Children's Oncology Group: Neuroblastoma trials

The registry lists 59 Neuroblastoma studies with Children's Oncology Group as lead sponsor. 2 are open to participants now and 18 have results posted.

Phase 1 11Phase 2 17Phase 3 10No phase 23(a study in two phases counts in both)

Studies

Open to participants first, then studies with results posted, then the rest; newest registration first within each.

• Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid TumorsRecruitingNCT04851119Phase 1/2
• Testing the Addition of 131I-MIBG or Lorlatinib to Intensive Therapy in People With High-Risk Neuroblastoma (NBL)RecruitingNCT03126916Phase 3
• Treatment With Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination With Irinotecan and Temozolomide After Intensive Therapy for People With High-Risk Neuroblastoma (NBL)Active, not recruitingNCT04385277Phase 2Results posted
• Irinotecan Hydrochloride, Temozolomide, and Dinutuximab With or Without Eflornithine in Treating Patients With Relapsed or Refractory NeuroblastomaActive, not recruitingNCT03794349Phase 2Results posted
• Lorvotuzumab Mertansine in Treating Younger Patients With Relapsed or Refractory Wilms Tumor, Rhabdomyosarcoma, Neuroblastoma, Pleuropulmonary Blastoma, Malignant Peripheral Nerve Sheath Tumor, or Synovial SarcomaCompletedNCT02452554Phase 2Results posted
• Busulfan, Melphalan, and Stem Cell Transplant After Chemotherapy in Treating Patients With Newly Diagnosed High-Risk NeuroblastomaCompletedNCT01798004Phase 1Results posted
• Crizotinib and Combination Chemotherapy in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell LymphomaCompletedNCT01606878Phase 1Results posted
• Biological Therapy, Sargramostim, and Isotretinoin in Treating Patients With Relapsed or Refractory NeuroblastomaCompletedNCT01334515Phase 2Results posted
• Supersaturated Calcium Phosphate Rinse in Preventing Oral Mucositis in Young Patients Undergoing Autologous or Donor Stem Cell TransplantCompletedNCT01305200Phase 3Results posted
• Induction Therapy Including 131 I-MIBG and Chemotherapy in Treating Patients With Newly Diagnosed High-Risk Neuroblastoma Undergoing Stem Cell Transplant, Radiation Therapy, and Maintenance Therapy With IsotretinoinCompletedNCT01175356Phase 1Results posted
• Alisertib in Treating Young Patients With Recurrent or Refractory Solid Tumors or LeukemiaCompletedNCT01154816Phase 2Results posted
• Crizotinib in Treating Younger Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell LymphomaCompletedNCT00939770Phase 1/2Results posted
• Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other MalignancyCompletedNCT00716976Phase 3Results posted
• Comparing Two Different Myeloablation Therapies in Treating Young Patients Who Are Undergoing a Stem Cell Transplant for High-Risk NeuroblastomaCompletedNCT00567567Phase 3Results posted
• Combination Chemotherapy and Surgery With or Without Isotretinoin in Treating Young Patients With NeuroblastomaCompletedNCT00499616Phase 3Results posted
• ABT-751 in Treating Children With Neuroblastoma That Has Relapsed or Not Responded to Previous TreatmentCompletedNCT00436852Phase 2Results posted
• Irinotecan and Temozolomide in Treating Young Patients With Recurrent NeuroblastomaCompletedNCT00311584Phase 2Results posted
• Etanercept in Treating Young Patients With Idiopathic Pneumonia Syndrome After Undergoing a Donor Stem Cell TransplantCompletedNCT00309907Phase 2Results posted
• hu14.18-Interleukin-2 Fusion Protein in Treating Young Patients With Recurrent or Refractory NeuroblastomaCompletedNCT00082758Phase 2Results posted
• Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With NeuroblastomaCompletedNCT00033293Phase 3Results posted
• Late Effects After Treatment in Patients With Previously Diagnosed High-Risk NeuroblastomaActive, not recruitingNCT03057626
• MLN8237 to Treat Children With Relapsed/Refractory Solid TumorsCompletedNCT02444884Phase 1
• Response and Biology-Based Risk Factor-Guided Therapy in Treating Younger Patients With Non-high Risk NeuroblastomaActive, not recruitingNCT02176967Phase 3
• Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid TumorsWithdrawnNCT02011126Phase 2
• Studying Chromosomes in Samples From Younger Patients With NeuroblastomaCompletedNCT01589341
• Studying Gene Expression in Samples From Younger Patients With NeuroblastomaCompletedNCT01553448
• Gene Expression in Predicting Outcome in Samples From Patients With High-Risk NeuroblastomaCompletedNCT01520233
• Studying Biomarkers in Samples From Patients With High-Risk NeuroblastomaCompletedNCT01510600
• Biomarkers in Tumor Samples From Younger Patients With NeuroblastomaCompletedNCT01493830
• Protein Expression in Human Neuroblastoma Tumor SamplesCompletedNCT01407731
• Biomarkers in Blood and Tissue Samples From Patients With Newly Diagnosed NeuroblastomaCompletedNCT01387724
• Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With NeuroblastomaCompletedNCT01358617
• Biomarkers in Samples From Young Patients With NeuroblastomaCompletedNCT01358604
• Gene Mutation in Samples From Young Patients With Pleuropulmonary Blastoma Syndrome at Risk for Developing CancerCompletedNCT01353300
• Biomarkers in Young Patients With NeuroblastomaCompletedNCT01169376
• Genetic Susceptibility Biomarkers in Children With Neuroblastoma (Also Known as Neuroblastoma Epidemiology in North America [NENA])CompletedNCT01119560
• Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine FeaturesCompletedNCT01048892Phase 1
• Study of Specimens From Young Patients With NeuroblastomaCompletedNCT00958659
• Studying Tumor Samples From Young Patients With NeuroblastomaCompletedNCT00907920
• Biomarkers in Tumor Tissue Samples From Patients With Newly Diagnosed Neuroblastoma or GanglioneuroblastomaCompletedNCT00904241
• Collecting and Storing Tissue From Young Patients With CancerCompletedNCT00898755
• Study of DNA in Blood Samples From Patients With NeuroblastomaCompletedNCT00898391
• Natural History Study of Infants With Adrenal Masses Found on Prenatal and/or Neonatal ImagingCompletedNCT00445718
• Genetic Analysis Using Blood or Bone Marrow From Participants With Neuroblastoma or Noncancerous ConditionsCompletedNCT00436696
• Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell TransplantationCompletedNCT00080873Not applicable
• Induction Chemotherapy Using Cyclophosphamide and Topotecan in Treating Patients Who Are Undergoing Autologous Peripheral Stem Cell Transplantation for Newly Diagnosed or Progressive NeuroblastomaCompletedNCT00070200Phase 1
• Electroacupuncture in Treating Delayed Nausea and Vomiting in Patients Receiving Chemotherapy For Newly Diagnosed Childhood Sarcoma, Neuroblastoma, Nasopharyngeal Cancer, Germ Cell Tumors, or Hodgkin LymphomaCompletedNCT00040911Not applicable
• Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed NeuroblastomaCompletedNCT00017368Phase 2
• Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With NeuroblastomaCompletedNCT00004188Phase 3
• Irinotecan in Treating Children With Refractory Solid TumorsCompletedNCT00004078Phase 2
• Radiation Therapy, Chemotherapy, and Peripheral Stem Cell Transplantation in Treating Patients With Primitive Neuroectodermal TumorsCompletedNCT00003846Phase 2
• Biological Therapy in Treating Children With Refractory or Recurrent Neuroblastoma or Other TumorsCompletedNCT00003750Phase 1
• Vinorelbine in Treating Children With Recurrent or Refractory CancersCompletedNCT00003234Phase 2
• Carboplatin and Vincristine Plus Radiation Therapy Followed By Adjuvant Chemotherapy in Treating Young Patients With Newly Diagnosed CNS Embryonal TumorsCompletedNCT00003203Phase 2
• Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord TumorsCompletedNCT00003141Phase 1
• Surgery in Treating Children With NeuroblastomaCompletedNCT00003119Phase 3
• Combination Chemotherapy in Treating Children With NeuroblastomaCompletedNCT00003093Phase 3
• Combination Chemotherapy Plus Peripheral Stem Cell Transplantation Followed by Surgery and/or Radiation Therapy in Treating Young Patients With Advanced NeuroblastomaCompletedNCT00002740Phase 1
• Development of Strategies to Increase Enrollment in Clinical Trials for Children With CancerCompletedNCT00002485