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Primary Ovarian Insufficiency clinical trials

The registry lists 181 studies for Primary Ovarian Insufficiency across more than 10 countries. 48 are recruiting or about to start. 134 of them are mainly about Primary Ovarian Insufficiency (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12.

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Status

Completed
56
Status unknown
48
Recruiting
27
Not yet recruiting
19
Active, not recruiting
10
Terminated
9

Phase

Phase 2
37
Phase 1
35
Phase 4
10
Phase 3
10
Early Phase 1
5

Where

United States
45
China
40
France
10
Egypt
10
Turkey
10
Netherlands
8

Who runs them

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (11) · University of Pennsylvania (7) · Assistance Publique - Hôpitaux de Paris (6) · Cengiz Gokcek Women's and Children's Hospital (4) · Shi Yun (4) · Center for Human Reproduction (4) · Peking University Third Hospital (4) · University Hospital, Bordeaux (3)

What is being tested here

Drugs under test in Primary Ovarian Insufficiency studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted

DrugOpenPhase 3All
Progesterone213
Estradiol118
Platelet rich plasma113
Chorionic Gonadotropin102
Leuprolide102
Goserelin112
Solizmestrocel102
Inavolisib101
Finerenone101
Ascorbic Acid101

Drug classes tested here Estrogens 2 open

Coming up

2phase 3 studies under way
18studies finish main data collection within a year1 of them phase 3

Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.

The 10 nearest, phase 3 first

Who these studies take

Of the 27 Primary Ovarian Insufficiency studies recruiting now, 1 (4%) set no upper age limit and 24 (89%) stop at 75 or younger. 8 (30%) take children under 18. 25 (93%) are for women only and 0 (0%) for men only; 10 (37%) take healthy volunteers.

Recruiting studies that take each age, of 27
AgeWomenMen
103 (11%)0 (0%)
1818 (67%)1 (4%)
3023 (85%)2 (7%)
4019 (70%)2 (7%)
506 (22%)2 (7%)
654 (15%)1 (4%)
753 (11%)1 (4%)
853 (11%)1 (4%)

Across all 181 studies, recruiting or not: 88% stop at 75 or younger and 86% at 65; 19% take children; 97% are for women only and 0% for men only; 34% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.

How long Primary Ovarian Insufficiency studies take

Of 24 interventional studies with no phase under Primary Ovarian Insufficiency, half reached primary completion within 40 months of starting, counting those still running.

Start to primary completionEvery sponsorIndustryNon-industry
Interventional, no phase40 mo32–68 · 24 studies——

Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out

What changed recently

From the registry's own updates since Oct 14, 2026.

Newly registered2

Studies

Recruiting first, then most recently updated. Showing 50 of 181. Browse all 181 → or search them.