitingNCT06499233Phase 41 country
- TPO-RAs Combined With Anti-CD20 Antibody in the Treatment of Adult Immune Thrombocytopenia With AutoantibodiesRecruitingNCT04915482Phase 2/31 country
- University of Virginia Natural History StudyEnrolling by invitationNCT048961381 country
- Identification of New Biomarkers to Promote Personalized Treatment of Patients With Inflammatory Rheumatic DiseasesRecruitingNCT032142631 country
- The Clinical Features and Pregnancy Outcomes of CTD PatientsRecruitingNCT049185241 country