Intracranial Arteriosclerosis clinical trials
The registry lists 102 studies for Intracranial Arteriosclerosis across more than 10 countries. 48 are recruiting or about to start. 53 of them are mainly about Intracranial Arteriosclerosis (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10. Counting its 2 narrower conditions too, such as Dementia, Vascular: 315 studies, 108 open.
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Who runs them
Xuanwu Hospital, Beijing (6) · Chinese University of Hong Kong (5) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Can Tho Stroke International Services Hospital (3) · Peking Union Medical College Hospital (3) · Acotec Scientific Co., Ltd (2) · Beijing Tiantan Hospital (2) · Second Affiliated Hospital, School of Medicine, Zhejiang University (2)
What is being tested here
Drugs under test in Intracranial Arteriosclerosis studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Recaticimab | 3 | 0 | 3 |
| Rivaroxaban | 2 | 3 | 3 |
| Evolocumab | 2 | 0 | 3 |
| Aspirin | 1 | 1 | 2 |
| Alirocumab | 1 | 1 | 2 |
| Tocilizumab | 1 | 1 | 1 |
| Butylphthalide | 1 | 0 | 1 |
| Colchicine | 1 | 0 | 1 |
| Probucol | 1 | 0 | 1 |
| PCSK9 Inhibitor | 1 | 0 | 1 |
Drug classes tested here PCSK9 inhibitors 3 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Jan 2027Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular Atherostenosis · Phase 3 · University of Florida
- Oct 2027A Randomized Trial of the Rapamycin Target Eluting Stent for the Treatment of Symptomatic Cerebral Artery Atherosclerotic Disease(TARGET-DREAM) · Phase 3 · MicroPort NeuroTech Co., Ltd.
- Nov 2026A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical Thrombectomy · Changhai Hospital
- Nov 2026Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic Disorders · Research Center of Neurology, Russia
- Dec 2026Plaque Characteristics Predict Recurrent Stroke in MCA Stroke Patients · University Medical Center Ho Chi Minh City (UMC)
- Dec 2026Digital Secondary Prevention After Atherosclerotic Cardiovascular Disease · Vestre Viken Hospital Trust
- Dec 2026Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential · Chinese University of Hong Kong
- Dec 2026Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography · Chinese University of Hong Kong
- Dec 2026Tanhuo Decoction for Acute Coronary Syndrome With Cerebral Atherosclerosis in Elderly Patients · Jinggang Xia, MD
- Dec 2026BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease · Fujian Medical University Union Hospital
Who these studies take
Of the 28 Intracranial Arteriosclerosis studies recruiting now, 11 (39%) set no upper age limit and 1 (4%) stop at 75 or younger. 0 (0%) take children under 18. 0 (0%) are for women only and 0 (0%) for men only; 2 (7%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 0 (0%) | 0 (0%) |
| 18 | 20 (71%) | 20 (71%) |
| 30 | 24 (86%) | 24 (86%) |
| 40 | 27 (96%) | 27 (96%) |
| 50 | 28 (100%) | 28 (100%) |
| 65 | 28 (100%) | 28 (100%) |
| 75 | 28 (100%) | 28 (100%) |
| 85 | 17 (61%) | 17 (61%) |
Across all 102 studies, recruiting or not: 13% stop at 75 or younger and 3% at 65; 4% take children; 0% are for women only and 1% for men only; 7% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
What changed recently
From the registry's own updates since Oct 14, 2026.
Newly registered2
- Integrated PET/MR Assessment of Brain Recovery After Recanalization of Non-Acute Atherosclerotic MCA OcclusionNov 10, 2026NCT07927569
- Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic DisordersNov 6, 2026NCT07923240
Studies
Recruiting first, then most recently updated. Showing 50 of 102. Browse all 102 → or search them.
- Integrated PET/MR Assessment of Brain Recovery After Recanalization of Non-Acute Atherosclerotic MCA OcclusionRecruitingNCT079275691 country
- EDAS Revascularization for Symptomatic Intracranial Atherosclerotic Steno-occlusive DiseaseNot yet recruitingNCT07864649Not applicable
- BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic DiseaseRecruitingNCT068814201 country
- Efficacy and Safety Study of Digital Cognitive Training and PCSK9 Inhibitor-Enhanced Lipid-lowering Strategy in Patients With Intracranial Atherosclerotic Stenosis: A 2x2 Factorial, Randomized, Parallel-Group, Multicenter TrialNot yet recruitingNCT07605130Phase 41 country
- RESCUE: PCSK9 Inhibitors for Carotid Vulnerable Plaque RemodelingNot yet recruitingNCT07819643Phase 4
- High-resolution Magnetic Resonance Imaging of Intracranial Atherosclerotic Plaques in Ischemic StrokeRecruitingNCT058976451 country
- Moderate Versus Intensive Lipid-lowering for Events in Asymptomatic Intracranial StenosisNot yet recruitingNCT07791823Not applicable1 country
- Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe (CATIS- ICAS)Not yet recruitingNCT07468448Phase 3
- Plaque Characteristics Predict Recurrent Stroke in MCA Stroke PatientsRecruitingNCT064042421 country
- Colchicine Use in Intracranial Atherosclerotic DiseaseRecruitingNCT05503225Phase 21 country
- Drug Eluting Stenting and Aggressive Medical Treatment for Preventing Recurrent Stroke in Intracranial Atherosclerotic Disease TrialRecruitingNCT04948749Not applicable1 country
- PCSK9 Inhibitor for Intracranial Atherosclerosis Related Acute Ischemic StrokeNot yet recruitingNCT07466251Phase 41 country
- PCSK9 Inhibitor With Statin Therapy for Asymptomatic Intracranial AtherosclerosisRecruitingNCT06902740Phase 41 country
- The Effect of InTensive Statin in Ischemic Stroke With inTracranial Atherosclerotic PlaquesRecruitingNCT03753555Phase 41 country
- Tanhuo Decoction for Acute Coronary Syndrome With Cerebral Atherosclerosis in Elderly PatientsNot yet recruitingNCT07445581Not applicable1 country
- Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational AngiographyRecruitingNCT032957731 country
- CUHK Stroke BiobankRecruitingNCT032913921 country
- Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic PotentialRecruitingNCT032916521 country
- The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Symptomatic Intracranial Atherosclerotic StenosisRecruitingNCT05757505Not applicable1 country
- MPR for Stroke Risk Assessment of ICASRecruitingNCT073097181 country
- Role of GLP1 RA Dulaglutide on Severe Intracranial AtherosclerosisRecruitingNCT07282041Phase 2/31 country
- IntraCranial Atherosclerosis Related Large-vessel Occlusion Treated With Urgent Stenting (ICARUS)RecruitingNCT06472336Not applicable1 country
- Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy in Symptomatic ICADRecruitingNCT06714526Not applicable1 country
- Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Artery Stenosis Patients: A Cohort StudyRecruitingNCT063361741 country
- Interleukin-6 Receptor Inhibition for Symptomatic Intracranial AtherosclerosisNot yet recruitingNCT06447701Phase 3
- Stenting for Ischemic Strokes Secondary to Medically Refractory Intracranial Atherosclerotic DiseaseNot yet recruitingNCT067901471 country
- A Randomized Trial of the Rapamycin Target Eluting Stent for the Treatment of Symptomatic Cerebral Artery Atherosclerotic Disease(TARGET-DREAM)Not yet recruitingNCT06925971Phase 31 country
- A Registry Study of Intracranial Atherosclerotic Stenosis Treatment by Intracranial Drug-eluting Stenting in ChinaRecruitingNCT05692882Not applicable1 country
- A Randomized Clinical Trial on Urgent Angioplasty for IntraCranial Atherosclerotic Stenosis-related Large-Vessel Occlusion After Mechanical ThrombectomyNot yet recruitingNCT06702657Not applicable
- Digital Secondary Prevention After Atherosclerotic Cardiovascular DiseaseRecruitingNCT06738381Not applicable1 country
- ICAS Screen Based on RICRecruitingNCT066105781 country
- Balloon-expandable DES for ICAS Registry Study (BDES-ICAS Registry)Not yet recruitingNCT06614972
- ACOART Intracranial ISR Pilot:Intracranial DCB in the Treatment of Intracranial In-stent RestenosisRecruitingNCT04627870Not applicable1 country
- Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort StudyNot yet recruitingNCT064532522 countries
- Feedback Loop Between Intracranial Atherosclerosis and Cerebral Small Vessel DiseaseRecruitingNCT056776071 country
- Pair Antiplatelet THerapy in Ischemic Stroke With Intracranial Artery StenosisNot yet recruitingNCT06243133Phase 41 country
- Efficacy of Butylphthalide on Symptomatic Atherosclerotic Stenosis in Middle Cerebral ArteryNot yet recruitingNCT06331494Not applicable1 country
- Combination of Antiplatelet and Anticoagulation for AIS Patients Witn Concomitant NVAF and Extracranial/Intracranial Artery StenosisRecruitingNCT06058130Not applicable1 country
- Effects of Medical Treatment of ICAS With Hemodynamic Disorders Based on MR-FFRRecruitingNCT061963981 country
- Anticoagulation Using Rivaroxaban on Top of Aspirin in Intracranial Atherosclerotic StenosisNot yet recruitingNCT05700266Phase 2/3
- Extra Alirocumab in Addition to Statin Therapy in Asymptomatic Intracranial Atherosclerotic Stenosis (EAST-aICAS)Not yet recruitingNCT06080256Phase 31 country
- High-Resolution Assessment of Extracranial Plaques in a Multiple Centers Evolocumab Randomized StudyRecruitingNCT05585151Phase 41 country
- IntraCranial Angiography-derived Fraction Flow-guided Percutaneous Transluminal Angioplasty and Stenting Versus Medical Therapy (ICAS-MT)Not yet recruitingNCT05974033Not applicable
- Remote Ischemic Conditioning Combined With Endovascular Stenting for Symptomatic Intracranial Atherosclerotic StenosisNot yet recruitingNCT056535051 country
- The Efficacy and Safety of Intracranial Stent (Tonbridge) in Endovascular Treatment of Intracranial Atherosclerotic StenosisNot yet recruitingNCT05593224Not applicable1 country
- Optical Coherence Tomography for Intracranial Atherosclerotic StenosisRecruitingNCT055500771 country
- Change of Hemodynamics and Cerebral Functions After Carotid Artery RevascularizationRecruitingNCT055397811 country
- Coexistence of Cerebral and Coronary Atherosclerosis in Acute Ischemic Cerebrovascular Disease Patients RegistryRecruitingNCT037885121 country
- Comparison of Anti-coagulation and Anti-Platelet Therapies for Intracranial Vascular AtherostenosisActive, not recruitingNCT05047172Phase 31 country
- Effects of Sequential Therapy With Mexidol® (Intravenous) and Mexidol® FORTE 250 (Oral) on Functional Brain Activity Assessed by Functional Magnetic Resonance Imaging and Biochemical Parameters in Patients With Chronic Cerebral Ischemia: A Comparison of Patients With and Without Metabolic DisordersActive, not recruitingNCT07923240Phase 41 country