Leukemia, B-Cell clinical trials
The registry lists 190 studies for Leukemia, B-Cell across more than 10 countries. 52 are recruiting or about to start. 81 of them are mainly about Leukemia, B-Cell (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its narrower condition Leukemia, Lymphocytic, Chronic, B-Cell too: 2,164 studies, 274 open.
Get an email when these change. Save the Leukemia, B-Cell studies recruiting or about to start — once a week, free: studies that open, close, add sites or post results.
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Example · made-up studies
Breast cancer · Recruiting: 2 came in, 3 changed
What changed in your saved searches, Oct 31 – Nov 6:
A study of drug A after surgery for early breast cancer
Came in · now Recruiting
Drug B with hormone therapy in advanced breast cancer
Changed
· Sites: 4 added, including Seoul and Busan
· Enrollment: 300 → 450 participants
Exercise during chemotherapy
Now Active, not recruiting
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Status
Who runs them
GlaxoSmithKline (7) · AstraZeneca (7) · German CLL Study Group (6) · National Heart, Lung, and Blood Institute (NHLBI) (6) · Pharmacyclics LLC. (4) · Baylor College of Medicine (4) · National Cancer Institute (NCI) (4) · Novartis Pharmaceuticals (4)
What is being tested here
Drugs under test in Leukemia, B-Cell studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Drug classes tested here Tyrosine kinase inhibitors (TKIs) 8 open · Alkylating agents 1 open · Antimitotic agents 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Apr 2027Study of Acalabrutinib (ACP-196) in Combination With Venetoclax (ABT-199), With and Without Obinutuzumab (GA101) Versus Chemoimmunotherapy for Previously Untreated CLL · Phase 3 · Acerta Pharma BV
- Sep 2027Ibrutinib Monotherapy Versus Fixed-duration Venetoclax Plus Obinutuzumab Versus Fixed-duration Ibrutinib Plus Venetoclax in Patients With Previously Untreated Chronic Lymphocytic Leukaemia (CLL) · Phase 3 · German CLL Study Group
- Oct 2027A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL) · Phase 3 · Loxo Oncology, Inc.
- Nov 2026A Study of MGD024 in Patients With Relapsed or Refractory Hematologic Malignancies · MacroGenics
- Dec 2026CD19-targeted CAR T Cell Autotransfusion for the Treatment of Recurrent/Refractory B-cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma in Children With CD19+ · Zhu Xiaofan
- Dec 2026HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis · Center for International Blood and Marrow Transplant Research
- Jan 2027U96-CAR-T-Cells For R/R B-ALL · The First Affiliated Hospital of Soochow University
- Jan 2027CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and Lymphoma · Affiliated Hospital to Academy of Military Medical Sciences
- Feb 2027Sequential Regimen of Bendamustine Followed by Obinutuzumab (GA101), Zanubrutinib (BGB-3111) and Venetoclax (ABT-199) in Patients With Relapsed/Refractory CLL · German CLL Study Group
- Feb 2027Reticulocyte Parameters as Early Indicators of Bone Marrow Erythropoietic Activity in Chronic B Lymphoproliferative Neoplasms · Huda Ahmed Abdelsabour Abdelwahab
Who these studies take
Of the 39 Leukemia, B-Cell studies recruiting now, 18 (46%) set no upper age limit and 16 (41%) stop at 75 or younger. 16 (41%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (3%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 14 (36%) | 14 (36%) |
| 18 | 39 (100%) | 39 (100%) |
| 30 | 33 (85%) | 33 (85%) |
| 40 | 32 (82%) | 32 (82%) |
| 50 | 32 (82%) | 32 (82%) |
| 65 | 32 (82%) | 32 (82%) |
| 75 | 30 (77%) | 30 (77%) |
| 85 | 22 (56%) | 22 (56%) |
Across all 190 studies, recruiting or not: 34% stop at 75 or younger and 14% at 65; 36% take children; 0% are for women only and 0% for men only; 3% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leukemia, B-Cell studies take
Of 32 phase 1 interventional studies under Leukemia, B-Cell, half reached primary completion within 61 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 61 mo33–119 · 32 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Started recruiting2
Studies
Recruiting first, then most recently updated. Showing 50 of 190. Browse all 190 → or search them.
- Natural History Study of Monoclonal B Cell Lymphocytosis (MBL), Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL), Lymphoplasmacytic Lymphoma (LPL)/Waldenstrom Macroglobulinemia (WM), and Splenic Marginal Zone Lymphoma (SMZL)RecruitingNCT009235071 country
- A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006)RecruitingNCT07709000Phase 23 countries
- ROCKET-CLL Global Phase 3 Study: Rocbrutinib vs Pirtobrutinib in cBTKi-Pretreated R/R CLL/SLLRecruitingNCT07342478Phase 31 country
- Epcoritamab as Consolidation Therapy for High-Risk Pts w/CLL on BTKINot yet recruitingNCT07819214Phase 21 country
- Gene Therapy Follow-up Protocol for People Previously Enrolled in CAR-T Cell StudiesEnrolling by invitationNCT024737571 country
- CAR-T Immunotherapy Targeting CD19- ALLNot yet recruitingNCT04016129Phase 1/21 country
- A Multi-site Study to Evaluate the Persistence of Protective Immunity to Routine Childhood Vaccinations in Participants With B-ALL/Ly Who Have Received BlinatumomabRecruitingNCT074223371 country
- A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell MalignanciesRecruitingNCT06564038Phase 1/213 countries
- Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)RecruitingNCT04728893Phase 222 countries
- A Trial to Evaluate the Efficacy and Safety of a Fitness-adapted Thera-py Approach With Either Continuous Zanubrutinib Monotherapy or Time-limited Zanubrutinib + Sonrotoclax in Older and/or Frail Patients With Treatment-naïve CLLNot yet recruitingNCT07899398Phase 2
- CD19/CD22 Bicistronic Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell MalignanciesRecruitingNCT05442515Phase 1/21 country
- CLIC-2201 for the Treatment of Relapsed/Refractory B Cell MalignanciesRecruitingNCT06208735Phase 11 country
- Reassessment of the Risk of Hemolytic Syndrome in Patients With Chronic Lymphocytic Leukemia Treated With a Regimen Containing VenetoclaxRecruitingNCT07691047Not applicable1 country
- Surovatamig as Consolidation Therapy in Participants With Chronic Lymphocytic Leukaemia or Small Lymphocytic Lymphoma With Unmutated Immunoglobulin Heavy Chain Variable (IGHV)RecruitingNCT07509151Phase 35 countries
- A Study to Evaluate Safety, PK, PD and Efficacy of AZD5492, a T Cell-engaging Antibody Targeting CD20 in Subjects With R/R B-Cell Malignancies.RecruitingNCT06542250Phase 1/210 countries
- Acalabrutinib Monotherapy vs Investigator's Choice of Treatment in Patients With CL Leukaemia and Heart FailureRecruitingNCT06651970Phase 46 countries
- Chimeric Antigen Receptor Treatment Targeting CD70 (SEVENTY)RecruitingNCT06345027Phase 11 country
- Study to Characterize Mismatched to Fully HLA-Matched Ossium HPC, Marrow and Living Donor Transplantation in Patients With Hematologic MalignanciesNot yet recruitingNCT07710781Not applicable
- Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United KingdomRecruitingNCT055576951 country
- Trivalent CAR-T Cell in Acute B-Lineage Leukemia (TRICAR-ALL)RecruitingNCT05010564Phase 11 country
- Clonal Dynamics of Chronic Lymphocytic Leukaemia Treated With Pirtobrutinib After Previous Treatment With ZanubrutinibRecruitingNCT06812715Phase 21 country
- Caloric Restriction and Activity to Reduce Chemoresistance in B-ALLRecruitingNCT05082519Phase 21 country
- A Study of Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)RecruitingNCT05254743Phase 323 countries
- Phase I/II Open-label Study Evaluating The Safety And Efficacy of Concomitant Administration of Anti-CD19 CAR T-cell Therapy and Lenalidomide in Refractory/Relapsed Chronic Lymphocytic Leukemia Patients.RecruitingNCT06762431Phase 1/21 country
- A Study of Lonitoclax (ZE50-0134) in Relapsed or Refractory B-cell MalignanciesRecruitingNCT06708897Phase 11 country
- A Study of MRD-Guided Zanubrutinib Plus Sonrotoclax in Treatment-Naïve, High-Risk CLL/SLL PatientsRecruitingNCT07671378Phase 21 country
- Fixed Duration Treatment With Combined Pirtobrutinib and Short Course Immuno-chemotherapy in Fit Patients With Previously Untreated Symptomatic Chronic Lymphocytic Leukemia (CLL).Not yet recruitingNCT07624799Phase 2
- U96-CAR-T-Cells For R/R B-ALLNot yet recruitingNCT07511426Phase 11 country
- The OPAL Study: AVM0703 for Treatment of Lymphoid MalignanciesRecruitingNCT04329728Phase 1/21 country
- CLL-IMPACT: A Clinical Nutrition Trial Investigating Immune and Metabolic Changes in Early-Stage CLLRecruitingNCT07487428Not applicable1 country
- A Platform Protocol to Investigate Post-Transplant Cyclophosphamide-Based Graft-Versus-Host Disease Prophylaxis in Patients With Hematologic Malignancies Undergoing Mismatched Unrelated Donor Peripheral Blood Stem Cell TransplantationRecruitingNCT06859424Phase 21 country
- Transgene Assay Testing Service of Tumor Samples From Patients Who Received a Bristol-Myers Squibb Manufactured Gene Modified Cell Therapy and Have a Qualifying Second Primary MalignancyRecruitingNCT063577544 countries
- Reticulocyte Parameters as Early Indicators of Bone Marrow Erythropoietic Activity in Chronic B Lymphoproliferative NeoplasmsNot yet recruitingNCT07337967
- Bispecific CAR T Cells for B-cell Malignancies (BaseCAR-01 Trial)Not yet recruitingNCT07166549Phase 11 country
- A Phase Ib Study of the Selective PKC-β Inhibitor MS-553 in Patients With Refractory or Relapsed CLL/SLLNot yet recruitingNCT06979076Phase 1/2
- Safety and Feasibility of CD19 CAR T Cells Using CliniMACS Prodigy for Relapsed/Refractory CD19 Positive ALL and NHLNot yet recruitingNCT05779930Early Phase 11 country
- Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic LeukemiaNot yet recruitingNCT07113132
- CAR2219 CAR-T Cells for the Treatment of R/R B Cell Leukemia and LymphomaRecruitingNCT06834529Phase 1/21 country
- Developing a Patient-Reported Outcome (PRO) Screening Measure for Infections and Measuring Quality of Life in Hematological Patients With Secondary Immunodeficiency (SID) Across the Treatment Trajectory - The PRO SID ProjectRecruitingNCT068218802 countries
- CD19-BAFF CAR-T Cells Therapy for Patients With Relapsed / Refractory B-cell ALL and B-cell NHLRecruitingNCT06346912Early Phase 11 country
- CD19-targeted CAR T Cell Autotransfusion for the Treatment of Recurrent/Refractory B-cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma in Children With CD19+RecruitingNCT06355739Not applicable1 country
- INS19 CAR-T Cells for the Treatment of Relapsed or Refractory Acute B Lymphoblastic LeukemiaNot yet recruitingNCT06209671Phase 1
- Precision Exercise in Children With Malignant HemopathiesRecruitingNCT04090268Not applicable1 country
- CD19/CD22-targeted Chimeric Antigen Receptor Engineered T Cell (CART) in B-Cell Acute Lymphoblastic Leukemia.RecruitingNCT03614858Phase 1/21 country
- Evaluation of the Ambulatory Medical Assistance Nurse Program in Chronic Lymphocytic LeukemiaRecruitingNCT05350826Not applicable1 country
- A Study of Novel Anti-CD19 CAR-T in Patients With r/r B-Cell MalignanciesRecruitingNCT05932173Phase 1/21 country
- Allogeneic NK T-Cells Expressing CD19 Specific CAR in B-Cell MalignanciesRecruitingNCT05487651Phase 11 country
- CD19+Targeted CAR-T Cell Therapy for Relapsed/Refractory CD19+ B Cell Leukemia and LymphomaRecruitingNCT04271410Phase 1/21 country
- Allogeneic Hematopoietic Cell Transplantation From HLA-matched Donor After Flu-Mel-PTCy Versus Flu-Mel-ATG Reduced-intensity ConditioningRecruitingNCT03852407Phase 21 country
- Profiling Program of Cancer Patients With Sequential Tumor and Liquid Biopsies (PLANET)RecruitingNCT05099068Not applicable1 country