A Phase 2/3 interventional study of Autologous Platelet Rich Plasma and Placebo-Platelet Free Plasma in Menopause, Premature, Menopause Related Conditions and Menopausal Syndrome, sponsored by Genesis Athens Clinic. Recruiting at 1 site in Greece. Open to female participants aged 25 Years to 39 Years, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-07-08.
Sponsored by Genesis Athens Clinic · Phase 2/3, Interventional, and Treatment
Autologous PRP intra ovarian infusion may restore ovarian function, may promote folliculogenesis and may improve patients' hormonal profile in patients presenting with POI.
This triple-blind Randomized Controlled Trial (RCT) aims to investigate the effectiveness of autologous PRP intra ovarian infusion on reactivating ovarian functionality and on promoting folliculogenesis in regard to patients presenting with POI. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. It is collected from peripheral veins and contains several growth factors such as vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), platelet derived growth factor (PDGF), transforming growth factor (TGF) and other cytokines all of which stimulate tissue proliferation and growth. PRP has been employed in several medical conditions in Orthopedics, Dermatology, and Ophthalmology for wound healing. It's efficacy in ovarian rejuvenation and reactivation and endometrial regeneration has not been fully elucidated. This study aims to investigate the effect of autologous PRP intra ovarian infusion on restoring ovarian tissue functionality in POI patients.
24 studies on the registry are indexed under Menopause, Premature; 5 are open to participants now.
This study's planned enrollment of 100 is above the median of 39 across 14 interventional studies indexed under Menopause, Premature.
Browse Menopause, Premature studies →Genesis Athens Clinic is the lead sponsor of 7 studies on the registry; 5 are open to participants now.
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Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Neoadjuvant treatment is given before the main treatment (usually surgery), often to shrink a tumour. Adjuvant treatment is given after it, to lower the chance of the cancer coming back.
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Adjuvant and neoadjuvant
Neoadjuvant treatment is given before the main treatment (usually surgery), often to shrink a tumour. Adjuvant treatment is given after it, to lower the chance of the cancer coming back.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
BMI (body mass index)
Weight in kilograms divided by height in metres squared. Example: 70 kg and 1.75 m gives 70 ÷ (1.75 × 1.75) ≈ 22.9.
What counts as overweight or obesity differs between countries (some use lower cut-offs), so go by the range the study states.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Women presenting with POI, 25-39 years of age, treated with autologous PRP intra ovarian infusion
Biological: Autologous Platelet Rich Plasma
Women presenting with POI, 25-39 years of age, treated with autologous PFP intra ovarian infusion
Biological: Placebo-Platelet Free Plasma
Autologous PRP intra ovarian infusion
Also known as: PRP, Platelet Rich Plasma
Autologous PFP intra ovarian infusion
Also known as: PFP
Restoration of menstrual cycle
Regular menstrual cycle
Time frame: Three months
Serum FSH levels
Serum FSH levels evaluated monthly for three consecutive months
Time frame: Follow-up period of three months entailing monthly evaluation
Serum AMH levels
Serum ΑΜΗ levels evaluated monthly for three consecutive months
Time frame: Follow-up period of three months entailing monthly evaluation
Serum LH levels
Serum LH levels evaluated monthly for three consecutive months
Time frame: Follow-up period of three months entailing monthly evaluation
Serum Estradiol levels
Serum estradiol levels evaluated monthly for three consecutive months
Time frame: Follow-up period of three months entailing monthly evaluation
Serum Progesteron levels
Serum progesterone levels evaluated monthly for three consecutive months
Time frame: Follow-up period of three months entailing monthly evaluation
Antral Follicle Count (AFC)
AFC evaluated monthly, on day 2 of the menstrual cycle, for three consecutive months
Time frame: Follow-up period of three months entailing monthly evaluation
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Studies of the drug tested here: Platelet rich plasma
Genesis Athens Clinic