A Phase 4 interventional study of Dexamethasone and NaCl 0.0308 MEQ/ML Injectable Solution in Postoperative Pain and Lower Limb Injury, sponsored by Eric Albrecht. Completed at 1 site in Switzerland. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2022-07-20.
Sponsored by Eric Albrecht · Phase 4, Interventional, and Treatment
Among 148 studies testing dexamethasone in Pain, Postoperative — 27 open to participants now, 30 under way, 2 of them phase 3. Dexamethasone · Pain, Postoperative.
Among the 148 studies testing dexamethasone in Pain, Postoperative, this one is the 123rd largest by enrollment, is one of 10 that started in 2018, is one of 75 in phase 4, and was the 52nd registered.
5,640 studies on the registry are indexed under Pain, Postoperative; 1,230 are open to participants now.
This study's enrollment of 50 is below the median of 75 across 4,821 interventional studies indexed under Pain, Postoperative.
Browse Pain, Postoperative studies →27 of the 148 studies testing dexamethasone in Pain, Postoperative are open now, in 8 countries. Each count lists the studies.
Dexamethasone: first FDA approval 1958 (DECADRON), first EMA approval 2010. What it is approved for, and how studies give it, is on its page →
Of the 679 Pain, Postoperative studies recruiting now, 241 (35%) set no upper age limit and 328 (48%) stop at 75 or younger; 74 take children under 18; 128 take healthy volunteers.
This study: 18 Years and older · all sexes · no healthy volunteers.
The full table on the hub →148 studies; the count open now beside each. This study's row is marked.
First in 2005; this study’s year is marked. 10 started in 2018.
Median enrollment 89 across the 148 interventional studies. Of the 96 that completed or were terminated, 22 (23%) have results posted.
1 of 148 have an industry lead sponsor. The 10 most frequent:
Eric Albrecht is the lead sponsor of 7 studies on the registry; none are open to participants now.
Eric Albrecht has 3 studies filed under Pain, Postoperative — fewer than ten, so there is no comparison to draw.
11 of the studies testing dexamethasone in Pain, Postoperative that are under way reach primary completion within a year, 2 of them phase 3. Phase 3 first, then by date:
| Study | Primary completion |
|---|---|
| NCT07413055Phase 3Oman Ministry of HealthComparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial | 2026-11-15 |
| NCT07847047Phase 3Assiut UniversitySafety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain Management | 2027-10 |
| NCT07795281Gaziantep City HospitalIntravenous Dexamethasone Added to Dexmedetomidine After Superior Trunk Block | 2026-12 |
| NCT07380139Ain Shams UniversityDexamethasone vs Dexmedetomidine in Sphenopalatine Ganglion Block for Rhinoplasty Pain | 2026-12-01 |
| NCT07672873Marmara UniversityLocal Dexamethasone Administration in Symptomatic Irreversible Pulpitis | 2026-12-15 |
Among the 148 studies testing dexamethasone in Pain, Postoperative, from their registry updates:
It has been largely demonstrated that iv dexamethasone prolongs the duration of analgesia after peripheral nerve block. However, data are missing regarding the duration of analgesia after spinal block. The objective of this randomized controlled double-blinded trial is to assess whether intravenous dexamethasone administered after a spinal block, before the surgery would prolong sensory block characteristics without impacting the motor block duration.
Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.
Exclusion Criteria:
Underlined terms in the criteria open these too. Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
ASA physical status
The anaesthetists’ scale of health before surgery: I is healthy, II has a mild illness that is under control, III a severe one, IV a severe illness that is a constant threat to life. V and VI are used for the critically ill and for organ donors.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Contraindication
A reason a treatment, test or procedure should not be given to a particular person, such as an allergy, another illness or a medicine they take.
Explained by clinicaltrials.gg, not part of the registry record. The study team decides who can take part.
Intravenous injection of 0.15 mg/kg of dexamethasone before the surgery.
Drug: Dexamethasone
Intravenous injection of NaCl 0,9% before the surgery.
Drug: NaCl 0.0308 MEQ/ML Injectable Solution
Intravenous injection of 0.15 mg/kg of dexamethasone before the surgery.
Intravenous injection of NaCl 0.9% before the surgery.
Duration of sensory block (minutes)
Time interval between injection of the local anaesthetic and the regression of 2 dermatoma, compared to the highest dermatoma reached
Time frame: Postoperative day 0
Highest dermatoma reached (level)
Time frame: Postoperative day 0
Onset time between injection and highest dermatoma (minutes)
Time frame: Postoperative day 0
Total duration of the sensory block (minutes)
Time frame: Postoperative day 0
Total duration of the motor block (minutes)
Time frame: Postoperative day 0
Time to the first analgesic request (minutes)
Time frame: Postoperative day 0
Cumulative consumption of morphine (mg)
Time frame: Postoperative days 0, 1 and 2
Pain score
Numeric rating scale (0-10)
Time frame: Postoperative days 0, 1 and 2
Rate of postoperative nausea and vomiting
YES/NO
Time frame: Postoperative day 0, 1 and 2
Rate of pruritus
YES/NO
Time frame: Postoperative day 0, 1 and 2
Rate of urinary retention
YES/NO
Time frame: Postoperative day 1 and 2
Satisfaction level
Numeric rating scale (0-10)
Time frame: Postoperative day 2
Length of stay
Days
Time frame: up to 14 days
Persistent pain
YES/NO
Time frame: 3 and 6 postoperative months
Pain score if persistent pain
Numeric rating scale (0-10)
Time frame: 3 and 6 postoperative months
Plan to share: Undecided
No publications or documents are linked to this record.
Ran from May 2018 to primary completion in Nov 2021, 42 months.
Of 531 non-industry phase 4 interventional studies under Pain, Postoperative, half reached primary completion within 16 months of starting (the median), counting those still running; a quarter within 8 and three quarters within 32. This study's 42 months is above that.
Counting every sponsor, half of 541 studies reached it within 16 months; a quarter within 8 and three quarters within 32.
How these figures are worked out, and which studies are left out of them.
This study is completed, as verified in Jul 2022. You cannot join it, but the record below documents what was studied.
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Studies of the drug tested here: Dexamethasone
Eric Albrecht