Hypospadias clinical trials
The registry lists 123 studies for Hypospadias across more than 10 countries. 34 are recruiting or about to start. 104 of them are mainly about Hypospadias (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-02.
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Who runs them
Assiut University (8) · Tanta University (6) · Ain Shams University (6) · Yonsei University (5) · Sohag University (4) · Hospices Civils de Lyon (3) · Cairo University (3) · Mansoura University (3)
What is being tested here
Drugs under test in Hypospadias studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
| Drug | Open | Phase 3 | All |
|---|---|---|---|
| Dexmedetomidine | 1 | 0 | 4 |
| Oxybutynin | 1 | 0 | 1 |
| Oxygen | 1 | 0 | 1 |
| Esketamine | 1 | 0 | 1 |
| Ropivacaine | 1 | 0 | 1 |
| Ketamine | 1 | 0 | 1 |
| Magnesium Sulfate | 1 | 0 | 1 |
| Bupivacaine | 0 | 1 | 3 |
| Dexamethasone | 0 | 0 | 1 |
| Prednisolone | 0 | 0 | 1 |
Drug classes tested here Local anesthetics 1 open
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
All 7
- Nov 2026Worldwide Yearly Screening for Hypospadias · University of Wisconsin, Madison
- Nov 2026Breaking Silence Through Story: A Narrative Medicine Intervention for Parents of Children With Urogenital Conditions · Sarah Schlegel
- Apr 2027Microsurgical Single Versus Double Dartos Flap in Distal Hypospadias Repair · Tanta University
- Aug 2027Efficacy of PRF in Hypospadias Repair · Ain Shams University
- Sep 2027A Multimodal Study of the Relationship Between Exposure to Endocrine Disruptors and Occurrence of Hypospadias - HYPOLLUT · University Hospital, Montpellier
- Nov 2027Urethral Mobilisation Versus Mathieu Technique for Repair of Distal Hypospadias · Assiut University
- Nov 2027Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in Hypospadias · The Children's Hospital of Zhejiang University School of Medicine
Who these studies take
Of the 20 Hypospadias studies recruiting now, 4 (20%) set no upper age limit and 16 (80%) stop at 75 or younger. 18 (90%) take children under 18. 0 (0%) are for women only and 16 (80%) for men only; 3 (15%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 3 (15%) | 12 (60%) |
| 18 | 4 (20%) | 11 (55%) |
| 30 | 3 (15%) | 5 (25%) |
| 40 | 3 (15%) | 5 (25%) |
| 50 | 3 (15%) | 5 (25%) |
| 65 | 3 (15%) | 5 (25%) |
| 75 | 3 (15%) | 4 (20%) |
| 85 | 3 (15%) | 4 (20%) |
Across all 123 studies, recruiting or not: 83% stop at 75 or younger and 83% at 65; 98% take children; 0% are for women only and 80% for men only; 22% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypospadias studies take
Of 60 interventional studies with no phase under Hypospadias, half reached primary completion within 15 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Interventional, no phase | 15 mo8–39 · 60 studies | — | 15 mo8–39 · 60 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 13, 2026.
Newly registered1
- Effect of Oxybutynin on Opioid Use After Urologic Surgery in ChildrenNov 2, 2026NCT07911137
Studies
Recruiting first, then most recently updated. Showing 50 of 123. Browse all 123 → or search them.
- Effect of Oxybutynin on Opioid Use After Urologic Surgery in ChildrenNot yet recruitingNCT07911137Phase 41 country
- Worldwide Yearly Screening for HypospadiasRecruitingNCT06966375Not applicable1 country
- Emerging Indications for Hyperbaric Oxygen TreatmentNot yet recruitingNCT07240649Phase 4
- Efficacy of PRF in Hypospadias RepairNot yet recruitingNCT07757828Not applicable1 country
- Genetics of Differences of Sex Development and HypospadiasEnrolling by invitationNCT03102554Not applicable1 country
- Microsurgical Single Versus Double Dartos Flap in Distal Hypospadias RepairRecruitingNCT07676916Not applicable1 country
- Effect of Caudal Block on Urethrocutaneous Fistula After Distal Hypospadias RepairRecruitingNCT07675798Not applicable1 country
- Improving Parental Support in Hypospadias CareRecruitingNCT06832280Not applicable1 country
- Comparison of Sacral ESP Block and Caudal Block in Pediatric Hypospadias SurgeryRecruitingNCT07619651Not applicable1 country
- Breaking Silence Through Story: A Narrative Medicine Intervention for Parents of Children With Urogenital ConditionsRecruitingNCT06989593Not applicable1 country
- Urethral Plate Flap vs. Tunica Vaginalis Flap for Residual Severe Ventral Curvature in HypospadiasNot yet recruitingNCT07404722Not applicable1 country
- Fibrin-Enhanced TIP Versus Grafted TIP Urethroplasty in Distal HypospadiasRecruitingNCT07319780Not applicable2 countries
- A Multimodal Study of the Relationship Between Exposure to Endocrine Disruptors and Occurrence of Hypospadias - HYPOLLUTRecruitingNCT066283751 country
- Comparison of Caudal Block and Sacral Erector Spinae Plane Block With Dexmedetomidine in Pediatric Penile Hypospadias RepairNot yet recruitingNCT07197203Phase 3
- Ultrasound Guided Sacral Erector Spinae Plane Block Versus Ultrasound Guided Caudal Block in Pediatric Undergoing Hypospadias SurgeryRecruitingNCT07099560Not applicable1 country
- Is Dorsal Inlay Graft (DIG) With TIP Repair Superior to TIP Alone for Primary Hypospadias?RecruitingNCT07086963Not applicable1 country
- A Multicenter Randomized Controlled Trial Comparing Platelet-Rich Fibrin and Ventral Dartos Flap as Intermediate Layers in Tabularized Incised Plate (TIP) Urethroplasty for Distal Hypospadias With Mild Penile CurvatureEnrolling by invitationNCT07045545Not applicable1 country
- PREDICT-H Study: Prospective Research on Essential Determinants Influencing Complication Trends in Hypospadias - a Landmark Prospective Multicenter Cohort Study Aimed at Improving Outcome Prediction in Hypospadias SurgeryRecruitingNCT070178421 country
- Pearls and Pitfalls in Usage of Plasma-Rich Platelet Graft Versus Dartos Flap in Distal Penile Hypospadias RepairNot yet recruitingNCT06808139Not applicable
- Comparison of the Efficacy of Bupivacaine with and Without Dexmedetomidine As an Adjuvant on Penile Block for Postoperative Pain Relief in Pediatrics Undergoing Hypospadias Repair SurgeryNot yet recruitingNCT06789393Phase 3
- Urethral Mobilisation Versus Mathieu Technique for Repair of Distal HypospadiasNot yet recruitingNCT06705699Not applicable
- Distal Hypospadias Repair OutcomeNot yet recruitingNCT06700629Not applicable1 country
- Hybrid Duckett vs Modified Duckett Urethroplasty for Proximal HypospadiasRecruitingNCT06598215Not applicable1 country
- Graft Versus Flap in Management of Proximal Penile HypospadiasRecruitingNCT06565286Not applicable1 country
- Caudal Anesthesia Versus Local Anesthesia in HypospadiasRecruitingNCT06417060Not applicable3 countries
- Analgesia in Pediatric Hypospadias SurgeriesNot yet recruitingNCT06410482Not applicable
- Snodgrass Versus Grafted Snodgrass Repair in Narrow Urethral Plate in Distal Penile HypospadiasRecruitingNCT06405763Not applicable1 country
- Efficacy of Fibrin Sealant in Hypospadias SurgeryRecruitingNCT05666206Not applicable1 country
- Modified TIP (Snodgrass) Using Interrupted Sutures in HypospadiasNot yet recruitingNCT06180018Not applicable1 country
- Preputial Graft Versus Preputial Flap in Treatment of Proximal Hypospadias With Marked Ventral Curvature (a Comparative Study)RecruitingNCT06165120Not applicable1 country
- Analgesic Effects of Caudal S-ketamine for Supplementation of Ropivacaine Caudal Analgesia in Children With HypospadiasRecruitingNCT05922605Phase 41 country
- Dexmedetomidine, Ketamine and Magnesium Sulphate in Caudal Block for Hypospadias RepairRecruitingNCT05837000Phase 41 country
- Long-term Assesment of Patients Operated for Hypospadias in Their Childhood : Urinary, Aesthetical, Sexual and Psycho-social ConsequencesRecruitingNCT05319782Not applicable1 country
- Urothelium Tissue Engineering Using Biopsies From Transurethral Resection of ProstateNot yet recruitingNCT03698721
- Topography Guided Repair Versus TIP for Distal HypospadiasCompletedNCT07832760Not applicable1 country
- Comparison of Sacral ESP Block and Dorsal Penile Nerve Block in Pediatric Hypospadias SurgeryCompletedNCT07426731Not applicable1 country
- Evaluating the Efficacy and Safety of Tranexamic Acid in Reducing Perioperative Bleeding During Recurrent Hypospadias Repair.Active, not recruitingNCT07778992Not applicable1 country
- Comparison Between Ultrasound Guided Caudal Block and Ultrasound Guided Dorsal Penile Block in Hypospadias Surgery in ChildrenCompletedNCT07615335Not applicable1 country
- Virtual Reality Intervention in Children After Hypospadias SurgeryCompletedNCT07752680Not applicable1 country
- Evaluation of Slit-like Adjusted Mathieu Versus Onlay Island Flap for Hypospadias Repair in PediatricsCompletedNCT07592026Not applicable1 country
- Ultrasound-Guided Pudendal vs Dorsal Penile Nerve Block for Pediatric Hypospadias SurgeryCompletedNCT07575204Not applicable1 country
- Effect of Adding Byar's Flap to Double Dartos Coverage in TIP Urethroplasty for Distal Hypospadias: A Randomized TrialCompletedNCT07525570Not applicable1 country
- USC-Exos in Corpus Spongiosum Reconstruction for HypospadiasCompletedNCT07495176Not applicable1 country
- Multifidus Plane Block Versus Caudal Block for HypospadiasCompletedNCT06561269Not applicable1 country
- Re-operative Hypospadias Repair Using Tubularized Incised Plate UrethroplastyCompletedNCT074247681 country
- Evaluation of the Method and Duration of Urinary Diversion in the Management of Distal Penile Hypospadias Following Surgical Repair.CompletedNCT07421271Not applicable1 country
- Long Term Follow-up for HypospadiasCompletedNCT041426321 country
- Caudal vs Dorsal Penile Nerve Block for Postoperative Analgesia in Children Undergoing Hypospadias Repair (CaD-DPNB)CompletedNCT07306806Not applicable1 country
- Effectiveness of Urethral Stent Irrigation in Preventing Surgical Site Infections in Adolescents With HypospadiasActive, not recruitingNCT06520423Not applicable1 country
- Comparison of Analgesic Efficacy of Sacral Erector Spinae Plane Block and Caudal Epidural Block in Pediatric Patients Undergoing Hypospadias SurgeryCompletedNCT072867861 country