Drug
ARQ531 clinical trials
Also written Nemtabrutinib, MK-1026 and ARQ 531.
Keep track of what changes. Save the ARQ531 studies recruiting or about to start, and get an email each week — studies that open, close, add sites or post results.
Watch these studiesHow studies write it
Studies that test it under each name
Studies by the year they started
21 studies that test it; most in 2023 (8)
| Year | Studies |
|---|---|
| 2017 | 1 |
| 2021 | 1 |
| 2022 | 1 |
| 2023 | 8 |
| 2024 | 1 |
| 2025 | 1 |
| 2026 | 8 |
By phase
A phase 1/2 study counts in both.
What it is tested for
Each study’s main condition, where its own words name it.
Who runs them
Industry 13 · Other 8
Merck Sharp & Dohme LLC (12) · City of Hope Medical Center (2) · ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) (1) · National Heart, Lung, and Blood Institute (NHLBI) (1) · Medical College of Wisconsin (1) · Jennifer Woyach (1) · Roswell Park Cancer Institute (1) · Fred Hutchinson Cancer Center (1)
Often tested with
Tested in the same studies.
Venetoclax (2) · Rituximab (2) · Obinutuzumab (1) · Pembrolizumab (1) · Lisocabtagene maraleucel (1)
Studies
Open first, then newest update. How each study uses ARQ531 is read from its arms, and is right about nine times in ten.
Testing it · 21
- Nemtabrutinib for Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Leukemia (SLL) Refractory to Covalent Bruton Tyrosine Kinase Inhibitor or Pirtobrutinib and Previously Treated With a BCL2 InhibitorNot yet recruitingPhase 2National Heart, Lung, and Blood Institute (NHLBI)NCT07796373Written as Nemtabrutinib
- A Study of Nemtabrutinib Plus Venetoclax vs Venetoclax + Rituximab (VR) in Second-line (2L) + Relapsed/Refractory (R/R) Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) (MK-1026-010/BELLWAVE-010).RecruitingPhase 3Merck Sharp & Dohme LLCNCT05947851Written as Nemtabrutinib
- Efficacy and Safety of Nemtabrutinib (MK-1026) in Participants With Hematologic Malignancies (MK-1026-003)RecruitingPhase 2Merck Sharp & Dohme LLCNCT04728893Written as Nemtabrutinib
- Nemtabrutinib and Venetoclax for the Treatment of Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic LymphomaRecruitingPhase 2Jennifer WoyachNCT07557056Written as Nemtabrutinib
- A Study of Nemtabrutinib (MK-1026) Versus Comparator (Investigator's Choice of Ibrutinib or Acalabrutinib) in First Line (1L) Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic Lymphoma (SLL) (MK-1026-011/BELLWAVE-011)RecruitingPhase 3Merck Sharp & Dohme LLCNCT06136559Written as Nemtabrutinib
- Nemtabrutinib and Pembrolizumab for the Treatment of Richter Transformation, Diffuse Large B-cell Lymphoma SubtypeRecruitingPhase 2Roswell Park Cancer InstituteNCT06863402Written as Nemtabrutinib
- Non-covalent BTK Inhibitor Nemtabrutinib in Combination With the CD20 Monoclonal Antibody Rituximab for the Treatment of Marginal Zone LymphomaRecruitingPhase 2City of Hope Medical CenterNCT07583810Written as Nemtabrutinib
- A Clinical Trial of Nemtabrutinib in Participants With Severe Kidney Disease (MK-1026-027)RecruitingPhase 1Merck Sharp & Dohme LLCNCT07734610Written as Nemtabrutinib
- Nemtabrutinib and Lisocabtagene Maraleucel for the Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic LymphomaRecruitingPhase 2Fred Hutchinson Cancer CenterNCT07194980Written as Nemtabrutinib
- Nemtabrutinib With CAR T Therapy in Relapsed/Refractory Mantle Cell LymphomaRecruitingPhase 2Vanderbilt-Ingram Cancer CenterNCT07673367Written as Nemtabrutinib
- Nemtabrutinib With Venetoclax and Obinutuzumab in Patients With Chronic Lymphocytic LeukemiaNot yet recruitingPhase 2Medical College of WisconsinNCT07690891Written as Nemtabrutinib
- Nemtabrutinib With Rituximab for the Treatment of Patients With Mantle Cell LymphomaRecruitingPhase 2City of Hope Medical CenterNCT06572618Written as Nemtabrutinib
- A Study of Nemtabrutinib in Participants With Moderate Hepatic Impairment (MK-1026-015)CompletedPhase 1Merck Sharp & Dohme LLCNCT06442436Written as Nemtabrutinib
- A Study of Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)Active, not recruitingPhase 1/2ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA)NCT03162536Written as Nemtabrutinib
- A Clinical Study of Nemtabrutinib in Japanese Participants With Hematological Malignancies (MK-1026-002)CompletedPhase 1Merck Sharp & Dohme LLCNCT05673460Written as Nemtabrutinib
- A Study of Nemtabrutinib (MK-1026) in China Participants With Relapsed or Refractory Hematologic Malignancies (MK-1026-005)Active, not recruitingPhase 1Merck Sharp & Dohme LLCNCT05347225Written as Nemtabrutinib
- A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)Active, not recruitingPhase 3Merck Sharp & Dohme LLCNCT05624554Written as Nemtabrutinib
- A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-017)CompletedPhase 1Merck Sharp & Dohme LLCNCT06772818Written as Nemtabrutinib
- A Study to Evaluate the Effect of Food on Nemtabrutinib (MK-1026) in Healthy Participants (MK-1026-016)CompletedPhase 1Merck Sharp & Dohme LLCNCT06772805Written as Nemtabrutinib
- A Study of the Effect of Nemtabrutinib (MK-1026) on the Plasma Levels of Digoxin in Healthy Participants (MK-1026-012)CompletedPhase 1Merck Sharp & Dohme LLCNCT06625827Written as Nemtabrutinib
See all 21 studies that test ARQ531 →
Given in every arm · 4 — ARQ531 is usual care beside what is tested
- A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies (MK-2140-006)Active, not recruitingPhase 2Merck Sharp & Dohme LLCNCT05458297Written as Nemtabrutinib
- A Study of the Effect of Diltiazem on the Plasma Levels of Nemtabrutinib (MK-1026-022)CompletedPhase 1Merck Sharp & Dohme LLCNCT07232589Written as Nemtabrutinib
- A Study of the Effect of Efavirenz on the Plasma Levels of Nemtabrutinib (MK-1026-014)CompletedPhase 1Merck Sharp & Dohme LLCNCT06698016Written as Nemtabrutinib
- A Study of the Effects of Itraconazole on the Plasma Levels of Nemtabrutinib (MK-1026-013)CompletedPhase 1Merck Sharp & Dohme LLCNCT06688045Written as Nemtabrutinib
Codes
What other systems call ARQ531 · ClinicalTrials.gg INT001794
- MeSH (NLM) C000721068ARQ531One source ClinicalTrials.gov
| System | Code | Name there | Checked by |
|---|---|---|---|
| MeSH (NLM) | C000721068 | ARQ531 | One source ClinicalTrials.gov |
“Confirmed” means two independent publishers link the code to this drug; “one source”, one does and its name agrees.