An observational study in Peri-implantitis, sponsored by University of Turin, Italy. Enrolling by invitation at 1 site in Italy. Open to participants aged 18 Years and older, including healthy volunteers. Per ClinicalTrials.gov, last updated 2026-09-09.
Sponsored by University of Turin, Italy · Observational
To report the 10 years outcomes of a reconstructive surgical protocol for peri-implantitis defects with different morphologies, by means of deproteinized bovine bone mineral with 10% collagen (DBBMC).
The original population of this case series consisted of 75 patients with one crater-like defect and probing depth (PD) ≥6 mm. After flap elevation, defects were assigned to one characteristic class and treated by means of DBBMC. Following healing, patients were enrolled in an individualized supportive periodontal/ peri-implant (SPT) program.
322 studies on the registry are indexed under Peri-Implantitis; 88 are open to participants now.
This study's planned enrollment of 75 is close to the median of 83 across 121 observational studies indexed under Peri-Implantitis.
Browse Peri-Implantitis studies →University of Turin, Italy is the lead sponsor of 214 studies on the registry; 35 are open to participants now.
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Subjects rehabilitated with oral dental implants who presented a single peri-implantitis crater-like lesion with a PD of ≥6 mm
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Exclusion Criteria:
Subjects, who presented a single peri-implantitis crater-like lesion with a PD of ≥6 mm and no implant mobility. Exclusion criteria were as follows: 1. PD \<6 mm; 2. Class II defects (characterized by consistent horizontal bone loss); 3. Multiple defects; 4. Implant mobility; 5. No interest in participating in the study; 6. Implants placed by other clinicians.
Procedure: Reconstructive therapy
Intervention: Following the elevation of a muco-periosteal flap, all granulation tissue was completely removed from the defect area, by means of titanium curettes and a titanium brush under irrigation. Consequently, implant surfaces were covered with EDTA 24% for 2 min and chlorhexidine 1% gel for 2 min. Thereafter, the infrabony defects were filled with a deproteinized bovine bone mineral with 10% collagen. All patients were asked to follow an individualized supportive care program.
Implant survival rate
Clinical Examination: Number of implants treated for peri-implantitis present in the oral cavity at the latest follow-up over the overall number of implants treated, expressed in %
Time frame: From enrollment to the end of treatment at the 10-year follow-up visit
Implant survival rate
Percentage of implants still in place after surgical intervention
Time frame: 10-year
Plan to share: No
Start is estimated for Sep 2026; primary completion for Jun 2027, 9 months later.
Of 33 non-industry observational studies under Peri-Implantitis, half reached primary completion within 17 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 77. This study's planned 9 months is below that.
Counting every sponsor, half of 35 studies reached it within 17 months; a quarter within 8 and three quarters within 77.
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