Keratoconjunctivitis Sicca clinical trials
The registry lists 85 studies for Keratoconjunctivitis Sicca across more than 10 countries. 1 are recruiting or about to start. 63 of them are mainly about Keratoconjunctivitis Sicca (how this is decided). Per ClinicalTrials.gov, last updated 2026-09-18.
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Who runs them
Oculeve, Inc. (4) · Allergan (4) · Sun Pharmaceutical Industries Limited (4) · Kala Pharmaceuticals, Inc. (3) · Rigel Pharmaceuticals (3) · Mimetogen Pharmaceuticals USA, Inc. (3) · Otsuka Pharmaceutical Development & Commercialization, Inc. (2) · Instituto Universitario de Oftalmobiología Aplicada (Institute of Applied Ophthalmobiology) - IOBA (2)
What is being tested here
Drugs under test in Keratoconjunctivitis Sicca studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Lubricant Eye Drops | 1 | 0 | 2 |
| Fulipiftide | 1 | 0 | 1 |
| Cyclosporine | 0 | 1 | 6 |
| Loteprednol Etabonate | 0 | 2 | 5 |
| Rebamipide | 0 | 2 | 4 |
| Tavilermide | 0 | 3 | 3 |
| Lifitegrast | 0 | 1 | 3 |
| Cyclosporine Ophthalmic Emulsion | 0 | 0 | 3 |
| INV-102 | 0 | 0 | 2 |
| Tivanisiran | 0 | 2 | 2 |
Drug classes tested here Calcineurin inhibitors 7 · Corticosteroids 3
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The study
- Nov 2026A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye Disease · BRIM Biotechnology Inc.
Who these studies take
No Keratoconjunctivitis Sicca study is recruiting now.
Across all 85 studies, recruiting or not: 12% stop at 75 or younger and 7% at 65; 6% take children; 4% are for women only and 0% for men only; 21% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Keratoconjunctivitis Sicca studies take
Of 12 phase 3 interventional studies under Keratoconjunctivitis Sicca, half reached primary completion within 14 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 3 | 14 mo7–18 · 12 studies | — | — |
| Interventional, no phase | 7 mo2–17 · 10 studies | — | — |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
Studies
Recruiting first, then most recently updated. Showing 50 of 85. Browse all 85 → or search them.
- A Dose Regimen Study of BRM421 Ophthalmic Solution in Patients With Dry Eye DiseaseNot yet recruitingNCT07078955Phase 21 country
- Study of INV-102 Ophthalmic Solution in Adults With Moderate Symptomatic Dry Eye DiseaseCompletedNCT05586152Phase 1/21 country
- Study of INV-102 Ophthalmic Solution in Adults With Moderate to Severe Dry Eye DiseaseCompletedNCT06370039Phase 21 country
- Safety Study of Tivanisiran to Treat Dry EyeCompletedNCT05310422Phase 31 country
- Study of Rebamipide Eye Drops to Treat Dry EyeCompletedNCT00201955Phase 31 country
- A 1-Year Study in Multiple Clinics Testing Rebamipide Eye Drops for Dry Eye Compared With a PlaceboCompletedNCT00201981Phase 31 country
- Tolerability and Efficacy Study of Reinnerva/Lubristil+G vs VismedCompletedNCT07422259Not applicable1 country
- Levocarnitine for Dry Eye in Sjogren's SyndromeCompletedNCT03953703Phase 21 country
- Medical vs Acupuncture for Dry EyeCompletedNCT07185854Not applicable1 country
- Vizol S DIGI EYE Efficacy and Safety Study in Patients With Dry EyeCompletedNCT07050446Phase 31 country
- Phase 4 Study Evaluating the Safety of the Nasal Guide With TyrvayaCompletedNCT05918406Phase 41 country
- A Study to Assess the Safety and Efficacy of ECF843 vs Vehicle in Subjects With Dry Eye DiseaseCompletedNCT04391894Phase 21 country
- Sphenopalatine Ganglion Stimulation for Ocular and Oral DrynessCompletedNCT05187533Not applicable1 country
- Goblet Cell Response and Dry Eye Symptoms After PRK and LASIKCompletedNCT00411827Not applicable1 country
- A Randomized Study of Smile Exercise for Dry EyeCompletedNCT04421300Not applicable1 country
- Vizol S Lipid Balance Efficacy and Safety Study in Patients With Dry EyeCompletedNCT06323395Phase 31 country
- Tivanisiran for Dry Eye in Subjects With Sjögren's SyndromeCompletedNCT04819269Phase 32 countries
- Effect of Cequa™ in Subjects With Dry Eye DiseaseCompletedNCT04357795Phase 41 country
- Pilot Study to Investigate the Feasibility, Reliability and Efficacy of Utilizing OCT to Automate PROSE FittingCompletedNCT04649177Not applicable1 country
- Safety, Tolerability, Plug Retention and Preliminary Efficacy of Tacrolimus-loaded Punctal Plug in Patients With Moderate to Severe Dry Eye Disease - Cohort BActive, not recruitingNCT05618730Phase 11 country
- Tavilermide Ophthalmic Solution for the Treatment of Dry EyeCompletedNCT03925727Phase 31 country
- Mesenchymal Stem Cell Therapy of Dry Eye Disease in Patients With Sjögren's SyndromeCompletedNCT04615455Phase 21 country
- Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry EyeCompletedNCT044936581 country
- Intra-Nasal Mechanical Stimulation (INMEST) as a Treatment of Keratoconjunctivitis Sicca (Dry Eye Syndrome)CompletedNCT03418259Not applicable1 country
- Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis SiccaCompletedNCT02688556Phase 31 country
- Phase 2/3 Dose-Ranging Study of the Safety and Efficacy of OTX-101 in the Treatment of Keratoconjunctivitis SiccaCompletedNCT02254265Phase 2/31 country
- Trial of CF101 to Treat Patients With Dry Eye DiseaseCompletedNCT01235234Phase 31 country
- Safety and Efficacy Study of CF101 to Treat Keratoconjunctivitis SiccaCompletedNCT00349466Phase 21 country
- Ocular Manifestations in Rheumatic DiseasesCompletedNCT03753893
- Dose Ranging Study to Assess the Efficacy and Safety of Voclosporin Ophthalmic Solution in Subjects With Dry Eye SyndromeCompletedNCT04147650Phase 2/31 country
- An Open-Label Extension of a Phase 3 Study of OTX-101 in the Treatment of Keratoconjunctivitis SiccaCompletedNCT02845674Phase 3
- Tear Production by Nasal Neurostimulation Compared to Active ControlCompletedNCT02970799Not applicable
- Safety and Efficacy Study of SAR 1118 to Treat Dry Eye Conducted in a Controlled Adverse Environment (CAE) (OPUS-1)CompletedNCT01421498Phase 31 country
- Treatment of Dry Eye Disease Using Pro-ocular™ - A Proof of Concept, Safety, and Efficacy StudyStatus unknownNCT04884217Phase 21 country
- Safety and Efficacy of KPI-121 in Subjects With Dry Eye DiseaseCompletedNCT02813265Phase 31 country
- Safety and Efficacy of KPI-121 in Subjects With Dry Eye DiseaseCompletedNCT02188160Phase 21 country
- Safety and Efficacy of KPI-121 Compared to Placebo in Subjects With Dry Eye DiseaseCompletedNCT02819284Phase 31 country
- A Clinical Study to Assess the Safety and Efficacy of an Ophthalmic Solution (SkQ1) in the Treatment of Dry Eye Syndrome (DES)CompletedNCT02121301Phase 21 country
- Safety and Efficacy of Pimecrolimus Ophthalmic Suspension in Patients With Moderate to Severe Keratoconjunctivitis SiccaCompletedNCT00128245Phase 21 country
- Effects of Dry Eye Treatments on the Ocular SurfaceCompletedNCT01797822Phase 41 country
- Effects of RP101 in Post-menopausal Women With Dry Eye SyndromeCompletedNCT03821415Phase 23 countries
- Lotemax® Gel 0.5% and Restasis 0.05% in Participants With Mild or Moderate Keratoconjunctivitis Sicca (Dry Eye Disease)CompletedNCT01817582Phase 21 country
- A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry EyeCompletedNCT02634853Phase 31 country
- A Safety and Efficacy Study of Tavilermide (MIM-D3) Ophthalmic Solution for the Treatment of Dry Eye DiseaseCompletedNCT02665234Phase 31 country
- Tear Lipid Layer Thickness Changes With Use of Emollient and Non-Emollient Eye DropsCompletedNCT03706443Not applicable1 country
- Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye DiseaseWithdrawnNCT03408015Phase 4
- A Study to Evaluate the Safety and Effectiveness of Oculeve Intranasal Lacrimal Neurostimulator in Participants With Dry Eye SyndromeCompletedNCT02680158Not applicable1 country
- A Safety and Efficacy Study of OPTIVE FUSION™ With VISMED® Multi for the Management of Dry EyeCompletedNCT02117687Phase 42 countries
- Repository Corticotropin Injection in Keratoconjunctivitis SiccaWithdrawnNCT03398018Phase 41 country
- A Study Of Tasocitinib In Dry Eye SubjectsWithdrawnNCT01226680Phase 2