An Early Phase 1 interventional study of test device GalvoSurge and Mechanical decontamination with titanium brush in Peri-Implantitis and Peri-implant Mucositis, sponsored by George Eastman Dental Hospital, Italy. Not yet recruiting. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by George Eastman Dental Hospital, Italy · Early Phase 1, Interventional, and Treatment
Implants diagnosed with peri-implantitis and amenable for bone reconstructive treatment will be enrolled in the study. The implants will randomly be treated with either an electrolytic or a mechanical cleaning of the implant surface (with titanium brushes). In all cases, a bone graft will be used to rebuild missing bone.
Implants diagnosed with peri-implantitis and amenable for bone reconstructive treatment will be enrolled in the study. All implants will receive reconstructive therapy by means of a collagenated bone graft, however the method of decontamination will be randomized between electrolytic cleaning or titanium rotating brushes. In both cases, titanium curettes will be used to remove hard deposits on the implant surface and degranulation will be completed with curettes.
322 studies on the registry are indexed under Peri-Implantitis; 88 are open to participants now.
This study's planned enrollment of 38 is close to the median of 40 across 195 interventional studies indexed under Peri-Implantitis.
Browse Peri-Implantitis studies →George Eastman Dental Hospital, Italy is the lead sponsor of 4 studies on the registry; 2 are open to participants now.
Counted across the registry records on this site, refreshed daily.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Corticosteroids (steroids)
Anti-inflammatory medicines such as prednisone, prednisolone and dexamethasone — not the anabolic steroids used for muscle.
Studies differ in what they allow: check which steroid medicines, routes (tablets, injections, creams, inhalers, eye drops) and doses this study accepts.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Autoimmune disease
A condition in which the immune system attacks the body’s own tissues, such as rheumatoid arthritis, lupus, psoriasis, type 1 diabetes or inflammatory bowel disease.
Immunotherapy studies often leave out active autoimmune disease, and some name exceptions, such as thyroid disease on replacement hormone. Check the exceptions this study lists.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Electrolytic decontamination with GalvoSurge (Straumann AG)
Procedure: test device GalvoSurge
Mechanical rotating brush used with titanium curettes to remove hard tissue deposits from the implant surface
Electrolytic decontamination
Also known as: electrolytic decontamination
Reconstructive treatment of peri-implantitis after removal of hard and soft tissue deposits from the implant surface followed by mechanical decontamination with titanium brush
Also known as: tibrush
Change in Probing pocket depth
distance (mm) between marginal mucosa and bottom of probable pocket
Time frame: from baseline to 12, 24 months post-surgery
change in recession
change between baseline and 24 months (mm)
Time frame: baseline to 12 and 24 months post-op
change in CAL
change in CAL between baseline and 24 months (mm)
Time frame: between baseline and 24 months
Suppuration on probing (SoP)
Dichotomic variable
Time frame: baseline, 12, 24 months
Bleeding on probing
Dichotomic variable (yes/ no)
Time frame: baseline, 12, 24 months
Keratinized mucosa (KM)
continuous, measured in mm, from the margin of the mucosa to the mucogingival junction
Time frame: baseline, 12, 24 months
Treatment Success
Composite outcome comprising implant not lost, no more than 1 mm of buccal recession, no more than 5 mm of PPD, no SOP, no more than 1 bleeding spot on probing, no loss of crestal bone (mm)
Time frame: 24 months
No study locations are listed for this record.
Plan to share: Yes
Supporting information: Study protocol, Statistical analysis plan
Time frame: duration of study
Access criteria: all de-identified information
Start is estimated for Jan 2027; primary completion for Apr 2027, 3 months later.
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This study is not yet recruiting, as verified in Aug 2026. You cannot join it, but the record below documents what was studied.
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George Eastman Dental Hospital, Italy