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RecruitingNCT07230470Updated May 4, 2026

Comparative Study of LoKomat® Exoskeleton VS C-Mill® Treadmill for Gait Recovery in Rehabilitation.

An interventional study of Lokomat® and C-Mill in Stroke, sponsored by Universidad Pontificia de Salamanca. Recruiting at 1 site in Spain. Open to participants aged 18 Years to 65 Years. Per ClinicalTrials.gov, last updated 2026-05-04.

Sponsored by Universidad Pontificia de Salamanca · Not applicable, Interventional, and Treatment

From the registry’s dates

  • Started Dec 2025; still recruiting 9 months later.
Phase
Not applicable
Study type
Interventional
Enrollment
40
Allocation
Randomized
Ages
18 Years to 65 Years
Sex
All
01

Study summary

The use of robotic technology for the treatment of gait in neurological pathologies has provided different results in scientific evidence. In patients with some types of acquired brain damage, such as stroke, the use of Lokomat® therapy can bring improvements in aspects such as gait speed and balance, among other parameters and report greater functional recovery in subacute patients with greater deterioration. Similarly, the use of another technological element such as the C-Mill® reports improvements in various aspects of ambulation and balance in gait treatments for stroke patients. Likewise, the impact on the person's recovery is not only beneficial for gait rehabilitation, but also improves the perception of well-being, which can be positive in the process of readaptation to daily life.

The effect of both treatments for gait rehabilitation in adults with stroke and their impact on quality of life in the neurorehabilitation clinic will be studied.

adults with stroke and their impact on quality of life at the Lescer neurorehabilitation clinic Lescer, Madrid (Spain). Participants will be assessed at baseline, 4 weeks, 8 weeks and 12 weeks.

02

Conditions studied

  • Stroke

Keywords

  • Stroke
  • Quality of life
  • Spasticity
03

In context

Stroke

7,286 studies on the registry are indexed under Stroke; 2,007 are open to participants now.

This study's planned enrollment of 40 is below the median of 50 across 5,369 interventional studies indexed under Stroke.

Browse Stroke studies →

Lead sponsor

Universidad Pontificia de Salamanca is the lead sponsor of 9 studies on the registry; 2 are open to participants now.

Counted across the registry records on this site, refreshed daily.

04

Who can participate

Ages eligible
18 Years to 65 Years
Sexes eligible
All
Accepts healthy volunteers
No

Inclusion criteria

  • Diagnosis of stroke (haemorrhagic and/or ischaemic) by a specialist physician. .
  • Subjects who are cognitively capable and who sign the informed consent form.

Exclusion criteria

Exclusion Criteria:

  • Severe cognitive impairment (Mini-Mental State Examination \< 24.), or impairment that prevents correct understanding of the correct understanding of the messages and explanatory orders of the treatment and its conditions.
  • Diagnosis of concomitant neurological diseases and craniocerebral trauma. cranioencephalic trauma.
  • Other diseases that interfere with the gait process (e.g. disabling arthritis or arthrosis, other neurological diseases, other neurological diseases).

disabling arthritis or osteoarthritis, other concomitant neurological diseases, etc.).

- Contraindications of the robotic tools themselves.

05

Study design

Phase
Not applicable
Primary purpose
Treatment
Allocation
Randomized
Intervention model
Parallel assignment
Masking
Double (Participant, Investigator)
Enrollment
40 participants (estimated)

Study arms

  • Experimental
    Lokomat

    To compare the effectiveness of gait rehabilitation work in adult stroke patients using the Lokomat® tool vs. stroke with the Lokomat® tool.

    Device: Lokomat®

  • Active comparator
    C-Mill

    Exoelectric walking aid for patients who have suffered a stroke

    Device: C-Mill

Interventions

  • DeviceLokomat®

    To compare the effectiveness of gait rehabilitation work in adult stroke patients using the Lokomat® tool vs. stroke with the C-Mill® tool

  • DeviceC-Mill

    Exoelectric walking aid for patients who have suffered a stroke

06

What researchers measure

Primary outcomes

  1. quality of life scale

    QoL39 scale. 0 minimum - 100 maximum (higher scores mean a better outcome).

    Time frame: 12 weeks

  2. Spasticity index

    Tardieu scale 0 min - 5 max (higher scores mean a worse outcome).

    Time frame: 12 weeks

07

Study locations

1 of 1 sites recruiting
  • Universidad Pontificia de Salamanca
    Salamanca, 37002, Spain
    Recruiting
08

References and documents

Publications

  • Lefeber N, De Keersmaecker E, Henderix S, Michielsen M, Kerckhofs E, Swinnen E. Physiological Responses and Perceived Exertion During Robot-Assisted and Body Weight-Supported Gait After Stroke. Neurorehabil Neural Repair. 2018 Dec;32(12):1043-1054. doi: 10.1177/1545968318810810. Epub 2018 Nov 12. PubMed 30417724 ↗
  • Celedova L, Krsiak M, Janku I. Immunomodulator adamantylamide dipeptide antagonizes benzodiazepine-induced rota-rod deficit in mice. Act Nerv Super (Praha). 1989 Dec;31(4):291-3. No abstract available. PubMed 2638119 ↗
  • Park J, Kim TH. The effects of balance and gait function on quality of life of stroke patients. NeuroRehabilitation. 2019;44(1):37-41. doi: 10.3233/NRE-182467. PubMed 30741699 ↗
  • Callaly EL, Ni Chroinin D, Hannon N, Sheehan O, Marnane M, Merwick A, Kelly LA, Horgan G, Williams E, Harris D, Williams D, Moore A, Dolan E, Murphy S, Kelly PJ, Duggan J, Kyne L. Falls and fractures 2 years after acute stroke: the North Dublin Population Stroke Study. Age Ageing. 2015 Sep;44(5):882-6. doi: 10.1093/ageing/afv093. Epub 2015 Aug 12. PubMed 26271048 ↗

Individual participant data

Plan to share: Undecided

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on May 4, 2026, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
10

Registry details

Key details

Study ID
NCT07230470
Lead sponsor
Universidad Pontificia de Salamanca
Responsible party
Jorge Velazquez (PhD. Physiotherapy, Universidad Pontificia de Salamanca) — Principal investigator
First posted
Nov 17, 2025
Start date
Dec 9, 2025
Primary completion
Feb 25, 2026
Completion
Jun 20, 2026 (estimated)
Last update
May 4, 2026

Study contacts

Jorge V Velázquez Saornil, PhD.
Contact
jvelazquezsa@upsa.es
655909940

Oversight

Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

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