An observational study in Peri-Implantitis, sponsored by University of Pittsburgh. Enrolling by invitation at 1 site in United States. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-10.
Sponsored by University of Pittsburgh · Observational
Among 32 studies in Peri-Implantitis with a site in United States — 7 open to participants now, 9 under way, none of them phase 3. Peri-Implantitis · United States.
Among the 32 studies in Peri-Implantitis with a site in United States, this one is the 3rd largest by planned enrollment of the 10 observational ones, is one of 2 that started in 2024, is one of 10 observational ones, and was the 30th registered.
322 studies on the registry are indexed under Peri-Implantitis; 88 are open to participants now.
This study's planned enrollment of 50 is below the median of 83 across 121 observational studies indexed under Peri-Implantitis.
Browse Peri-Implantitis studies →7 of the 32 studies in Peri-Implantitis with a site in United States are open now, in 1 country. Each count lists the studies.
Of the 48 Peri-Implantitis studies recruiting now, 26 (54%) set no upper age limit and 9 (19%) stop at 75 or younger; 7 take children under 18; 25 take healthy volunteers.
This study: 18 Years and older · all sexes · healthy volunteers too.
The full table on the hub →32 studies; the count open now beside each. This study's row is marked.
First in 2008; this study’s year is marked. 2 started in 2024.
Median enrollment 42 across the 22 interventional studies, 40 across the 10 observational. Of the 21 that completed or were terminated, 7 (33%) have results posted.
6 of 32 have an industry lead sponsor. The 10 most frequent:
University of Pittsburgh is the lead sponsor of 1,419 studies on the registry; 168 are open to participants now.
Of its 9 completed or terminated interventional studies of FDA-regulated products, 4 (44%) have results posted.
University of Pittsburgh has 4 studies filed under Peri-Implantitis — fewer than ten, so there is no comparison to draw.
5 of the studies in Peri-Implantitis with a site in United States that are under way reach primary completion within a year, 0 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07325747University of MichiganImmediate Versus Delayed Surgical Reconstruction of Peri-implantitis Intra-bony Defects. | 2027-02 |
| NCT06063876University of PittsburghExperimental Peri-implant Mucositis on Implant Sites That Were Previously Treated With or Without Implantoplasty | 2027-04 |
| NCT06153212University of MichiganRegenerative Treatment of Peri-implantitis | 2027-06-01 |
| NCT06430268Andrea RavidaEfficacy of Non-surgical and Surgical Surface Decontamination Methods on Peri-implantitis-affected Implants | 2027-06-30 |
| NCT07550127University of PittsburghPeri-implantitis Management: Surgical and Maintenance Outcomes | 2027-06-30 |
Among the 32 studies in Peri-Implantitis with a site in United States, from their registry updates:
Nothing recorded among them since 2026-09-25.
The purpose of the study is to determine if there is an association between the intaglio shape of full-arch implant-supported prosthesis and marginal bone level around implants. The intaglio shape can be present as concave or convex and, depending on that, it can lead to more plaque accumulation on the fitting surface of the prosthesis.
Null Hypothesis (H0): Full-arch implant supported prosthesis with an increased depth of the intaglio shape demonstrate similar marginal bone levels as prosthesis with a reduced depth of the intaglio surface.
Alternative Hypothesis (H1): Full-arch implant supported prosthesis with an increased depth of the intaglio shape demonstrate increased/reduced marginal bone levels compared to prosthesis with a reduced depth of the intaglio surface.
The investigators will review dental records from the university and call eligible individuals for an appointment. During the research visit, the investigators will take new x-rays for marginal bone level assessment and a digital scan of the prosthesis to assess the shape of the intaglio. Also, remove the prosthesis, perform clinical measurements and collect plaque samples from the prosthesis and the implant sulcus. then, implants and prosthesis will be cleaned and placed in position.
The study will have only one appointment where every measurement will be assessed in this visit.
All patients treated with a full-arch implant-supported prothesis from the University of Pittsburgh will be screened for inclusion in the study.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Immunosuppression
A weakened immune system. It can come from an illness, such as HIV or some blood cancers, or from medicines that turn the immune system down, for example after an organ transplant or for an autoimmune disease; steroids at higher doses count.
Read whether the line is about a condition or about medicines, and which medicines and doses it means.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
All patients that are rehabilitated with full-arch implant-supported prosthesis
Device: Full arch
design
Evaluation of the depth of the shape of the intaglio surface of full-arch and its association with increased marginal bone level.
After the prosthesis is scanned, and evaluation of the 3D file of the prosthesis will occur. A virtual line will be traced between the Buccal to the Palatal/Lingual flange of the prosthesis. In the middle point of this line, a perpendicular line will be traced in direction of the fitting surface of the prosthesis, intaglio, and this distance will be measured in mm.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Probing Depth of the implants
Using a periodontal probe we will register Probing Depth in 6 sites per implant. All measures will be in mm.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Bleeding on Probing of the implants
Using a periodontal probe we will register Bleeding in 6 sites using the bleeding indexes modified for dental implants.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Modified Plaque Index
Plaque accumulation will be evaluated using the modified plaque index adapted for dental implants.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Marginal Recession
The distance, in mm, between the implant platform and the mucosal margin.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Suppuration
Assessed by the presence/absence of suppuration after gentle probing of the implants.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Keratinized mucosa width
Measured from the mucosal marginal level of the implants to the mucogingival junction. The band of keratinized mucosa will be characterized as narrow \< 2mm and wide \> 2mm.
Time frame: The measurements will be assessed during the unique visit of the patient in the study.
Started Jun 2024 (actual). Primary completion is estimated for Dec 2027, 42 months after the start.
How these figures are worked out, and which studies are left out of them.
Eligibility is decided by the study team. Share this record with your doctor or contact the team directly.
No contact was published for this record. The registry link below has the sponsor’s details.
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