Tibial Fractures clinical trials
The registry lists 135 studies for Tibial Fractures across more than 10 countries. 37 are recruiting or about to start. 104 of them are mainly about Tibial Fractures (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-12. Counting its narrower condition Tibial Plateau Fractures too: 164 studies, 48 open.
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Who runs them
AO Clinical Investigation and Publishing Documentation (7) · Wake Forest University Health Sciences (4) · Major Extremity Trauma Research Consortium (3) · Florida Orthopaedic Institute (2) · Hadassah Medical Organization (2) · Denver Health and Hospital Authority (2) · Assiut University (2) · Carmell Therapeutics Corporation (2)
What is being tested here
Drugs under test in Tibial Fractures studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027Intramedullary Calcium Sulfate Antibiotic Depot · Phase 3 · Wake Forest University Health Sciences
- Nov 2026Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Tibial Shaft Fractures · Comeback Mobility Inc
- Dec 2026Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical Trial · Wake Forest University Health Sciences
- Dec 2026Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS® · AO Innovation Translation Center
- Dec 2026Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft Fracture · Tampere University Hospital
- Jan 2027Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary Nailing · University of Alabama at Birmingham
- Apr 2027Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures · University of British Columbia
- Jun 2027Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS) · Major Extremity Trauma Research Consortium
- Jun 2027Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled Trial · Al-Azhar University
- Jun 2027Elastic Nailing With Kirschner Wires Versus Plate Fixation for Distal Tibial Fractures in Adolescents · Sohag University
Who these studies take
Of the 27 Tibial Fractures studies recruiting now, 13 (48%) set no upper age limit and 7 (26%) stop at 75 or younger. 5 (19%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 4 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 4 (15%) | 4 (15%) |
| 18 | 23 (85%) | 23 (85%) |
| 30 | 22 (81%) | 22 (81%) |
| 40 | 22 (81%) | 22 (81%) |
| 50 | 22 (81%) | 22 (81%) |
| 65 | 21 (78%) | 21 (78%) |
| 75 | 20 (74%) | 20 (74%) |
| 85 | 17 (63%) | 17 (63%) |
Across all 135 studies, recruiting or not: 35% stop at 75 or younger and 27% at 65; 23% take children; 0% are for women only and 0% for men only; 11% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Tibial Fractures studies take
Of 39 interventional studies with no phase under Tibial Fractures, half reached primary completion within 45 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 45 mo23–80 · 39 studies | — | — |
| Observational | 41 mo33–62 · 17 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 135. Browse all 135 → or search them.
- Evaluation of the Diagnostic and Therapeutic Value of Tissue Ultrafiltration in Patients at Risk of Acute Compartment Syndrome (ACS)RecruitingNCT05889559Not applicable1 country
- Local Antibiotic Delivery From an Intramedullary Nail After Surgical Treatment of Tibial Fractures at High Risk of InfectionNot yet recruitingNCT07927166Not applicable1 country
- Magnesium-Titanium Hybrid Intramedullary Nail System For Long Bone FracturesNot yet recruitingNCT07569575Not applicable1 country
- Outpatient Floor Pedal Bike UtilizationNot yet recruitingNCT06586190Not applicable
- MY01 Pressure Monitoring in Adolescent Tibia FracturesRecruitingNCT07674043Not applicable1 country
- Intramedullary Calcium Sulfate Antibiotic DepotRecruitingNCT05766670Phase 31 country
- Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled TrialRecruitingNCT07810478Not applicable1 country
- Assessment of the Verus Frame in Tibial Intramedullary NailingRecruitingNCT07362121Not applicable1 country
- Safety, Efficacy, & Use of ViviGen Cellular Bone Matrix Allograft in Orthopaedic Fracture CareRecruitingNCT042990221 country
- Low-cost Negative Pressure Wound Therapy vs Standard Dressings for Gustilo IIIb Tibial Fractures (Bukavu Pilot RCT)Not yet recruitingNCT07790991Not applicable1 country
- Elastic Nailing With Kirschner Wires Versus Plate Fixation for Distal Tibial Fractures in AdolescentsRecruitingNCT07783529Not applicable1 country
- Prophylactic Antibiotic Coated Nail to Prevent Infection: A Clinical TrialRecruitingNCT05421741Phase 41 country
- Robot-Assisted Closed Reduction and Internal Fixation for Extra-Articular Distal Tibial FracturesRecruitingNCT07733271Not applicable1 country
- Comparison of Healing Measures Tibial Fractures Following Standard Intramedullary Nailing or Micromotion Tibial Intramedullary NailingRecruitingNCT06679049Not applicable1 country
- Tibial IMN Vs. Tibial Micromotion IMNRecruitingNCT06976801Not applicable1 country
- Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk FracturesRecruitingNCT06337292Phase 31 country
- Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Tibial Shaft FracturesRecruitingNCT07092579Not applicable1 country
- A Case Series: TRUMATCH Graft Cage for Segmental Long Bone DefectsRecruitingNCT056681821 country
- Conjoint Analysis of Patient Preferences in Joint InterventionsEnrolling by invitationNCT02664337Not applicable1 country
- Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone HealingRecruitingNCT07299851Not applicable1 country
- Zimmer® Natural Nail® (ZNN) Bactiguard Tibia Post-Market Clinical Follow-up StudyRecruitingNCT050224858 countries
- Blood Flow Restriction Training in Patients With Lower Extremity FracturesRecruitingNCT06496035Not applicable1 country
- Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis ToolRecruitingNCT07193524Not applicable1 country
- Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb FracturesNot yet recruitingNCT07103252Not applicable1 country
- Limb Injuries and Post Injury Rehabilitation Trials - Tibial Shaft FractureRecruitingNCT05151926Not applicable1 country
- Effect of Tobacco Heating System (THS) on Closed Lower Limb Fracture HealingRecruitingNCT05859451Not applicable1 country
- Tibio-talo-calcaneal Fusion by Hindfoot Nail Versus Open Reduction and Internal Fixation in Treatment of Complex Fractures Distal Tibial and Fragility Ankle Fractures in ElderlyRecruitingNCT06709365Not applicable1 country
- Prosthesis Versus Osteosynthesis in Proximal Tibia FracturesRecruitingNCT03172715Not applicable1 country
- Management of Closed Diaphyseal Displaced Leg Fractures in Children and AdolescentsRecruitingNCT065037181 country
- Results of Cross-leg Free Vascularized Fibular GraftNot yet recruitingNCT064913161 country
- Knee Osteoarthritis in the Region of NorrbottenRecruitingNCT064515101 country
- Intramedullary Bone Grafting for Open Tibial Shaft FracturesRecruitingNCT03891888Not applicable1 country
- Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?RecruitingNCT05652881Not applicable1 country
- Unreamed Intramedullary Tibial Nailing in Treatment of Open IIIa Diaphyseal Tibial Fractures in AdultsNot yet recruitingNCT06280417
- 3D Planned Surgery of Acute Fractures Performed With 3D Guides Printed at the Point of CareRecruitingNCT05741892Not applicable1 country
- Conservative Versus Intramedullary Nailing for Pediatric Tibial Shaft FracturesNot yet recruitingNCT05501496Not applicable1 country
- Study of Prognostic Factors of the Distal Epiphysis of the Tibia Fracture PrognosisNot yet recruitingNCT02723825Not applicable
- Efficacy of the Use of 3D Printing Models in the Treatment of Tibial Plateau Fractures: a Randomized Clinical TrialCompletedNCT05571449Not applicable1 country
- EFFECT OF TRANEXAMIC ACID ON PERIOPERATIVE BLOOD LOSS IN REAMED INTRAMEDULLARY NAILING OF DIAPHYSEAL FEMORAL AND TIBIAL FRACTURES: A PROSPECTIVE COMPARATIVE STUDYCompletedNCT07625709Not applicable1 country
- Standard Versus Short Course Prophylactic Antibiotic in Femur and Tibia Shaft Fractures Managed With Intramedullary Interlocking NailCompletedNCT07554079Not applicable1 country
- Cancellous Bone Autograft, Bone Substitute, Local Antibiotic, and Fresh Blood for Ununited Fixed Femoral and Tibial FracturesCompletedNCT075617881 country
- Efficacy and Safety of SurgiFill™in Patients With Femur or Tibia FractureTerminatedNCT07518836Not applicable1 country
- Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening SystemTerminatedNCT064007321 country
- Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS®Active, not recruitingNCT041130446 countries
- Depuy Synthes Lower Extremity Shaft Nail RegistryCompletedNCT052726311 country
- Rehabilitation Strategies to Improve Outcomes For Patients With a Lower Extremity FractureCompletedNCT05274022Not applicable1 country
- OIF/β-TCP in Patients With Open Tibial Fractures in Need of Bone GraftingCompletedNCT04960722Not applicable1 country
- Fracture-Related Outcome Study for Operatively Treated Tibia Shaft FracturesActive, not recruitingNCT035985309 countries
- Toddlers Fractures - Cast Versus Removable BootCompletedNCT03971448Not applicable1 country
- Distal Targeter vs Free-handCompletedNCT05613257Not applicable1 country