Leg Injuries clinical trials
The registry lists 65 studies for Leg Injuries across more than 10 countries. 12 are recruiting or about to start. 34 of them are mainly about Leg Injuries (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02. Counting its 16 narrower conditions too, such as Hip Fractures: 2,863 studies, 650 open.
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Who runs them
Georgia Institute of Technology (2) · McGill University Health Centre/Research Institute of the McGill University Health Centre (2) · Major Extremity Trauma Research Consortium (2) · University Hospital, Clermont-Ferrand (2) · Johns Hopkins University (2) · US Department of Veterans Affairs (2) · Karolinska Institutet (2) · Hacettepe University (1)
What is being tested here
Drugs under test in Leg Injuries studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 5, phase 3 first
- Sep 2027PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation · Phase 3 · Major Extremity Trauma Research Consortium
- Apr 2027Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural Artery · Assiut University
- Apr 2027Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures · University of British Columbia
- Jun 2027Improving Walking After a Lower Limb Injury Using a Custom Motorized Orthosis · Kessler Foundation
- Jun 2027Blood Flow Restriction Training After Patellar INStability · Caitlin Conley
Who these studies take
Of the 8 Leg Injuries studies recruiting now, 4 (50%) set no upper age limit and 2 (25%) stop at 75 or younger. 2 (25%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 1 (13%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 8 (100%) | 8 (100%) |
| 30 | 8 (100%) | 8 (100%) |
| 40 | 8 (100%) | 8 (100%) |
| 50 | 7 (88%) | 7 (88%) |
| 65 | 7 (88%) | 7 (88%) |
| 75 | 6 (75%) | 6 (75%) |
| 85 | 4 (50%) | 4 (50%) |
Across all 65 studies, recruiting or not: 51% stop at 75 or younger and 43% at 65; 17% take children; 2% are for women only and 2% for men only; 32% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Leg Injuries studies take
Of 24 interventional studies with no phase under Leg Injuries, half reached primary completion within 27 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 27 mo7–40 · 24 studies | — | — |
| Observational | 30 mo9–37 · 13 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 65. Browse all 65 → or search them.
- Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal InjuriesNot yet recruitingNCT07828613Not applicable1 country
- Accelerated Flap Coverage in Severe Lower Extremity TraumaRecruitingNCT06293469Not applicable4 countries
- PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After FixationRecruitingNCT05699174Phase 31 country
- Blood Flow Restriction Training After Patellar INStabilityRecruitingNCT04554212Not applicable1 country
- IM ABLE 2: Injuries Managed With Advanced Bracing for Lower ExtremitiesRecruitingNCT07721792Not applicable1 country
- Thromboprophylaxis in Lower Limb ImmobilisationRecruitingNCT06370273Phase 31 country
- Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural ArteryNot yet recruitingNCT07453199Not applicable
- Procedural Sedation and Analgesia for Treatment of Adults With Fractures and Dislocations in the Emergency DepartmentRecruitingNCT073144501 country
- Blood Flow Restriction Therapy in Lower Limb Extensor InjuriesRecruitingNCT04149977Not applicable1 country
- Improving Walking After a Lower Limb Injury Using a Custom Motorized OrthosisRecruitingNCT06923293Not applicable1 country
- Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb FracturesNot yet recruitingNCT07103252Not applicable1 country
- Multimodal Analgesia Versus Peripheral Nerve Block for Postoperative Pain Management After Lower Limb Injury SurgeryNot yet recruitingNCT06779968Not applicable1 country
- Straight Leg Raise ContinuationCompletedNCT055687841 country
- Translation and Validation of the Limbs, Pain, Autonomy, Depression, Anxiety and Quality of Life Scales in AlbanianActive, not recruitingNCT066850941 country
- Soft Part Management for Surgical Fractures of the Lower LimbCompletedNCT03915223Not applicable1 country
- Surgery of the Pilon FracturesTerminatedNCT03367169Not applicable1 country
- PRIORITI-MTF Study- Testing Patient Response to the IDEOCompletedNCT02158884Not applicable1 country
- Medico Economic Evaluation of Dermal Substitute Integra® for Coverage of Inferior Limb Traumatic Skin LossCompletedNCT00906672Phase 31 country
- Sensors Prediction StudyCompletedNCT045419921 country
- Post Market Clinical Evaluation of Gamma 4CompletedNCT055236351 country
- Effect of Rapid Heat Stress on Firefighters Musculoskeletal Injury RiskCompletedNCT06442956Not applicable1 country
- Psychologically Informed Education Intervention for Adolescents With Atraumatic Lower-Extremity InjuriesCompletedNCT05701618Not applicable1 country
- Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and MechanicsCompletedNCT05456295Not applicable1 country
- Longitudinal Changes in Achilles Tendon and Medial Gastrocnemius Muscle Architecture During a 156-km Ultradistance Trail Running EventCompletedNCT062973171 country
- Neuromuscular Training to Reduce Sports Injuries Among Children and AdolescentsCompletedNCT01406054Not applicable1 country
- Study on the Functionality, Safety and Reliability of a Robotic Prosthesis for the Lower Limb At the Transfemoral LevelCompletedNCT06284005Not applicable1 country
- Virtual Reality for Pain in Acute Orthopedic InjuriesCompletedNCT05552430Not applicable1 country
- Efficacy of the Most Commonly Used Physiotherapeutic Treatments for Acute Lower Limb Fatigue in AthletesCompletedNCT05167162Not applicable1 country
- Effects of Foot Strengthening on the Incidence of Injuries in Long Distance RunnersCompletedNCT02306148Not applicable1 country
- Percussive Therapy Reduced EMG Activity During Calf Raise in Limbs With and Without Chronic Ankle InstabilityCompletedNCT06343207Not applicable1 country
- Serial Movement Assessment in Collegiate Athletes Who Perform Injury Prevention TrainingCompletedNCT04748718Not applicable1 country
- TRAUMED - a Clinical Trial in Acute Ankle SprainCompletedNCT06192420Phase 31 country
- Oncological and Functional Outcomes in Lower Limb Osteosarcoma Pediatric PatientCompletedNCT061629621 country
- Using Immersive Virtual Reality for Children's Lower Limb RehabilitationCompletedNCT05274152Not applicable1 country
- Clinical Trial Enzyme Application Targeting Venous Leg UlcersCompletedNCT04956900Phase 23 countries
- Electromiographic Analysis of the Quadriceps After TraumaCompletedNCT055745561 country
- Effects of ART® on Lower Limb Myofascial Pain and FunctionCompletedNCT04535635Not applicable1 country
- Block Duration After Spinal Block and iv Dexamethasone.CompletedNCT03527576Phase 41 country
- Antigravity Treadmill With Alter G on the Postural Stability of Traumatic Lower Limb InjuriesStatus unknownNCT05285020Not applicable
- Powered Hip Exoskeleton Assistance StudyCompletedNCT03924752Not applicable1 country
- Assistive Hip Exoskeleton Study for StrokeCompletedNCT03924765Not applicable1 country
- IV Steroids Versus Steroids Included in Block for Orthopedic Lower Limb SurgeryCompletedNCT03855059Early Phase 11 country
- A Prospective Study to Assess the Risk Factors That Contribute to Thrombosis in Patients With Lower Limb Injuries.Status unknownNCT046085911 country
- Dynamic Balance, Flexibility and Agility as Predictors of Lower-extremity Injury in Football PlayersCompletedNCT042325271 country
- Evaluation of Physical Functions in Lower Limb Burn InjuryCompletedNCT04157504Not applicable1 country
- Muscle Quality and Percentage of Fat Following a Lower Limb InjuryStatus unknownNCT035787051 country
- Translation and Psychometric Validation of an Italian Version of the Dance Functional Outcome Survey DFOS-ITCompletedNCT039188761 country
- Effectiveness of a Hydrophobic Dressing for Microorganisms' Colonization and Infection Control of Vascular UlcersStatus unknownNCT03667937Phase 41 country
- Predictive Models for Spine and Lower Extremity Injury After Discharge From RehabCompletedNCT027769301 country
- Comparison of Ropivacaine With or Without Fentanyl in Spinal Anaesthesia for Lower Limb SurgeriesStatus unknownNCT04199013Phase 41 country