An observational study in Stroke, Intracranial Atherosclerosis and High Resolution Magnetic Resonance Imaging, sponsored by General Hospital of Shenyang Military Region. Recruiting at 1 site in China. Open to participants aged 40 Years and older. Per ClinicalTrials.gov, last updated 2026-09-11.
Sponsored by General Hospital of Shenyang Military Region · Observational
Intracranial atherosclerotic disease is the most common cause of ischemic stroke in Asia, also in China. Currently, despite vascular recanalization therapy, statins are one of the main drug choices for treating atherosclerotic plaque. High resolution magnetic resonance imaging (HRMRI) can accurately assess the status of intracranial and extracranial arterial plaque, and has high consistency with histopathology. Thus, HRMRI technology has been widely used to monitor the efficacy of drug treatment for atherosclerotic plaque in clinical trials or practice.
As a non-invasive technique, HRMRI make it possible to assess the morphologic characteristics of vascular wall and plaque composition of intracranial artery in vivo. It can quantitative analysis including components such as lipid-rich necrotic core, fiber cap thickness, intra-plaque hemorrhage, calcification, etc. Therefore, it is crucial for evaluating the etiology of ischemic stroke and developing secondary prevention strategies.
At present, there is a lack of large-scale and prospective study to evaluate the etiology of ischemic stroke including cryptogenic stroke based on HRMRI. In this context, this study aims to establish a multi center HRMRI database of intracranial arteries among Chinese patients with ischemic stroke.
patients with ischemic stroke who performed HRMRI
Exclusion Criteria:
collect clinical date, assess the morphologic characteristics of plaque
Recurrence of stroke
including ischemic or hemorrhagic stroke
Time frame: 360 days
Recurrence of stroke
including ischemic or hemorrhagic stroke
Time frame: 90 days, 180 days
the composite events of cardiovascular events
Cardiovascular events include cardiovascular death, stroke, non-fatal myocardial infarction, and arterial revascularization
Time frame: 90 days, 180 days, 360 days
distribution of modified Rankin Scale (mRS) score
mRS score range from 0 to 6: 0 \[no symptoms\] to 6 \[death\]
Time frame: 90 days, 180 days 360 days
The relationship between characteristics of intracranial plaques and functional independence
characteristics of intracranial plaques includes plaque composition, location and morphology; functional independence is defined as modified Rankin Scale (mRS) score 0-1 (mRS score range from 0 to 6: 0 \[no symptoms\] to 6 \[death\])
Time frame: 90 days, 180 days, 360 days
The relationship between burden of cerebral small vessel disease and functional independence
burden of cerebral small vessel disease ranges from 0 to 4, with higher scores indicating greater burden; functional independence is defined as modified Rankin Scale (mRS) score 0-1 (mRS score range from 0 to 6: 0 \[no symptoms\] to 6 \[death\])
Time frame: 90 days, 180 days, 360 days
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General Hospital of Shenyang Military Region