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Not yet recruitingNCT06453252Updated Jul 10, 2024

Predictors of Intracranial Atherosclerotic Disease in Posterior Circulation: a Cohort Study

An observational study in Stroke, Ischemic, Intracranial Atherosclerosis and Posterior Circulation Brain Infarction, sponsored by Sohag University. Not yet recruiting at 2 sites in 2 countries. Open to participants aged 18 Years and older. Per ClinicalTrials.gov, last updated 2024-07-10.

Sponsored by Sohag University · Observational

From the registry’s dates

  • Primary completion was expected by Jun 2025, 1 year 5 months ago, but the record still lists the study as not yet recruiting.
Study type
Observational
Model
Cohort
Time perspective
Retrospective
Enrollment
150
Ages
18 Years and older
Sex
All
01

Study summary

Early identification of intracranial atherosclerotic disease (ICAD) may impact the management of patients undergoing mechanical thrombectomy (MT). The aim of the study is to develop and validate a scoring system for pre-thrombectomy diagnosis of ICAD in posterior circulation large vessel/distal medium vessel occlusion strokes (LVOs/DMVOs).

02

Conditions studied

  • Stroke, Ischemic
  • Intracranial Atherosclerosis
  • Posterior Circulation Brain Infarction
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In context

Ischemic Stroke

2,612 studies on the registry are indexed under Ischemic Stroke; 971 are open to participants now.

This study's planned enrollment of 150 is below the median of 300 across 771 observational studies indexed under Ischemic Stroke.

Browse Ischemic Stroke studies →

Lead sponsor

Sohag University is the lead sponsor of 1,230 studies on the registry; 636 are open to participants now.

Counted across the registry records on this site, refreshed daily.

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Who can participate

Ages eligible
18 Years and older
Sexes eligible
All
Accepts healthy volunteers
No
Sampling method
Non-probability sample

Study population

The cohort is divided into 2 groups;

  1. ICAD-related stroke made when a smooth-bordered lesions leading to delayed perfusion on conventional-angiography (without competing stroke etiology) or when irregular-surfaced lesions involving the target vessel during mechanical thrombectomy were unveiled (with or without competing stroke etiology).
  2. Non-ICAD cases (controls) includes patients with posterior circulation stroke attributed to stroke etiologies other than ICAD.

Go through the criteria one by one — yes, no or not sure — and take the list to your doctor or the study team. Kept in this browser only.

Inclusion criteria

  1. Adult ≥18 years
  2. Patient with posterior circulation strokes who underwent mechanical thrombectomy.

Exclusion criteria

Exclusion Criteria:

  1. Patients with anterior circulation stroke.
  2. Patients with intracranial hemorrhage
  3. Patients without baseline radiological data.
  4. Extracranial large vessel atherosclerosis related strokes.
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Study design

Observational model
Cohort
Time perspective
Retrospective
Enrollment
150 participants (estimated)
Patient registry
No

Groups and cohorts

  • ICAD group

    includes ICAD-related stroke made when a smooth-bordered lesions leading to delayed perfusion on conventional-angiography (without competing stroke etiology) or when irregular-surfaced lesions involving the target vessel during mechanical thrombectomy were unveiled (with or without competing stroke etiology).

    Other: we are aiming to develop a Scoring system based on certain variables derived from both groups

  • Non-ICAD cases (controls)

    Non-ICAD cases (controls) includes patients with posterior circulation stroke attributed to stroke etiologies other than ICAD.

    Other: we are aiming to develop a Scoring system based on certain variables derived from both groups

Interventions

  • Otherwe are aiming to develop a Scoring system based on certain variables derived from both groups

    We are aiming to develop a Scoring system based on certain variables derived from both group

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What researchers measure

Primary outcomes

  1. Post-procedural outcomes included any intracranial hemorrhage, symptomatic ICH (sICH)

    sICH is defined as local or remote parenchymal hemorrhage type 2, subarachnoid hemorrhage, and/or intraventricular hemorrhage, combined with a neurological deterioration of 4 points or more on the NIHSS from baseline or leading to death that the physician judged was causative of the deterioration) per ECASS III criteria

    Time frame: June 1st, 2025

Secondary outcomes

  1. 90 day modified Rankin scale (mRS)

    a score of 0 to 4 on the modified Rankin scale (range, 0 to 6, with a score of 0 indicating no disability, 4 moderately severe disability, and 6 death) at 90 days, was changed to a good functional status (a modified Rankin scale score of 0 to 3, with a score of 3 indicating moderate disability)

    Time frame: June 1st, 2025

  2. 90 day mortality

    Time frame: June 1st, 2025

07

Study locations

2 sites
  • Marcus stroke and neuroscience center, Grady Memorial Hospital
    Atlanta, Georgia 30303, United States
    • Diogo C Haussen, MD · Contactdiogo.haussen@emory.edu · 786-280-2098
    • Mohamed A Tarek, MD,MSc · Sub investigator
  • Sohag university hospitals
    Sohag, 82524, Egypt
    • Mohamed A Tarek, MD, MSc · Contactm.a.tarek91@gmail.com · +201011400632
    • Mohamed A Tarek, MD,MSc · Principal investigator
    • Mohamed Abdelmoneim Sayed, MD,MSc,PhD · Sub investigator
    • Hazem Kamal Ibrahim, MD,MSc,PhD · Sub investigator
    • Ahmed Borai Ahmed Mahran, MD,MSc,PhD · Sub investigator
08

References and documents

Individual participant data

Plan to share: Undecided

No publications or documents are linked to this record.

09

Updates

Tracking since Sep 25, 2026
No changes since tracking began. The registry record was last updated on Jul 10, 2024, before this site started recording changes on Sep 25, 2026. Its history is on ClinicalTrials.gov ↗
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Registry details

Key details

Study ID
NCT06453252
Lead sponsor
Sohag University
Collaborators
Emory University
Responsible party
Mohamed Ahmed Tarek,MD,MSc (Assistant lecturer of Neurology, Sohag University) — Principal investigator
First posted
Jun 11, 2024
Start date
Aug 1, 2024 (estimated)
Primary completion
Jun 1, 2025 (estimated)
Completion
Jun 30, 2026 (estimated)
Last update
Jul 10, 2024

Oversight

Data monitoring committee
No
FDA-regulated drug
Yes
FDA-regulated device
No
View the source record on ClinicalTrials.gov ↗

Not currently enrolling

This study is not yet recruiting, as verified in Jul 2024. You cannot join it, but the record below documents what was studied.

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