Temporomandibular Joint Dysfunction Syndrome clinical trials
The registry lists 54 studies for Temporomandibular Joint Dysfunction Syndrome across more than 10 countries. 14 are recruiting or about to start. 48 of them are mainly about Temporomandibular Joint Dysfunction Syndrome (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02.
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Who runs them
Hacettepe University (3) · University of Nove de Julho (2) · State University of New York at Buffalo (2) · Karadeniz Technical University (2) · Cairo University (2) · Jagiellonian University (2) · Universidad de Almeria (2) · Alabama Physical Therapy & Acupuncture (1)
What is being tested here
Drugs under test in Temporomandibular Joint Dysfunction Syndrome studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Glucose | 1 | 0 | 1 |
| Platelet rich plasma | 0 | 0 | 1 |
| Vitamin D | 0 | 0 | 1 |
| Erenumab | 0 | 0 | 1 |
| Nalbuphine | 0 | 0 | 1 |
| Naloxone | 0 | 0 | 1 |
| Cannabidiol | 0 | 0 | 1 |
| Botulinum toxin type A | 0 | 0 | 1 |
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5
- Nov 2026Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled Trial · Mudher MB Alsunbuli
- Dec 2026Tele-Rehabilitation in Patients With Temporomandibular Dysfunction · University of Nove de Julho
- Jun 2027Temporomandibular Joint (TMJ) Positioning Accuracy and Efficiency Using a Dental Compass. · Dr. Dean Reeves Clinic
- Oct 2027Comparison of Conventional,3D Printed and Novel Hybrid Stabilization Splints in the Management of Temporomandibular Joint Disorders · Postgraduate Institute of Dental Sciences Rohtak
- Nov 2027Effects of Focal Extracorporeal Shock Wave Therapy in the Treatment of Temporomandibular Disorders of Muscular Origin · University of Sao Paulo General Hospital
Who these studies take
Of the 8 Temporomandibular Joint Dysfunction Syndrome studies recruiting now, 1 (13%) set no upper age limit and 6 (75%) stop at 75 or younger. 0 (0%) take children under 18. 1 (13%) are for women only and 0 (0%) for men only; 2 (25%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 8 (100%) | 7 (88%) |
| 30 | 8 (100%) | 7 (88%) |
| 40 | 7 (88%) | 7 (88%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 3 (38%) | 3 (38%) |
| 75 | 2 (25%) | 2 (25%) |
| 85 | 2 (25%) | 2 (25%) |
Across all 54 studies, recruiting or not: 69% stop at 75 or younger and 67% at 65; 7% take children; 11% are for women only and 0% for men only; 19% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Temporomandibular Joint Dysfunction Syndrome studies take
Of 24 interventional studies with no phase under Temporomandibular Joint Dysfunction Syndrome, half reached primary completion within 9 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 9 mo4–29 · 24 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 54. Browse all 54 → or search them.
- Comparing Dextrose Prolotherapy vs. Sodium Hyaluronic Acid Injections for Jaw Joint Internal DerangementNot yet recruitingNCT07911358Not applicable1 country
- Temporomandibular Joint (TMJ) Positioning Accuracy and Efficiency Using a Dental Compass.RecruitingNCT06619574Not applicable1 country
- Comparison of Conventional,3D Printed and Novel Hybrid Stabilization Splints in the Management of Temporomandibular Joint DisordersNot yet recruitingNCT07760428Not applicable1 country
- Arthrocentesis Versus Botulinum Toxin Injection in Patients With Temporomandibular Joint Disorders: A Randomized Controlled TrialNot yet recruitingNCT07736521Not applicable
- Effects of Focal Extracorporeal Shock Wave Therapy in the Treatment of Temporomandibular Disorders of Muscular OriginRecruitingNCT05907239Not applicable1 country
- Low-Level Laser Auriculotherapy in the Treatment of Myogenic Temporomandibular Disorders and AnxietyNot yet recruitingNCT07125404Not applicable1 country
- Cognitive Exercise Therapy Approach Biopsychosocial Questionnaire (BETY-BQ) in Patient with Temporomandibular DisordersRecruitingNCT061868301 country
- Tele-Rehabilitation in Patients With Temporomandibular DysfunctionRecruitingNCT05006963Not applicable1 country
- Effect of Progressive Neck Motor Control Exercises on Temporomandibular Joint DysfunctionRecruitingNCT06148818Not applicable1 country
- Effects of Low-Level Laser Therapy on Mouth Opening and Surface Electromyography in Temporomandibular DisordersRecruitingNCT04831346Not applicable1 country
- Effect of High-intensity Laser Therapy on Patients With Myogenic Temporomandibular Joint DysfunctionNot yet recruitingNCT06495788Not applicable
- Effect of Exercises on Convergence Insufficiency in Individuals With Temporomandibular DisordersRecruitingNCT05761106Not applicable1 country
- Quality of Life in Temporomandibular Joint DysfunctionRecruitingNCT058029531 country
- Arthrocentesis Alone Versus Arthrocentesis With Hyaluronic Acid InjectionNot yet recruitingNCT05962619Not applicable
- Relationship Between Upper Cervical Mobility and Temporomandibular Joint Range of Motion in Patients With Temporomandibular DisordersCompletedNCT073711951 country
- Intra-Articular PRP Versus Dexamethasone for TMJ Internal DerangementCompletedNCT07691684Not applicable1 country
- Device for Alleviating Temporomandibular Joint (TMJ) PainCompletedNCT07624539Not applicable1 country
- Effects of Aerobic and Strength Exercice on Nociplastic Pain in Temporomandibular DisordersCompletedNCT06584526Not applicable1 country
- Central Sensitization and Clinical Parameters in Chronic Neck PainCompletedNCT074624161 country
- What Are the Clinical Factors Associated With a Significant Pain Reduction Following Physiotherapy in Patients With Temporomandibular Disorders?CompletedNCT039906621 country
- Effectiveness of the Fascial Distortion Model on the Cervical Spine in Individuals With Temporomandibular DisorderCompletedNCT06186817Not applicable1 country
- Comparative Study Between Level I and Level II Temporomandibular Joint Arthroscopy in Wilkes Stage III PatientsActive, not recruitingNCT06661096Not applicable1 country
- Efficacy of Manual Therapy Based on the Fascial Distortion Model in Individuals With Temporomandibular DisorderCompletedNCT06134310Not applicable1 country
- Novel Locator-Positioner Device for Temporomandibular Joint ArthroscopyCompletedNCT06520917Not applicable1 country
- The Effectiveness of Temporomandibular Joint Mobilization and Exercise in Individuals With Chronic Neck PainCompletedNCT06005922Not applicable1 country
- Erenumab-aooe for Temporomandibular Disorders Management: TMD Cgrp Antibody RElief (TMD CARE)TerminatedNCT05162027Phase 21 country
- The Effect of Vagus Nerve Stimulation on Temporomandibular Joint DysfunctionCompletedNCT05500716Not applicable1 country
- Temporomandibular Dysfunction in Patients With Cervical Disc HerniationCompletedNCT061418631 country
- Comparative Evaluation of the Effectiveness of Diclofenac Sodium Versus Vitamin D on Myofascial PainCompletedNCT06111573Phase 41 country
- Efficacy of Scapulothoracic Exercises on Postural Stability, Proprioception, Muscular Features and Mandibular FunctionsCompletedNCT05966103Not applicable1 country
- Efficacy of Low Level LASER Therapy in Treating Temporomandibular Muscle DisordersCompletedNCT05901701Not applicable1 country
- Effectiveness of Cervical Treatment in Wind Musicians With Temporomandibular DysfunctionCompletedNCT05893251Not applicable1 country
- Additional Effects of Therapeutic Exercises Under a Behavioral Umbrella for Chronic Temporomandibular Disorders TreatmentCompletedNCT03596606Not applicable1 country
- Analysis of Clinical Data of Patients With Temporomandibular Joint DisorderStatus unknownNCT057808271 country
- Effectiveness of Three Oral Devices as Mouthguard in Electroconvulsive Therapy. Randomized Crossover Clinical Trial.TerminatedNCT02678715Not applicable1 country
- Respiratory Functions and Respiratory Muscle Strength in Patients With Temporomandibular Joint DysfunctionCompletedNCT052713961 country
- Comparative Analysis of the Effectiveness of the Use of Nimesulide and CBD Oil in Patients With Pain in the Preauricular Region Due to the Pain-dysfunctional Syndrome of the Temporomandibular Joint.Status unknownNCT04609748Phase 21 country
- Effects of Radial Shock Wave Therapy in the Treatment of Temporomandibular Joint Syndrome.CompletedNCT04477122Not applicable1 country
- Dry Needling and Spinal Manipulation vs. Interocclusal Appliance (Splint), NSAIDs and Joint Mobs for Temporomandibular DysfunctionCompletedNCT03409874Not applicable1 country
- Feasibility Testing of a New Way to Support the Jaw During 3rd Molar ExtractionsCompletedNCT035127691 country
- Restoring Masticatory Function to Treat Chronic PainTerminatedNCT02144233Not applicable1 country
- Manual Therapy and Exercises Applied to Cervical Spine in Patients With Temporomandibular DisordersWithdrawnNCT01954511Not applicable
- The Application of Radio Frequency WavesCompletedNCT03773640Not applicable1 country
- Progressive Muscle Relaxation According to Jacobson in Treatment of the Patients With Temporomandibular Joint DisordersCompletedNCT03622684Not applicable
- Tailored Self-Management of Temporomandibular Disorders (TMD) Using Health Information TechnologyCompletedNCT03036215Not applicable1 country
- Immediate Effect of Ultrasound Therapy on Bilateral Masseter Myalgia: Randomized Single Blinded Investigational TrialCompletedNCT02295644Not applicable1 country
- Botox for Treatment of TMJ Disorder With BruxismWithdrawnNCT02202070Phase 11 country
- Brief Treatment for Temporomandibular PainCompletedNCT00067366Not applicable1 country
- Immediate Effect of Ultrasound Therapy on Bilateral Masseter MyalgiaCompletedNCT02892994Not applicable1 country
- Efficacy of Nalbuphine and Naloxone Administered as Nose Sprays in the Treatment of Orofacial PainTerminatedNCT00716807Not applicable1 country