Hypertriglyceridemia clinical trials
The registry lists 324 studies for Hypertriglyceridemia across more than 10 countries. 38 are recruiting or about to start. 198 of them are mainly about Hypertriglyceridemia (how this is decided). Per ClinicalTrials.gov, last updated 2026-11-10.
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Status
Who runs them
AstraZeneca (12) · Ionis Pharmaceuticals, Inc. (10) · Arrowhead Pharmaceuticals (8) · GlaxoSmithKline (7) · Essentialis, Inc. (6) · Abbott (5) · Novartis Pharmaceuticals (5) · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (5)
What is being tested here
Drugs under test in Hypertriglyceridemia studies, those with the most open studies first. Medicines only given beside them are not counted. How drugs are counted
Coming up
Studies recruiting or running, from their records. “Main data collection” ends at the primary completion date, the sponsor’s own estimate, which often moves.
The 10 nearest, phase 3 first
- Mar 2027A Study of SHR-1918 In Participants With Hypertriglyceridemia · Phase 3 · Beijing Suncadia Pharmaceuticals Co., Ltd
- Mar 2027CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG) · Phase 3 · Ionis Pharmaceuticals, Inc.
- Jul 2027Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy · Phase 3 · National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Dec 2026CS-121 APOC3 Base Editing in FCS · CorrectSequence Therapeutics Co., Ltd
- Dec 2026Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein Composition · Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
- Dec 2026MN-001 in Non-alcoholic Fatty Liver Disease, Type 2 Diabetes Mellitus, and Hypertriglyceridemia · MediciNova
- Dec 2026A Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic Plaque · Junbo Ge
- Dec 2026Adding Evolocumab to Conventional Lipid-lowering Therapy for Hypertriglyceridemia Induced Acute Pancreatitis · General Hospital of Shenyang Military Region
- Feb 2027Vitamin C Administration and Triglycerides Level in Critical Care Patients · Meir Medical Center
- Feb 2027First-in-Human Study of ISH0688: Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics · SUNHO(China)BioPharmaceutical CO., Ltd.
Who these studies take
Of the 22 Hypertriglyceridemia studies recruiting now, 9 (41%) set no upper age limit and 12 (55%) stop at 75 or younger. 2 (9%) take children under 18. 2 (9%) are for women only and 0 (0%) for men only; 4 (18%) take healthy volunteers.
| Age | Women | Men |
|---|---|---|
| 10 | 2 (9%) | 1 (5%) |
| 18 | 20 (91%) | 19 (86%) |
| 30 | 22 (100%) | 20 (91%) |
| 40 | 22 (100%) | 20 (91%) |
| 50 | 21 (95%) | 20 (91%) |
| 65 | 20 (91%) | 19 (86%) |
| 75 | 15 (68%) | 14 (64%) |
| 85 | 10 (45%) | 9 (41%) |
Across all 324 studies, recruiting or not: 56% stop at 75 or younger and 26% at 65; 11% take children; 2% are for women only and 2% for men only; 26% take healthy volunteers. From each study’s registry entry; the criteria on its page decide.
How long Hypertriglyceridemia studies take
Of 29 phase 3 interventional studies under Hypertriglyceridemia, half reached primary completion within 24 months of starting, counting those still running.
| Start to primary completion | Every sponsor | Industry | Non-industry |
|---|---|---|---|
| Phase 1 | 20 mo16–28 · 15 studies | — | — |
| Phase 2 | 21 mo10–40 · 23 studies | — | — |
| Phase 3 | 24 mo18–31 · 29 studies | 24 mo18–31 · 28 studies | — |
| Interventional, no phase | 23 mo7–33 · 45 studies | — | 23 mo7–39 · 42 studies |
Each figure is the month by which half the studies had reached primary completion, with the range in which the middle half did. Studies still running count until their last registry update; studies that stopped early are left out. Phase 1 includes early phase 1; observational means prospective or not stated, as retrospective and cross-sectional studies date a window of data rather than a study. How these figures are worked out
What changed recently
From the registry's own updates since Oct 11, 2026.
Stopped1
Newly registered1
Studies
Recruiting first, then most recently updated. Showing 50 of 324. Browse all 324 → or search them.
- Plasma Lipids-Dependent Vitamin E Metabolism During Dynamic HyperlipidemiaNot yet recruitingNCT07715890Not applicable1 country
- Pemafibrate for Symptomatic ICAS RCTRecruitingNCT07562178Not applicable1 country
- Effectiveness and Tolerability of a Treat-to-Target Versus Fixed-Dose Statin Strategy in Patients With Atherosclerotic Cardiovascular DiseaseNot yet recruitingNCT07909915Phase 41 country
- A Study of Solbinsiran (LY3561774) in Participants With Severe HypertriglyceridemiaRecruitingNCT07269210Phase 24 countries
- A Study to Assess the Safety, Tolerability and Efficacy of ION775RecruitingNCT07604974Phase 22 countries
- Phase 1b Study of VERVE-201 in Patients With Refractory HyperlipidemiaRecruitingNCT06451770Phase 16 countries
- Vitamin C Administration and Triglycerides Level in Critical Care PatientsRecruitingNCT062067591 country
- A Phase 2 Study to Evaluate the Efficacy and Safety of DR10624 in Subjects With Moderate Hypertriglyceridemia and Diabetic Kidney DiseaseNot yet recruitingNCT07848880Phase 21 country
- Adding Evolocumab to Conventional Lipid-lowering Therapy for Hypertriglyceridemia Induced Acute PancreatitisRecruitingNCT07388420Not applicable1 country
- Standardized Large Yellow Tea Extract for Glucose and Lipid Metabolism in Overweight Adults With HypertriglyceridemiaNot yet recruitingNCT07840846Not applicable
- Study of Plozasiran in Adults With Severe Hypertriglyceridemia at Risk of Acute PancreatitisRecruitingNCT06880770Phase 327 countries
- A Safety and Tolerability Trial Evaluating CTX310 in Participants With Refractory DyslipidemiasRecruitingNCT07491172Phase 14 countries
- Comparing Two Low-Carbohydrate Diets With a Standard Diet in Type 2 DiabetesNot yet recruitingNCT07801378Not applicable
- Study of MAR001 in Adults With Elevated Triglycerides and Remnant CholesterolRecruitingNCT07028749Phase 24 countries
- Icosapent Ethyl for High-Risk Coronary Plaques Assessed by 18F-NaF PET/CTNot yet recruitingNCT07762755Phase 41 country
- Culturally Adapted Dietary Clinical Trial in PRRecruitingNCT05962372Not applicable1 country
- Cardiovascular-Kidney-Metabolic Syndrome RegistryNot yet recruitingNCT07718789
- A Phase III Study to Evaluate the Efficacy and Safety of of DR10624 in Subjects With Severe HypertriglyceridemiaNot yet recruitingNCT07693777Phase 31 country
- A Phase 3 Trial of DR10624 Versus Placebo in Patients With Severe HypertriglyceridemiaNot yet recruitingNCT07680829Phase 31 country
- CS-121 APOC3 Base Editing in Severe HypertriglyceridemiaNot yet recruitingNCT07657780Early Phase 11 country
- A Trial to Evaluate the Efficacy and Safety of DR10624 in Patients With Hypertriglyceridemia and Carotid Atherosclerotic PlaqueEnrolling by invitationNCT07050134Not applicable1 country
- GLP-1 Agonists for Prevention of Recurrent Hypertriglyceridemic Acute PancreatitisNot yet recruitingNCT07617155Phase 41 country
- Effect of Consuming n-3 Polyunsaturated Fatty Acids Rich Foods on Triglyceride Concentration and Lipoprotein CompositionRecruitingNCT07004777Not applicable1 country
- Russian Extreme Hypertriglyceridemia RegistryRecruitingNCT075089301 country
- First-in-Human Study of ISH0688: Safety, Tolerability, Pharmacokinetics, and PharmacodynamicsNot yet recruitingNCT07505043Phase 11 country
- CS-121 APOC3 Base Editing in FCSRecruitingNCT07176923Early Phase 11 country
- a Phase 1b/2a Study of JMT202 Injection in Participants With HypertriglyceridemiaRecruitingNCT07140809Phase 1/21 country
- A Mechanistic Study of MAR001 in Adults With Elevated Triglycerides and Remnant CholesterolRecruitingNCT07199309Phase 21 country
- Differential Thrombogenesis by EPA and DHA Mediated by HDLRecruitingNCT06494488Early Phase 11 country
- Interest of High-speed Centrifugation for Measuring Anti-Xa Activity on Lipemic PlasmaRecruitingNCT072006741 country
- Phase 2a Study of Safety, Tolerability, and Efficacy of TLC-2716 in Subjects With Hypertriglyceridemia and NAFLDRecruitingNCT06564584Phase 21 country
- Exploring Physical Exercise for the Regulation and Control of Metabolic Disorders in College Students.Not yet recruitingNCT06555159Not applicable1 country
- Effects of Phytoestrogen From Pueraria Mirifica in Improvement of Serum Lipid Parameters in Postmenopausal WomenRecruitingNCT06220266Phase 2/31 country
- A Study on the Effects of Mastiha Oil in Adults With HypertriglyceridemiaNot yet recruitingNCT06323252Not applicable
- Study of the Efficacy and Safety of EPA in Patients With Type-2 DiabetesNot yet recruitingNCT06129526Phase 41 country
- Safety Study of Fenofibrate During PregnancyRecruitingNCT058838651 country
- Abnormal Lipids - Causes and EffectsRecruitingNCT021950501 country
- Impact of Foods on Bile Acids, Metabolites, and InflammationRecruitingNCT05245357Not applicable1 country
- Compassionate Use of Metreleptin in Previously Treated People With Partial LipodystrophyActive, not recruitingNCT02262806Phase 21 country
- Genes Involved in Lipid DisordersCompletedNCT023113351 country
- Compassionate Use of Metreleptin in Previously Treated People With Generalized LipodystrophyActive, not recruitingNCT02262832Phase 31 country
- Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance PhenotypesTerminatedNCT05743868Not applicable1 country
- A Study of SHR-1918 In Participants With HypertriglyceridemiaActive, not recruitingNCT07349615Phase 31 country
- Study of Plozasiran in Adults With Severe HypertriglyceridemiaCompletedNCT06347016Phase 316 countries
- Study of Plozasiran (ARO-APOC3) in Adults With Severe HypertriglyceridemiaCompletedNCT06347003Phase 317 countries
- Long-Term Safety and Efficacy of Plozasiran in Adults With HypertriglyceridemiaActive, not recruitingNCT06822790Phase 324 countries
- Phase 3 Study of Plozasiran in Adults With HypertriglyceridemiaCompletedNCT06347133Phase 315 countries
- Effects of DHA-NAT on Postprandial Lipidaemia in Healthy Male SubjectsCompletedNCT05953064Not applicable1 country
- Phase II Clinical Trial Evaluating the Efficacy and Safety of HRS-7249 and SHR-1918 in Patients With Severe Hypertriglyceridemia at High Risk of Acute PancreatitisActive, not recruitingNCT07308392Phase 21 country
- RBD5044 in Chinese Participants With HypertriglyceridemiaActive, not recruitingNCT07587788Phase 21 country